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GTPγS tetralithium (Alias: Guanosine 5'-[γ-thio]triphosphate tetralithium)

Name: GTPγS tetralithium
Brand: TargetMol
SKU: T82252
Rating: 4.5 (1 reviews)

Catalog No. T82252 Copy Product Info

Purity: 96.04%

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GTPγS tetralithium (Guanosine 5'-[γ-thio]triphosphate tetralithium) is a G-protein activator, a non-hydrolyzable GTP analog that protects proteins from proteolytic degradation.GTPγS tetralithium is involved in the detection of cells expressing recombinant receptors and endogenous receptors. GTPγS tetralithium is involved in the detection of GPCR signaling in cells expressing recombinant receptors as well as in cells and tissues expressing endogenous receptors, and can be assayed to measure agonist-induced desensitization of two human polymorphic α2B-adrenoceptor variants.

GTPγS tetralithium

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Catalog No. T82252

Alias Guanosine 5'-[γ-thio]triphosphate tetralithium

Cas No. 94825-44-2

Pack Size	Price	USA Stock	Global Stock	Quantity
1 mg	$197	35 days	35 days

In stock · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:96.04%

Appearance:Solid

Color:White

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COA

Product Introduction

Bioactivity

Description

Synonyms

Guanosine 5'-[γ-thio]triphosphate tetralithium

Chemical Properties

Molecular Weight	562.98
Formula	C₁₀H₁₂Li₄N₅O₁₃P₃S
Cas No.	94825-44-2
Smiles	O[C@H]1[C@@H](O[C@@H]([C@H]1O)COP(OP(OP([O-])([S-])=O)([O-])=O)([O-])=O)N2C3=C(C(N=C(N3)N)=O)N=C2.[Li+].[Li+].[Li+].[Li+]

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 80 mg/mL (142.1 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	1.7763 mL	8.8813 mL	17.7626 mL	88.8131 mL
5 mM	0.3553 mL	1.7763 mL	3.5525 mL	17.7626 mL
10 mM	0.1776 mL	0.8881 mL	1.7763 mL	8.8813 mL
20 mM	0.0888 mL	0.4441 mL	0.8881 mL	4.4407 mL
50 mM	0.0355 mL	0.1776 mL	0.3553 mL	1.7763 mL
100 mM	0.0178 mL	0.0888 mL	0.1776 mL	0.8881 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc