Ipramidil (C80-1324) reveals marked dilator activity in the coronary circulation of isolated working hearts.

The vasodilator action of Ipramidil on coronary vessels is more potent than that of glyceryl trinitrate (GTN) and appears to be biphasic. The increase in coronary flow caused by furoxans as well as by GTN is blunted upon the confusion of the guanylate cyclase inhibitor methylene blue. NO sign of tachyphylaxis of the vasodilator response is seen upon the repeated or continuous (60 min) application of Ipramidil at a concentration of 1 μg/mL, which induces an increase in the coronary flow of 67±9%. Moreover, the vasodilator effect of Ipramidil is not different from control when Ipramidil is given after a 60 min preinfusion of 10 μg/mL GTN, i.e. under conditions of nitrate tolerance. However, when GTN is applied after a 30 min infusion of Ipramidil, its dilator response is significantly diminished. Unlike GTN, Ipramidil concentration independently increases the spontaneous beating rate of the hearts by 10-30 beats per minute and appeared to have a weak positive inotropic effect.