Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GPX4 24, a derivative of (1S,3R)-RSL3, acts as a potent inhibitor of glutathione peroxidase 4 (GPX4) through covalent binding in a concentration-dependent manner within 4T1 murine mammary carcinoma cells. This compound effectively induces ferroptosis in GPX4-dependent HT-1080 fibrosarcoma cells with an EC50 value of 0.16 µM. Additionally, at a dose of 200 mg/kg, GPX4 24 elevates malondialdehyde (MDA) levels in both kidney and plasma of mice, highlighting its impact on lipid peroxidation.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | 35 days | $ 168.00 | |
5 mg | 35 days | $ 690.00 | |
10 mg | 35 days | $ 1,320.00 |
Description | GPX4 24, a derivative of (1S,3R)-RSL3, acts as a potent inhibitor of glutathione peroxidase 4 (GPX4) through covalent binding in a concentration-dependent manner within 4T1 murine mammary carcinoma cells. This compound effectively induces ferroptosis in GPX4-dependent HT-1080 fibrosarcoma cells with an EC50 value of 0.16 µM. Additionally, at a dose of 200 mg/kg, GPX4 24 elevates malondialdehyde (MDA) levels in both kidney and plasma of mice, highlighting its impact on lipid peroxidation. |
Synonyms | Phospholipid Hydroperoxide Glutathione Peroxidase 24, PHGPx 24, Glutathione Peroxidase 4 24 |
Molecular Weight | 460.93 |
Formula | C22H21ClN2O5S |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 30 mg/ml
Ethanol: 20 mg/ml
DMF: 30 mg/ml
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
GPX4 24 Phospholipid Hydroperoxide Glutathione Peroxidase 24 PHGPx 24 Glutathione Peroxidase 4 24 inhibitor inhibit