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Vaniprevir

Name: Vaniprevir
Brand: TargetMol
SKU: T8675
Price: 879 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T8675Cas No. 923590-37-8

Alias MK-7009, MK7009

Vaniprevir is a non-covalent competitive HCV NS3/4A protease inhibitor, an antiviral drug that acts directly on the hepatitis C virus. Vaniprevir blocks the viral replication process by inhibiting the activity of HCV NS3/4A protease.

Vaniprevir

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Purity: 97.41%

Catalog No. T8675Alias MK-7009, MK7009Cas No. 923590-37-8

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$879	In Stock	In Stock
5 mg	$1,790	-	In Stock
10 mg	$2,420	-	In Stock
25 mg	$3,600	-	In Stock
50 mg	$4,850	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:97.41%

ee:100%

Appearance:Viscous

Color:Transparent

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COA CSFC HNMR ORP LCMS

Product Introduction

Bioactivity

Description	Vaniprevir is a non-covalent competitive HCV NS3/4A protease inhibitor, an antiviral drug that acts directly on the hepatitis C virus. Vaniprevir blocks the viral replication process by inhibiting the activity of HCV NS3/4A protease.
In vitro	Sensitivity of 39 HCV-treated clinical isolates to VX-950 (telaprevir), SCH-503034 (boceprevir), ITMN-191, Vaniprevir, and TMC-435350 were evaluated using a replicon-based NS3 protease phenotype assay. Some natural changes in susceptibility between these isolates were observed when testing all five HCV PIs (VX-950, SCH-503034, ITMN-191, Vaniprevir, and TMC-435350). The order of variations is from minimum to maximum Vaniprevir < VX-950 < ITMN-191 < SCH-503034 < TMC-435350. [6]
Synonyms	MK-7009, MK7009

Chemical Properties

Molecular Weight	757.94
Formula	C₃₈H₅₅N₅O₉S
Cas No.	923590-37-8
Smiles	N(C(=O)[C@H]1N2C[C@@](C1)(OC(=O)N3CC=4C(C3)=CC=CC4CCCCC(C)(C)COC(=O)N[C@@H]([C@](C)(C)C)C2=O)[H])[C@@]5(C(NS(=O)(=O)C6CC6)=O)[C@H](CC)C5
Relative Density.	1.33g/cm3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 8 mg/mL (10.55 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.3194 mL	6.5968 mL	13.1937 mL	65.9683 mL
5 mM	0.2639 mL	1.3194 mL	2.6387 mL	13.1937 mL
10 mM	0.1319 mL	0.6597 mL	1.3194 mL	6.5968 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc