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N-Carbethoxy-4-piperidone

Name: N-Carbethoxy-4-piperidone
Brand: TargetMol
SKU: T1340
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1340Cas No. 29976-53-2

N-Carbethoxy-4-piperidone is an aminopyrimidine derivative, compositions containing them and there served as pharmaceuticals.

N-Carbethoxy-4-piperidone

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Purity: 97.82%

Catalog No. T1340Cas No. 29976-53-2

N-Carbethoxy-4-piperidone is an aminopyrimidine derivative, compositions containing them and there served as pharmaceuticals.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 g	$29	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:97.82%

Appearance:Liquid

Color:Transparent

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description

N-Carbethoxy-4-piperidone is an aminopyrimidine derivative, compositions containing them and there served as pharmaceuticals.

Kinase Assay

A crude cell-free extract is isolated from LI 210 cells in culture by suspension of the cells in a given volume of 0.05mol/LTris-HCl buffer, pH 7.4, and sonic extraction with a Biosonik at 70% maximal output for 30 sec. The supernatant is collected after centrifugation at 105,000 × g for 60 min (4°C) in a Model L Spinco ultracentrifuge. The final protein concentration of the cell-free extracts is approximately 3 mg/mL. The extracts are used as the source of enzymes. Ribonucleotide reductase activity is measured. A unit of enzyme is defined as the amount that catalyzed dCMP synthesis at a rate of 1 mμmole/hr. The assay systems for the measurement of pyrimidine nucleoside (CR) and deoxynucleoside (TdR, CdR) kinases are essentially those described by Chu and Fischer. However, reactions are terminated by heating for 2 min in a boiling water bath, and the phosphorylated derivatives are isolated according to the method of Bach. Fifty-jul aliquots are applied to 1-inch discs of diethylaminoethyl paper, which are then placed in counting vials and eluted with 0.5 mL of 0.5 mol/LPCA. After 1 hr, 12 mL of Diotol are added, and the radioactivity is determined.

Chemical Properties

Molecular Weight	171.19
Formula	C₈H₁₃NO₃
Cas No.	29976-53-2
Smiles	CCOC(=O)N1CCC(=O)CC1
Relative Density.	1.135g/mLat 25°C(lit.)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (350.49 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.8415 mL	29.2073 mL	58.4146 mL	292.0731 mL
5 mM	1.1683 mL	5.8415 mL	11.6829 mL	58.4146 mL
10 mM	0.5841 mL	2.9207 mL	5.8415 mL	29.2073 mL
20 mM	0.2921 mL	1.4604 mL	2.9207 mL	14.6037 mL
50 mM	0.1168 mL	0.5841 mL	1.1683 mL	5.8415 mL
100 mM	0.0584 mL	0.2921 mL	0.5841 mL	2.9207 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc