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Clomipramine

Name: Clomipramine
Brand: TargetMol
SKU: T21013
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T21013Cas No. 303-49-1

Alias Clomipramina, Clomicalm, Chlorimipramine, Anafranil (free base), Anafranil

Clomipramine (Clomicalm) is a tricyclic antidepressant (TCA). It is used for the treatment of the panic disorder, obsessive-compulsive disorder, major depressive disorder, and chronic pain. It may decrease the risk of suicide in those over the age of 65. It is similar to Imipramine in that selective inhibition of the serotonin uptake in the brain.

Clomipramine

🥰Excellent

Purity: 99.71%

Catalog No. T21013Alias Clomipramina, Clomicalm, Chlorimipramine, Anafranil (free base), AnafranilCas No. 303-49-1

Pack Size	Price	Availability
10 mg	$35	In Stock
25 mg	$55	In Stock
50 mg	$89	In Stock
100 mg	$129	In Stock
200 mg	$193	In Stock
1 mL x 10 mM (in DMSO)	$60	In Stock

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Purity:99.71%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Clomipramine (Clomicalm) is a tricyclic antidepressant (TCA). It is used for the treatment of the panic disorder, obsessive-compulsive disorder, major depressive disorder, and chronic pain. It may decrease the risk of suicide in those over the age of 65. It is similar to Imipramine in that selective inhibition of the serotonin uptake in the brain.
Synonyms	Clomipramina, Clomicalm, Chlorimipramine, Anafranil (free base), Anafranil

Chemical Properties

Molecular Weight	314.85
Formula	C₁₉H₂₃ClN₂
Cas No.	303-49-1
Smiles	CN(C)CCCN1c2ccccc2CCc2ccc(Cl)cc12
Relative Density.	1.119 g/cm3

Storage & Solubility Information

Storage

keep away from moisture | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 65 mg/mL (206.45 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.35 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1761 mL	15.8806 mL	31.7612 mL	158.8058 mL
5 mM	0.6352 mL	3.1761 mL	6.3522 mL	31.7612 mL
10 mM	0.3176 mL	1.5881 mL	3.1761 mL	15.8806 mL
20 mM	0.1588 mL	0.7940 mL	1.5881 mL	7.9403 mL
50 mM	0.0635 mL	0.3176 mL	0.6352 mL	3.1761 mL
100 mM	0.0318 mL	0.1588 mL	0.3176 mL	1.5881 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc