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Clomipramine

Name: Clomipramine
Brand: TargetMol
SKU: T21013
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T21013Cas No. 303-49-1

Alias Clomipramina, Clomicalm, Chlorimipramine, Anafranil (free base), Anafranil

Clomipramine (Clomicalm) is a tricyclic antidepressant (TCA). It is used for the treatment of the panic disorder, obsessive-compulsive disorder, major depressive disorder, and chronic pain. It may decrease the risk of suicide in those over the age of 65. It is similar to Imipramine in that selective inhibition of the serotonin uptake in the brain.

Clomipramine

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Purity: 99.71%

Catalog No. T21013Alias Clomipramina, Clomicalm, Chlorimipramine, Anafranil (free base), AnafranilCas No. 303-49-1

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$31	In Stock	In Stock
25 mg	$55	In Stock	In Stock
50 mg	$89	In Stock	In Stock
100 mg	$129	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$35	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.71%

Resource Download

COA LCMS HNMR

Product Introduction

Clomipramine AI Summary

Clomipramine exhibits a range of bioactivities, primarily involving the inhibition of neurotransmitter reuptake and various receptor bindings. It is notably potent in inhibiting norepinephrine (IC50 = 900 nM) and serotonin (IC50 = 90 nM) accumulation in mouse brain slices and exhibits antidepressant activity by inhibiting tetrabenazine (TBZ) ptosis and potentiating 5-hydroxytryptophan-induced head twitches in rats. Additionally, it demonstrates high affinity interactions with the dopamine D2, alpha-1 adrenergic, and serotonin receptors, with Ki values indicating significant binding strength, and shows inhibitory effects on multiple neurotransmitter transporters and voltage-dependent sodium channels. The compound also presents cytotoxicity and antitrypanosomal actions against Trypanosoma cruzi amastigotes, suggesting potential anti-parasitic applications. Long-term biological effects include a high volume of distribution, indicating extensive tissue penetration, and significant metabolic interactions with liver enzymes. Despite exhibiting some beneficial therapeutic activities, Clomipramine also has potential for neurotoxicity and hepatotoxicity, which necessitates careful consideration in therapeutic contexts..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Clomipramine (Clomicalm) is a tricyclic antidepressant (TCA). It is used for the treatment of the panic disorder, obsessive-compulsive disorder, major depressive disorder, and chronic pain. It may decrease the risk of suicide in those over the age of 65. It is similar to Imipramine in that selective inhibition of the serotonin uptake in the brain.
Synonyms	Clomipramina, Clomicalm, Chlorimipramine, Anafranil (free base), Anafranil

Chemical Properties

Molecular Weight	314.85
Formula	C₁₉H₂₃ClN₂
Cas No.	303-49-1
Smiles	CN(C)CCCN1c2ccccc2CCc2ccc(Cl)cc12
Relative Density.	1.119 g/cm3

Storage & Solubility Information

Storage

keep away from moisture | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 120 mg/mL (381.13 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.35 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1761 mL	15.8806 mL	31.7612 mL	158.8058 mL
5 mM	0.6352 mL	3.1761 mL	6.3522 mL	31.7612 mL
10 mM	0.3176 mL	1.5881 mL	3.1761 mL	15.8806 mL
20 mM	0.1588 mL	0.7940 mL	1.5881 mL	7.9403 mL
50 mM	0.0635 mL	0.3176 mL	0.6352 mL	3.1761 mL
100 mM	0.0318 mL	0.1588 mL	0.3176 mL	1.5881 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc