| Fr12275 |
7-Methoxy-1-tetralone |
7-Methoxy-1-tetralone may have insecticidal activity. |
| Fr12277 |
4-Hydroxy-6-methylcoumarin |
|
| Fr12290 |
4-Methoxycoumarine |
4-Methoxycoumarin has antitumour effects. |
| Fr12339 |
4-(4-Methoxyphenyl)-2-butanone |
|
| Fr12596 |
3-Acetylcoumarin |
|
| Fr12662 |
4-Ethoxycoumarin |
|
| Fr13711 |
Tropinone |
Tropinone is a decane alkaloid, used as an intermediate in the synthesis of atropine sulfate. |
| Fr13756 |
Isonicotinic acid |
Isonicotinic acid is a metabolite of Isoniazid. Isoniazid is converted to Isonicotinic acid by hydrazinolysis, with the biotransformation also to be catalyzed b...
|
| Fr13883 |
3-Methoxyphenylacetic acid |
3-Methoxyphenylacetic acid belongs to the class of organic compounds known as anisoles. 3-Methoxyphenylacetic acid is slightly soluble (in water) and a weakly a...
|
| Fr14207 |
Isopulegol |
|
| Fr14438 |
p-Toluic Acid |
p-Toluic Acid belongs to the class of organic compounds known as benzoic acids. 4-Methylbenzoic acid has been primarily detected in saliva. Within the cell, 4-...
|
| Fr16605 |
Lupinine |
|
| Fr16741 |
Oxindole |
Oxindole structure has been used in receptor tyrosine kinases (RTKs) inhibitors such as SU4984 and intedanib, the RTK family represents an important therapeutic...
|
| Fr16745 |
4-Hydroxyphenylacetonitrile |
4-Hydroxyphenylacetonitrile shows strong antioxidative activity. |
| S00015 |
Tea polyphenol |
Tea polyphenol, also called green tea extract, are a mixture of chemical compounds, such as flavanoids and tannins, found naturally in tea. Polyphenols are powe...
|
| T0001 |
Ferrous fumarate |
Iron(II) fumarate, also named as ferrous fumarate, is the iron(II) salt of fumaric acid, a reddish-orange powder, applied to supply iron intake. |
| T0003 |
Sodium Nitroprusside |
Sodium Nitroprusside is a potent vasodilator, releasing in blood with no spontaneously. |
| T0006 |
Methylene Blue trihydrate |
Methylene blue is a compound consisting of dark green crystals or crystalline powder, having a bronze-like luster. Solutions in water or alcohol have a deep blu...
|
| T0010 |
Mercaptopurine |
Mercaptopurine is an antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metab...
|
| T0011 |
Phenethyl alcohol |
Phenethyl alcohol is an antimicrobial, antiseptic, and disinfectant. It is used also as an aromatic essence and preservative in pharmaceutics and perfumery. |
| T0013 |
Mecarbinate |
Mecarbinate is arbidol hydrochloride's chemical intermediate. |
| T0014 |
cis-Anethol |
Anethole is a type of aromatic compound that exists widely in nature, widely utilized as a seasoning substance. |
| T0015 |
Mephenesin |
Mephenesin is a centrally acting muscle relaxant with a short duration of action. |
| T0016 |
Mexenone |
Mexenone is a benzophenone-derived sun protection. |
| T0017 |
Phenolphthalein |
Phenolphthalein is an acid-base indicator which is colorless in acid solution, but turns pink to red as the solution becomes alkaline. It is used medicinally as...
|
| T0019 |
Betaine hydrochloride |
Betaine hydrochloride is an acidic form of betaine, a vitamin-like substance observed in grains and other foods; gains the amplification of DNA by decreasing th...
|
| T0021 |
Vanatone |
It is an inhibitor of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1) |
| T0023 |
Valethamate bromide |
Valethamate bromide is an anticholinergic agent. |
| T0027 |
Octisalate |
Ethylhexyl salicylate, or octyl salicylate, is an organic compound used as an ingredient in sunscreens and cosmetics to absorb UVB (ultraviolet) rays from the s...
|
| T0028 |
4-Amino-3-hydroxybutyric Acid |
Agent for improving learning or memory [US6803366]Gamma Hydroxybutyric Acid, commonly abbreviated GHB, is an illegal therapeutic drug in multiple countries. In ...
|
| T0032 |
DL-Xylose |
Xylose is a sugar first derived from wood. Xylose is classified as a monosaccharide of the aldopentose type. |
| T0037 |
Halazone |
Halazone is fine white powder with an odor of chlorine. |
| T0043 |
2-Amino-6-methylheptane |
Octodrine is a stimulant drug,a platinum complex form of which was also investigated as a possible anti-tumor drug. |
| T0056 |
Oxeladin citrate |
Oxeladin is a highly potent and effective cough suppressant,which can treat all types of cough of various etiologies. It is not related to opium or its derivati...
|
| T0066 |
Dichlorophen |
Dichlorophen is a nontoxic laxative vermicide of chlorinated phenol compound. Dichlorophen is used as a veterinary fungicide, anthelmintic, and anti-protozoa...
|
| T0067 |
Oxiniacic Acid |
Oxiniacic Acid is a nicotinic acid derivative, used to treat hyperlipoidemia. |
| T0069 |
Uracil |
Uracil is a common naturally occurring pyrimidine found in RNA, it base pairs with adenine and is replaced by thymine in DNA. Methylation of uracil produces thy...
|
| T0071 |
Homosalate |
Homosalate is an organic compound used as a chemical UV filter. It is an ester formed from salicylic acid and 3,3,5-trimethylcyclohexanol, a derivative of cyclo...
|
| T0073 |
Octyl 4-methoxycinnamate |
Octinoxate is an organic compound that is used is in sunscreens and other cosmetics to absorb UV-B rays from the sun, protecting the skin from damage,primarily ...
|
| T0077 |
Dantrolene sodium salt |
Dantrolene is a skeletal muscle relaxant and can interfere with excitation-contraction coupling in the muscle fiber. It is used for the treatment of spasticity ...
|
| T0131 |
Cepharanthine |
Cepharanthine， a biscoclaurine alkaloid， suppresses tumor necrosis factor (TNF)-α-mediated NFκB stimulation, plasma membrane lipid peroxidation and platel...
|
| T0144 |
Ftaxilide |
Ftaxilide has antibacterial property, used as antiseptic. |
| T0148L |
Folinic Acid Calcium Salt Pentahydrate |
Folinic Acid, a reduced folic acid, is used in combination with other chemotherapeutics. |
| T0150 |
Hydroxyhexamide |
Hydroxyhexamide is a pharmacologically active metabolite of Acetohexamide, used as a hypoglycemic agents. |
| T0170 |
Fosfomycin calcium |
Fosfomycin calcium is an antibiotic, used for the treatment of urinary tract infections and intestinal infections caused by susceptible strains. |
| T0176 |
Aloin B |
It is used as a stimulant-laxative, treating constipation by inducing bowel movements.[2] The compound is present in what is commonly referred to as the aloe la...
|
| T0179 |
Ticagrelor |
Ticagrelor is an inhibitor of platelet aggregation. Unlike clopidogrel, ticagrelor is not a prodrug required metabolic activation. |
| T0183 |
Pramiracetam |
Pramiracetam, derived from piracetam, is a more effective nootropic drug . According to reports, Pramiracetam improved cognitive defects related with traumatic...
|
| T0187 |
Amorolfine hydrochloride |
Amorolfine Hydrochloride is an antifungal reagent. It exerts the antifungal activity by selectively interrupting two steps in the pathway of ergosterol synthesi...
|
| T0192 |
Levetiracetam |
Levetiracetam is a relatively unique anticonvulsant that is typically used in combination with other antiepileptic medications for partial onset seizures. Levet...
|
| T0195 |
Secnidazole |
Secnidazole is a second-generation 5-nitroimidazole antimicrobial that is structurally related to other 5-nitroimidazoles including [DB00916] and [DB00911], but...
|
| T0198 |
Sodium ceftiofur |
Ceftiofur sodium, an antibiotic of the cephalosporin type (third generation), is used as veterinary medicine. |
| T0200 |
Thioctic acid |
Thioctic acid is an octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by ...
|
| T0224 |
Meropenem |
Meropenem is a carbapenem antibiotic with broad spectrum of activity that is administered intravenously and used for severe bacterial infections due to sensitiv...
|
| T0227 |
Bromisoval |
Bromisoval is a mild hypnotic and sedative with potential toxicity. |
| T0233 |
Ethamivan |
Etamivan (INN) or ethamivan (USAN), is a respiratory stimulant drug concerned with nikethamide. Its trade name is Analepticon, and no longer used in the US. |
| T0237 |
Closantel |
Closantel, a salicylanilide anthelmintic compound, shows different anthelmintic spectra and obvious toxicity in mammals. |
| T0238 |
2-(Acetyloxy)-3-Methylbenzoic Acid |
2-(Acetyloxy)-3-Methylbenzoic Acid is used in qHTS Assay for Inhibitors of hydroxysteroid (17-beta) dehydrogenase 4, HSD17B4 with activity value of 19.95 µM |
| T0239 |
Lonidamine |
Lonidamine is an indazole carboxylic acid derivative, principally inhibiting aerobic glycolytic activity, by its effect on mitochondrially-bound hexokinase (HK)...
|
| T0240 |
Trimetozine |
Trimetozine is a sedative that has been marketed in Europe since 1959. It has mild tranquilizing effects and has been used to treat anxiety. |
| T0241 |
Sulfanilylurea |
Sulfacarbamide is a blood sugar-lowering agent. |
| T0243 |
Vanitiolide |
A choleretic. |
| T0244 |
Tilorone dihydrochloride |
Tilorone dihydrochloride is an orally active interferon inducer, and has antineoplastic and anti-inflammatory actions. |
| T0251 |
GemcitabineHOT |
Gemcitabine is a DNA synthesis inhibitor that can inhibit the growth of MIAPaCa2, BxPC3 and Capan2 cells (IC50s: 40/18/12 nM). It can also induce autophagy. |
| T0257 |
Mepiroxol |
Mepiroxol, an antihyperlipidemic, is also called 3-PYRIDINEMETHANOL N-OXIDE. |
| T0258 |
Carsalame |
Carsalam is a nonsteroidal anti-inflammatory drug. |
| T0259 |
Chromocarbe |
Chromocarb is a vascular protective agent used to treat venous disorders and microvascular affections. |
| T0265 |
Merbromin |
Merbromin is an organomercuric disodium salt compound and a fluorescein, used as a topical antiseptic for minor cuts and scrapes. |
| T0271 |
Iodipamide |
Iodipamide is a water-soluble radiographic contrast media for intravenous cholangiography and cholecystography. |
| T0273 |
Mefexamide hydrochloride |
Mefexamide hydrochloride is a central stimulant. |
| T0275 |
Meticrane |
Meticrane is a sulphonamide-derivative with thiazide-like diuretic activity. |
| T0278 |
Escin |
Escin is biosynthesized from protoaescigenin and barringtogenol, occurring in the seeds of Aesculus. |
| T0281 |
Meclocycline sulfosalicylate salt |
Meclocycline (INN), a tetracycline antibiotic, is used topically (i.e. for skin infections) as it is totally insoluble in water and may damage kidney and liver ...
|
| T0284 |
Sulfogaiacol |
Sulfogaiacol is an antitussive agent, used for acute respiratory tract infections and cough. |
| T0286 |
Bephenium Hydroxynaphthoate |
Bephenium hydroxynaphthoate is a B-type AChR activator, formerly used in the treatment of hookworm infections and ascariasis. |
| T0288 |
Procodazole |
Procodazole is a non-specific active immunoprotective agent against viral and bacterial infections. |
| T0289 |
Aminacrine |
9-Aminoacridine is a highly fluorescent anti-infective dye used clinically as a topical antiseptic and experimentally as a mutagen, due to its interaction with ...
|
| T0292 |
Orbifloxacin |
Orbifloxacin is a broad-spectrum fluoroquinolone antibiotic. |
| T0293 |
Metyrapone |
Metyrapone is an inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis o...
|
| T0296 |
Pempidine |
Pempidine is a nicotinic antagonist, has been used as a ganglionic blocker in the treatment of hypertension. |
| T0299 |
Lactitol monohydrate |
Lactitol monohydrate is a disaccharide analog of lactulose. It has been widely used to treat constipation and hepatic encephalopathy. |
| T0306 |
Undecenoic acid |
Undecylenic Acid is a natural or synthetic fungistatic fatty acid, with antifungal activity. |
| T0307 |
Tyloxapol |
Tyloxapol is a non-ionic liquid polymer used as a surfactant. |
| T0308 |
Etidronate |
Etidronic is a diphosphonate which affects calcium metabolism. It inhibits ectopic calcification and slows down bone resorption and bone turnover. |
| T0310 |
Actarit |
Actarit is an anti-inflammatory drug. |
| T0311 |
Diathesin |
Diathesin is an intermediate for medicine, perfume, pesticide. |
| T0312 |
Blutene chloride |
Blutene chloride, a phenothiazine, is used as a biological stain, a hemostatic, and a dye for silk and wool. Blutene chloride is also used as a diagnostic aid f...
|
| T0315 |
Acedoben |
Acedoben (4-acetamidobenzoic acid) is the acetyl derivative of para-aminobenzoic acid (PABA). |
| T0316 |
Citiolone |
Citiolone, a drug used in liver treatment, is a derivative of the amino acid cysteine. |
| T0323 |
Oxantel Pamoate |
Oxantel pamoate is used as an Antinematodal agent. |
| T0325 |
Diperodon hydrochloride |
Diperodon is a local anaesthetics. |
| T0328 |
Hexetidine |
Hexetidine is a bactericidal and fungicidal antiseptic. It is used as a 0.1% mouthwash for local infections and oral hygiene. |
| T0332 |
D-Sorbitol |
Sorbitol is a polyhydric alcohol with about half the sweetness of sucrose. Sorbitol occurs naturally and is also produced synthetically from glucose. It was for...
|
| T0336 |
Benzalkonium chloride |
Benzalkonium chloride is a cationic surface-acting agent containing the quaternary ammonium group. It has three main categories of use: as a cationic surfactant...
|
| T0339 |
Resorcin monoacetate |
Resorcinol monoacetate is an antiseptic and a disinfectant, is a chemical intermediate for the production of many other pharmaceuticals, and can be used to trea...
|
| T0340 |
Bisoctrizole |
Bisoctrizole is a benzotriazole-based organic compound that is added to sunscreens to absorb UV rays. |
| T0341 |
Dimethyl sulfoxide |
Dimethyl sulfoxide is a highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is ...
|
| T0342 |
Carvedilol phosphate |
Carvedilol Phosphate is the phosphate salt form of carvedilol, a racemic mixture and adrenergic blocking agent with antihypertensive activity and devoid of intr...
|
| T0344L |
Miconazole nitrate |
Miconazole nitrate, an imidazole antifungal agent, selectively affects the integrity of fungal cell membranes, high in ergosterol content and different in compo...
|
| T0346 |
Camylofin |
Camylofin is an antimuscarinic, used for relaxing smooth muscle. |
| T0347 |
Phenol Red |
Phenol Red is a pH indicator, red dye, and diagnostic aid for measurement of renal function. It is used also for researches of the gastrointestinal and other sy...
|
| T0352 |
Dibenzothiophene |
Dibenzothiophene, a component of petroleum oils, is a sulfur-containing polycyclic aromatic hydrocarbon (PAH) derivate consisting of 3 fused rings with keratoly...
|
| T0355 |
Valpramide |
Valpromide is a carboxamide derivative of valproic acid, used in the treatment of epilepsy and some affective disorders. |
| T0356 |
Nitromide |
Nitromide is an anti-parasitic drug. |
| T0359 |
2-Aminoheptane |
2-Aminoheptane is used for proteomics research. |
| T0363 |
Morantel tartrate |
Morantel tartrate is an antinematodal agent used mainly for livestock. |
| T0367 |
Fluocinolone acetonide |
Fluocinolone acetonide is a glucocorticoid derivative used topically in the treatment of various skin disorders. It is usually employed as a cream, gel, lotion,...
|
| T0368 |
Cinepazide maleate |
Cinepazide maleate, a maleate salt form of cinepazide, is a vasodilator. |
| T0376 |
Crotamiton |
Crotamiton is an antipruritic and a scabicidal agent available as a lotion or cream for topical use only. It is a colorless to slightly yellowish oil with a fai...
|
| T0377 |
Clofazimine |
Clofazimine is a phenazine dye with anti-mycobacterial and anti-inflammatory activities. Clofazimine has a slow bactericidal effect on Mycobacterium leprae and ...
|
| T0379 |
Risedronic Acid |
Risedronic acid (Risedronate ), a pyridinyl biphosphonate, can inhibit osteoclast-mediated bone resorption. |
| T0382 |
Eprodisate disodium |
Eprodisate Disodium is a negatively charged sulfonated inhibitor of fibrillogenesis, that can be used in the treatment of amyloid A (AA) amyloidosis. |
| T0390 |
Alkomide |
Aklomide is used in poultry to treat parasites. |
| T0392 |
Artemisinin |
Artemisinin is an ancient Chinese herbal therapy for malarial fevers which has been recently found to have potent activity against many forms of malarial organi...
|
| T0395 |
Pyrantel tartrate |
Pyrantel tartrate is broad spectrum anthelmintic for livestock. |
| T0396 |
Pipemidic acid |
Pipemidic acid, a new antibacterial agent, inhibits the activity of Pseudomonas aeruginosa. |
| T0398 |
Carzenide |
Carzenide is an organic synthesis intermediate. |
| T0399 |
Methyl salicylate |
Methyl salicylate (oil of wintergreen or wintergreen oil) is an organic ester naturally produced by many species of plants, particularly wintergreens. For acute...
|
| T0400 |
Nitroxoline |
Nitroxoline is a urinary antibacterial agent active against susceptible gram-positive and gram-negative organisms commonly found in urinary tract infections. |
| T0402 |
Octocrilene |
Octocrylene is used as an ingredient in sunscreens and cosmetics. This organic compound can penetrate into the skin where it acts as a photosensitizer. This res...
|
| T0404 |
Hydroxyquinoline |
Oxyquinoline is a heterocyclic phenol and derivative of quinoline with antiseptic, disinfectant, and pesticide properties. It is used as a stabilizer for hydrog...
|
| T0408 |
Dehydrocholic acid |
Dehydrocholic acid is a synthetic bile acid, produced by the oxidation of cholic acid. |
| T0409 |
Phthalylsulfacetamide |
Phthalylsulfacetamide is a sulfonamide antibiotic used for topical application to the skin and the conjunctiva. |
| T0411 |
Calcium gluconate |
Calcium gluconate is the calcium salt of gluconic acid, used as a calcium replenisher in hypocalcemic states. |
| T0413 |
Cinromide |
Cinromide is used as a novel anticonvulsant agent. |
| T0415 |
Guanidine hydrochloride |
Guanidine hydrochloride is a strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of prote...
|
| T0416 |
Sodium gluconate |
Sodium Gluconate is the sodium salt of gluconic acid with a chelating property. |
| T0420 |
Pentetic Acid |
Pentetic Acid is an edetate and a chelating agent used in preparing radiopharmaceuticals. |
| T0422 |
Talc |
Talc is a mineral composed of hydrated magnesium silicate. |
| T0423 |
Edetate Trisodium |
Edetate Trisodiumis used to bind metal ions in the chelation therapy. |
| T0429 |
Glucosamine |
Glucosamine is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. Supplemental glucosamine may help to r...
|
| T0430 |
Imidazolidinyl urea |
Imidazolidinyl urea is an antimicrobial preservative used in cosmetics. |
| T0432 |
Diclofenac diethylamine |
Diclofenac Diethylamine， a non-selective COX inhibitor， is utilized as a nonsteroidal anti-inflammatory drug (NSAID). |
| T0434 |
Dicurone |
Glucuronolactone is a naturally occurring chemical that is an important structural component of nearly all connective tissues. Glucuronolactone is also found in...
|
| T0435 |
Sulfinpyrazone |
Sulfinpyrazone is a uricosuric drug that is used to reduce the serum urate levels in gout therapy. It lacks anti-inflammatory, analgesic, and diuretic propertie...
|
| T0438 |
Proflavine Hemisulfate |
Proflavine Hemisulfate is the hemisulfate salt form of proflavine, an acridine-derived fluorescent contrast and disinfectant agent that can potentially be used ...
|
| T0442 |
Bucetin |
Bucetin is a pharmaceutical drug that acts as an analgesic and antipyretic. Bucetin was withdrawn from use in 1986 due to renal toxicity. |
| T0447 |
Carvedilol |
Carvedilol Phosphate is the phosphate salt form of carvedilol, a racemic mixture and adrenergic blocking agent with antihypertensive activity and devoid of intr...
|
| T0452 |
Dropropizine |
Dropropizine, a racemic non-opiate antitussive agent, is served as a cough suppressant. |
| T0454 |
Florfenicol |
Florfenicol is a fluorinated synthetic analog of thiamphenicol. In the United States, florfenicol is currently used to treat bovine respiratory disease (BRD) as...
|
| T0454L |
Florfenicol |
Florfenicol, a fluorinated synthetic analog of thiamphenicol, is currently indicated for the therapy of bovine respiratory disease (BRD) associated with Mannhei...
|
| T0461 |
Berberine hydrochloride |
Berberine hydrochloride is an alkaloid from Hydrastis canadensis L., Berberidaceae and also found in many other plants. It is relatively toxic to parenterally b...
|
| T0464 |
Carbetapentane citrate |
Pentoxyverine Citrate, an antitussive (cough suppressant), is frequently used for a cough related to illnesses like the common cold. |
| T0471 |
Decoquinate |
Decoquinate is a coccidiostat for poultry. |
| T0491 |
Ethyl vanillin |
Ethylvanillin is a flavorant used in the production of chocolate. It is about three times as potent as vanillin. |
| T0492 |
Dimethyl fumarate |
Dimethyl fumarate, a fumarate derivative, is used as antiinflammatory and immunomodulatory agent. |
| T0495 |
Aminothiazole |
Aminothiazole, a thyroid inhibitor，displays antibacterial activity. |
| T0496 |
Creatinine |
Creatinine is the breakdown product of creatine, a constituent of muscle tissue, that is excreted by the kidney and whose serum level is used to evaluate kidney...
|
| T0497 |
Lauroseptol |
Cetrimonium Bromide is is a mixture of different quaternary ammonium salts, which is a known component of the broad-spectrum antiseptic cetrimide. |
| T0499 |
Oxybenzone |
Oxybenzone is an organic compound used in sunscreens. It is a derivative of benzophenone. |
| T0500 |
Capitrol |
Capitrol is a synthetic quinoline derivative with antibacterial activity. Although the mechanism of action is not fully understood, topical administration of ch...
|
| T0501 |
Leucobasal |
Leucobasal is a synthetic derivate of hydroquinone and depigmenting agent. Although the exact mechanism of the depigmenting effects of mequinol remains unclear,...
|
| T0503 |
Meglumine |
Meglumine, a derivative of sorbitol, is used in conjunction with iodinated organic compounds as contrast medium. |
| T0507 |
L-Pyroglutamic acid |
L-Pyroglutamic acid, a cyclized derivative of the L-GLUTAMIC ACID, can elevate blood levels. This function may be associated with problems of GLUTATHIONE or GLU...
|
| T0509 |
Dermofongin |
Cloxyquin is a monohalogenated 8-hydroxyquinoline with activity against bacteria, fungi, and protozoa. |
| T0513 |
Iodoquinol |
Diiodohydroxyquinoline, a topical therapeutic agent, has satisfactory antibacterial properties. |
| T0517 |
Pancreatin |
Pancreatin is a mixture of several digestive enzymes secreted by the exocrine cells of the pancreas. It is composed of amylase, lipase and protease. |
| T0519 |
Euquinine |
Euquinine generally is served as the febrifuge, antimalarial, and tonic. |
| T0526 |
2-Amino-5-nitrobenzophenone |
2-Amino-5-nitrobenzophenone is used as industrial and organic intermediate. |
| T0527 |
2,3,4-Trimethoxybenzaldehyde |
2,3,4-Trimethoxybenzaldehyde is used as medicine intermediate. |
| T0528 |
4-Fluoroanisole |
4-Fluoroanisole is a intermediates in medicine, pesticide, liquid crystal materials. |
| T0529 |
Dulcitol |
Dulcitol is a sugar alcohol that is a metabolic breakdown product of galactose. |
| T0530 |
Flavanone |
Flavanones from citrus fruits have also been shown to exert beneficial effects on human vascular function. In particular, chronic interventions with orange juic...
|
| T0531 |
Intermediate of Pregabalin |
Intermediate of Pregabalin. |
| T0533 |
N-Aminopiperidine hydrochloride |
1-Aminopiperidine is a metabolite (M1) of the canabinoid receptor 1 antagonist Rimonabant, an antiobesity agent. |
| T0534 |
Bis(4-cyanophenyl)methanol |
Bis(4-cyanophenyl)methanol is a metabolite of Letrozole. |
| T0535 |
Memantine Related Compound B |
Memantine impurity B is an impurity of Memantine. |
| T0536 |
Cyclopropanecarbonitrile |
Cyclopropyl cyanide is the minimum carbon ring molecule with a cyanide group attached. It has mainly used in experiments with microwave spectroscopy, photodisso...
|
| T0537 |
Desbenzyl Donepezil Hydrochloride |
Desbenzyl Donepezil Hydrochloride is an impurity of Donepezil. |
| T0538 |
3-Methyloxindole |
3-Methyl-2-oxindole is a reactant for O-acetylation reactions, enantioselective α-amination reactions and for aldol reactions with glyoxal derivatives and more...
|
| T0539 |
Hydrocaffeic acid |
Dihydrocaffeic Acid is a natural product containing a catechol group with an α,β-unsaturated carboxylic acid chain. Dihydrocaffeic Acid has been shown to have...
|
| T0540 |
Dibenzosuberol |
Dibenzosuberol, an organic compound, is used as a Pharmaceutical intermediate. |
| T0541 |
Fluoronaphthalene |
Fluoronaphthalene is incompatible with strong oxidizing agents. |
| T0542 |
Homoisovanillic acid |
Homoisovanillic acid is used as pharmaceutical intermediates. |
| T0544 |
Dichlorodiphenylmethane |
Dichlorodiphenylmethane is used as pharmaceutical intermediates. |
| T0545 |
1-(2-Hydroxyethyl)imidazolidine-2-thione |
1-(2-Hydroxyethyl)imidazolidine-2-thione is used as pharmaceutical intermediates. |
| T0546 |
Trimethylacetic anhydride |
Trimethylacetic anhydride is used as medical intermediate |
| T0547 |
FlutaMide Related CoMpound B |
FlutaMide Related CoMpound B is used as pharmaceutical intermediates. |
| T0548 |
Methyl 5-methylnicotinate |
Methyl 5-methylnicotinate is used as pharmaceutical intermediates. |
| T0549 |
4'-tert-Butylacetophenone |
4'-tert-Butylacetophenone is used as medical intermediate |
| T0550 |
Domperidone EP Impurity A |
Domperidone EP Impurity A is used as pharmaceutical intermediates. |
| T0551 |
D-Ornithine monohydrochloride |
D-Ornithine monohydrochloride is used as pharmaceutical intermediates. |
| T0552 |
Isonicotinamide |
Isonicotinamide is used as pharmaceutical intermediate to synthesis Cefalonium, etc. |
| T0553 |
4-Hydroxyisophthalic acid |
4-Hydroxyisophthalic acid is used as medical intermediate |
| T0554 |
Dibutylurea |
Dibutylurea is used as pharmaceutical intermediates. |
| T0555 |
4-Diethylamino-2-butyn-1-ol |
4-Diethylamino-2-butyn-1-ol is used as pharmaceutical intermediates. |
| T0556 |
6-Methoxy-2-naphthoic acid |
6-Methoxy-2-naphthoic acid is an modulator of NMDAR. |
| T0557 |
3-(Methylamino)toluene |
3-(Methylamino)toluene is used as dye intermediates |
| T0558 |
Hydroferulic acid |
Hydroferulic acid is used as the intermediates of perfume and essence. |
| T0559 |
Dibenzosuberone |
Dibenzosuberone, pharmaceutical intermediates, is used for the synthesis of drug amitriptyline. |
| T0560 |
3,3-Diphenylpropylamine |
3,3-Diphenylpropylamine is used for synthetic drugs Mepramidil |
| T0561 |
2-Methoxy-5-sulfamoylbenzoic acid |
2-Methoxy-5-sulfamoylbenzoic Acid is a metabolite of the antipsychotic drug, Sulpiride. |
| T0562 |
Protocatechuic acid |
Protocatechuic acid (3, 4-dihydroxybenzoic acid) is a natural phenolic compound found in many edible and medicinal plants. Recent studies indicate that it could...
|
| T0563 |
Homoveratronitrile |
Homoveratronitrile is an impurity of Verapamil. It is also an intermediate in the preparation of the muscle relaxant Papverine. |
| T0564 |
1-Indanone |
1-Indanone is the intermediate od Indinavir. |
| T0565 |
Bis(2-chloroethyl)amine hydrochloride |
Bis(2-chloroethyl)amine hydrochloride is used as pharmaceutical intermediate. |
| T0566 |
2-Methylbenzhydrol |
2-Methylbenzhydrol is used as pharmaceutical intermediates. |
| T0567 |
2-Amino-5-chlorobenzoic acid |
5-Chloroanthranilic Acid is a metabolite of the pesticide Chlordimeform. It can be used in the preparation of disease-modifying antirheumatic drugs (DMARDs). |
| T0568 |
Homoveratrumic acid |
Homoveratrumic acid is the papaverine intermediate, used to synthesis cardiovascular drugs. |
| T0569 |
Pyrazinoic acid |
Pyrazinoic acid is the intermediate of pyrazole thiamethoxam sulfur. |
| T0570 |
3,5-Dihydroxybenzoic acid |
3,5-Dihydroxybenzoic Acid is a metabolite of alkylresorcinol in human urine and plasma. It is also used as a biomarker of whole grain wheat and rye. |
| T0571 |
2-Methylbenzene-1-sulfonamide |
2-Methylbenzene-1-sulfonamide is used for saccharin, pharmaceutical intermediates, etc. |
| T0572 |
Methyl EudesMate |
Methyl EudesMate is the intermediate of antibacterial efficiency medicine trimethoprim. |
| T0573 |
2-Methoxynaphthalene |
2-Methoxynaphthalene is served as Odor agents. |
| T0574 |
Diphenyl sulfide |
Diphenyl sulfide is used as pesticide, medicine, dye intermediates. |
| T0575 |
1-Methylimidazole |
1-Methylimidazole is a metabolite of 1-methyl-2-thioimidazole (methimazole) which inhibits bone resorption. |
| T0576 |
Diethylaminoethoxyethanol |
Diethylaminoethoxyethanol is served in the production of cough medicine Toclase and so on. |
| T0577 |
Chlorobenzothiazolinone |
Chlorobenzothiazolinone inhibits recombinant human chymase using bis(succinoyl-L-alanyl-L-prolyl-L-phenylalanylamide) as substrate after 1 hr by fluorescence as...
|
| T0578 |
Erythrosin B |
Iodeosin, a tetraiodofluorescein, is used as a red coloring in some foods (cherries, fish), as a stain of some cell types, and as a disclosure of DENTAL PLAQUE....
|
| T0580 |
4-Pentynoic acid |
4-Pentynoic acid has been used in reactions with 1-bromo-1-alkynes in the presence of a Pd catalyst yields biologically active ynenol lactones. It also is used ...
|
| T0581 |
Isomaltose |
Isomaltose is a reducing disaccharide, similar to maltose, but with an α-(1-6)-linkage instead of the α-(1-4)-linkage. |
| T0582 |
Fructooligosaccharides |
Fructooligosaccharides is a levorotatory monosaccharide and an isomer of glucose. |
| T0583 |
Erythritol |
Erythritol is a four-carbon sugar that is found in algae, fungi, and lichens. It is twice as sweet as sucrose and can be used as a coronary vasodilator. |
| T0584 |
Maltose |
Maltose is a dextrodisaccharide from malt and starch. It is used as a sweetening agent and fermentable intermediate in brewing. |
| T0584L |
D-(+)-Maltose monohydrate |
D-(+)-Maltose monohydrate, a dextrodisaccharide from starch and malt, is used as a fermentable intermediate and sweetening agent in brewing. |
| T0585 |
Maltitol |
Maltitol is a sugar alcohol (polyol) used as a sugar substitute. |
| T0586 |
Lactose |
Lactose is a disaccharide derived from galactose and glucose that is found in milk. |
| T0587 |
L(+)-Arabinose |
Arabinose is an aldopentose, including an aldehyde (CHO) functional group. |
| T0589 |
Xylitol |
Xylitol is a five-carbon sugar alcohol derived from XYLOSE by reduction of the carbonyl group. It is as sweet as sucrose and used as a noncariogenic sweetener. |
| T0591 |
Alpha-D-galactose |
D-Galactose is an aldohexose that exists naturally in the D-form in lactose, cerebrosides, gangliosides, and mucoproteins and is converted enzymatically into D-...
|
| T0592 |
Mannose |
Mannose is a hexose or fermentable monosaccharide and isomer of glucose from manna, the ash Fraxinus ornus and related plants. |
| T0596 |
Phenylhydantoin |
5-Phenylhydantoin is a metabolite of Mephenytoin. 5-Phenylhydantoin has been shown to bind to voltage-dependent sodium channels (NVSC) and has anti-epileptic pr...
|
| T0598 |
Iminostilbene |
Iminostilbene (Dibenzazepine) is a chemical precursor of carbamazepine which is used primarily in the treatment of epilepsy and neuropathic pain. |
| T0599 |
N-Methyl-N-(trimethylsilyl)trifluoroacetamide |
N-Methyl-N-(trimethylsilyl)trifluoroacetamide is a metabolite of Famprofazone in humans. |
| T0600 |
10,11-Dihydrocarbamazepine |
10,11-Dihydrocarbamazepine is used as pharmaceutical intermediates. |
| T0601 |
Phthalic Acid Monobenzyl Ester |
Monobenzyl Phthalate is Phthalate metabolite. |
| T0604 |
Desalkylterbuthylazine |
Desalkylterbuthylazine is used as pharmaceutical intermediates. |
| T0606 |
Monobutyl Phthalate |
Monobutyl Phthalate is a di-n-Butylphthalate (DBP) metabolite. |
| T0607 |
Dihydroartemisinin |
Dihydroartemisinin is a metabolite of artemisinin. |
| T0608 |
Heptachlor-endo-epoxide |
Heptachlor-endo-epoxide is a degradation product of heptachlor that occurs in soil and in or on crops when treatments with heptachlor, an insecticide, have been...
|
| T0609 |
Azobenzene |
Azobenzene is a compound constituted of two phenyl rings linked by an N=N double bond. Azobenzene is the simplest example of an aryl azo chemical compound. The ...
|
| T0611 |
4-Hydroxy-3-methoxymandelic acid |
4-Hydroxy-3-methoxymandelic acid is a chemical intermediate. |
| T0612 |
DL-6-Methoxy-Alpha-Methyl-2-Naphthalenemethanol |
DL-6-Methoxy-Alpha-Methyl-2-Naphthalenemethanol is used as pharmaceutical intermediates. |
| T0613 |
Beta-Hydroxyisovaleric acid |
Used as medical intermediates |
| T0614 |
4-Amino-5-Chloro-2-Methoxybenzoic Acid |
4-Amino-5-chloro-2-methoxybenzoic Acid (Metoclopramide EP Impurity C) is a Metoclopramide metabolite. |
| T0615 |
1-(3-Chlorophenyl)piperazine hydrochloride |
1-(3-Chlorophenyl)piperazine hydrochloride is used for the synthesis of trazodone, Etoperidone, Nefazodone, etc. |
| T0621 |
Diphenyl oxide |
Diphenyl oxide is used in the manufacture of spices and dyes. |
| T0622 |
2-Chlorophenothiazine |
2-Chlorophenothiazine is used as the intermediate of Chlorpromazine hydrochloride. |
| T0623 |
Diphenylacetonitrile |
Diphenylacetonitrile is used as herbicide and industrial intermediate. |
| T0624 |
4-Hydroxybenzophenone |
4-Hydroxybenzophenone is used as an intermediate of infertility drugs Clomifene. |
| T0628 |
Iminodibenzyl |
Iminodibenzyl is used for the intermediates of antiepileptic drug carbamazepine. |
| T0629 |
Atropic acid |
Atropic acid (Ipratropium EP Impurity D) is an impurity of Ipratropium bromide and Atropine Sulfate. |
| T0630 |
Ethyleneurea |
Ethyleneurea is used as a formaldehyde scavenger and intermediate. |
| T0631 |
2-Phenylbutyric acid |
2-Phenylbutyric Acid is used as an industrial intermediate. |
| T0632 |
Gallic acid trimethyl ether |
Gallic acid trimethyl ether are potent antioxidants and inhibitor of cytokine production. It can ameliorate chronic stress-induced various behavioral and bioche...
|
| T0633 |
(2-Chlorophenyl)phenyl-methanone |
(2-Chlorophenyl)phenyl-methanone is used as pharmaceutical intermediate. |
| T0634 |
2-Acetyl-4-butyramidophenol |
2-Acetyl-4-butyramidophenol is gray crystalline powder. |
| T0635 |
p-(2-Methoxyethyl) phenol |
p-(2-Methoxyethyl) phenol, an important kind of pharmaceutical intermediates, is primarily used in the synthesis of metoprolol which is effective drugs in the t...
|
| T0636 |
4-Methylmorpholine N-oxide |
4-Methylmorpholine N-oxideis an organic compound, used in organic chemistry as a co-oxidant and sacrificial catalyst in oxidation reactions. |
| T0637 |
2-Acetyl-6-methoxynaphthalene |
2-Acetyl-6-methoxynaphthalene, the key intermediate of naphthalene tome and naproxen, is used in synthetic non-steroidal anti-inflammatory analgesic medicine an...
|
| T0638 |
2-Methyl-4-nitroimidazole |
2-Methyl-5-nitroimidazole is a kind of small molecular compounds. |
| T0640 |
Butyl benzyl phthalate |
Butyl benzyl phthalate is used as a plasticizer for PVC. |
| T0643 |
Diclofenac Amide |
Diclofenac Amide is used as a intermediates of Diclofenac. |
| T0644 |
3-Amino-5-methylisoxazole |
3-Amino-5-methylisoxazole is pharmaceutical intermediates, used in the production of sulfonamide drugs. |
| T0645 |
N-(1-Adamantyl)acetamide |
N-(1-Adamantyl)acetamide is used as intermediates for synthesis of amantadine hydrochloride. |
| T0650 |
Phenyl acetate |
Phenyl acetate, the ester of a phenol and acetic acid, can be produced by reacting acetic anhydride with phenol. Another way is produced by decarboxylation of a...
|
| T0653 |
Tris(2-chloroethyl) phosphate |
Tris(2-chloroethyl) phosphate is served as flame retardants. |
| T0657 |
3,4-Dimethoxybenzyl alcohol |
3,4-Dimethoxybenzyl Alcohol is an organic compound. |
| T0658 |
2-(2-Hydroxyethyl)pyridine |
2-Pyridineethanol is used as an industrial chemistry intermediate. |
| T0659 |
Bispyrazolone |
Bispyrazolone is light yellow or white crystalline powder. |
| T0661 |
Dimethylsulfamoyl chloride |
Dimethylsulfamoyl Chloride is a kind of small molecular compound. |
| T0662 |
2-Hydroxybenzimidazole |
2-Hydroxybenzimidazole is used as an intermediate in industry. |
| T0664 |
Nicotinic acid hydrazide |
Nicotinic acid hydrazide is a small molecular compound. |
| T0665 |
2,6-Dihydroxypurine |
Xanthine is a product on the pathway of purine degradation. Xanthine is subsequently converted to uric acid by the action of the Xanthine oxidase enzyme. Xanthi...
|
| T0666 |
4-Chlorosalicylic acid |
4-Chlorosalicylic acid is antimicrobial compositions comprising a metal salt and a benzoic acid analog. |
| T0667 |
Flecainide Impurity D |
Flecainide Impurity D is used as an intermediate in industry. |
| T0668 |
1-Aminohydantoin hydrochloride |
1-Aminohydantoin hydrochloride is an organic compound. |
| T0669 |
Chloramine-T |
Chloramine-T is a N-chlorinated, and N-deprotonated sulfonamide, used as a biocide and a mild disinfectant. |
| T0671 |
2-Naphthol |
2-Naphthol is an isomer of 1-naphthol, differing by the location of the hydroxyl group on the naphthalene ring. |
| T0686 |
Orlistat |
Orlistat is an Intestinal Lipase Inhibitor. The mechanism of action of orlistat is as a Lipase Inhibitor. |
| T0690 |
Quinine |
Quinine is a natural cinchona alkaloid that has been used for centuries in the prevention and therapy of malaria. Quinine is also used for idiopathic muscle cra...
|
| T0691 |
Sulisobenzone |
Sulisobenzone (benzophenone-4), an ingredient in certain sunblocks, protects the skin against damage by short-wave UVA ultraviolet light and UVB. |
| T0693 |
Niflumic acid |
Niflumic acid is a Ca2+-activated Cl- channel blocker and an analgesic and anti-inflammatory agent used in the therapy of rheumatoid arthritis. |
| T0694 |
Pranlukast |
Pranlukast is a cysteinyl leukotriene receptor-1 antagonist. It antagonizes or reduces bronchospasm caused, principally in asthmatics, by an allergic reaction t...
|
| T0695 |
Avobenzone |
Avobenzone, an oil-soluble ingredient, is a dibenzoylmethane derivative used in sunscreen products to absorb the full spectrum of UVA rays. |
| T0697 |
Aspartame |
Aspartame, an artificial, non-carbohydrate sweetener, is aspartyl-phenylalanine-1-methyl ester. |
| T0698 |
Dioxybenzone |
Dioxybenzone (benzophenone-8) is a derivative of benzophenone, used in sunscreen to block UVB and short-wave UVA (ultraviolet) rays. |
| T0699 |
Sulfamonomethoxine |
Sulfamonomethoxine is a long-acting sulfonamide antibacterial agent, blocks the synthesis of folic acid by inhibiting synthetase of dihydropteroate. |
| T0701 |
Broxyquinoline |
Broxyquinoline is an antiprotozoal agent, and it can release oxygen free radicals from the water in mucous membranes. |
| T0710 |
L-Cycloserine |
L-cycloserine irreversibly inhibits GABA pyridoxal 5′-phosphate-dependent aminotransferase in E. coli, as well in the brains of various animals, results in in...
|
| T0715 |
Chlormezanone |
Chlormezanone is a non-benzodiazepine that is used in the management of anxiety. It has been suggested for use in the treatment of muscle spasm. |
| T0719 |
Tetrabenazine |
Tetrabenazine is a drug formerly used as an antipsychotic and treatment of various movement disorders. Tetrabenazine blocks neurotransmitter uptake into adrener...
|
| T0721 |
Piroctone olamine |
Piroctone olamine is a compound sometimes used in the treatment of fungal infections. Piroctone olamine is the ethanolamine salt of the hydroxamic acid derivati...
|
| T0722 |
Ursolic acid |
Ursolic acid(Bungeolic acid), a natural pentacyclic triterpenoid carboxylic acid, shows anti-tumor effects. |
| T0724 |
Formononetin |
Formononetin is an O-methylated isoflavone and a phytoestrogen from the root of Astragalus membranaceus. |
| T0727 |
Piperonyl butoxide |
Piperonyl butoxide is an insecticide synergist, particularly for rotenone and pyrethroids. |
| T0729 |
Benzyl benzoate |
Benzyl benzoate is one of the older preparations used for the therapy of scabies. Scabies is a skin infection caused by the Sarcoptes scabiei. Its symptoms are ...
|
| T0730 |
Triacetin |
Triacetin is a triglyceride that is used as an antifungal agent. |
| T0738 |
Urea |
Urea is formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end metabolite of protein catabolism and accounts for a...
|
| T0739 |
Guaifenesin |
Guaifenesin is an expectorant that also has some muscle relaxing action. It is used in many cough preparations. |
| T0741 |
Sulfamethazine |
Sulfamethazine is a sulfanilamide anti-infective agent. It has a spectrum of antimicrobial action similar to other sulfonamides. |
| T0743 |
DL-Carnitine |
DL-Carnitine is the constituent of liver and striated muscle. In therapeutically It is used to stimulate pancreatic and gastric secretions and to treat hyperlip...
|
| T0744 |
Zinc undecylenate |
10-Undecenoic acid zinc salt, a synthetic or natural fungistatic fatty acid, is used topically in creams against eczemas, fungal infections, ringworm, and other...
|
| T0755 |
Carbaglu |
Carglumic acid is an orphan drug used to treat hyperammonemia in patients with N-acetyl glutamate synthase absence. This rare hereditary disease results in elev...
|
| T0756 |
Ethoxyquin |
Ethoxyquin is an antioxidant used in animal feeds. |
| T0762 |
Trans-Anethole |
Anethole (anise camphor), an organic compound, is widely served as a condiment substance. It is a derivative of phenylpropene, a type of aromatic compound that ...
|
| T0763 |
Diolane |
Diolane, colorless liquid, is a chiral diol. It is an industrial compound produced from diacetone alcohol by hydrogenation. |
| T0768 |
Oxolamine citrate |
Oxolamine is a cough suppressant that is able to be used as a generic drug in many jurisdictions. |
| T0770 |
Carbadox |
Carbadox is an antibacterial agent that has been used in veterinary practice for treating swine dysentery and enteritis and for promoting growth. However, its u...
|
| T0771 |
Casanthranol |
Casanthranol is a concentrated mixture of anthranol glycosides from cascara sagrada (dried bark of Rhamnus p.) and used as a laxative in constipation and variou...
|
| T0772 |
Troxerutin |
Troxerutin, a natural bioflavonoid, is isolated from Sophora japonica. It has many benefits and medicinal properties. |
| T0777 |
Tilmicosin |
Tilmicosin is a macrolide antibiotic. It is used in veterinary medicine for the treatment of bovine respiratory disease and ovine respiratory disease associated...
|
| T0781 |
Dithiopropanol |
An anti-gas warfare agent that is effective against Lewisite (dichloro(2-chlorovinyl)arsine) and formerly known as British Anti-Lewisite or BAL. It acts as a ch...
|
| T0787 |
Butylated hydroxyanisole |
Butylated hydroxyanisole (BHA) is an antioxidant consisting of a mixture of two isomeric organic compounds, 2-tert-butyl-4-hydroxyanisole and 3-tert-butyl-4-hyd...
|
| T0791 |
Reserpine |
Reserpine is an alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resu...
|
| T0799 |
Lactulose |
Lactulose ,a synthetic disaccharide ,is used in the treatment of constipation and hepatic encephalopathy. |
| T0801 |
Tannic acid |
Tannic acid is a novel hERG channel blocker. |
| T0803 |
Acetrizoic acid |
Acetrizoic acid is the first monomeric ionic compound used as an X-ray contrast agent. |
| T0807 |
Basibrol |
2,2,2-Tribromoethanol is an organic compound used to anesthetize mice. |
| T0819 |
Spiramycin |
Spiramycin is a macrolide antibiotic produced by Streptomyces ambofaciens. The drug is effective against gram-positive aerobic pathogens, N. gonorrhoeae, and st...
|
| T0823 |
Thioctamide |
Lipoamide is a trivial name for 6,8-dithiooctanoic amide. It is 6,8-dithiooctanoic acid's functional form where the carboxyl group is attached to protein (or an...
|
| T0827 |
Cefsulodine sodium |
Cefsulodin sodium salt hydrate is a β lactam antibiotic. |
| T0828 |
Bromhexine hydrochloride |
Bromhexine hydrochloride is a mucolytic agent used in the treatment of respiratory disorders associated with viscid or excessive mucus. |
| T0829 |
Etofylline |
Etofylline is used for difficulty in breathing, asthma, breathing difficulty and other conditions. |
| T0833 |
Benzoic acid |
Benzoic acid is a fungistatic compound that is widely used as a food preservative. It is conjugated to GLYCINE in the liver and excreted as hippuric acid. |
| T0834 |
Ethylparaben |
Ethylparaben is a Standardized Chemical Allergen. The physiologic effect of ethylparaben is by means of Increased Histamine Release, and Cell-mediated Immunity. |
| T0844 |
Sulfamethoxypyridazine |
Sulfamethoxypyridazine is a sulfanilamide antibacterial agent. |
| T0845 |
Cyromazine |
Cyromazine is an ectoparasiticide. Insect growth regulator. Specific activity against dipterous larvae. Cyromazine is a fda approved for use in livestock. |
| T0850 |
Primaquine diphosphate |
Primaquine Phosphate is the phosphate salt form of primaquine, a synthetic, 8-aminoquinoline derivative with antimalarial properties. Although its mechanism...
|
| T0852 |
Carbazochrome sodium sulfonate |
Carbazochrome sodium sulfonate (AC-17) is an antihemorrhagic for the treatment of hemorrhoids. |
| T0860 |
Mefloquine hydrochloride |
Mefloquine is a quinoline derivative used for the prevention and therapy of P. falciparum malaria. |
| T0861 |
Tylosin tartrate |
Tylosin tartrate, a macrolide antibiotic, is approved for the control of mycoplasmosis in poultry. |
| T0872L |
Amprolium Hydrochloride |
Amprolium is a coccidiostat that interferes with thiamine metabolism. |
| T0873 |
Dinitolmide |
Dinitolmide, a poultry feed additive, is a coccidiostat for poultry. |
| T0874 |
Dimetridazole |
Dimetridazole is a drug that combats protozoan infections. It is a nitroimidazole class drug. It has been banned by the Canadian government as a livestock feed ...
|
| T0875 |
Acetylcysteine |
Acetylcysteine is the N-acetyl derivative of CYSTEINE. It is used as a mucolytic agent to reduce the viscosity of mucous secretions. It has also been shown to h...
|
| T0876 |
Clioquinol |
Clioquinol is an orally bioavailable, lipophilic, copper-binding, halogenated 8-hydroxyquinoline with antifungal, antiparasitic and potential antitumor activiti...
|
| T0877 |
Gallic acid |
Ursolic acid (UA), a pentacyclic triterpene acid, is used in anticancer chemotherapies. |
| T0881 |
6-Aminocaproic acid |
Aminocaproic acid is an antifibrinolytic agent that acts by inhibiting plasminogen activators which have fibrinolytic properties. |
| T0885 |
Sulfamethoxazole |
Sulfamethoxazole is a Sulfonamide Antimicrobial. The mechanism of action of sulfamethoxazole is as a Cytochrome P450 2C9 Inhibitor. The chemical classification ...
|
| T0887 |
D(+)-Glucose |
D(+)-Glucose is a primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. I...
|
| T0889 |
Saccharin |
Flavoring agent and non-nutritive sweetener. |
| T0891 |
Sulphadione |
4,4'-Diaminodiphenylsulfone has activity against a wide range of bacteria but mainly employed for its actions against mycobacterium leprae. |
| T0896 |
Furaltadone hydrochloride |
Furaltadone hydrochloride is an antibacterial and shows distinct curative effect in the treatment of coccidiosis. |
| T0898 |
Chloroxylenol |
Chloroxylenol (4-chloro-3,5-dimethylphenol), a broad spectrum antimicrobial chemical compound, is used to control virus, bacteria, fungi, and algae. It is used ...
|
| T0899 |
Dehydroacetic acid |
Dehydroacetic acid, a pyrone derivative, is served frequently as a fungicide and bactericide. |
| T0900 |
Cetylpyridinium chloride monohydrate |
Cetylpyridinium chloride (CPC), a cationic quaternary ammonium compound, is used in certain classes of throat sprays, mouthwashes, lozenges, toothpaste, nasal s...
|
| T0901 |
Chlorobutanol |
Chlorobutanol is a chemical preservative, sedative hypnotic and weak local anaesthetic similar in nature to chloral hydrate. It has antibacterial and antifungal...
|
| T0908 |
Chloquinan |
Chlorquinaldol is a Standardized Chemical Allergen. The physiologic effect of chlorquinaldol is by means of Increased Histamine Release, and Cell-mediated Immun...
|
| T0910 |
Terpin Monohydrate |
Terpin hydrate, a cis-form hydrate, is derived from sources such as oil of turpentine, oregano, thyme, and eucalyptus. It is used as an insect repellent and exp...
|
| T0912L |
Tetracycline |
Tetracycline is a naphthacene antibiotic that inhibits AMINO ACYL TRNA binding during protein synthesis. |
| T0914 |
Metacetamol |
METACETAMOL is an organic compound. |
| T0917 |
Sulfaquinoxaline sodium |
Sulfa drugs, used in the treatment of avian coccidiosis. |
| T0919 |
Benfluorex hydrochloride |
Tamoxifen is an antineoplastic nonsteroidal selective estrogen receptor modulator (SERM). |
| T0921 |
Sulfabenzamide |
Sulfabenzamide is a sulfonamide antibacterial agent used alone or with sulfathiazole and sulfacetamide as a topical, intravaginal antibacterial preparation...
|
| T0922 |
Zoxazolamine |
Zoxazolamine is a uricosuric and muscle relaxant. Zoxazolamine acts centrally as a muscle relaxant, but the mechanism of its action is not understood. |
| T0924 |
Benzocaine |
Benzocaine is a surface anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings. |
| T0925 |
Allantoin |
Allantoin, a urea hydantoin found in urine and plants, is used in dermatological preparations. |
| T0926 |
Azelaic acid |
Azelaic acid is bactericidal against Propionibacterium acnes and Staphylococcus epidermidis due to its inhibitory effect on the synthesis of microbial cellular ...
|
| T0927 |
Butylparaben |
Butylparaben is a standardized chemical allergen, increasing histamine release, and cell-mediated immunity. |
| T0933 |
Delta-Gluconolactone |
Gluconolactone is a naturally-occurring food additive used as a sequestrant, an acidifier, or a curing, pickling, or leavening agent. It is a cyclic ester of D-...
|
| T0940 |
Acesulfame Potassium |
Acesulfame potassium is a non-nutritive sweetener. |
| T0941 |
Cyclamic acid |
Cyclamic acid is an artificial sweetening agent, usually employed as Na or Ca salt (cyclamate). Use suspended in some countries, including USA, because of possi...
|
| T0949 |
Amstat |
Tranexamic acid is an Antifibrinolytic Agent. The physiologic effect of tranexamic acid is by means of Decreased Fibrinolysis. |
| T0953 |
Cefazolin sodium salt |
Cefazolin binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. Cefazolin Sodium is the sodium sa...
|
| T0955 |
Oxyclozanide |
Oxyclozanide is a salicylanilide anthelmintic used in grazing animals for fasciola and cestode infestations. |
| T0956 |
Abamectin |
Avermectin B1 (Abamectin) is served as anthelmintic and insecticide. |
| T0959 |
Ethopabate |
Ethopabate is an inhibitor of folate metabolism, used as a coccidiostat in poultry. |
| T0960 |
Iopanoic acid |
Iopanoic acid is an iodine-containing radiocontrast medium used in cholecystography. |
| T0961 |
Trometamol |
Trometamol is a proton acceptor used to treat acidemia. It inhibits both isoforms of cyclooxygenases (COX1 and COX2), thereby blocking the conversion of arachid...
|
| T0967 |
Teicoplanin |
Teicoplanin is a semisynthetic glycopeptide antibiotic, used to treat Gram-positive bacteria. |
| T0969 |
Doramectin |
Doramectin is an antiparasitic agent. |
| T0977 |
Medrysone |
Medrysone is a topical, synthetic glucocorticoid with metabolic, anti-inflammatory and anti-allergic properties. Medrysone exerts its effect by interacting with...
|
| T0982 |
(+)-Emetine dihydrochloride hydrate |
Emetine is a drug used as both an anti-protozoal and to induce vomiting. It is produced from the ipecac root. |
| T0983 |
Artamine |
Artamine, possessing antineoplastic properties, induces apoptosis by a p53-mediated mechanism and inhibits angiogenesis by chelating with copper, a cofactor for...
|
| T0983L |
DL-Penicillamine |
DL-Penicillamine is a chelating agent recommended for the removal of excess copper in patients with Wilson's disease. DL-Penicillamine is only found in individu...
|
| T0985 |
Oxacillin sodium |
Oxacillin sodium is an antibiotic similar to FLUCLOXACILLIN used in resistant staphylococci infections. |
| T0989 |
7-Aminocephalosporanic acid |
7-Aminocephalosporanic acid is used for synthesis of cephalosporin antibiotics and intermediates. |
| T10001 |
(E)-Alprenoxime |
(E)-Alprenoxime is the isomer of the Alprenoxime which is a site-activated ocular β-blocker. |
| T10002 |
(E)-Crotylbarbital |
(E)-Crotylbarbital is the isomer of Crotylbarbital. Crotylbarbital has sedative and hypnotic effects and can be used for the treatment of insomnia. |
| T10003 |
α1 adrenoceptor-MO-1 |
α1 adrenoceptor-MO-1 (S enantiomer) has affinity at alpha 1 adrenergic receptor with alphalytic activity and analgesic action. It has more active than R enanti...
|
| T10004 |
Palmitodiolein |
Palmitodiolein is a triacylglycerol existed in vegetable oils. |
| T10005 |
1,2-Dipalmitoyl-sn-glycerol 3-phosphate |
1,2-Dipalmitoyl-sn-glycerol 3-phosphate, a phosphatidic acid, is a human endogenous metabolite. |
| T10005L |
1,2-Dipalmitoyl-sn-glycerol 3-phosphate sodium |
1,2-Dipalmitoyl-sn-glycerol 3-phosphate sodium, a phosphatidic acid, is a human endogenous metabolite. |
| T10008 |
BTM-1086 |
BTM-1086 is a potent gastric secretory inhibitor and an anti-ulcer agent. |
| T1001 |
Dicloxacillin sodium |
Dicloxacillin NaOH is a narrow-spectrum β-Lactam antibiotic of the penicillin class, used to treat infections caused by susceptible Gram-positive bacteria. |
| T10010 |
1-(2-Quinoxalinyl)-1,2,3,4-butanetetrol |
1-(2-Quinoxalinyl)-1,2,3,4-butanetetrol is an endogenous metabolite. |
| T10011 |
1,3,5-Tricaffeoylquinic acid |
1,3,5-Tricaffeoylquinic acid is a tricaffeoylquinic acid derivative isolated from Helichrysum populifolium with anti-HIV effect. |
| T10012 |
P7C3-OMe |
P7C3-OMe, a pro-neurogenic agent, has therapeutic benefits in neurodegenerative diseases. The R-enantiomer of P7C3-OMe is far more active than the S-enantiomer. |
| T10013 |
1-Acetyl-3-o-toluyl-5-fluorouracil |
1-Acetyl-3-o-toluyl-5-fluorouracil is a potent antineoplastic agent. |
| T10014 |
(1α,1'S,4β)-Lanabecestat |
(1α,1'S,4β)-Lanabecestat is a Beta site APP Cleaving Enzymel (BACE1) inhibitor, and has IC50s of 2.2 nM (TR-FRET assay) and 0.28 nM (sAPPp release assay), res...
|
| T10015 |
1-Deazaadenosine |
1-Deazaadenosine is a potent Adenosine deaminase inhibitor (Ki: 0.66 μM). It exhibits anti-cancer activities in vitro and has the potential to be a chemotherap...
|
| T10016 |
Hydrocarbon chain derivative 1 |
Hydrocarbon chain derivative 1 has inhibitory activities against lipid synthesis. |
| T10017 |
1-Linoleoyl Glycerol |
1-Linoleoyl Glycerol is a fatty acid glycerol that has been isolated from Saururus chinensis roots. |
| T10018 |
1-Methyladenine |
1-Methyladenine is a product of alkylation damage in DNA which can be repaired by damage reversal by oxidative demethylation. |
| T10019 |
1-Methylcytosine |
1-Methylcytosine is a methylated form of cytosine. It is used as a nucleobase of hachimoji DNA, in which it pairs with Isoguanine. |
| T10020 |
1-Methyluric acid |
1-Methyluric acid acts on the urinary bladder mucosa and increases blood glucose, triglyceride, insulin, and cholesterol levels. |
| T10021 |
1-Methylxanthine |
1-Methylxanthine is an essential human urinary metabolite of caffeine and theophylline. 1-Methylxanthine enhances the radiosensitivity of tumor cells. |
| T10022 |
1-Myristoyl-2-stearoyl-sn-glycero-3-phosphocholine |
1-Myristoyl-2-stearoyl-sn-glycero-3-phosphocholine is an endogenous metabolite. |
| T10023 |
1-Naphthol |
1-naphthol is an excited state proton transfer (ESPT) fluorescent molecular probe. |
| T10024 |
1-Octanol |
1-Octanol (Octanol), a saturated fatty alcohol, is a T-type calcium channels (T-channels) inhibitor with an IC50 of 4 μM for native T-currents[1]. 1-Octanol is...
|
| T10025 |
1-PeCSO |
1-PeCSO is isolated from onion or garlic bulbs. It acts as a key compound in garlic greening and reacts with lachrymatory factor synthase. |
| T10026 |
Tachykinin antagonist 1 |
Tachykinin antagonist 1 is an antagonist of neurokinin receptors extracted from patent US5968923 (example 32). |
| T10027 |
Anticonvulsant agent 1 |
Anticonvulsant agent 1 is an anticonvulsant compound extracted from patent WO2001062726A2 (Compound 156). |
| T10028 |
PDE4 inhibitor intermediate 1 |
PDE4 inhibitor intermediate 1 is a PDE4 inhibitor synthesis intermediate. |
| T10029 |
1-Stearoyl-2-arachidonoyl-sn-glycero-3-phosphocholine |
1-Stearoyl-2-arachidonoyl-sn-glycero-3-phosphocholine is an endogenous metabolite. |
| T1003 |
Tylosin |
Tylosin is a macrolide antibiotic obtained from cultures of Streptomyces fradiae. The drug is effective against many microorganisms in animals but not in humans...
|
| T10030 |
1-Stearoyl-2-linoleoyl-sn-glycero-3-phosphocholine |
1-Stearoyl-2-linoleoyl-sn-glycero-3-phosphocholine is an endogenous metabolite. |
| T10031 |
EP1-antanoist-1 |
EP1-antagonist-1 is an EP1 antagonist (pKi: 7.54; pIC50: 8.5). |
| T10034 |
10,11-Dehydrocurvularin |
10,11-Dehydrocurvularin is an antibiotic and a strong activator of the heat shock response. It inhibits the TGF-β signaling pathway and has anti-tumorous activ...
|
| T10035 |
10,12-Tricosadiynoic acid |
10,12-Tricosadiynoic acid is a highly selective and orally active inhibitor of acyl-CoA oxidase-1 (ACOX1). It can treat the high-fat diet- or obesity-induced me...
|
| T10036 |
10β,17β-dihydroxyestra-1,4-dien-3-one |
10β,17β-dihydroxyestra-1,4-dien-3-one is a brain-targeting bioprecursor prodrug of the main human estrogen, 17β-estradiol. It alleviates hot flushes in rat m...
|
| T10037 |
10-Isobutyryloxy-8,9-epoxythymol isobutyrate |
10-Isobutyryloxy-8,9-epoxythymol isobutyrate is a major constituent of Inula helenium and Inula royleana root cultures. |
| T10038 |
11-cis-Vaccenyl acetate |
11-cis-Vaccenyl acetate is a male-specific lipid that mediates aggregation behavior in both male and female flies, which activates olfactory neurons located in ...
|
| T10039 |
11-Deoxymogroside IIE |
11-Deoxymogroside IIE is a cucurbitane glycoside, isolated from Siraitia grosvenorii fruits. |
| T1004 |
Benzyladenine |
6-Benzylaminopurine, benzyl adenine or BAP is a first-generation synthetic cytokinin that elicits plant growth and development responses, setting blossoms and s...
|
| T10040 |
11-Deoxymogroside IIIE |
11-Deoxymogroside IIIE is a natural compound isolated from Siraitia grosvenorii. |
| T10041 |
11-Ketodihydrotestosterone |
11-Ketodihydrotestosterone is a metabolite of 11β-Hydroxyandrostenedione. It is an active androgen and is also a potent androgen receptor (AR) agonist (Ki: 20....
|
| T10042 |
11-Oxomogroside IIa |
11-Oxomogroside IIa is a cucurbitane glycoside extracted from the fruits of Siraitia grosVenorii. It has inhibitory effects against the EBV-EA activation induce...
|
| T10043 |
11-Oxomogroside IIe |
11-Oxomogroside IIe is a triterpene glycoside isolated from Siraitia grosvenori[1]. |
| T10045 |
15-Acetyl-deoxynivalenol |
15-Acetyl-deoxynivalenol is a highly toxic trichothecene found in cereals and exhibits toxicity to HepG2 cells. |
| T10047 |
16-Methoxystrychnine |
16-Methoxystrychnine is a alkaloid[1]. |
| T10048 |
17a-Hydroxypregnenolone |
17a-Hydroxypregnenolone is a pregnane steroid. It is a prohormone in the formation of dehydroepiandrosterone (DHEA). |
| T10049 |
1alpha, 25-Dihydroxy VD2-D6 |
1alpha, 25-Dihydroxy VD2-D6 is a deuterated form of vitamin D. |
| T1005 |
Amoxicillin |
Amoxicillin binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. Amoxicillin Anhydrous is the a...
|
| T10050 |
1alpha-Hydroxy VD4 |
1alpha-Hydroxy VD4 can effectively induce the differentiation of monoblastic leukaemia U937, P39/TSU, and P31/FUJ cells. |
| T10051 |
5-HT3 antagonist 1 |
5-HT3 antagonist 1 is a potent and selective antagonist of 5-HT3 receptor. |
| T10052 |
AR-08 |
AR-08 is an α2-adrenergic receptor agonist, used for the treatment of attention-deficit hyperactivity disorder (ADHD). |
| T10054 |
CI-949 |
CI-949 is an allergic mediator release inhibitor, which inhibits leukotriene C4/D4 (LTC4/LTD4), histamine, and thromboxane B2 (TXB2) release (IC50s: 0.5 μM, 11...
|
| T10055 |
CHEMBL333994 |
CHEMBL333994 is a potent and orally effective antagonist of Cholecystokinin A (CCK-A; IC50: 0.67 nM). |
| T10056 |
Neurokinin antagonist 1 |
Neurokinin antagonist 1 is an antagonist of Neurokinin extracted from patent WO1998045262A1. |
| T10057 |
LTD4 antagonist 1 |
LTD4 antagonist 1 is a potent and orally active antagonist of leukotriene D4 (LTD4; Ki: 0.57 nM). |
| T10059 |
Neuromuscular Disorder-Targeting Compound 1 |
Neuromuscular Disorder-Targeting Compound 1 is a compound used in the research of neuromuscular disorders, for example, symptoms of chronic fatigue syndrome and...
|
| T10060 |
(1S,2S,3R)-DT-061 |
(1S,2S,3R)-DT-061 is an enantiomer of DT-061 which is an orally bioavailable activator of PP2A. |
| T10062 |
(-)-GSK598809 |
(-)-GSK598809 is an isomer of GSK598809 that is a potent and selective antagonist of dopamine D3 Receptor. |
| T10063 |
LDL-IN-3 |
LDL-IN-3 is an anti-atherosclerotic agent extracted from patent WO/2005/039596A1 (example C25). |
| T10064 |
LH secretion antagonist 1 |
LH secretion antagonist 1 is an antagonist of luteinizing hormone secretion with analgesic activity. |
| T10065 |
2',3'-cGAMP |
2',3'-cGAMP is an endogenous cGAMP in mammalian cells. It binds to STING with a high affinity and is a potent inducer of IFN-β. |
| T10065L |
2',3'-cGAMP sodium |
2',3'-cGAMP sodium is an endogenous cGAMP in mammalian cells. It binds to STING with a high affinity and is a potent inducer of IFN-β. |
| T10066 |
2',5'-Dideoxyadenosine |
2',5'-Dideoxyadenosine is a potent and non-competitive adenylyl cyclase inhibitor via binding the P-site (IC50: 3 µM). |
| T10068 |
2'-Azido-2'-deoxyuridine |
2'-Azido-2'-deoxyuridine (N3dUrd) is a ribonucleotide reductase inhibitor with anti-cancer activity. |
| T10069 |
AMPK activator 1 |
AMPK activator 1 is an AMPK activator extracted from patent WO2013116491A1 (compound No.1-75, EC50: <0.1μM). |
| T1007 |
Lupetidin |
Lupetidin is a neuropathic blocker, with antihypertensive effect. |
| T10071 |
Itch-Targeting Compound 1 |
Itch-Targeting Compound 1 is an anti-itching compound. |
| T10072 |
2-Hydroxy Ibuprofen |
2-Hydroxy Ibuprofen is a metabolite of Ibuprofen. Ibuprofen is an anti-inflammatory inhibitor targeting COX-1/COX-2 (IC50s: 13 μM/370 μM). |
| T10073 |
2-Iodomelatonin |
2-Iodomelatonin is a potent agonist of melatonin receptor 1 (MT1, Ki: 28 pM), it is more 5-fold selective for MT1 over MT2. |
| T10074 |
2-Keto-D-Glucose |
2-Keto-D-Glucose (D-Glucosone) is a key intermediate in a secondary metabolic pathway leading to the antibiotic Cortalcerone. It is found in various natural sou...
|
| T10076 |
2-Methylcitric acid |
2-Methylcitric acid (Methylcitric acid) is an endogenous metabolite in the 2-methylcitric acid cycle. It accumulates in methylmalonic and propionic acidemias. |
| T10076L |
2-Methylcitric acid trisodium |
2-Methylcitric acid trisodium (Methylcitric acid) is an endogenous metabolite in the 2-methylcitric acid cycle. It accumulates in methylmalonic and propionic ac...
|
| T10077 |
2-O-β-D-Glucopyranosyl-L-ascorbic acid |
2-O-β-D-Glucopyranosyl-L-ascorbic acid (AA-2βG) is isolated from Lycium Fruit. It is a stable vitamin C analog with anti-tumor activity. |
| T10078 |
2-PCCA hydrochloride |
2-PCCA hydrochloride is an agonist of GPR88 receptor. It inhibits GPR88-mediated cAMP production (EC50: 116 nM in HEK293 cells). |
| T10080 |
PF-592379 |
PF-592379 is a potent agonist of dopamine D3 receptor (EC50: 21 nM). |
| T10082 |
DPP-IV-IN-1 |
DPP-IV-IN-1 is an effective inhibitor of dipeptidyl peptidase IV (DPP-IV), a serine protease (IC50: 4.6 nM). |
| T10083 |
Desethyl KBT-3022 |
Desethyl KBT-3022 is an active metabolite of the antiplatelet compound KBT-3022. |
| T10085 |
20(S)-Hydroxycholesterol |
20(S)-hydroxyCholesterol is an allosteric activator of the oncoprotein smoothened (Smo) that activates the hedgehog signaling pathway with an EC50 of 3 μM in N...
|
| T10086 |
24-Hydroxycholesterol |
24-Hydroxycholesterol is a natural sterol, which serves as a positive allosteric modulator of NMDA receptors, and a potent activator of the transcription factor...
|
| T10087 |
24-Norursodeoxycholic acid |
24-norursodeoxycholic acid is a side chain-shortened C23 homolog of UDCA. It has shown potent anti-inflammatory, anti-cholestatic, and anti-fibrotic properties. |
| T10088 |
24R-Calcipotriol |
24R-Calcipotriol(PRI 2202) is an impurity of Calcipotriol which is a ligand of VDR-like receptors. |
| T10089 |
2614W94 |
2614W94 is a selective, competitive, and reversible inhibitor of monoamine oxidase-A with IC50 of 5 nM and Ki of 1.6 nM with serotonin as a substrate. |
| T10090 |
264W94 |
264W94 is a potent ileal bile acid transporter (IBAT) inhibitor and a new cholesterol-lowering agent. 264W94 has CYP7A1 induction and antilipemic action. |
| T10091 |
Anti-inflammatory agent 1 |
Anti-inflammatory agent 1 is an anti-inflammatory compound extracted from patent WO 2009003229 A1 (example 36). |
| T10092 |
PSN-GK1 |
PSN-GK1 is a potent activator of glucokinase (EC50: 0.13 μM). |
| T10093 |
(2R,3R)-E1R |
(2R,3R)-E1R is an enantiomer of E1R. (2R,3R)-E1R is a sigma-1 receptor positive allosteric modulator for the treatment of cognition/memory disorders. |
| T10093L |
E1R |
E1R is a positive sigma-1 receptor (Sig1R PAM) allosteric modulator. It has a cognition-enhancing activity. |
| T10094 |
(2R,3S)-E1R |
(2R,3S)-E1R (Compound 2c) is an enantiomer of E1R. (2R,3R)-E1R is a sigma-1 receptor positive allosteric modulator for the treatment of cognition/memory disorde...
|
| T10095 |
(2R,4R)-APDC |
(2R,4R)-APDC is a selective group II metabotropic glutamate receptors (mGluRs) agonist. It has anticonvulsant and neuroprotective effects. |
| T10096L |
Voruciclib |
Voruciclib is an orally active and selective CDK inhibitor (Ki: 0.626 nM-9.1 nM). Voruciclib represses the expression of MCL-1 in multiple models of diffuse lar...
|
| T10096L2 |
(2S,3R)-Voruciclib hydrochloride |
(2S,3R)-Voruciclib hydrochloride is the (2S,3R)-enantiomer of Voruciclib. It is an orally active CDK inhibitor. |
| T10097 |
(2S,3S)-E1R |
(2S,3S)-E1R (Compound 2d) is an enantiomer of E1R. (2R,3R)-E1R is a sigma-1 receptor positive allosteric modulator for the treatment of cognition/memory disorde...
|
| T10099 |
2'-Deoxypseudoisocytidine |
2'-Deoxypseudoisocytidine is a nucleoside analogue. |
| T10100 |
QF0301B |
QF0301B is an antagonist of the α1 adrenergic receptor. It also is a low α2 adrenoceptor, 5-HT2A, and histamine H1 receptor blocker. |
| T10101 |
Calcium channel-modulator-1 |
Calcium channel-modulator-1 is a modulator of calcium channel and blocks aortic contraction (IC50: 0.8 μM). |
| T10102 |
3,6-DMAD hydrochloride |
3,6-DMAD hydrochloride is an inhibitor of the IRE1α-XBP1 pathway of the unfolded protein response. |
| T10103 |
3,3'-Diiodo-L-thyronine |
3,3'-Diiodo-L-thyronine (3,3'-T2) is an endogenous metabolite of thyroid hormone. It significantly enhances COX activity. |
| T10104 |
3,4-Dihydroxybenzylamine hydrobromide |
3,4-Dihydroxybenzylamine hydrobromide (NSC 263475 hydrobromide) is a dopamine analog with cytotoxic and inhibits DNA polymerase activity in melanoma cells. |
| T10106 |
3-arylisoquinolinamine derivative |
3-arylisoquinolinamine derivative is a compound with antitumor activity. |
| T10108 |
3-Bromocytisine |
3-Bromocytisine (3-Br-cytisine) is a potent nACh receptors agonist, (IC50s: 0.28, 0.30 and 31.6 nM for hα4β4, hα4β2, and hα7-nACh). |
| T10109 |
3-Carene |
3-Carene is a bicyclic monoterpene in essential oils extracted from pine trees. |
| T10110 |
3-CPs |
3-CPs (3-Carbethoxypsoralen) is a serotype capsular polysaccharide which can interfere with antibody-mediated bacterial killing. |
| T10112 |
3-Hydroxy-4-methoxyacetophenone |
3-Hydroxy-4-methoxyacetophenone(Acetoisovanillone) is an active compound isolated from Pycnocycla spinosa. It possesses anti-inflammatory activity and prevents ...
|
| T10115 |
3-Nitrocoumarin |
3-Nitrocoumarin (3-NC) is a potent and selective Phospholipase C-γ (PLCγ) inhibitor. |
| T10116 |
3-O-Acetylbufotalin |
3-O-Acetylbufotalin is a derivate of bufadienolide with anti-cancer activity. |
| T10117 |
3'-O-Acetylhamaudol |
3'-O-Acetylhamaudol, isolated from the roots of Angelica japonica, exhibits anti-tumor activity through dual actions, anti-angiogenesis and intestinal intraepit...
|
| T10120 |
3-Oxo Atorvastatin |
3-Oxo Atorvastatin is an impurity of Atorvastatin. Atorvastatin is an HMG-CoA reductase inhibitor and has the ability to effectively decrease blood lipids. |
| T10121 |
Substance P Receptor Antagonist 1 |
Substance P Receptor Antagonist 1 has the potential function in gastrointestinal disorders, inflammatory diseases, respiratory, and central nervous system disor...
|
| T10122 |
Anti-neurodegeneration agent 1 |
Anti-neurodegeneration agent 1 a neurodegeneration-targeting agent extracted from patent WO2008039514A1 (Compound I). |
| T10124 |
Antiulcer Agent 1 |
Antiulcer Agent 1 is a 2-(3,4-dimethoxyphenyl)ethylamine derivative for oral administration. |
| T10125 |
(3R,4R)-A2-32-01 |
(3R,4R)-A2-32-01 (compound 2) is a specific caseinolytic protein proteases (ClpP) inhibitor (EC50: 4.5 μM). |
| T10126 |
(3R,5R)-Rosuvastatin |
(3R,5R)-Rosuvastatin is the (3R,5R)-enantiomer of Rosuvastatin. Rosuvastatin is a competitive HMG-CoA reductase inhibitor (IC50: 11 nM). |
| T10127 |
(3R,5S)-Atorvastatin sodium |
(3R,5S)-Atorvastatin sodium is an impurity of Atorvastatin. Atorvastatin is an HMG-CoA reductase inhibitor and has the ability to effectively decrease blood lip...
|
| T10128 |
(3S,5R)-Fluvastatin D6 sodium |
(3S,5R)-Fluvastatin D6 sodium is the deuterium-labeled (3S,5R)-Fluvastatin sodium. Fluvastatin is a first fully synthetic, competitive HMG-CoA reductase inhibit...
|
| T10129 |
(3S,5R)-Fluvastatin sodium |
(3S,5R)-Fluvastatin sodium is the (3S,5R)-enantiomer of Fluvastatin. Fluvastatin is a first fully synthetic, competitive HMG-CoA reductase inhibitor (IC50: 8 nM...
|
| T10130 |
(3S,5R)-Pitavastatin calcium |
(3S,5R)-Pitavastatin calcium is the enantiomer of Pitavastatin which is a potent HMG-CoA reductase inhibitor. |
| T10131 |
(3S,5R)-Rosuvastatin |
(3S,5R)-Rosuvastatin is the (3R,5R)-enantiomer of Rosuvastatin. Rosuvastatin is a competitive HMG-CoA reductase inhibitor (IC50: 11 nM). |
| T10132 |
(3S,5S)-Pitavastatin calcium |
(3S,5S)-Pitavastatin calcium is the 3-epimer of Pitavastatin which is a potent HMG-CoA reductase inhibitor. |
| T10133 |
3'-Azido-3'-deoxy-5-methylcytidine |
3'-Azido-3'-deoxy-5-methylcytidine (CS-92) is a potent xenotropic murine leukemia-related retrovirus (XMRV) inhibitor (CC50: 43.5 μM) in MCF-7 cells. It also i...
|
| T10134 |
4,7,10,13,16-Docosapentaenoic acid |
4,7,10,13,16-Docosapentaenoic acid is an endogenous metabolite. |
| T10135 |
4-Acetamidophenyl acetate |
4-Acetamidophenyl acetate is an impurity of Acetaminophen. Acetaminophen is a selective COX-2 inhibitor (IC50: 25.8 μM) and is a potent hepatic N-acetyltransfe...
|
| T10136 |
4-Acetylsimvastatin |
4-Acetylsimvastatin is acetylated simvastatin. Simvastatin is a competitive inhibitor of HMG-CoA reductase (Ki: 0.2 nM). |
| T10137 |
4-Bromo A23187 |
4-Bromo A23187 is a halogenated analog of the calcium ionophore A-23187. 4-Bromo A23187 is a calcium modulator and induces apoptosis in different cells. |
| T10138 |
4-Desmethoxy Omeprazole |
4-Desmethoxy Omeprazole is the active metabolite of Omeprazole. Omeprazole is a proton pump inhibitor (PPI). Omeprazole shows competitive inhibition of CYP2C19 ...
|
| T10139 |
4-Desmethyl Istradefylline |
4-Desmethyl Istradefylline is a Istradefylline metabolite. Istradefylline is a very potent, selective, and orally active adenosine A2A receptor antagonist with ...
|
| T10140 |
4-Diethylaminobenzaldehyde |
4-Diethylaminobenzaldehyde is a reversible aldehyde dehydrogenase (ALDH) inhibitor (Ki: 4 nM for ALDH1). It displays a potent anti-androgenic effect (IC50: 1.71...
|
| T10141 |
4'-Ethynyl-2'-deoxyadenosine |
4'-Ethynyl-2'-deoxyadenosine (4'-E-dA) is a nucleoside reverse transcriptase (RT) inhibitor. It is potent against drug-resistant HIV variants (EC50: 98 nM in MT...
|
| T10142 |
4-Ethynyl-L-phenylalanine |
4-Ethynyl-L-phenylalanine is a selective, reversible and competitive inhibitor of tryptophan hydroxylase (TPH). 4-Ethynyl-L-phenylalanine is a competitive inhib...
|
| T10143 |
4-Hydroxyacetophenone oxime |
4-Hydroxyacetophenone oxime is an impurity of Acetaminophen (Paracetamol). Acetaminophen is a potent COX-2 and hepatic NAT2 inhibitor and used antipyretic and a...
|
| T10144 |
4-Hydroxyatomoxetine D3 |
4-Hydroxyatomoxetine D3 is a deuterium labeled 4-Hydroxyatomoxetine. 4-Hydroxyatomoxetine is an active metabolite of Atomoxetine. 4-Hydroxyatomoxetine is metabo...
|
| T10145 |
4-Hydroxyatomoxetine |
4-Hydroxyatomoxetine is an active metabolite of Atomoxetine. 4-Hydroxyatomoxetine is metabolized by CYP2D6. Atomoxetine is a noradrenaline reuptake inhibitor. |
| T10147 |
4-Hydroxymephenytoin |
4-Hydroxymephenytoin is the metabolism of an antiepileptic drug mephenytoin. Mephenytoin is used as a CYP2C19 substrate. |
| T10148 |
4-Hydroxynonenal |
4-Hydroxynonenal (4-HNE) is an oxidative/nitrosative stress biomarker. It is a substrate and an inhibitor of acetaldehyde dehydrogenase 2 (ALDH2). |
| T10149 |
4-Hydroxypropranolol D7 hydrochloride |
4-Hydroxypropranolol D7 hydrochloride is deuterium-labeled 4-Hydroxypropranolol hydrochloride. 4-Hydroxypropranolol hydrochloride is an active metabolite of Pro...
|
| T10150 |
4-Hydroxypropranolol hydrochloride |
4-Hydroxypropranolol hydrochloride is an active metabolite of Propranolol, with a potency comparable to Propranolol. It inhibits β1- and β2-adrenergic recepto...
|
| T10153 |
4-O-Methyl honokiol |
4-O-Methyl honokiol, a natural neolignan isolated from Magnolia officinalis, acts as a PPARγ agonist and inhibits NF-κB activity, used for cancer and inflamma...
|
| T10154 |
MAO-B-IN-1 |
MAO-B-IN-1 is a monoamine oxidase B inhibitor and can be used for the research of neurological diseases. |
| T10155 |
4'-Raloxifene-β-D-glucopyranoside |
4'-Raloxifene-β-D-glucopyranoside is a metabolite of Raloxifene. 4'-Raloxifene-β-D-glucopyranoside is a selective and orally active estrogen receptor antagoni...
|
| T10157 |
Regorafénib N-oxyde (M2) |
Regorafénib N-oxyde M2 is an active metabolite of Regorafenib. Regorafenib is a multi-target inhibitor for VEGFR1/2/3, PDGFRβ, RET, Kit, and Raf-1 (IC50s: 13/...
|
| T10158 |
42-(2-Tetrazolyl)rapamycin |
42-(2-Tetrazolyl)rapamycin is a prodrug compound of a rapamycin analog extracted from patent US 20080171763 A1, Example 1. |
| T10159 |
48740 RP |
48740 RP (RP-55778) is a platelet-activating factor (PAF) antagonist. |
| T10161 |
Antiasthmatic Compound 1 |
Antiasthmatic Compound 1 is an antiasthmatic agent. |
| T10163 |
4'-Methylchrysoeriol |
4'-Methylchrysoeriol is a potent inhibitor of cytochrome P450 enzymes (IC50: 19 nM for human P450 1B1-dependent EROD). |
| T10164 |
5,6-Dihydroxyindole |
5,6-Dihydroxyindole is a melanin precursor and has a broad-spectrum antibacterial, antiviral, antifungal, antiparasitic activity. It has cytotoxic effects and i...
|
| T10165 |
5-A-RU |
5-A-RU (5-Amino-6-(D-ribitylamino)uracil), a precursor of bacterial Riboflavin, is a mucosal-associated invariant T (MAIT) cells activator. 5-A-RU forms potent ...
|
| T10165L |
5-A-RU hydrochloride |
5-Amino-6-(D-ribitylamino)uracil hydrochloride, a precursor of bacterial Riboflavin, is a mucosal-associated invariant T (MAIT) cells activator. 5-A-RU forms po...
|
| T10166 |
Lipid peroxidation inhibitor 1 |
Lipid peroxidation inhibitor 1 is an inhibitor of lipid peroxidation (IC50: 0.07 μM). |
| T10167 |
5-Dehydroepisterol |
5-Dehydroepisterol is an episterol derivative with anti-fungal activities. It can be formed by C-5 sterol desaturase and converted into 24-methylenecholesterol ...
|
| T1017 |
Fluoroethyl |
Flurothyl is a convulsant used in experimental animals. |
| T10171 |
5-Hydroxypyrazine-2-Carboxylic Acid |
5-Hydroxypyrazine-2-Carboxylic Acid is a metabolite of anti-tuberculosis drug pyrazinamide. |
| T10172 |
5-Iodo-indirubin-3'-monoxime |
5-Iodo-indirubin-3'-monoxime is a potent GSK-3β, CDK5/P25 and CDK1/cyclin B inhibitor, competing with ATP for binding to the catalytic site of the kinase (IC50...
|
| T10173 |
MCHR1 antagonist 1 |
MCHR1 antagonist 1 is a selective antagonist of melanin-concentrating hormone-1 (MCH1) receptor (Kb: 1 nM, Ki: 4 nM at human MCH1). |
| T10174 |
5-R-Rivaroxaban |
5-R-Rivaroxaban is (R)-enantiomer of Rivaroxaban. Rivaroxaban (BAY 59-7939) is a highly potent and selective, direct Factor Xa (FXa) inhibitor (IC50 0.7 nM; Ki ...
|
| T10175 |
(5E,9E,13E)-Teprenone |
(5E,9E,13E)-Teprenone is an isomer of Teprenone with antiulcer activity. It induces transcriptional activation of HSP genes that may increase gastric mucosal de...
|
| T10176 |
TRPV antagonist 1 |
TRPV antagonist 1 is an antagonist of transient receptor potential vanilloid (TRPV; IC50 < 250 nM). |
| T10177 |
(5Z,2E)-CU-3 |
(5Z,2E)-CU-3 is a selective inhibitor against the α-isozyme of DGK (IC50: 0.6 μM), competitively inhibits the affinity of DGKα for ATP (Km: 0.48 mM). |
| T10178 |
Guanosine 5'-triphosphate trisodium salt hydrate |
5'-GTP trisodium salt hydrate, an activator of the signal-transducing G proteins, serves as a precursor of mononucleotide units in the enzymatic biosynthesis of...
|
| T10179 |
5β-Dutasteride |
5β-Dutasteride is the S configuration of Dutasteride. It is a potent inhibitor of both 5 alpha-reductase isozymes. |
| T10180 |
6-Alpha Naloxol |
6-Alpha Naloxol(Alpha-Naloxol) is an opioid antagonist and is a human metabolite of naloxone. |
| T10181 |
6-beta-Naloxol D5 hydrochloride |
6-beta-Naloxol D5 hydrochloride is the deuterium-labeled 6-beta-Naloxol, which is an opioid antagonist closely related to naloxone. |
| T10182 |
6-Hydroxybenzbromarone |
6-Hydroxybenzbromarone is the major metabolite of Benzbromarone. 6-Hydroxybenzbromarone is a protein Eyes Absent 3 (EYA3) inhibitor (IC50: 21.5 μM). It is an a...
|
| T10183 |
6-Methoxytricin |
6-Methoxytricin is a flavonoid isolated from Artemisia iwayomogi. It is an inhibitor on aldose reductase (AR) and advanced glycation endproduct (AGE) formation ...
|
| T10184 |
6-Methyl-5-azacytidine |
6-Methyl-5-azacytidine is a potent DNMT inhibitor. |
| T10185 |
6-Phosphogluconic acid |
6-Phosphogluconic acid is a potent and competitive phosphoglucose isomerase (PGI) inhibitor (Kis: 48 μM for glucose 6-phosphate and 42 μM for fructose 6-phosp...
|
| T10186 |
6-Quinoxalinecarboxylic acid, 2,3-bis(bromomethyl)- |
6-Quinoxalinecarboxylic acid, 2,3-bis(bromomethyl)-, derived from 2,3-Bis(bromomethyl)quinoxaline, shows antibacterial activity. |
| T10187 |
6-Raloxifene-β-D-glucopyranoside |
6-Raloxifene-β-D-glucopyranoside is a benzothiophene glucuronidated at the 6' position. It is a selective and orally active estrogen receptor antagonist. 6-Ral...
|
| T10188 |
6RK73 |
6RK73 is a covalent irreversible and specific UCHL1 inhibitor (IC50: 0.23 µM). 6RK73 shows almost no inhibition of UCHL3 (IC50: 236 µM). |
| T10189 |
7-[4-(2-Piperidinyl)ethoxy]benzoyl Raloxifene |
7-[4-(2-Piperidinyl)ethoxy]benzoyl Raloxifene is a liver receptor homolog-1 (LRH-1) antagonist (IC50: 3.1 μM). |
| T10190 |
7-BIA |
7-BIA is a receptor-type protein tyrosine phosphatase D (PTPRD) inhibitor (IC50: 1-3 μM). |
| T10191 |
7-Chlorokynurenic acid sodium salt |
7-Chlorokynurenic acid sodium salt (7-CKA sodium salt) is a potent and selective antagonist of the glycine B coagonist site of the NMDA receptor (IC50: 0.56 μM...
|
| T10191L |
7-Chlorokynurenic acid |
7-Chlorokynurenic acid (7-CKA) is a potent and selective antagonist of the glycine B coagonist site of the N-methyl-D-aspartate (NMDA) receptor (IC50=0.56 μM)....
|
| T10193 |
7-Desmethyl-agomelatine |
7-Desmethyl-agomelatine is a metabolite of Agomelatine and has less activity than Agomelatine. Agomelatine is a melatonergic (MT1 and MT2) agonist and 5-HT2C an...
|
| T10194 |
7-Methylguanine |
7-Methylguanine is a metabolite of DNA methylation. It can be generated by methylating agents and used as a probe of DNA–protein interactions and a key compon...
|
| T10195 |
7-O-Geranylscopoletin |
7-O-Geranylscopoletin is a natural coumarin from the root of Atalantia monophylla. Various parts of this plant have been used for folk medicine for several purp...
|
| T10196 |
7α-Hydroxy-4-cholesten-3-one |
7α-Hydroxy-4-cholesten-3-one is an intermediate in the synthesis of bile acids from cholesterol. It is a PXR agonist. 7α-Hydroxy-cholest-4-en-3-one is a bioma...
|
| T10197 |
8,9-Epoxy-3-isobutyryloxy-10-(2-methylbutanoyl)thymol |
8,9-Epoxy-3-isobutyryloxy-10-(2-methylbutanoyl)thymol is a chemical composition of essential oils from Telekia speciosa. It also shows marked antipro-liferative...
|
| T10198 |
8-M-PDOT |
8-M-PDOT (AH-002) is a selective melatonin MT2 receptor agonist. It is 5.2-fold selective for MT2 over MT1 receptors. 8-M-PDOT binds human recombinant MT2 and M...
|
| T10199 |
GNF-PF-3777 |
GNF-PF-3777 (8-Nitrotryptanthrin) is a potent inhibitor of human indoleamine 2,3-dioxygenase 2 (hIDO2; Ki: 0.97 μM). |
| T10200 |
9-Hydroxyellipticine hydrochloride |
9-Hydroxyellipticine hydrochloride is a inhibitor of Topo II and RyR. It exhibits antitumor, antioxidant and catecholamine-releasing activities. 9-Hydroxyellipt...
|
| T10201 |
PDE IV-IN-1 |
PDE IV-IN-1 is a phosphodiesterase IV inhibitor used for the research of COPD, asthma, or other inflammatory diseases. |
| T10203 |
A 1120 |
A 1120 is a nonretinoid retinol-binding protein 4 (RBP4) antagonist (Ki: 8.3 nM), which disrupts the interaction between RBP4 and its binding partner transthyre...
|
| T10204 |
A-317491 sodium salt hydrate |
A-317491 sodium salt hydrate is a non-nucleotide P2X3 and P2X2/3 receptor antagonist, which inhibits calcium flux mediated by the receptors. |
| T10205 |
A-395 |
A-395 is an antagonist of polycomb repressive complex 2 (PRC2) protein-protein interactions that potently inhibits the trimeric PRC2 complex (EZH2-EED-SUZ12, IC...
|
| T10209 |
A-887826 |
A-887826 is a selective, orally bioavailable, and voltage-dependent Na(v1.8) channel blocker (IC50: 11 nM). It attenuates neuropathic tactile allodynia in vivo. |
| T10211 |
Aβ42-IN-1 |
Aβ42-IN-1 is a novel and orally active γ-secretase modulator (GSM). Aβ42-IN-1 potently reduced Aβ42 levels (IC50: 0.091 µM) without CYP3A4 inhibition. |
| T10212 |
A2AR-agonist-1 |
A2AR-agonist-1 is a potent A2AR and ENT1 agonist (Ki: 4.39 and 3.47 for A2AR and ENT1. It targets the Adenosine A2A Receptor and Adenosine Transporter for Neuro...
|
| T10215 |
AAPK-25 |
AAPK-25 is a potent and selective Aurora/PLK dual inhibitor with anti-tumor activity, which can cause mitotic delay and arrest cells in prometaphase, followed b...
|
| T10216 |
AB-680 |
AB-680 is a highly potent, reversible, and selective inhibitor of CD73 (an ectonucleotidase, Ki: 4.9 pM for hCD73) with anti-tumor activity, displays >10,000-fo...
|
| T10217 |
Abarelix Acetate |
Abarelix (PPI 149; R 3827) Acetate is a potent gonadotrophin-releasing hormone (GnRH) antagonist, used for prostate cancer research. |
| T10217L |
Abarelix |
Abarelix (R3827; PPI 149) is a potent gonadotrophin-releasing hormone (GnRH) antagonist, which is used for prostate cancer treatment. |
| T10218 |
Abatacept |
Abatacept (CTLA4lg) is a soluble fusion protein consisting of the extracellular domain of human CTLA4 and a fragment of the Fc portion of human IgG1 (hinge and ...
|
| T10219 |
ABBV-4083 |
ABBV-4083 is a Tylosin A analog that has potent anti-Wolbachia and anti-filarial activity. |
| T10221 |
Abeprazan hydrochloride |
Abeprazan (DWP14012) hydrochloride is a potassium-competitive acid blocker. It inhibits H+, K+- ATPase by reversible potassium-competitive ionic binding with no...
|
| T10221L |
Abeprazan |
Abeprazan (DWP14012) is a potassium-competitive acid blocker and it is developed as a potential alternative to proton pump inhibitor for the treatment of acid-r...
|
| T10222 |
ABMA |
ABMA is a broad-spectrum inhibitor of intracellular toxins and pathogens. ABMA efficiently protects cells against various pathogens including viruses, intracell...
|
| T10223 |
ABT-100 |
ABT-100 is a potent, highly selective, and orally active farnesyl transferase inhibitor with broad-spectrum antitumor activity. |
| T10224 |
ABT-418 hydrochloride |
ABT-418 hydrochloride is a selective agonist of nAChRs with cognitive enhancing and anxiolytic activities. It activates cholinergic channel and can be used for ...
|
| T10225 |
ABT-546 |
ABT-546 (A-216546) is a potent, highly selective, and active endothelin ETA receptor antagonist with a Ki of 0.46 nM for [125I]endothelin-1 binding to cloned hu...
|
| T10226 |
Sofiniclin |
Sofiniclin (ABT 894) is an agonist of nicotinic acetylcholine receptor (nAChR). It is used for the research for attention-deficit/hyperactivity disorder (ADHD). |
| T10227 |
Ac-Gly-BoroPro |
Ac-Gly-BoroPro is a selective FAP inhibitor (Ki: 23 nM). |
| T10229 |
Acebutolol D7 |
Acebutolol D7 is a deuterium-labeled Acebutolol. Acebutolol is a selective antagonist of the β1 adrenergic receptor used in the treatment of angina pectoris, h...
|
| T1023 |
Cefoxitin sodium |
Cefoxitin sodium is a semisynthetic cephamycin antibiotic resistant to beta-lactamase. |
| T10230 |
MC-4R Agonist 1 |
MC-4R Agonist 1 is an agonist of human melanocortin-4 receptor (MC-4R) and can be used in the research of sexual dysfunction, obesity, and diabetes. |
| T10231 |
Acetazolamide D3 |
Acetazolamide D3 is a deuterium-labeled Acetazolamide. Acetazolamide is a potent carbonic anhydrase inhibitor. |
| T10232 |
Acetophenazine dimaleate |
Acetophenazine dimaleate is an antipsychotic agent, effective in anxious depression. |
| T10233 |
Acetylarenobufagin |
Acetylarenobufagin is a steroidal hypoxia-inducible factor-1 (HIF-1) modulator. |
| T10235 |
Acetyllovastatin |
Acetyllovastatin (acetate of Lovastatin) presents a moderate inhibitory effect against the acetylcholinesterase (IC50: 79 μg/mL). Lovastatin displays antifunga...
|
| T10236 |
ACHN-975 TFA |
ACHN-975 TFA is a selective LpxC inhibitor with a subnanomolar inhibitory. It is against a wide range of gram-negative bacterias with low MIC values (≤1 μg/m...
|
| T10236L |
ACHN-975 |
ACHN-975 is against a wide range of gram-negative bacterias with low MIC values (≤1 μg/mL)[1]. ACHN-975 is a selective LpxC inhibitor and exhibits a subnanom...
|
| T10237 |
ACHP Hydrochloride |
ACHP Hydrochloride (IKK-2 Inhibitor VIII) is a highly potent and selective IKK-β inhibitor (IC50: 8.5 nM). |
| T10239 |
Acolbifene |
Acolbifene (EM-652; SCH 57068) is a fourth-generation selective estrogen receptor antagonist (LC50: 22 nM). |
| T10241 |
Acrivastine D7 |
Acrivastine D7 is a deuterium labeled Acrivastine. Acrivastine is a short acting antagonist of histamine 1 receptor. |
| T10242 |
ACT-389949 |
ACT-389949 is a potent and selective agonist of formyl peptide receptor type 2 (FPR2)/Lipoxin A4 receptor (ALX), with an EC50 of 3 nM for FPR2/ALX internalizati...
|
| T10243 |
ACX-362E |
ACX-362E is an orally available DNA polymerase IIIC (pol IIIC) inhibitor, acts as an antimicrobial agent to treat Gram-positive infections (MIC50: 2 μg/mL for ...
|
| T10246 |
Adapalene sodium salt |
Adapalene (CD 271; Differin) sodium salt is a synthetic retinoid and a Retinoic acid receptor agonist. |
| T10248 |
Adenosine antagonist-1 |
Adenosine antagonist-1 is an adenosine A3 receptor (AA3R) antagonist. |
| T10249 |
Adoprazine |
Adoprazine is a potential atypical antipsychotic bearing potent D2 receptor antagonist and 5-HT1A receptor agonist properties. |
| T10250 |
ADRA1D receptor agonist 1 |
ADRA1D receptor agonist 1 is a potent, selective, and orally active α1D adrenoceptor antagonist (Ki: 1.6 nM). |
| T10251 |
Adrenocorticotropic Hormone (ACTH) (1-39), rat TFA |
Adrenocorticotropic Hormone (ACTH) (1-39), rat (TFA) is a potent melanocortin 2 receptor (MC2) agonist. |
| T10252 |
ADU-S100 disodium salt |
ADU-S100 (MIW815) disodium salt is an activator of stimulator of interferon genes (STING). |
| T10252L |
ADU-S100 enantiomer ammonium salt |
ADU-S100 (MIW815) enantiomer ammonium salt is the less active enantiomer of ADU-S100. ADU-S100 is an activator of the stimulator of interferon genes (STING). |
| T10252L2 |
ADU-S100 ammonium salt |
ADU-S100 ammonium salt is an stimulator of interferon genes (STING) activator. |
| T10252L3 |
ADU-S100 |
ADU-S100 is an activator of stimulator of interferon genes (STING). |
| T10253 |
AD 0261 |
AD 0261 is a radical scavenger. It has a strong inhibitory action on the generation of lipid peroxides and superoxide anions. |
| T10257 |
Afatinib N-Oxide |
Afatinib N-Oxide is an impurity of Afatinib in oxidative degradation. Afatinib is an irreversible EGFR family inhibitor. |
| T10259 |
AGI-25696 |
AGI-25696 is a methionine adenosyltransferase 2A (MATA2 ) inhibitors useful for the treatment of cancer. It blocks the growth of MTAP-deleted tumors in vivo. |
| T10260 |
Aglafoline |
Aglafoline inhibits in a concentration-dependent manner the aggregation and ATP release reaction induced in washed rabbit platelets by PAF (platelet-activating ...
|
| T10261 |
AGN 196996 |
AGN 196996 is a potent and selective RARα antagonist (Ki: 2 nM) and little binding affinity for RARβ (Ki: 1087 nM) and RARγ (Ki: 8523 nM). |
| T10262 |
AGN 205327 |
AGN 205327 is a potent synthetic RARs agonist (EC50s: 3766/734/32 nM for RARα/β/γ) and has no inhibition on RXR. |
| T10263 |
AGN 205728 |
AGN 205728 is a potent and selective RARγ antagonist (Ki: 3 nM; IC95: 0.6 nM) and has no inhibition on RARα and RARβ. |
| T10264 |
AGN 192836 |
AGN 192836 is a potent and selective α2 adrenergic agonist (EC50s: 8.7, 41 and 6.6 nM for α2A, α2B and α2C receptor). |
| T10265 |
AGN 194078 |
AGN 194078 is a selective RARα agonist (Kd: 3 nM; EC50: 112 nM). |
| T10266 |
Agomelatine D6 |
Agomelatine D6 (S-20098 D6) is a deuterium-labeled Agomelatine. Agomelatine is a specific agonist of MT1 and MT2 receptors. |
| T10268 |
AGX51 |
AGX51 is a first-in-class pan-Id (inhibitors of DNA-binding/differentiation proteins) antagonist and degrader. |
| T10269 |
AHR antagonist 2 |
AHR antagonist 2 is a potent aryl hydrocarbon receptor (AHR) antagonist, extracted from patent WO2019101641A1, compound example 1 (IC50s: 0.885 and 2.03 nM for ...
|
| T10270 |
BAY 2416964 |
BAY 2416964 is a potent and orally active aryl hydrocarbon receptor (AHR) antagonist extracted from patent WO2018146010A1 (example 192, IC50: 341 nM). It has th...
|
| T10271 |
AHR antagonist 4 |
AHR antagonist 4 is a potent aryl hydrocarbon receptor (AHR) antagonist extracted from patent WO2018146010A1 (example 293; IC50: 82.2 nM). It has anti-cancer ef...
|
| T10272 |
AHR antagonist 5 |
AHR antagonist 5 is a potent and orally active aryl hydrocarbon receptor (AHR) antagonist extracted from patent WO2018195397 (example 39; IC50 < 0.5 µΜ). It s...
|
| T10273 |
AhR modulator-1 |
AhR modulator-1 is a selective and orally active aryl hydrocarbon receptor (AhR) modulator. It inhibits metastasis, in part, by inhibiting prostatic VEGF produc...
|
| T10278 |
Alamethicin |
Alamethicin is isolated from Trichoderma viride. It is a channel-forming peptide antibiotic and induces voltage-gated conductance in model and cell membranes. |
| T10279 |
Alfacalcidol-D6 |
Alfacalcidol-D6 is a deuterated Alfacalcidol. Alfacalcidol is a non-selective VDR activator medication. |
| T1028 |
Moxonidine |
Moxonidine is a selective agonist at the imidazoline receptor subtype 1， acting as an antihypertensive drug. |
| T10280 |
Alimemazine D6 |
Alimemazine D6 is a deuterium-labeled Alimemazine. Alimemazine is an antihistamine. |
| T10281 |
Alimemazine |
Alimemazine (Trimeprazine) is generally used as an antipruritic agent and also a hemagglutinin (HA)-receptor antagonist. Alimemazine also acts as a partial agon...
|
| T10282 |
Aliskiren D6 Hydrochloride |
Aliskiren (CGP 60536) D6 Hydrochloride is a deuterium-labeled Aliskiren. Aliskiren hemifumarate is a direct and orally active renin inhibitor (IC50: 1.5 nM). |
| T10284 |
ALK-IN-6 |
ALK-IN-6 is an orally bioavailable inhibitor of anaplastic lymphoma kinase (ALK, IC50s: 71 nM, 18.72 nM, and 36.81 nM for ALK wild, ALK F1196M and ALK F1174L). |
| T10285 |
ALK inhibitor 1 |
ALK inhibitor 1 is a selective ALK kinase inhibitor. |
| T10286 |
ALK/ROS1-IN-1 |
ALK/ROS1-IN-1 is a potent and selective anti-crizotinib-resistant ALK/ROS1 dual inhibitor (IC50s: 0.530 μM and 0.174 μM for ROS1 and ALK enzyme). |
| T10288 |
Alogliptin (13CD3) |
Alogliptin (SYR-322) 13CD3 is the deuterium-labeled Alogliptin. Alogliptin is a selective inhibitor of DPP-4. |
| T10289 |
Alosetron ((Z)-2-butenedioate) |
Alosetron (GR 68755) (Z)-2-butenedioate is a Serotonin 5HT3-receptor antagonist that is used in the treatment of irritable bowel syndrome. |
| T10290 |
Alpertine |
Alpertine is an antipsychotic agent extracted from patent US 5955459 A. |
| T10291 |
α-Truxillic acid |
α-Truxillic acid is formed by the dimerization of two molecules of α-trans-cinnamic acid with anti-inflammatory activities. |
| T10295 |
Amantanium bromide |
Amantanium bromide is a quaternary ammonium compound used as an antiseptic/disinfectant for therapeutic function. |
| T10297 |
AMG 487 (S-enantiomer) |
AMG 487 S-enantiomer is the S enantiomer of AMG 487. AMG 487 is an CXCR3 antagonist. |
| T10297L |
AMG 487 |
AMG 487 is an orally active and selective antagonist of CXC chemokine receptor 3 (CXCR3). It inhibits the binding of CXCL10 and CXCL11 to CXCR3 with IC50s of 8....
|
| T10301 |
AMG8380 |
AMG8380 is an orally active and less active enantiomer of AMG8379 served as a negative control. AMG8380 inhibits human and mouse voltage-gated sodium channel Na...
|
| T10301L |
AMG8379 |
AMG8379 potently and reversibly blocks endogenous Tetrodotoxin (TTX)-sensitive sodium channels in dorsal root ganglia (DRG) neurons with an IC50 of 3.1 nM[1]. A...
|
| T10302 |
Amibegron hydrochloride |
Amibegron hydrochloride is a selective β3-adrenoceptor agonist (EC50: 3.5 nM for β-adrenoceptor in rat colon). It has anxiolytic and antidepressant activity. |
| T10303 |
Aminoacyl tRNA synthetase-IN-1 |
Aminoacyl tRNA synthetase-IN-1 is an inhibitor of bacterial aminoacyl tRNA synthetase (aaRS). |
| T10304 |
Aminochlorthenoxazin |
Aminochlorthenoxazin is an antipyretic and analgesic agent. |
| T10305 |
Amiselimod hydrochloride |
Amiselimod hydrochloride is a sphingosine 1-phosphate receptor-1 (S1P1) modulator. |
| T10306 |
Amoxicillin D4 |
Amoxicillin D4 (Amoxycillin D4) is a deuterium-labeled Amoxicillin. Amoxicillin is an antibiotic with broad-spectrum antimicrobial activity. |
| T10307 |
AMPA receptor modulator-1 |
AMPA receptor modulator-1 is an orally active, and selective AMPAR regulatory protein TARP γ-8 negative modulator (pIC50: 9.7), more selective over GluA1/γ-2 ...
|
| T10308 |
AMPD2 inhibitor 1 |
AMPD2 inhibitor 1 is an inhibitor of adenosine monophosphate deaminase 2 (AMPD2), used in the research of salt craving, sugar craving, umami craving, and addict...
|
| T10309 |
Amphethinile |
Amphethinile is an anti-tubulin agent. The Ka of Amphethinile with tubulin is 1.3 μM. |
| T1031 |
Cloxacillin sodium monohydrate |
Cloxacillin Sodium is the sodium salt of cloxaclliin, a semisynthetic beta-lactamase resistant penicillin antibiotic with antibacterial activity. |
| T10310 |
Amphotericin B methyl ester |
Amphotericin B methyl ester is the derivative of the antibiotic Amphotericin B. Amphotericin B methyl ester is the cholesterol-binding compound that possesses s...
|
| T10311 |
Amphotericin X1 |
Amphotericin X1 is a derivative of Amphotericin B with good antifungal activity. Amphotericin X1 inhibits Candida albicans 33/079, Cryptococcus neoformans 451, ...
|
| T10313 |
AMXT-1501 tetrahydrochloride |
AMXT-1501 tetrahydrochloride is an inhibitor of polyamine transport. It blocks tumor growth in immunocompetent mice but not in athymic nude mice lacking T cells...
|
| T10314 |
AM 103 |
AM 103 is a potent and selective FLAP inhibitor (IC50: 4.2 nM). |
| T10315 |
AN-3485 |
AN-3485 is a Toll-Like Receptor(TLR) inhibitor (IC50s: 18 to 580 nM). |
| T10316 |
AN3199 |
AN3199 is a PDE4 inhibitor (IC50: 94.5 nM). |
| T10319 |
Anamorelin |
Anamorelin is a novel ghrelin receptor agonist (EC50: 0.74 nM in the FLIPR assay). |
| T10319L |
Anamorelin Fumarate |
Anamorelin Fumarate is a novel ghrelin receptor agonist (EC50: 0.74 nM in the FLIPR assay). |
| T10320 |
Androgen receptor antagonist 1 |
Androgen receptor antagonist 1 is an orally available full androgen receptor antagonist (IC50: 59 nM). It can be used in the synthesis of PROTAC AR degraders, w...
|
| T10322 |
Angiotensin III |
Angiotensin III is an agonist of angiotensin 1 (AT1) and AT2 receptor. |
| T10322L |
Angiotensin III TFA |
Angiotensin III TFA is an agonist of angiotensin 1 (AT1) and AT2 receptor. |
| T10324 |
Anhydrosimvastatin |
Anhydrosimvastatin is an impurity of Simvastatin. Simvastatin is an HMG-CoA reductase inhibitor. |
| T10326 |
Aniline-MPB-amino-C3-PBD |
Aniline-MPB-amino-C3-PBD is a cytotoxic agent comprised of the non-alkylating group. It is a sequence-selective DNA minor-groove binding agent. |
| T10328 |
Anti-parasitic agent 3 |
Anti-parasitic agent 3 is an anti-parasitic agent. |
| T10329 |
anti-TB agent 1 |
anti-TB agent 1 is a potent and orally active anti-tuberculosis agent (MICs: < 2 nM against the Mtb strains H37Rv, rRMP and rINH). |
| T1033 |
Monensin sodium salt |
Monensin sodium is an antiprotozoal agent produced by Streptomyces cinnamonensis.Monensin sodium salt causes a marked enlargement of the MVBs and regulates exos...
|
| T10331 |
Anticancer agent 3 |
Anticancer agent 3 (Compound 4) is a anti-cancer agent. |
| T10332 |
Antidepressant agent 1 |
Antidepressant agent 1 is a pyrazidole-halogeno-derivative with antidepressant effects. It also can be used to increase body temperature. |
| T10333 |
Antifungal agent 1 |
Antifungal agent 1 is an effective antifungal agent. |
| T10334 |
Antifungal agent 2 |
Antifungal agent 2 is a broad-spectrum fungal inhibitor that inhibits the growth of pertinent species of Cryptococcus, Candida, and Aspergillus at a concentrati...
|
| T10336 |
Antimalarial agent 1 |
Antimalarial agent 1 is an effective antimalarial agent. |
| T10338 |
Antisauvagine-30 TFA |
Antisauvagine-30 TFA (aSvg-30 TFA) is a highly selective and competitive antagonist of CRF2 receptor peptidic. It shows a Kd of 1.4 nM and 150 nM for mCRFR2β a...
|
| T1034 |
DocetaxelHOT |
Docetaxel is a microtubule inhibitor that inhibits microtubule disassembly (IC50: 0.2 μM). |
| T10340 |
Antitrypanosomal agent 2 |
Antitrypanosomal agent 2 is a potent and selective inhibitor of trypanosoma brucei. |
| T10341 |
Antitumor agent-19 |
Antitumor agent-19 is an antitumor agent targeting tumor-associated macrophages (TAMs) to serve as an effective TAMs modulator (EC50s: 17.18 μM and 18.87 μM i...
|
| T10342 |
Antitumor agent-2 |
Antitumor agent-2 has antitumor action and anti-inflammatory action. It is sourced from patent CN102250203 (compound 6a-r). |
| T10343 |
AOH1160 |
AOH1160 is a potent orally available small molecule proliferating cell nuclear antigen (PCNA) inhibitor. It interferes with DNA replication, blocks homologous r...
|
| T10345 |
Apcin-A |
Apcin-A is an anaphase-promoting complex (APC) inhibitor. It interacts strongly with Cdc20 and inhibits the ubiquitination of Cdc20 substrates. Apcin-A can be u...
|
| T10346 |
Apelin agonist 1 |
Apelin agonist 1 is an oral selective apelin agonist AM-2995, an agonist of the APJ (APLNR, angiotensin receptor like-1) receptor. It may be used in the treatme...
|
| T10348 |
Apigenin-7-diglucuronide |
Apigenin-7-diglucuronide is a flavonoid glycoside that exists in an assortment of medicinal plants with anti-inflammatory or ant-oxidant activities. It protects...
|
| T10349 |
Apixaban 13CD3 |
Apixaban 13CD3 (BMS-562247-01 13CD3) is a deuterium-labeled Apixaban. Apixaban is a reversible inhibitor of Factor Xa (Ki: 0.08 nM and 0.17 nM in human and rabb...
|
| T1035 |
Hesperidin |
Hesperidin is a flavanone glycoside found in citrus fruits with antioxidant, anti-inflammatory, anti-carcinogenic, and antihypertensive and lipid-lowering activ...
|
| T10351 |
Aprocitentan D4 |
Aprocitentan D4 (ACT-132577 D4) is a deuterium-labeled Aprocitentan. Aprocitentan is a major and pharmacologically active metabolite of Macitentan. Aprocitentan...
|
| T10355 |
Apyramide |
Apyramide is an anti-inflammatory compound. |
| T10356 |
AQ-13 dihydrochloride |
AQ-13 dihydrochloride is an antimalarial drug. It is effective against drug-resistant strains of Plasmodium falciparum. |
| T10357 |
AR-13324 analog mesylate |
AR-13324 analog mesylate is an inhibitor of Rho-kinase and a norepinephrine transporter and reduces intraocular pressure in normotensive monkey eyes. |
| T10358L |
AR-13324 M1 metabolite |
AR-13324 M1 metabolite is a hydrolysis metabolite of AR-13324 mesylate. |
| T10358L2 |
Netarsudil mesylate |
Netarsudil mesylate is an inhibitor of Rho-associated protein kinase (ROCK) and norepinephrine transporter (NET) with effective in intraocular pressure (IOP) re...
|
| T10359 |
AR antagonist 1 |
AR antagonist 1 is a potent antagonist of the androgen receptor. It binds to E3 ligase ligands with weak binding affinities to VHL protein in the synthesis of P...
|
| T1036 |
Netilmicin sulfate |
Netilmicin Sulfate is an aminoglycoside antibiotic. |
| T10360 |
AR-A 2 |
AR-A 2 is a selective 5-HT1B receptor antagonist, with a high affinity to guinea pig cortex 5HT1B/1D and recombinant guinea pig 5-HT1B receptors (Ki: 0.24 and 0...
|
| T10361 |
AR-C102222 hydrochloride |
AR-C102222 hydrochloride is a competitive, orally active, and highly selective inducible nitric oxide synthase (iNOS) inhibitor (IC50: 37 nM). It has antinocice...
|
| T10362 |
AR453588 |
AR453588 is an orally bioavailable anti-diabetic glucokinase activator (EC50: 42 nM) with anti-hyperglycemic activity. |
| T10362L |
AR453588 hydrochloride |
AR453588 hydrochloride is an orally bioavailable anti-diabetic glucokinase activator (EC50: 42 nM) with anti-hyperglycemic activity. |
| T10363 |
Arazine |
Arazine (N-Acetyl-S-farnesyl-L-cysteine) is a cell-permeable modulator of G protein and GPCR signaling. Arazine can be a substrate for isoprenylcysteine methylt...
|
| T10365 |
Arg-AMS |
Arg-AMS is a potent arginyl tRNA synthetase inhibitor that displays tightly bound inhibitory characteristics for the A-domains in non-ribosomal peptide syntheta...
|
| T10366 |
Arg-Gly-Asp-Ser |
Arg-Gly-Asp-Ser is an integrin-binding sequence that inhibits integrin receptor function. It decreases systemic inflammation via inhibition of collagen-triggere...
|
| T10367 |
Arginase inhibitor 1 |
Arginase inhibitor 1 is a potent inhibitor of human arginases I and II (IC50s: 223 and 509 nM). |
| T10368 |
Aripiprazole (D8) |
Aripiprazole D8 (OPC-14597 D8) is the deuterium-labeled Aripiprazole. Aripiprazole is a human 5-HT1A receptor partial agonist (Ki: 4.2 nM). |
| T10369 |
Aristeromycin |
Aristeromycin is an adenosine analog and an antibiotic and. It is a potent S-adenosylhomocysteine hydrolase (AHCY) inhibitor. |
| T1037 |
Doripenem Hydrate |
Doripenem Hydrate is a broad-spectrum injectable antibiotic, used for Gram-positive, Gram-negative and anaerobic pathogens. |
| T10370 |
ARN 077 |
ARN 077 is a selective N-acylethanolamine acid amidase (NAAA) inhibitor (IC50: 7 nM for human NAAA). ARN 077 significantly increases palmitoyl ethanolamine (PEA...
|
| T10372 |
ARQ 069 |
ARQ 069 (3.8-60 μM; for 2 hours) reduces the degree of phosphorylation of FGFR (predominantly FGFR2) in a concentration-dependent manner, without decreasing β...
|
| T10373 |
(R)-Filanesib |
(R)-Filanesib is the R-enantiomer of ARRY-520. (R)-Filanesib is a synthetic kinesin spindle protein (KSP) inhibitor (IC50: 6 nM). |
| T10377 |
Artefenomel |
Artefenomel (OZ439) is a synthetic antimalarial agent with the artemisinin pharmacophore. |
| T10378 |
Artelinic acid |
Artelinic acid, a derivative of Artemisinin, is an antimalarial drug for the treatment of multidrug-resistant strains of Plasmodium falciparum. |
| T10379 |
Arzoxifene hydrochloride |
Arzoxifene hydrochloride is a selective estrogen receptor modulator that is a potent estrogen antagonist in mammary and uterine tissue. |
| T10381 |
AS2717638 |
AS2717638 is an orally active and selective lysophosphatidic acid receptor 5 (LPA5) antagonist (IC50: 38 nM for hLPA5). It also significantly improves PGF2α-, ...
|
| T10386 |
Asp-AMS |
Asp-AMS is a strong competitive inhibitor of the mitochondrial enzyme and also an aspartyl-tRNA synthetase inhibitor. |
| T10387 |
ASP1126 |
ASP1126 is a selective and orally active sphingosine-1-phosphate (S1P) agonist (EC50s: 7.12 nM, 517 nM for hS1P1 and hS1P3). |
| T10388 |
Asparagusic acid |
Asparagusic acid is unique to asparagus. It is responsible for the odorous urine excreted after eating asparagus. Its derivatives ihydroasparagusic acid have an...
|
| T10389 |
Aspartyl-alanyl-diketopiperazine |
Aspartyl-alanyl-diketopiperazine (DA-DKP) is an immunomodulatory molecule generated by cleavage and cyclization from the N-terminus of human albumin. |
| T10390 |
Asperphenamate |
Asperphenamate is a fungal metabolite of Aspergillus flatiipes with anti-cancer effect (IC50s: 92.3 μM, 96.5 μM, and 97.9 μM in T47D, MDA-MB-231, and HL-60 c...
|
| T10391 |
Aspirin Aluminum |
Aspirin Aluminum is an intermolecular compound that can inhibit gastrointestinal mucosal disorders induced by NSAIDs extracted from patent WO 2010064441 A1. |
| T10392 |
Aspoxicillin |
Aspoxicillin is a broad-spectrum antimicrobial agent against 68 isolates of Actinobacillus pleuropneumoniae (MIC90 <= 0.05 μg/ml). Aspoxicillin has a long half...
|
| T10394 |
ATB107 |
ATB107 is a potent and novel inhibitor of indole-3-glycerol phosphate synthase (IGPS, KD: 3 μM). |
| T10395 |
ATM-3507 trihydrochloride |
ATM-3507 trihydrochloride is a potent tropomyosin inhibitor (IC50s: 3.83-6.84 μM in human melanoma cell lines). |
| T10395L |
ATM-3507 |
ATM-3507 is an inhibitor of tropomyosin. In human melanoma cell lines, the IC50s are from 3.83-6.84 μM. |
| T10397 |
ATN-161 trifluoroacetate salt |
ATN-161 trifluoroacetate salt is a novel integrin α5β1 antagonist that inhibits angiogenesis and growth of liver metastases in a murine model. |
| T10398 |
ATN-161 |
ATN-161 is a novel integrin α5β1 antagonist that inhibits angiogenesis and growth of liver metastases in a murine model. |
| T10399 |
Atorvastatin 3-Deoxyhept-2E-Enoic Acid |
Atorvastatin 3-Deoxyhept-2E-Enoic Acid is an impurity of Atorvastatin. Atorvastatin is an HMG-CoA reductase inhibitor and has the ability to effectively decreas...
|
| T10400 |
Atorvastatin acetonide tert-butyl ester |
Atorvastatin acetonide tert-butyl ester is a useful pharmaceutical intermediate in the preparation of Atorvastatin salts. Atorvastatin is an HMG-CoA reductase i...
|
| T10401 |
Atorvastatin acetonide |
Atorvastatin acetonide is an impurity of Atorvastatin and extracted from patent WO2011131605A1 (Compound 4). Atorvastatin is an HMG-CoA reductase inhibitor and ...
|
| T10402 |
Atorvastatin Epoxy Tetrahydrofuran Impurity |
Atorvastatin Epoxy Tetrahydrofuran Impurity is an impurity isolated oxidative degradation products of Atorvastatin. Atorvastatin is an orally active HMG-CoA red...
|
| T10403 |
Atorvastatin ethyl ester |
Atorvastatin ethyl ester is a derivative of Atorvastatin. It displays strong inhibition of the 9-cis-RA-induced Gal4 reporter activity. |
| T10404 |
ATP synthase inhibitor 1 |
ATP synthase inhibitor 1 is an inhibitor of the c subunit of the F1/FO-ATP synthase complex. It inhibits mitochondrial permeability transition pore (mPTP) openi...
|
| T10405 |
ATPA |
ATPA is a selective glutamate receptor GluR5 activator (EC50s: 0.66, 1.4, 9.5, 23, 32, 18, and 14 μM for GluR5wt, GluR5(S721T), GluR5(S741M), GluR5(S721T, S741...
|
| T10406 |
ATR inhibitor 1 |
ATR inhibitor 1 is an ATR inhibitor extracted from patent WO2015187451A1 (compound I-l, Ki< 1 µΜ). |
| T10408 |
ATWLPPR Peptide TFA |
ATWLPPR Peptide TFA is a selective neuropilin-1 inhibitor and inhibits VEGF165 binding to NRP-1. It has the potential in reducing the early retinal damage cause...
|
| T1041 |
Risedronate Sodium |
Risedronate sodium is an aminobisphosphonate derivative of etidronic acid and CALCIUM CHANNEL BLOCKER that inhibits BONE RESORPTION and is used for the treatmen...
|
| T10410 |
ATX inhibitor 1 |
ATX inhibitor 1 is a potent ATX inhibitor (IC50: 1.23 nM, FS-3 and 2.18 nM, bis-pNPP). |
| T10411 |
AU1235 |
AU1235 is a Mycobacterium tuberculosis inhibitor. |
| T10413 |
Autogramin-1 |
Autogramin-1 potently inhibits autophagy induced by either mTORC1 inhibition (Rapamycin; IC50: 0.44 μM) or starvation (IC50: 0.17 μM). |
| T10414 |
Autogramin-2 |
Autogramin-2 potently inhibits autophagy induced by either mTORC1 inhibition (Rapamycin; IC50: 0.14 μM) or starvation (IC50: 0.27 μM). |
| T10420 |
Avarofloxacin |
Avarofloxacin (JNJ-Q2) is a broad-spectrum fluoroquinolone antibacterial drug being developed for the treatment of acute bacterial skin and community-acquired p...
|
| T10421 |
AVE5688 |
AVE5688 is an inhibitor of glycogen phosphorylase (GP, IC50s: 430 nM and 915 nM; Kds: 170 nM and 530 nM for rmGPb and rmGPa). It can be used for the research of...
|
| T10423 |
AWZ1066S |
AWZ1066S is a highly specific anti-Wolbachia drug candidate for the short-course treatment of filariasis (EC50: 2.5 nM in cell assay). |
| T1043 |
Salifungin |
Detail unknown. |
| T10430 |
AZD 2066 |
AZD 2066 is a selective, orally active, and brain-penetrant mGluR5 antagonist with analgesic activity. |
| T10432 |
AZD-8529 |
AZD-8529 is a highly selective, and orally bioavailable positive allosteric modulator of mGluR2 (EC50: 285 nM). It shows no positive allosteric modulator respon...
|
| T10432L |
AZD-8529 mesylate |
AZD-8529 mesylate is a highly selective, and orally bioavailable positive allosteric modulator of mGluR2 (EC50: 285 nM). It shows no positive allosteric modulat...
|
| T10435 |
Linaprazan |
Linaprazan inhibits gastric H+, K+-ATPase by K+-competitive binding (IC50: 1.0 μM). It is an acid-suppressing compound with a rapid onset of action and potent ...
|
| T10439 |
Azelnidipine D7 |
Azelnidipine D7 is a deuterium-labeled Azelnidipine. Azelnidipine is an L-type calcium channel blocker. |
| T1044 |
Clopidol |
Clopidol is a very effective anticoccidial agent used in poultry. |
| T10440 |
Azilsartan D5 |
Azilsartan (TAK-536) D5 is the deuterium-labeled Azilsartan. Azilsartan is a specific antagonist of the angiotensin II type 1 receptor. |
| T10441 |
Azosemide |
Azosemide is a potent NKCC1 inhibitor (IC50s: 0.246 µM and 0.197 µM for hNKCC1A and NKCC1B). |
| T10443 |
Aβ42-IN-1 free base |
Aβ42-IN-1 free base is an orally active, high brain exposure γ-secretase modulator. It potently reduces Aβ42 levels (IC50: 0.091 µM), and significantly redu...
|
| T10444 |
TAK1/MAP4K2 inhibitor 1 |
TAK1/MAP4K2 inhibitor 1 is a potent dual inhibitor of TGFβ-activated kinase 1 (TAK1) and MAP4K2 (IC50s: 41.1 nM and 18.2 nM). |
| T10446 |
BA-53038B |
BA-53038B is an HBV core protein allosteric modulator (CpAM), binding to the HAP pocket and modulating HBV capsid assembly in a distinct manner (EC50: 3.32 μM)...
|
| T10447 |
BAA473 |
BAA473, a bile acid analog, is a potent activator of the pyrin inflammasome. It induces the secretion of IL-18 through activation of the inflammasome in both my...
|
| T10448 |
Bacampicillin |
Bacampicillin is an improved oral bioavailability penicillin antibiotic which is a prodrug of ampicillin. |
| T10448L |
Bacampicillin hydrochloride |
Bacampicillin hydrochloride is an improved oral bioavailability penicillin antibiotic which is a prodrug of ampicillin. |
| T10449 |
BACE-1 inhibitor 1 |
BACE-1 inhibitor 1 (Compound 8a) is an effective BACE-1 inhibitor (IC50: 56 nM). |
| T10455 |
Bafilomycin B1 |
Bafilomycin B1, a macrolide antibiotic isolated from Streptomyces sp, acts as an inhibitor of K+-dependent ATPase of E. coli. It also inhibits Gram-positive bac...
|
| T10457 |
BAN ORL 24 |
BAN ORL 24 is a potent and selective NOP receptor antagonist (IC50s: 0.27, 2500, 6700 and > 10000 nM for NOP, κ-, μ- and δ-receptors). |
| T10458 |
Banoxantrone D12 |
Banoxantrone D12 (AQ4N D12) is the deuterium-labeled Banoxantrone. Banoxantrone is a bioreductive agent that can be reduced to a stable, DNA-affinity compound A...
|
| T10459 |
Banoxantrone dihydrochloride |
Banoxantrone dihydrochloride (AQ4N dihydrochloride) is a bioreductive agent that can be reduced to a stable, DNA-affinity compound AQ4, which is a topoisomerase...
|
| T10460 |
Batabulin |
Batabulin is an antitumor compound, which binds covalently and selectively to a subset of the β-tubulin isotypes, thereby disrupting microtubule polymerization...
|
| T10462 |
Bavisant dihydrochloride |
Bavisant (JNJ-310010740) dihydrochloride is a highly selective, orally active antagonist of the human H3 receptor with a novel mechanism of action, involving wa...
|
| T10462L |
Bavisant dihydrochloride hydrate |
Bavisant dihydrochloride hydrate (JNJ31001074AAC) is a highly selective, orally active antagonist of the human H3 receptor with a novel mechanism of action, inv...
|
| T10467 |
BAY-1816032 |
BAY-1816032 is a potent and orally available inhibitor of bidding uninhibited by benzimidazoles 1 ( BUB1) kinase (IC50: 7 nM). |
| T10469 |
BAY-298 |
BAY-298 is an orally active and selective luteinizing hormone receptor (LH-R) antagonist (IC50s: 96 nM, 23 nM, and 78 nM for hLH (human LH) and rLH (rat LH) and...
|
| T10471 |
BAY 60-2770 |
BAY 60-2770 is a selective and orally active soluble guanylyl cyclase (sGC) activator with antifibrotic effect. It increases the activity of sGC in a nitric oxi...
|
| T10472 |
Bay 65-1942 R form |
Bay 65-1942 R form is the less active R-form of Bay 65-1942. Bay 65-1942 is a selective and ATP-competitive IKKβ inhibitor. |
| T10473 |
BAY-678 |
BAY-678 is an orally bioavailable, selective and cell-permeable inhibitor of human neutrophil elastase (HNE; IC50: 20 nM). |
| T10473L |
BAY-677 |
BAY-677 is an inactive control for BAY-678. BAY-678 is an orally bioavailable, highly potent, selective and cell-permeable inhibitor of human neutrophil elastas...
|
| T10474 |
BAY-7598 |
BAY-7598 is a potent, selective, and orally bioavailable MMP12 inhibitor (IC50s: 0.085, 0.67, and 1.1 nM for human/murine/rat MMP12). |
| T10475 |
BAY-784 |
BAY-784 is a gonadotropin-releasing hormone receptor (GnRH-R) antagonist (IC50s: 21 and 24 nM for human and rat GnRH-R). |
| T10476 |
BAY-899 |
BAY-899 is an orally active and selective of antagonist luteinizing hormone receptor (LH-R; IC50s: 185 nM and 46nM for human LH and rat LH). It can reduce sex h...
|
| T10478 |
BAY-Y 3118 |
BAY-Y 3118, a new chlorofluoroquinolone, has antimicrobial activity. |
| T10481 |
BAY 73-6691 racemate |
BAY 73-6691 racemate is a phosphodiesterase 9 inhibitor sourced from patent WO 2017070293 A1. |
| T10482 |
BB-Cl-Amidine |
BB-Cl-Amidine is an inhibitor peptidyl arginine deminase (PAD). |
| T10482L |
BB-Cl-Amidine hydrochloride |
BB-Cl-Amidine hydrochloride is an inhibitor peptidyl arginine deminase (PAD). |
| T10484 |
BCL2-IN-1 |
BCL2-IN-1 is a potent Bcl-2 inhibitor (Ki <0.01 nM). |
| T10486 |
BCI |
BCI is an allosteric inhibitor of dual-specificity phosphatase (DUSP; EC50s: 13.3 and 8.0 μM for DUSP6 and DUSP1 in cells) and does not inhibit DUSP5. |
| T10486L |
BCI hydrochloride |
BCI hydrochloride specifically inhibits DUSP6 and DUSP1 with EC50s of 13.3 and 8.0 μM in cells, respectively. BCI hydrochloride does not inhibit DUSP5. BCI h...
|
| T10487 |
BCL6-IN-3 |
BCL6-IN-3 is a BCL6 inhibitor with anti-tumor activity, extracted from patent WO2018215801A1 (example 20a). It exhibits a GI50 of 70 nM in SU-DHL4 cells. |
| T10489 |
BCR-ABL-IN-2 |
BCR-ABL-IN-2 is a BCR-ABL1 tyrosine kinase inhibitor (IC50s: 57 nM, 773 nM for ABL1 native and ABL1 T315I). |
| T10490 |
(S)-ML753286 |
(S)-ML753286 is a breast cancer resistance protein (BCRP) inhibitor (IC50: 0.6 μM on BCRP efflux transporter). |
| T10491 |
Galidesivir |
Galidesivir is an inhibitor of viral RNA-dependent RNA polymerase (RdRp). It inhibits SARS-CoV-2 by tightly binding to its RdRp. |
| T10491L |
Galidesivir hydrochloride |
Galidesivir hydrochloride is an inhibitor of viral RNA-dependent RNA polymerase (RdRp). It inhibits SARS-CoV-2 by tightly binding to its RdRp. |
| T10492 |
BD-AcAc 2 |
BD-AcAc 2 (Ketone Ester), added in diet, could elevate mean blood ketone bodies of 3.5 mm and lowered plasma glucose, insulin, and leptin in animals. |
| T10493 |
Beclabuvir |
Beclabuvir is an allosteric inhibitor that binds to thumb site 1 of the HCV NS5B RNA-dependent RNA polymerase. It inhibits recombinant NS5B proteins from HCV ge...
|
| T10494 |
Beclomethasone 17-propionate |
Beclomethasone 17-propionate is an active metabolite of Beclomethasone dipropionate and an agonist of the glucocorticoid receptor (GR). It exhibits greater affi...
|
| T10495L |
Befiradol |
Befiradol (NLX-112) is an agonist of 5-HT1A receptor. |
| T10496 |
Bencianol |
Bencianol is a semisynthetic flavonoid with anti-spasmogenic activities. |
| T10499 |
H3 receptor-MO-1 |
H3 receptor-MO-1 is a histamine H3 receptor modulator. |
| T10501 |
YM158 free base |
YM158 free base is a potent and selective antagonist of TXA2 and LTD4 receptor (pA2s: about 8.81 and 8.87). |
| T10502 |
Benzcyclane |
Benzcyclane (Bencyclane) is an inhibitor of platelet aggregation and a vasodilator effective in a variety of peripheral circulation disorders. |
| T10504 |
Implitapide Racemate |
Implitapide Racemate is the racemate of Implitapide. Implitapide is an inhibitor of microsomal triglyceride transfer protein (MTP). |
| T10508 |
Asthma relating compound 1 |
Asthma relating compound 1 is an anti-asthmatic compound extracted from patent EP0295656A1. |
| T10509 |
Xanthine oxidase-IN-1 |
Xanthine oxidase-IN-1 is an inhibitor of xanthine oxidase (IC50: 6.5 nM) extracted from patent WO2008126898A1 (example 3). |
| T10511 |
Anti-hypertensive sulfonanilide 1 |
Anti-hypertensive sulfonanilide 1 is an antihypertensive compound extracted from patent EP0338793A2 (compound XVIIIa,b*). |
| T10512 |
Prenyl-IN-1 |
Prenyl-IN-1 is an inhibitor of protein prenylation, especially a farnesyltransferase (FT) or a geranylgeranyltransferase (GGT) inhibitor. It shows potent activi...
|
| T10513 |
Benzothiohydrazide |
Benzothiohydrazide is an analog of Isoniazid. Benzothiohydrazide exhibits antitubercular activity (MICs: 132 μM and 264 μM for M. tuberculosis wild type (H37R...
|
| T10514 |
FR252384 |
FR252384 is an antagonist of the neuropeptide Y-Y5 receptor (IC50: 2.3 nM). |
| T10515 |
Anti-Heart Failure Agent 1 |
Anti-Heart Failure Agent 1 is an orally available compound suitable for the treatment of heart failure without inducing vomiting, nausea, and restlessness. |
| T10516 |
Beperidium iodide |
Beperidium iodide is a competitive antagonist of the acetylcholine receptor (pA2: 7.93). |
| T10517 |
BET-BAY 002 (S enantiomer) |
BET-BAY 002 S enantiomer is an enantiomer of BET-BAY 002 which is a BET inhibitor. |
| T10518 |
BET-BAY 002 |
BET-BAY 002 is an effective BET inhibitor and exhibits efficacy in a multiple myeloma model. |
| T10519 |
BET-IN-1 |
BET-IN-1 is a bromodomain inhibitor extracted from patent WO/2013024104A1 (example 2, plC50: 6.0 - 7.0). |
| T10523 |
β3-AR agonist 1 |
β3-AR agonist 1 is a highly selective, and orally available agonist of β3-adrenergic receptor (EC50: 18 nM), being inactive to β1-, β2-, and α1A-AR (β1/β...
|
| T10524 |
β-Cryptoxanthin |
β-Cryptoxanthin is isolated from Satsuma mandarin orange with an anti-stress effect. It is an oxygenated carotenoid and an antioxidant. |
| T10526 |
β-NF-JQ1 |
β-NF-JQ1 is a PROTAC that recruits AhR E3 ligase to target proteins. β-NF-JQ1 is directed against BRD proteins using β-NF as an AhR ligand, induces the inter...
|
| T10527 |
Betrixaban D6 |
Betrixaban D6 is a deuterium-labeled Betrixaban. Betrixaban is a selective and orally efficacious FXa inhibitor. |
| T10528 |
Bexarotene D4 |
Bexarotene D4 is a deuterium-labeled Bexarotene (LGD1069). Bexarotene is a selective RXR agonist used in the treatment of cutaneous T-cell lymphoma. |
| T10529 |
BF-168 |
BF-168 is a candidate probe for PET and specifically recognizes both neuritic and diffuse plaques (Ki: 6.4 nM for Aβ1-42). |
| T1053 |
Mebeverine hydrochloride |
Mebeverine hydrochloride, a β-phenylethylamine derivative, is a potent α1 repector inhibitor, relaxing the muscles in and around the gut. |
| T10530 |
BF 227 |
BF 227 is a candidate for an amyloid imaging probe for PET (Ki: 4.3 nM for Aβ1-42 fibrils). |
| T10532 |
BI-1408 |
BI-1408 is a modulator potent of γ secretase (IC50: 0.04 μM for Aβ42). |
| T10536 |
BI 703704 |
BI 703704 is a potent activator of soluble guanylate cyclase (sGC). It inhibits the progression of diabetic nephropathy in the ZSF1 rat. |
| T10537 |
BI-749327 |
BI-749327 is a high selectivity and orally bioavailable antagonist of TRPC6 (IC50s: 13 nM, 19 nM and 15 nM for mouse, human and guinea pig TRPC6). |
| T10538 |
BI-9321 |
BI-9321 is a selective and cellular active nuclear receptor-binding SET domain 3 (NSD3)-PWWP1 domain antagonist (Kd: 166 nM). BI-9321 is inactive against NSD2-P...
|
| T10538L |
BI-9321 trihydrochloride |
BI-9321 trihydrochloride is a selective and cellular active nuclear receptor-binding SET domain 3 (NSD3)-PWWP1 domain antagonist (Kd: 166 nM). BI-9321 is inacti...
|
| T10539 |
BIBO3304 TFA |
BIBO3304 TFA is an effective, orally active, and selective neuropeptide Y (NPY) Y1 receptor antagonist (IC50:0.38 and 0.72 nM for the human and the rat Y1 recep...
|
| T10540 |
BIBP3226 TFA |
BIBP3226 TFA is an effective and selective antagonist of neuropeptide Y Y1 (NPY Y1) and neuropeptide FF (NPFF) receptor (Kis: 1.1, 79, and 108 nM for rNPY Y1, h...
|
| T10541 |
Bicyclomycin benzoate |
Bicyclomycin benzoate, an antibiotic, exhibits activity against a broad spectrum of Gram-negative/Gram-positive bacteria. |
| T10542 |
Bifeprunox |
Bifeprunox is a potent partial agonist of dopamine D2-like and 5-HT1A receptor (pEC50: 6.37 for hippocampus 5-HT1A; pKis: 7.19 and 8.83 for cortex 5-HT1A and st...
|
| T10543 |
BIIL-260 hydrochloride |
BIIL-260 hydrochloride is a potent and long-acting orally active antagonist of leukotriene B4 (LTB4) receptor with anti-inflammatory activity. It has a high aff...
|
| T10544 |
Bimatoprost D5 |
Bimatoprost (AGN 192024) D5 is a deuterium-labeled Bimatoprost. Bimatoprost is a topical hypotensive agent frequently used for treating glaucoma and ocular hype...
|
| T10545 |
BIO-32546 |
BIO-32546 is a modulator of autotaxin (ATX) extracted from the patent US20170158687A1 (example 12b, S-isomer). |
| T10547 |
BioE-1115 |
BioE-1115 is a highly selective PAS kinase (PASK) inhibitor (IC50: ~4 nM). It is also a potent inhibitor of casein kinase 2α (IC50: ~10 μM). |
| T10551 |
Bithionol sulfoxide |
Bithionol sulfoxide is a clinically approved antiparasitic drug with the inhibitory against solid tumor growth in several preclinical cancer models. |
| T10553 |
BIX-01338 hydrate |
BIX-01338 hydrate is an inhibitor of histone lysine methyltransferase. |
| T10554 |
Bixin |
Bixin is isolated from the seeds of Bixa orellana and possesses anti-tumor, anti-inflammatory, and antioxidant activities. Bixin treatment ameliorated cardiac d...
|
| T10557 |
BLM-IN-1 |
BLM-IN-1 is an effective Bloom syndrome protein (BLM) inhibitor (KD: 1.81 μM; IC50: 0.95 μM). It induces DNA damage response, apoptosis and proliferation arre...
|
| T10558 |
Blonanserin D5 |
Blonanserin D5 is a deuterium-labeled Blonanserin. Blonanserin (AD-5423) is a dopamine D2/5-HT2 receptor antagonist with an atypical antipsychotic effect. |
| T10559 |
Blonanserin D8 |
Blonanserin D8 is a deuterium-labeled Blonanserin. Blonanserin (AD-5423) is a dopamine D2/5-HT2 receptor antagonist with an atypical antipsychotic effect. |
| T10561 |
BM-131246 |
BM-131246 is an oral antidiabetic compound. |
| T10562 |
(4-Acetamidocyclohexyl) nitrate |
(4-Acetamidocyclohexyl) nitrate (BM121307) is an activator of guanylate cyclase. |
| T10563 |
BM635 |
BM635 is an MmpL3 inhibitor with outstanding anti-mycobacterial activity (MIC50: 0.12 μM against M. tuberculosis H37Rv). |
| T10563L |
BM635 hydrochloride |
BM635 hydrochloride is an MmpL3 inhibitor with outstanding anti-mycobacterial activity (MIC50: 0.12 μM against M. tuberculosis H37Rv). |
| T10563L2 |
BM635 mesylate |
BM635 mesylate is an MmpL3 inhibitor with outstanding anti-mycobacterial activity (MIC50: 0.12 μM against M. tuberculosis H37Rv). |
| T10564 |
(8R,9S)-Talazoparib |
(8R,9S)-Talazoparib is Talazoparib enantiomer , less active than Talazoparib on the inhibition of PARP1 (IC50: 144 nM). |
| T10565 |
BMS-1001 hydrochloride |
BMS-1001 hydrochloride is an orally active inhibitor of human PD-L1/PD-1 immune checkpoint with low-toxicity in cells. |
| T10566 |
BMS-191095 |
BMS-191095 is mitochondrial ATP-sensitive potassium (mitoKATP) channel activator. |
| T10568 |
BMS-470539 dihydrochloride |
BMS-470539 dihydrochloride is a highly potent and selective agonist of the melanocortin-1 receptor (MC-1R; IC50: 120 nM; EC50: 28 nM) with anti-inflammatory pro...
|
| T10569 |
BMS-654457 |
BMS-654457 is a small-molecule, reversible inhibitor of factor XIa (FXIa; Kis: 0.2 and 0.42 nM for human and rabbit FXIa). |
| T10571 |
BMS-901715 |
BMS-901715 is an effective and selective inhibitor of adapter protein-2 associated kinase 1 (AAK1; IC50: 3.3 nM). |
| T10572 |
BMT-124110 |
BMT-124110 is an effectivet, selective AAK1 inhibitor (IC50: 0.9 nM) with antinociceptive activity. BMT-090605 inhibits BMP-2-inducible protein kinase (BIKE; IC...
|
| T10576 |
BMY-43748 |
BMY-43748 is an antibacterial compound with great in vitro and in vivo antibacterial activity. |
| T10579 |
BO3482 |
BO3482 is an antimicrobial compound and can inhibit the growth of methicillin-resistant Staphylococci (MIC90: 6.25 mg/mL). |
| T10581 |
Boc-MLF TFA |
Boc-MLF (TFA) is a specific antagonist of formyl peptide receptor (FPR) and also inhibits signaling through FPRL1 at higher concentrations. |
| T10582 |
Borrelidin |
Borrelidin (Treponemycin) is a bacterial and eukaryal threonyl-tRNA synthetase inhibitor. It is a macrolide antibiotic isolated from Streptomyces rochei. |
| T10584 |
Bovinic acid |
Bovinic acid is a conjugated linoleic acid with anti-atherogenic and anticarcinogenic activities. |
| T10585 |
Bozitinib |
Bozitinib (PLB-1001) is a highly selective inhibitor of the c-MET kinase with blood-brain barrier permeability. Bozitinib binds to the conventional ATP-binding ...
|
| T10586 |
BPH-1358 free base |
BPH-1358 (NSC50460) free base is a potent human undecaprenyl diphosphate synthase (UPPS) and farnesyl diphosphate synthase (FPPS) inhibitor (IC50s: 110 nM and 1...
|
| T10586L |
BPH-1358 |
BPH-1358 (NSC50460) is a potent human farnesyl diphosphate synthase (FPPS) and undecaprenyl diphosphate synthase (UPPS) inhibitor. With IC50s of 1.8 μM and 110...
|
| T10587 |
BPH-652 |
BPH-652 is an S. aureus dehydrosqualene synthase (CrtM) inhibitor (Ki: 1.5 nM; IC50: 100-300 nM for S. aureus pigment formation). |
| T10588 |
BPI-9016M |
BPI-9016M is an effective, orally active, and selective dual inhibitor of c-Met and AXL tyrosine kinases. It suppresses tumor cell growth, invasion, and migrati...
|
| T10589 |
BPN-15606 besylate |
BPN-15606 besylate is a highly potent, orally active γ-secretase modulator, attenuates the production of Aβ40 and Aβ42 by SHSY5Y neuroblastoma cells (IC50s: ...
|
| T10589L |
BPN-15606 |
BPN-15606 is a highly potent, orally active γ-secretase modulator (GSM), attenuates the production of Aβ42 and Aβ40 by SHSY5Y neuroblastoma cells with IC50 v...
|
| T1059 |
Retinol palmitate |
Vitamin A Palmitate is a naturally-occurring phenyl analogue of retinol, with potential antineoplastic and chemopreventive activities. |
| T10590 |
BPN14770 |
BPN14770 is an allosteric inhibitor of selective phosphodiesterase 4D (PDE4D; IC50s: 7.8 nM and 7.4 nM for PDE4D7 and PDE4D3). |
| T10591 |
BPO-27 (racemate) |
BPO-27 racemate is an effective inhibitor of CFTR (IC50: 8 nM). |
| T10591L |
(R)-BPO-27 |
(R)-BPO-27 is an effective inhibitor of the CFTR (IC50: 4 nM). |
| T10593 |
BPR1M97 |
BPR1M97 is a dual-acting mu-opioid receptor (MOP) and nociceptin-orphanin FQ peptide (NOP) receptor agonist (Kis: 1.8 and 4.2 nM) with blood-brain barrier penet...
|
| T10595 |
BQ-788 |
BQ-788 is a potent, selective antagonist of ETB receptor (IC50: 1.2 nM for inhibition of ET-1 binding to human Girardi heart cells), poorly inhibiting the bindi...
|
| T10595L |
BQ-788 sodium salt |
BQ-788 sodium salt is a potent and selective antagonist of ETB receptor(ETB receptors with an IC50 of 1.2 nM in human Girrardi heart cells). |
| T10596 |
BR102375 |
BR102375 is a non-TZD PPAR γ full agonist (EC50: 0.28 μM) for the treatment of type 2 diabetes. |
| T10598 |
BR351 precursor |
BR351 precursor is a precursor of BR351. BR351 is a brain penetrant MMP inhibitor (IC50s: 4, 2, 11, 50 nM for MMP2, MMP8, MMP9 and MMP13). |
| T10600 |
BRCA1-IN-1 |
BRCA1-IN-1 is a novel small-molecule-like inhibitor of BRCA1 (IC50: 0.53 μM; Ki: 0.71 μM). |
| T10601 |
BRCA1-IN-2 |
BRCA1-IN-2 is a cell-permeable protein-protein interaction (PPI) inhibitor for BRCA1 (IC50: 0.31 μM; Kd: 0.3 μM). It has antitumor activities via the disrupti...
|
| T10604 |
BRD-IN-3 |
BRD-IN-3 is a highly potent PCAF bromodomain (BRD) inhibitor (IC50: 7 nM). It also exhibits activity against GCN5 and FALZ. |
| T10605 |
BRD-K98645985 |
BRD-K98645985 is a BAF transcriptional repression inhibitor (EC50: ~2.37 µM). It binds ARID1A-specific BAF complexes, potently reverses HIV-1 latency and preve...
|
| T10606 |
BRD0705 |
BRD0705 is a potent, paralog selective and orally active GSK3α inhibitor (IC50: 66 nM; Kd: 4.8 μM). BRD0705 displays increased selectivity for GSK3α (8-fold)...
|
| T10608 |
BRD5648 |
BRD5648 ((R)-BRD0705) is an inactive (R)-enantiomer of BRD0705. BRD0705 is a GSK3α inhibitor (IC50: 66 nM; Kd: 4.8 μM). |
| T10609 |
Brevetoxin-3 |
Brevetoxin-3 (PbTx-3) is a potent allosteric voltage-gated Na+ channel activator. Brevetoxin-3 has a high affinity to site 5 of the voltage-sensitive Na+ channe...
|
| T1061 |
Toltrazuril |
Toltrazuril, an antiprotozoal agent, has effect on Coccidia parasites. |
| T10610 |
Brexpiprazole D8 |
Brexpiprazole D8 (OPC-34712 D8) is a deuterium-labeled Brexpiprazole. Brexpiprazole is a partial agonist of human 5-HT1A and dopamine receptors (Ki: 0.12 nM and...
|
| T10613 |
BRL 37344 sodium |
BRL 37344 sodium is a specific agonist of the β3-adrenergic receptor. The treatment of BRL 37344 sodium significantly lowers the bodyweight of obese mice. |
| T10614 |
BRL-42715 |
BRL-42715 is an effective inhibitor of bacterial beta-lactamases. |
| T10616 |
BRM/BRG1 ATP Inhibitor-1 |
BRM/BRG1 ATP Inhibitor-1 is an allosteric dual Brahma homolog (BRM)/SWI/SNF related matrix-associated actin-dependent regulator of chromatin subfamily A member ...
|
| T10618 |
Broflanilide |
Broflanilide is metabolized to desmethyl-broflanilide, which is a potent antagonist at the insect resistant-to-dieldrin GABA receptor and inhibits S. litura RDL...
|
| T10619 |
Bromelain |
Bromelain is an anti-inflammatory drug derived from pineapple stem. It acts through down-regulation of plasma kininogen, degradation of advanced glycation end-p...
|
| T10620 |
Bromodomain IN-1 |
Bromodomain IN-1 is an inhibitor of Bromodomain extracted from patent WO2016069578A1 (compound 4). |
| T10621 |
Bromodomain inhibitor-8 |
Bromodomain inhibitor-8 is an inhibitor of BET bromodomain used to treat autoimmune and inflammatory diseases. |
| T10622 |
BSc5371 |
BSc5371 is a potent and irreversible FLT3 inhibitor (Kds: 1.3, 0.83, 1.5, 5.8, and 2.3 nM for mutant FLT3 D835H, FLT3 ITD/D835V, FLT3 ITD/F691L, FLT3-ITD, and w...
|
| T10623 |
BSH-IN-1 |
BSH-IN-1 is a potent and covalent inhibitor of gut bacterial recombinant bile salt hydrolases (BSHs; IC50s: 108 nM and 427 nM for B. longum BSH and B. theta BSH...
|
| T10624 |
BT-13 |
BT-13 is a selective agonist of glial cell line-derived neurotrophic factor (GDNF) receptor RET independently of GFLs. BT-13 promotes neurite growth from sensor...
|
| T10625 |
IBT6A |
IBT6A is an impurity of Ibrutinib. Ibrutinib is a Btk inhibitor (IC50: 0.5 nM). IBT6A can be used in the synthesis of IBT6A Ibrutinib dimer and IBT6A adduct. |
| T10625L |
(Rac)-IBT6A hydrochloride |
(Rac)-IBT6A hydrochloride is a racemate of IBT6A. IBT6A is an impurity of Ibrutinib. IBT6A can be used in the synthesis of IBT6A Ibrutinib dimer and IBT6A adduc...
|
| T10625L2 |
IBT6A hydrochloride |
IBT6A hydrochloride is an impurity of Ibrutinib. Ibrutinib is a Btk inhibitor (IC50: 0.5 nM). IBT6A can be used in the synthesis of IBT6A Ibrutinib dimer and IB...
|
| T10626 |
(Rac)-IBT6A |
(Rac)-IBT6A is a racemate of IBT6A. IBT6A is an impurity of Ibrutinib. IBT6A can be used in the synthesis of IBT6A Ibrutinib dimer and IBT6A adduct. Ibrutinib i...
|
| T10627 |
BTK inhibitor 10 |
BTK inhibitor 10 is a potent and orally active BTK inhibitor extracted from patent WO2018145525 (example 33). It has the potential for rheumatoid arthritis trea...
|
| T10628 |
BTK inhibitor 13 |
BTK inhibitor 13 (compound 8) is an effective and selective BTK inhibitor(IC50: 1.2 nM). |
| T1063 |
Ticarcillin disodium |
Ticarcillin Disodium is the disodium salt form of ticarcillin, a broad-spectrum, semi-synthetic penicillin antibiotic with bactericidal and beta-lactamase resis...
|
| T10630 |
BuChE-IN-TM-10 |
BuChE-IN-TM-10 (TM-10) is a potent inhibitor of butyrylcholinesterase (BuChE; IC50: 8.9 nM) with the potential to treat Alzheimer’s disease. |
| T10631 |
Bucindolol |
Bucindolol is a blocker of the β1-adrenergic receptor and has intrinsic sympathomimetic activity used in the research of heart failure. |
| T10632 |
Bucolome |
Bucolome is a CYP2C9 inhibitor used as an anti-inflammatory agent or uricosuric agent. |
| T10633 |
Bumetanide D5 |
Bumetanide D5 is a deuterium-labeled Bumetanide. Bumetanide is a Na+-K+-Cl- (NKCC1) inhibitor (IC50s: 0.68 and 4.0 μM for hNKCC1A and hNKCC2A). |
| T10634 |
Bunaftide |
Bunaftide (Bunaftine) is an antiarrhythmic compound. |
| T10636 |
5α-reductase-IN-1 |
5α-reductase-IN-1 is an inhibitor of 5α-reductase, used for the research of patterned alopecia in combination with minoxidil. |
| T10637 |
Butin |
Butin, a major biologically active flavonoid isolated from the Dalbergia odorifera, has strong antioxidant, anti-inflammatory and antiplatelet activities. |
| T10638 |
BY27 |
BY27 is a potent and selective BET BD2 inhibitor (Ki: 3.1 nM) with anti-cancer activity and shows 38, 5, 7, and 21-fold BD1/BD2 selectivity for BRD2, BRD3, BRD4...
|
| T10639 |
C-021 dihydrochloride |
C-021 dihydrochloride is a potent CCR4 antagonist. It potently inhibits functional chemotaxis in human and mouse (IC50s: 140 nM and 39 nM). |
| T10640 |
C-11 |
C-11 is a tubulin inhibitor and acts as an ADC cytotoxin with cytotoxicity for carcinoma cell lines. |
| T10642 |
c-di-AMP |
c-di-AMP (Cyclic diadenylate) is a STING agonist. It binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway. |
| T10643 |
c-Fms-IN-1 |
c-Fms-IN-1 is an inhibitor of FMS kinase (IC50: 0.0008 μM). |
| T10644 |
c-Fms-IN-10 |
c-Fms-IN-10 is the derivative of thieno [3,2-d] pyrimidine, a kinase inhibitor of FMS (Colony-stimulating factor-1 receptor, CSF-1R; IC50: 2 nM) with anti-tumor...
|
| T10646 |
c-Fms-IN-7 |
c-Fms-IN-7 is a cFMS inhibitor (IC50: 18.5 nM) extracted from patent WO2011079076A1 (example159). |
| T10649 |
c-Fms-IN-3 |
c-Fms-IN-3 is a novel inhibitor of the c-Fms kinase with potential as an antirheumatic agent and anti-inflammatory agent. |
| T10651 |
c-Kit-IN-3 |
c-Kit-IN-3 is a potent and selective c-KIT kinase inhibitor (IC50s: 4 nM, 8 nM for c-KIT wt, and c-KIT T670I). |
| T10652 |
DCC-3014 |
DCC-3014 is a c-FMS (CSF-IR) and c-Kit dual inhibitor (IC50s: <0.01 μM and 0.1-1 μM) extracted from the patent WO2014145025A2 (Example 10). |
| T10655 |
c-Met inhibitor 1 |
c-Met inhibitor 1 is a c-Met receptor signaling pathway inhibitor, used for the treatment of cancer including glioblastoma, gastric, and pancreatic cancer. |
| T10656 |
trans-C75 |
trans-C75 is an enantiomer of C75. C75 is an inhibitor of fatty acid synthase (FASN). |
| T10657 |
C75 |
C75 is an inhibitor synthetic fatty-acid synthase (FASN) and inhibits prostate cancer cells PC3 (IC50: 35 μM). |
| T10659 |
Ca2+ channel agonist 1 |
Ca2+ channel agonist 1 is an agonist of N-type Ca2+ channel and an inhibitor of Cdk2 (EC50s: 14.23 μM and 3.34 μM) and is used as a potential treatment for mo...
|
| T10661 |
Calcifediol-D6 |
Calcifediol-D6 is the deuterated form of Calcifediol, which is a prehormone that is produced in the liver by hydroxylation of vitamin D3 by the enzyme cholecalc...
|
| T10662 |
Calcimycin hemicalcium salt |
Calcimycin (A-23187) hemicalcium salt is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). It induces Ca2+-dependent cell death...
|
| T10662L |
Calcimycin |
Calcimycin (A-23187) is an antibiotic and a unique divalent cation ionophore and induces Ca2+-dependent cell death by increasing intracellular calcium concentra...
|
| T10663 |
Calcitriol D6 |
Calcitriol D6 is the deuterated form of Calcitriol, which is the hormonally active form of vitamin D. Calcitriol is the active metabolite of vitamin D3 that act...
|
| T10664 |
Calcium 2-oxoglutarate |
Calcium 2-oxoglutarate is an intermediate in the production of GTP or ATP in the Krebs cycle. It is a reversible inhibitor of tyrosinase (IC50: 15 mM). |
| T10665 |
Calcium-Sensing Receptor Antagonists I |
Calcium-Sensing Receptor Antagonists I is an antagonist of calcium-sensing parathyroid hormone receptors. |
| T10667 |
Calmidazolium chloride |
Calmidazolium chloride (R 24571) is a calmodulin (CaMK) antagonist (Kd: 3 nM), antagonizing CaM-dependent phosphodiesterase and calmodulin-induced activation of...
|
| T10668 |
Camalexin |
Camalexin is a phytoalexin isolated from Camelina sativa. It has antifungal, antibacterial, antiproliferative, and anticancer activities. Camalexin can induce R...
|
| T10669 |
Canagliflozin D4 |
Canagliflozin D4 is a deuterium-labeled Canagliflozin. Canagliflozin is an SGLT2 inhibitor. |
| T1067 |
Amphotericin B |
Amphotericin B is an antifungal agent with a broad spectrum of activity against many fungal species. |
| T10670 |
Candesartan D4 |
Candesartan D4 is the deuterium labeled Candesartan. Candesartan is an antagonist of angiotensin II receptor. |
| T10671 |
Candoxatril |
Candoxatril is an inhibitor neutral endopeptidase (NEP). |
| T10672 |
Capzimin |
Capzimin is an effective and moderately specific inhibitor of proteasome isopeptidase Rpn11. |
| T10673 |
Carbacyclin |
Carbacyclin, a PGI2 analog, is a prostacyclin (PGI2) receptor agonist and vasodilator with potent inhibitory platelet aggregation. |
| T10674 |
Potassium Channel Activator 1 |
Potassium Channel Activator 1 is a compound for treating one or more disorders or conditions wherein the dopaminergic system is disrupted. |
| T10676 |
Carbodenafil |
Carbodenafil is a Sildenafil related compound found in healthy foods. Sildenafil is a PDE5 inhibitor (IC50: 5.22 nM). |
| T10677 |
Carbodine |
Carbodine (Carbocyclic cytidine) is a broad-spectrum antiviral agent and targets CTP synthetase that converts UTP to CTP. It possesses significant antiviral act...
|
| T10678 |
Carboxypeptidase G2 (CPG2) Inhibitor |
Carboxypeptidase G2 (CPG2) Inhibitor is a new CPG2 Inhibitor with antitumor activity. |
| T10679 |
Carcainium chloride |
Carcainium chloride (QX 572) is a derivative of Lidocaine with antitussive effect. |
| T1068 |
Anthralin |
Anthralin is an anthracene derivative that disrupts MITOCHONDRIA function and structure and is used for the treatment of DERMATOSES, especially PSORIASIS. It ma...
|
| T10682 |
CARM1-IN-1 hydrochloride |
CARM1-IN-1 shows high and selective CARM1 inhibition, with lower or no activity against a panel of different PRMTs or HKMTs. In human LNCaP cells, CARM1-IN-1 do...
|
| T10682L |
CARM1-IN-1 |
CARM1-IN-1 is a potent and specific inhibitor of Coactivator-associated arginine methyltransferase 1(CARM1; IC50: 8.6 μM). It shows very low activity against P...
|
| T10684 |
Carnostatine |
Carnostatine (SAN9812) is a potent and selective carnosinase 1 (CN1) inhibitor (Ki: 11 nM for recombinant hCN1) and can be used for the treatment of diabetic ne...
|
| T10684L |
Carnostatine hydrochloride |
Carnostatine (SAN9812) hydrochloride is a potent and selective carnosinase 1 (CN1) inhibitor (Ki: 11 nM for recombinant hCN1) and can be used for the treatment ...
|
| T10685 |
Carpaine |
Carpaine, an alkaloid isolated from Carica papaya Linn, has anti-thrombocytopenic activity. It has the anti-plasmodial activity to prevent malaria. |
| T10685L |
Carpaine hydrochloride |
Carpaine hydrochloride, an alkaloid isolated from Carica papaya Linn, has anti-thrombocytopenic activity. It has the anti-plasmodial activity to prevent malaria...
|
| T10686 |
Carvedilol metabolite 4-Hydroxyphenyl Carvedilol |
4-Hydroxyphenyl Carvedilol is a metabolite of Carvedilol. Carvedilol is a beta-blocker/alpha-1 blocker. |
| T10687 |
Casein Kinase II Inhibitor IV |
Casein Kinase II Inhibitor IV is an inducer of epidermal keratinocyte differentiation. |
| T10687L |
Casein Kinase II Inhibitor IV Hydrochloride |
Casein Kinase II Inhibitor IV Hydrochloride is an inducer of epidermal keratinocyte differentiation. |
| T10689 |
Cauloside D |
Cauloside D, a triterpene glycoside isolated from Caulophyllum robustum Max, inhibits the expression of iNOS and proinflammatory cytokines with anti-inflammato...
|
| T10690 |
Cav 2.2 blocker 1 |
Cav 2.2 blocker 1 is an N-type calcium channel (Cav 2.2; IC50: 1 nM) blocker for the treatment of pain. |
| T10692 |
CB-1158 dihydrochloride |
CB-1158 dihydrochloride is an effective and orally active inhibitor of arginase (IC50s: 86 nM and 296 nM for recombinant human arginase 1 and 2). |
| T10692L |
CB-1158 |
CB-1158 is a potent and orally bioavailable inhibitor of arginase (IC50s: 86 and 296 nM for recombinant human arginase 1 and 2). |
| T10693 |
CB-6644 |
CB-6644 is a selective inhibitor of the RUVBL1/2 complex and blocks the ATPase activity of RUVBL1/2 (IC50: 15 nM). |
| T10695 |
CB1151 |
CB1151 is a 20-epi analogue of 1,25 dihydroxyvitamin D3 with anti-tumor effects. It inhibits MCF-7 cell growth (IC50: 0.82 nM). |
| T10696 |
CB2 modulator 1 |
CB2 modulator 1 is a potent CB2 modulator. It can be used for the research for immune disorders, osteoporosis, inflammation, renal ischemia. |
| T10697 |
CB2R-IN-1 |
CB2R-IN-1 is a potent inverse agonist of the cannabinoid CB2 receptor (Ki: 0.9 nM). |
| T10698 |
CBB1003 |
CBB1003 is a new inhibitor of histone demethylase LSD1 (IC50: 10.54 μM). |
| T10698L |
CBB1003 hydrochloride |
CBB1003 hydrochloride is a new inhibitor of histone demethylase LSD1 (IC50: 10.54 μM). |
| T10699 |
CBB1007 hydrochloride |
CBB1007 Hcl is a selective, reversible, and substrate competitive LSD1 inhibitor (IC50: 5.27 μM for hLSD1). |
| T10699L |
CBB1007 |
CBB1007 is a potent, reversible, and substrate competitive LSD1 inhibitor (IC50: 5.27 μM for hLSD1). |
| T10699L2 |
CBB1007 trihydrochloride |
CBB1007 trihydrochloride is a selective, reversible, and substrate competitive LSD1 inhibitor (IC50: 5.27 μM for hLSD1). |
| T1070 |
Cefmetazole sodium |
Cefmetazole sodium is a semisynthetic cephamycin antibiotic with a broad spectrum of activity against both gram-positive and gram-negative microorganisms. It ha...
|
| T10700 |
(+)-CBI-CDPI1 |
(+)-CBI-CDPI1 is an enhanced functional analog of CC-1065. It is a DNA alkylating agent and an antibody-drug conjugates (ADCs) toxin. |
| T10701 |
(+)-CBI-CDPI2 |
(+)-CBI-CDPI2 is an enhanced functional analog of CC-1065. |
| T10704 |
CCB02 |
CCB02 is a selective CPAP-tubulin interaction inhibitor (IC50: 689 nM) with anti-tumor activity. CCB02 shows no inhibition on the cell cycle- and centrosome-rel...
|
| T10706 |
CCI-006 |
CCI-006 is a selective inhibitor and chemosensitizer of MLL-rearranged leukemia cells. It inhibits mitochondrial respiration resulting in insurmountable mitocho...
|
| T10707 |
CCK-B Receptor Antagonist 2 |
CCK-B Receptor Antagonist 2 is a potent and orally active antagonist of Gastrin/CCK-B (IC50: 0.43 nM). It also inhibits gastrin/CCK-A activity (IC50: 1.82 μM). |
| T10715 |
CCR6 inhibitor 1 |
CCR6 inhibitor 1 is a potent and selective CCR6 inhibitor (IC50s: 0.45 and 6 nM for monkey and human CCR6), much more selective at CCR6 over human CCR1 (IC50, >...
|
| T10716 |
CCR7 Ligand 1 |
CCR7 Ligand 1 (CCR7-Cmp2105) is an allosteric Ligand and antagonist for human CC chemokine receptor 7 (CCR7) with a Kd of 3 nM. CCR7 Ligand 1, thiadiazole-dioxi...
|
| T10720 |
CD235 |
CD235 is a structurally similar analog of CD161. CD161 is an orally bioavailable inhibitor of BET bromodomain. |
| T10721 |
CD73-IN-1 |
CD73-IN-1 is an inhibitor of CD73 with anticancer activity extracted from patent WO 2017153952 A1 (example 80). |
| T10722 |
CD80-IN-3 |
CD80-IN-3 is a potent CD80 inhibitor and inhibits CD80/CD28 interaction (Kd: 125 nM; EC50: 630 nM). |
| T10723 |
CDC25B-IN-1 |
CDC25B-IN-1 is a potent inhibitor of cell division cycle 25B (CDC25B) phosphatase (Ki: 8.5 μM). It potently inhibits cell proliferation and colony formation. |
| T10725 |
Cdc7-IN-3 |
Cdc7-IN-3 is a potent inhibitor of Cdc7 kinase extracted from patent WO2019165473A1 (compound I-A). |
| T10726 |
Cdc7-IN-4 |
Cdc7-IN-4 is a potent inhibitor of Cdc7 kinase extracted from patent WO2019165473A1 (compound I-C). |
| T10727 |
Cdc7-IN-5 |
Cdc7-IN-5 is a potent inhibitor of Cdc7 kinase extracted from patent WO2019165473A1 (compound I-B). |
| T10728 |
Cdc7-IN-6 |
Cdc7-IN-6 is a potent Cdc7 kinase inhibitor (IC50=4 nM) extracted from patent WO2019165473A1(compound I- D) with anti-tumor activity. |
| T10729 |
Cdc7-IN-7 |
Cdc7-IN-7 is a potent inhibitor of Cdc7 kinase extracted from patent WO2019165473A1 (compound I-E). |
| T10732 |
Tematropium |
Tematropium (CDDD3602) is an anticholinergic. |
| T10734 |
CDK ligand for PROTAC |
CDK ligand for PROTAC is a CDK inhibitor with antitumor activity. It has been used to design PROTAC CDK4/6 degraders. |
| T10734L |
CDK ligand for PROTAC hydrochloride |
CDK ligand for PROTAC hydrochloride is a CDK inhibitor with antitumor activity. It has been used to design PROTAC CDK4/6 degraders. |
| T10748 |
CE(20:5(5Z,8Z,11Z,14Z,17Z) |
CE(20:5(5Z,8Z,11Z,14Z,17Z) is an endogenous metabolite. |
| T10749 |
Cebranopadol ((1α,4α)stereoisomer) |
Cebranopadol ((1α,4α)stereoisomer) is a stereoisomer of cebranopadol which is a potent ORL-1 agonist. |
| T1075 |
Vitamin K1 |
Vitamin K1 a fat-soluble, naturally occurring vitamin with antihemorrhagic and prothrombogenic activity. |
| T10750 |
Cecropin A TFA |
Cecropin A TFA is an antimicrobial polypeptide isolated from Hyalaphora cecropia pupae with anti-inflammatory, anti-bacterial, and anti-cancer activity. |
| T10752 |
Ceftezole |
Ceftezole is an alpha-glucosidase inhibitor with in vivo anti-diabetic activity. It is a broad-spectrum cephem antibiotic against many species of gram-positive ...
|
| T10753 |
Ceftibuten |
Ceftibuten is a third-generation cephalosporin antibiotic. |
| T10754 |
Ceftriaxone sodium salt |
Ceftriaxone sodium salt is an antibiotic useful for the treatment of a number of bacterial infections. |
| T10755 |
Celgosivir hydrochloride |
Celgosivir hydrochloride (MBI 3253 hydrochloride) is an α-glucosidase I inhibitor and inhibits bovine viral diarrhoea virus (BVDV) (IC50: 1.27 μM). |
| T10755L |
Celgosivir |
Celgosivir (MBI 3253; MDL 28574) is an inhibitor of α-glucosidase I. In vitro assay, it inhibits bovine viral diarrhoea virus (BVDV) ( IC50: 1.27 μM). |
| T10757 |
Cenobamate S-Entiomer |
Cenobamate S-Enantiomer is a Cenobamate's S-enantiomer. |
| T10758 |
Centafadine |
Centanafadine is a dual inhibitor of norepinephrine (NE)/dopamine (DA) transporter, also inhibits serotonin transporter (IC50s: 6 nM, 38 nM, and 83 nM for human...
|
| T10758L |
Centafadine hydrochloride |
Centanafadine hydrochloride is a dual inhibitor of norepinephrine (NE)/dopamine (DA) transporter, also inhibits serotonin transporter (IC50s: 6 nM, 38 nM, and 8...
|
| T10759 |
CEP-28122 mesylate salt |
CEP-28122 mesylate salt is a highly selective orally active ALK inhibitor (IC50: 1.9 nM in an enzyme-based TRF assay). |
| T10760 |
Ceramides Mixture |
Ceramides Mixture, an endogenous ceramide, consists of hydroxy and non-hydroxy fatty acid-containing ceramides. It is involved in the regulation of cell cycle a...
|
| T10761 |
Ceranib-2 |
Ceranib-2 is a potent and nonlipid ceramidase inhibitor that inhibits cellular ceramidase activity (IC50: 28 μM in SKOV3 cells). It induces the accumulation of...
|
| T10762 |
Ceranib1 |
Ceranib1 is an inhibitor of ceramidase. It inhibits the proliferation of ovarian cancer cells. Ceranib1 inhibits ceramidase activity toward an exogenous ceramid...
|
| T10763 |
Ceratamine A |
Ceratamine A is an antimitotic heterocyclic alkaloid isolated from the marine sponge Pseudoceratina sp., acts as a microtubule-stabilizing agent with cytotoxici...
|
| T10764 |
Cercosporamide |
Cercosporamide is a ATP-competitive Pkc1 kinase inhibitor (IC50 <50 nM; Ki <7 nM). It also is a unique Mnk inhibitor. |
| T10765 |
Cereblon modulator 1 |
Cereblon modulator 1 is a cereblon (CRBN) E3 ligase modulator. It specifically binds to CRBN, thereby affecting the activity of the ubiquitin E3 ligase complex. |
| T10766 |
Ceritinib D7 |
Ceritinib D7 (LDK378 D7) is a deuterium-labeled Ceritinib. Ceritinib is an ATP-competitive inhibitor of ALK tyrosine kinase. |
| T10768 |
Cetilistat impurity 1 |
Cetilistat impurity 1 is an impurity of Cetilistat. Cetilistat is an inhibitor of pancreatic lipase. Cetilistat inhibits rat and human pancreatic lipase activit...
|
| T10771 |
CETP-IN-3 |
CETP-IN-3 is an inhibitor of the plasma glycoprotein cholesterol ester transfer protein (CETP), elevating HDL-C through inhibition of CETP. |
| T10772 |
Cevipabulin |
Cevipabulin (TTI-237) is a microtubule-active antitumor compound and inhibits the binding of [3H] vinblastine to tubulin (IC50: 18-40 nM in the human tumor cell...
|
| T10772L |
Cevipabulin fumarate |
Cevipabulin (TTI-237) fumarate is a microtubule-active antitumor compound and inhibits the binding of [3H] vinblastine to tubulin (IC50: 18-40 nM in the human t...
|
| T10774 |
CFM-2 |
CFM-2 is a selective non-competitive AMPAR antagonist. |
| T10776 |
CFTR corrector 4 |
CFTR corrector 4 is a highly potent and orally active corrector of cystic fibrosis transmembrane conductance regulator (CFTR). It can increase CFTR levels at th...
|
| T10779 |
CGP 25454A |
CGP 25454A is a novel and selective antagonist of the presynaptic dopamine autoreceptor. |
| T1078 |
Sulfadimethoxine |
Sulfadimethoxine is a sulfanilamide that is used as an anti-infective agent. |
| T10780 |
CGP-53153 |
CGP-53153 is a steroidal inhibitor of 5 alpha-reductase (IC50s: 36 and 262 nM in rat and human prostatic tissue). |
| T10781 |
CGP 78608 hydrochloride |
CGP 78608 hydrochloride is a highly selective antagonist at the glycine binding site of the NMDA receptor (IC50: 6 nM). CGP 78608 acts as a potentiator of GluN1...
|
| T10782 |
CGP52411 |
CGP52411 (DAPH) is a highly selective, orally active, and ATP-competitive EGFR inhibitor (IC50: 0.3 μM). It blocks the toxic influx of Ca2+ ions into neuronal ...
|
| T10783 |
CGS 15435 |
CGS 15435 is a potent inhibitor of thromboxane (TxA2) synthetase (IC50: 1 nM). It has a selectivity for Tx synthetase 100000-fold greater than that for PGI2 syn...
|
| T10785 |
Chalcone 4 (hydrate) |
Chalcone 4 hydrate, an anti-parasite compound, inhibits the growth of Theileria and Babesia. |
| T10787 |
Chitise-IN-1 |
Chitinase-IN-1 is an insect chitinase and N- acetyl hexosaminidase inhibitor and pesticide. |
| T10788 |
Chitise-IN-2 |
Chitinase-IN-2 is an insect chitinase and N- acetyl hexosaminidase inhibitor and pesticide. |
| T10788L |
Chitise-IN-2 hydrochloride |
Chitinase-IN-2 hydrochloride is an insect chitinase and N- acetyl hexosaminidase inhibitor and pesticide. |
| T10795 |
Chlordantoin |
Chlordantoin is an antifungal agent with the potential for vaginal candidiasis treatment. |
| T10796 |
Chlormethiazole hydrochloride |
Clomethiazole hydrochloride is an anticonvulsant and sedative. It is neuroprotective and prevents the degeneration of serotonergic nerve terminals induced by 3,...
|
| T10797 |
Chlormidazole hydrochloride |
Chlormidazole hydrochloride has inhibitory activity against many fungi and some gram-positive cocci. It can be applied in fungal and bacterial infections of ski...
|
| T10798 |
Chlorpromazine D6 hydrochloride |
Chlorpromazine D6 hydrochloride is the deuterium-labeled Chlorpromazine. Chlorpromazine is an inhibitor of dopamine receptors, potassium channels, 5-HT receptor...
|
| T1080 |
2-Aminoethanethiol |
Cysteamine is a Cystine Depleting Agent. The mechanism of action of cysteamine is as a Cystine Disulfide Reduction. |
| T10803 |
CHMFL-KIT-033 |
CHMFL-KIT-033 is a potent and selective inhibitor of the c-KIT T670I mutant (IC50: 0.045 μM) for gastrointestinal stromal tumors (GISTs). |
| T10805 |
Cholesterol glucuronide |
Cholesterol glucuronide is an endogenous metabolite of lipid generated by UDP glucuonyltransferase in the liver. |
| T10806 |
Cholesteryl arachidote |
Cholesteryl arachidonate is a human endogenous metabolite. |
| T10807 |
Cholesteryl Linolete |
Cholesteryl Linolenate is a human endogenous metabolite. |
| T10808 |
CHPG sodium salt |
CHPG sodium salt is a selective agonist of mGluR5. In BV2 microglial cells, it attenuates SO2-induced oxidative stress and inflammation through the TSG-6/NF-κB...
|
| T10809 |
CHPG |
CHPG is a selective agonist of mGluR5. In BV2 microglial cells, it attenuates SO2-induced oxidative stress and inflammation through the TSG-6/NF-κB pathway. |
| T10810 |
Chromomycin A3 |
Chromomycin A3 is an aureolic acid-type antitumor antibiotic. Chromomycin A3 has a variety of utilities as a staining agent for human sperm chromatin, autophagy...
|
| T10811 |
Chymase-IN-1 |
Chymase-IN-1 is a selective, orally active inhibitor of human mast cell chymase (IC50: 29 nM). |
| T10812 |
Cicloprolol hydrochloride |
Cicloprolol is a partial agonist of β 1-adrenoceptor. |
| T10813 |
Cilobradine hydrochloride |
Cilobradine is an HCN Channel blocker and an open channel blocker of neuronal Ih and related cardiac If channels. |
| T10814 |
Cicalcet metabolite M4 |
Cinacalcet metabolite M4 is a metabolite of Cinacalcet. Cinacalcet is an allosteric agonist of Ca receptor. |
| T10815 |
Cinmoylglycine |
Cinnamoylglycine is a glycine conjugate of cinnamic acid and a urinary metabolite in humans. It is used as a potential urinary biomarker. |
| T10816 |
Cinrizine D8 |
Cinnarizine D8 is a deuterium-labeled Cinnarizine which is an antihistamine and a calcium channel blocker. |
| T10817 |
Cipemastat |
Cipemastat is a competitive inhibitor of human collagenases 1, 2, and 3 (Kis: 3.0, 4.4, and 3.4 nM). |
| T10818 |
Ciprofibrate D6 |
Ciprofibrate D6 is a deuterium-labeled Ciprofibrate. Ciprofibrate is an agonist of peroxisome proliferator-activated receptor. |
| T10819 |
Cipropride S entiomer |
Cipropride S enantiomer is the S enantiomer of cipropride which is an antiemetic drug. |
| T1082 |
Benzyl isothiocyanate |
Benzyl isothiocyanate (BITC) is an isothiocyanate originally found in cruciferous vegetables. It shows immunomodulatory, anti-parasitic, antibiotic, antioxidati...
|
| T10820 |
Ciraparantag |
Ciraparantag is an inhibitor of thrombin and factor Xa. Ciraparantag is a broad-spectrum reversal agent for anticoagulants, including unfractionated heparin, lo...
|
| T10820L |
Ciraparantag TFA |
Ciraparantag TFA is an inhibitor of thrombin and factor Xa. Ciraparantag is a broad-spectrum reversal agent for anticoagulants, including unfractionated heparin...
|
| T10822 |
Cirsimarin |
Cirsimarin is a flavonoid isolated from Microtea debilis. It shows a potent antilipogenic effect and decreases adipose tissue deposition in mice. Cirsimarin has...
|
| T10825 |
Citrinin |
Citrinin is a mycotoxin that causes contamination in the food and is associated with different toxic effects. Citrinin also possesses a broad spectrum of bioact...
|
| T10826 |
CK-666 |
CK-666 is a cell-permeable inhibitor of actin-related protein Arp2/3 complex. It binds to the Arp2/3 complex, stabilizes the inactive state of the complex, bloc...
|
| T10828 |
CK2/PIM1-IN-1 |
CK2/PIM1-IN-1 is an inhibitor of CK2 and PIM1 (IC50s: 3.787 μM and 4.327 μM). It is developed for the research of proliferative disorders such as cancer, as w...
|
| T10830 |
CL 316243 |
CL316243 is a highly potent selective agonist of β3-adrenoceptor (EC50: 3 nM) but is an extremely poor to β1/2- receptors. CL316243 is an effective stimulant ...
|
| T10831 |
Cl-amidine |
Cl-amidine is an orally active inhibitor of peptidyl arginine deminase (PAD) (IC50s: 0.8 μM, 6.2 μM, and 5.9 μM for PAD1, PAD3, and PAD4). Cl-amidine induces...
|
| T10831L |
Cl-amidine hydrochloride |
Cl-amidine hydrochloride is an orally active peptidyl arginine deaminase (PAD) inhibitor (IC50: 5.9 μM for PAD4). It induces apoptosis in cancer cells and it a...
|
| T10831L2 |
Cl-amidine TFA |
Cl-amidine TFA is an orally active inhibitor of peptidyl arginine deminase (PAD) (IC50s: 0.8 μM, 6.2 μM, and 5.9 μM for PAD1, PAD3, and PAD4). Cl-amidine ind...
|
| T10832 |
CL2-SN-38 |
CL2-SN-38, a part of the antibody-drug conjugate (ADC), can conjugate with the anti-Trop-2-humanized antibody hRS7. SN-38 is an inhibitor of DNA topoisomerase I...
|
| T10834 |
CL656 |
CL656 is a stimulator of interferon genes (STING) activator. |
| T10835 |
Cletoquine |
Cletoquine (Desethylhydroxychloroquine) is a major active metabolite of Hydroxychloroquine. Cletoquine has the ability to against the chikungunya virus (CHIKV)....
|
| T10835L |
Cletoquine oxalate |
Cletoquine oxalate (Desethylhydroxychloroquine oxalate) is a major active metabolite of Hydroxychloroquine. Cletoquine has the ability to against the chikunguny...
|
| T10837 |
Clocapramine hydrochloride hydrate |
Clocapramine hydrochloride hydrate is an antagonist of the 5-HT2A and D2 receptors. |
| T10839 |
Clozic |
Clozic is a potential anti-arthritic compound. |
| T10842 |
Clomipramine D3 |
Clomipramine D3 is the deuterium-labeled Clomipramine. Clomipramine is a serotonin transporter, norepinephrine transporter dopamine transporter blocker (Ki: 0.1...
|
| T10842L |
Clomipramine D3 hydrochloride |
Clomipramine D3 hydrochloride is the deuterium-labeled Clomipramine. Clomipramine is a serotonin transporter, norepinephrine transporter dopamine transporter bl...
|
| T10843 |
CMF019 |
CMF019 is a potent agonist of the Apelin receptor (APJ) with G protein bias. CMF019 binds to APJ (pKis: 8.58, 8.49, and 8.71 for the human, rat, and mouse). |
| T10844 |
CMI-392 |
CMI-392 is a dual 5-lipoxygenase inhibitor and platelet-activating factor (PAF) receptor antagonist (IC50s: 100 and 10 nM). |
| T10845 |
CMK |
CMK, an RSK2 kinase inhibitor, shows similar potency but less chemical stability compared with FMK. |
| T10846 |
CMLD010509 |
CMLD010509 (SDS-1-021) is a highly selective inhibitor of the oncogenic translation program supporting multiple myeloma (MM)-including key oncoproteins such as ...
|
| T10847 |
CMLD012072 |
CMLD012072 is a potent eukaryotic initiation factor 4A (eIF4A) inhibitor with potent anti-neoplastic activity. It can induce RNA clamping of eIF4A1 and eIF4A2. |
| T10848 |
CMLD012073 |
CMLD012073 is a potent eukaryotic initiation factor 4A (eIF4A) inhibitor. It inhibits NIH/3T3 cells (IC50: 10 nM). CMLD012073 inhibits eukaryotic translation in...
|
| T10849 |
CMLD012612 |
CMLD012612 is a potent eukaryotic initiation factor 4A (eIF4A) inhibitor. It inhibits cell translation and is cytotoxic to NIH/3T3 cells (IC50: 2 nM). |
| T10850 |
CMP-5 |
CMP-5 is a potent and selective PRMT5 inhibitor, while displays no activity against PRMT1/4/7 enzymes. It selectively blocks S2Me-H4R3 by inhibiting PRMT5 methy...
|
| T10851 |
CMP-Sialic acid sodium salt |
CMP-Sialic acid sodium salt is an allosteric inhibitor of UDP-GlcNAc 2-epimerase. It provides a substrate for Golgi sialyltransferases. UDP-GlcNAc 2-epimerase i...
|
| T10852 |
CNS-5161 hydrochloride |
CNS-5161 hydrochloride is a new antagonist of NMDA ion-channel. It interacts with the NMDA receptor/ion channel site to produce a noncompetitive blockade of the...
|
| T10853 |
CNT2 inhibitor-1 |
CNT2 inhibitor-1 is a potent inhibitor of concentrative nucleoside transporter 2 (CNT2; IC50: 640 nM for hCNT2). |
| T10854 |
CNX-500 |
CNX-500 is a probe consisting of a covalent Btk inhibitor chemically linked to biotin. CNX-500 has inhibitory activity against Btk (IC50: 0.5 nM) and the abilit...
|
| T10856 |
Cobimetinib R-enantiomer |
Cobimetinib R-enantiomer is the less active R-enantiomer of Cobimetinib which is a selective MEK inhibitor. |
| T10857 |
Coenzyme A |
Coenzyme A is an obligatory cofactor in all living cells synthesized from pantothenate (Vitamin B5), adenosine triphosphate (ATP), and cysteine. |
| T10858 |
COH34 analog 1 |
COH34 analog 1 is an oxidized analog of COH34. COH34 is a potent inhibitor of poly(ADP-ribose) glycohydrolase (PARG). |
| T10859 |
COH34 |
COH34 is a potent and specific inhibitor of poly(ADP-ribose) glycohydrolase (PARG; IC50: 0.37 nM). COH34 binds to the catalytic domain of PARG (Kd: 0.547 μM), ...
|
| T10860 |
Col003 |
Col003 is a selective and potent inhibitor of Hsp47 and competitively binds to the collagen-binding site on Hsp47 (IC50: 1.8 μM). It can be used for the invest...
|
| T10861 |
Collagen proline hydroxylase inhibitor-1 |
Collagen proline hydroxylase inhibitor-1 is an antifibroproliferative compound. |
| T10862 |
Collagen proline hydroxylase inhibitor |
Collagen proline hydroxylase inhibitor is an inhibitor collagen proline hydroxylase and useful for antifibrotic proliferative agents. |
| T10863 |
Complement C5-IN-1 |
Complement C5-IN-1 is a small-molecule inhibitor of complement component 5 protein (C5). |
| T10865 |
Cot inhibitor-1 |
Cot inhibitor-1 is an inhibitor of COT/Tpl2. |
| T10866 |
Cot inhibitor-2 |
Cot inhibitor-2 is an inhibitor of COT/Tpl2. |
| T10868 |
CP-28888 |
CP-28888 is an interferon inducer, more potent in mice but less active in man and devoid of antirhinovirus effects. |
| T10869 |
CP-409092 hydrochloride |
CP-409092 hydrochloride is a partial agonist of the GABAA receptor with anti-anxiety activity. |
| T10871 |
CP-809101 hydrochloride |
CP-809101 hydrochloride is a potent and selective 5-HT2C receptor agonist (pEC50: 9.96/7.19/6.81 for human 5-HT2C/5-HT2B/5-HT2A receptors). |
| T10872 |
CP-96021 hydrochloride |
CP-96021 hydrochloride is a potent and orally active antagonist of leukotriene D4 (LTD4)/platelet activating factor receptor (Kis: 34 nM and 37 nM). |
| T10873 |
CP-96486 |
CP-96486 is a potent and orally active antagonist of leukotriene D4 (LTD4)/platelet activating factor (PAF) receptor (Kis: 20 and 24 nM). |
| T10874 |
CP-060 |
CP-060 is a potent Ca2+ antagonist and inhibits Ca2+ overload with antioxidant and cardioprotective activities. |
| T10875 |
CP5V |
CP5V, a PROTAC, induces mitotic inhibition, and suppresses cancer cell proliferation. It specifically degrades Cdc20 by linking Cdc20 to the VHL/VBC complex for...
|
| T10876 |
CPA inhibitor |
CPA inhibitor is a potent carboxypeptidase A (CPA) inhibitor. |
| T10877 |
CPDA |
CPDA is a new potent inhibitor of SH2 domain-containing inositol phosphatase 2 (SHIP2). |
| T10878 |
CPFX2090 |
CPFX2090, a cephalosporin antibacterial compound, is extracted from patent WO2013052568A1 (Example 16g). |
| T10880 |
CPPG |
CPPG is a potent antagonist of group II/III mGlu receptors. CPPG exhibits some selectivity (approximately 20 fold) for group III (IC50: 2.2 nM) over group II (I...
|
| T10881 |
CPPHA |
CPPHA is a selective positive allosteric modulator of the mGluR5 receptor. |
| T10884 |
CRAC intermediate 1 |
CRAC intermediate 1 is a key intermediate in the chemical synthesis of a series of CRAC channel inhibitors. |
| T10885 |
CRAC intermediate 2 |
CRAC intermediate 2 is an intermediate for CRAC inhibitor synthesis extracted from patent WO 2013059666A1. |
| T10886 |
Crocetine dimethyl ester |
Crocetine dimethyl ester (Dimethylcrocetin) is found in the stigmas of saffron (Crocus sativus L.) with antioxidant activity. |
| T10890 |
CRTh2 antagonist 3 |
CRTh2 antagonist 3 is a powerful chemokine receptor homologous molecule expressed on Th2 cell (CRTh2) antagonists. CRTh2 antagonist 3 enhanced the activity of P...
|
| T10893 |
CS-722 Free base |
CS-722 free base is a synthetic central muscle relaxant with muscle relaxant activity and inhibitory effect on spinal reflex. CS-722 free base may inhibit spont...
|
| T10895 |
CSN5i-3 |
CSN5i-3 is an effective, selective, oral CSN5 inhibitor that can inhibit CSN-catalyzed Cul1 adenylation with IC50 value of 5.8 nM. |
| T10896 |
CSRM617 |
CSRM617 is a selective small molecule inhibitor of the transcription factor ONECUT2 (OC2, the main regulator of androgen receptor). The Kd in SPR analysis is 7....
|
| T10897 |
CT-721 |
CT-721 is a potent and time-dependent Bcr-Abl kinase inhibitor with an IC50 of 21.3 nM against wild-type Bcr-Abl kinase and has anti-chronic myeloid leukemia (C...
|
| T10900 |
CUDA |
CUDA is an effective soluble cyclohydrolase inhibitor with IC50 of 11.1 nM and 112 nM for mouse sEH and human sEH, respectively. CUDA selectively increases the ...
|
| T10901 |
Curcumin D6 |
Curcumin D6 (difluoroformylmethane D6) is deuterium-labeled curcumin (Turmeric yellow). Curcumin (Turmeric yellow) is a natural phenolic compound with various p...
|
| T10902 |
CWHM-1008 |
CWHM-1008 is an effective oral antimalarial drug. The EC50 values of the drug-sensitive Plasmodium falciparum 3D7 and drug-resistant Dd2 strains are 46 and 21 n...
|
| T10903 |
CWHM-1552 |
CWHM-1552 is an effective oral inhibitor of Plasmodium falciparum. For the 3D7 and Dd2 strains, the IC50 is 51 nM and 53 nM, respectively. |
| T10906 |
CXCR7 modulator 1 |
CXCR7 modulator 1 is an effective and orally bioavailable peptoid hybrid CXCR7 modulator with Ki of 9 nM. |
| T10907 |
CXCR7 modulator 2 |
CXCR7 modulator 2 is a 7-type C-X-C chemokine receptor (CXCR7) modulator with a Ki of 13 nM. |
| T10909 |
Cyclic-di-GMP |
Cyclic-di-GMP is a STING agonist and ubiquitous second messenger, which regulates the formation, motility and virulence of biofilms in various bacterial species...
|
| T1091 |
Chlortalidone |
Chlorthalidone is a benzenesulfonamide-phthalimidine that tautomerizes to a BENZOPHENONES form. It is considered a thiazide-like diuretic. |
| T10910 |
Cycloartenol |
Cyclopentanol is a plant sterol compound and one of the key precursors for biosynthesis of various sterol compounds. Cycloartenol inhibits the migration of glio...
|
| T10912 |
S1PR1-MO-1 |
S1PR-MO-1 is a modulator of sphingosine-1-phosphate receptor and is used to study hyperproliferative inflammatory diseases. |
| T10913 |
Cyclobuxine D |
Cyclobuxine D is a steroidal alkaloid extracted from Buxus microphylla. Cyclostatin D has obvious bradycardia effect on rat heart, and inhibits acetylcholine an...
|
| T10915 |
Cycloguanil D6 Nitrate |
Cycloguanil D6 Nitrate is a dihydrofolate reductase inhibitor, deuterium-labeled Cycloguanil. |
| T10916 |
Cycloguanil D6 |
Cycloguanil D6 is a dihydrofolate reductase inhibitor, deuterium-labeled Cycloguanil. |
| T10918 |
NEP-In-1 |
NEP-IN-1 is a neutral endopeptidase (NEP) inhibitor with IC50 of 2 nM for dNEP. |
| T10919 |
Cyclophilin inhibitor 1 |
Cyclophilin inhibitor 1 is an effective and orally bioavailable cyclophilin A inhibitor with a Kd of 5 nM, showing potent anti-HCV activity, and an EC50 for HCV...
|
| T10920 |
Cyclo(Arg-Gly-Asp-D-Phe-Val) TFA |
Arg-Gly-Asp-D-Phe-Val (TFA) has anti-tumor activity and is an inhibitor of integrin αvβ3. |
| T10921 |
CYM 9484 |
CYM 9484 is a selective and potent neuropeptide Y (NPY) Y2 receptor antagonist with IC50 value of 19 nM. |
| T10922 |
CYP11B2-IN-1 |
CYP11B2-IN-1 is a CYP11B2 inhibitor with IC50 of 2.3 nM. CYP11B2-IN-1 inhibits CYP11B1 with IC50 of 142 nM. |
| T10925 |
Cysteine Protease inhibitor |
Cysteine protease inhibitors are inhibitors of cysteine proteases. Target: Cysteine Protease |
| T10925L |
Cysteine Protease inhibitor hydrochloride |
Cysteine protease inhibitor hydrochloride is an inhibitor of cysteine protease. Target: Cysteine Protease |
| T10926 |
CYT-1010 |
CYT-1010 is an mu-opioid receptor agonist extracted from patent WO2013173730A2. The EC50 for the inhibition of β-arrestin recruitment and cAMP production is 13...
|
| T10926L |
CYT-1010 hydrochloride |
CYT-1010 hydrochloride is an mu-opioid receptor agonist extracted from patent WO2013173730A2. The EC50 for β-arrestin recruitment and cAMP production inhibitio...
|
| T10927 |
cyt-PTPε Inhibitor-1 |
cyt-PTPε inhibitor 1 is a potent cytosolic protein tyrosine phosphatase epsilon (cyt-PTPε) inhibitor, which binds to the catalytic domain of cyt-PTPε and blo...
|
| T10929 |
D-3263 |
D-3263 is an agonist of transient receptor potential melatonin member 8 (TRPM8) with potential antitumor activity. |
| T10929L |
D-3263 hydrochloride |
D-3263 hydrochloride is enteric-coated, orally bioavailable (transient receptor potential melatonin member 8) TRPM8 agonist. |
| T10930 |
D-AP5 |
D-AP5 is a NMDA receptor antagonist. |
| T10931 |
d-Atabrine dihydrochloride |
d-Atabrine hydrochloride is the active enantiomer of quinacrine and has anti-pr virus activity. |
| T10932 |
D-Cl-amidine |
D-Cl-amidine is an effective and highly selective PAD1 inhibitor. D-Cl-amidine has a good correlation and no obvious toxicity. |
| T10933 |
D-Cysteine |
D-cysteine is the D-isomer of cysteine and a powerful inhibitor of the growth of E. coli. D-cysteine is mediated by D-amino acid oxidase to produce H2S, and is ...
|
| T10934 |
D-Gluconic acid |
D-gluconic acid is a carboxylic acid that has antiseptic and chelating properties through oxidation. |
| T10935 |
D-Glutamic acid |
D-glutamic acid, the enantiomer of L-glutamic acid, is widely used in medicine and food. |
| T10936 |
D-I03 |
D-I03 is a selective RAD52 inhibitor with a Kd of 25.8 µM. D-I03 specifically inhibits RAD52-dependent single-chain annealing (SSA) and D-loop formation, with ...
|
| T10938 |
D-Kynurenine |
D-kynurenine is a metabolite of D-tryptophan, which can be used as a biological precursor of KYNA and 3-hydroxykynurenine. D-Kynurenine is an agonist of G prote...
|
| T10939 |
D,L-Cystathionine dihydrochloride |
D,L-Cystathionine dihydrochloride is an intermediate in the synthesis of cysteine, which acts from the isotype of cysteine-β-synthase (CBS) produced by leucine...
|
| T10939L |
L-Cystathionine |
L-Cystathionine is a key nonprotein amino acid. Which is related to metabolic conditions. |
| T10940 |
D-Mannoheptulose |
D-mannoheptose is the main non-structural carbohydrate in avocado. D-mannoheptose is a specific inhibitor of D-glucose phosphorylation. D-mannoheptose can preve...
|
| T10941 |
D-Ribonolactone |
D-ribolactone is a sugar lactone, an inhibitor of E. coli β-galactosidase, and Ki is 26 mM. |
| T10942 |
D-Threitol |
D-threitol is used as an antifreeze. |
| T10943 |
D-(-)-Lactic acid |
D-(-)-lactic acid is a normal intermediate in sugar fermentation (oxidation, metabolism). D-(-)-lactic acid is identified as a competitive inhibitor of ProDH (p...
|
| T10944 |
D13-9001 |
The KD values of D13-9001 in Escherichia coli and Pseudomonas aeruginosa were 1.15μM and 3.57μM, respectively. D13-9001 has antibiotic activity. It is an effe...
|
| T10945 |
D18024 |
D18024 is a phthalazinonderivat with anti-allergic and anti-histamine effect. |
| T10947 |
D8-MMAD |
D8-MMAD is a deuterated form of MMAD, which is a microtubule destroyer. |
| T10948 |
D8-MMAE |
D8-MMAE (D8-Monomethyl auristatin E) is an effective mitotic inhibitor and tubulin inhibitor, deuterated MMAE. |
| T10949 |
D8-MMAF |
D8-MMAF is a microtubule destroyer, deuterated form of MMAF. |
| T10950 |
Dabigatran D4 hydrochloride |
Dabigatran D4 hydrochloride is deuterium-labeled dabigatran, which is a reversible and selective direct thrombin inhibitor (DTI) with a Ki value of 4.5 nM. |
| T10951 |
Dabigatran ethyl ester hydrochloride |
Dabigatran ethyl ester hydrochloride is an effective inhibitor of ribosyl dihydronicotinic acid amide dehydrogenase (NQO2) with an IC50 value of 0.8 μM and is ...
|
| T10952 |
Dabuzalgron |
Dabuzalgron (Ro 115-1240) is an orally active selective alpha-1A adrenergic receptor agonist used to treat urinary incontinence. Dabuzaron prevents cardiotoxici...
|
| T10953 |
Dafadine-A |
Dafadine-A is an analog of dafadine and a novel inhibitor of DAF-9 cytochrome P450 in the nematode Caenorhabditis elegans. Mammalian orthologs that also inhibit...
|
| T10954 |
DAGLβ-IN-1 |
DAGLβ-IN-1 is a universal intermediate for designing DAGL tailored activity-based probes, and is an inhibitor of diacylglycerol lipase-β (DAGLβ). |
| T10956 |
Dansyl glutathione |
Dansyl glutathione is a capture agent used for quantitative assessment and identification of reactive metabolites. |
| T10957 |
Dapagliflozin impurity |
Dapagliflozin impurity is the enantiomer of Dapagliflozin, Dapagliflozin is a sodium glucose transporter 2 inhibitor. |
| T10958 |
Dapagliflozin D5 |
Dapagliflozin D5 (BMS-512148 D5) is deuterated Dapagliflozin. Dapagliflozin is a competitive SGLT2 inhibitor. |
| T10959 |
Daphnin |
Daphnin is one of the main coumarin bioactive ingredients with antibacterial activity. Daphnine is isolated from the entire Daphne fragrance, which is a folk me...
|
| T10960 |
Darbufelone |
Darbufelone is a dual inhibitor of cellular PGF2α and LTB4 production. Dabfilon effectively inhibited PGHS-2 (IC50 = 0.19 μM), but had a much smaller effect o...
|
| T10960L |
Darbufelone mesylate |
Darbufelone mesylate (CI-1004 mesylate) is a dual inhibitor of cellular PGF2α and LTB4 production. Dabfilon effectively inhibited PGHS-2 (IC50 = 0.19 μM), but...
|
| T10961 |
Darenzepine |
Darenzepine is a muscarinic receptor inhibitor extracted from patent US 20170095465 A1. |
| T10962 |
Dasatinib D8 |
Dasatinib D8 is deuterium-labeled dasatinib. Dasatinib is a dual Bcr-Abl and Src family tyrosine kinase inhibitor. |
| T10963 |
Dazopride |
Dazopride is an antiemetic agent. |
| T10964 |
DB1976 |
DB1976 is a selenium-thiophene analogue of DB270, a potent, cell-permeable and highly effective transcription factor PU.1 inhibitor. DB1976 strongly inhibits PU...
|
| T10964L |
DB1976 hydrochloride |
DB1976 hydrochloride is a selenium selenium analogue of DB270, a potent and permeable cell transcription factor PU.1 inhibitor. In vitro, DB1976 hydrochloride e...
|
| T10966 |
DC-5163 |
DC-5163 is a potent inhibitor of glyceraldehyde 3-phosphate dehydrogenase (GAPDH) with IC50 of 176.3 nM and Kd of 3.192 μM. DC-5163 selectively inhibits cancer...
|
| T10967 |
DC_C66 |
DC_C66 DC_C66 has good selectivity for CARM1, PRMT1 (IC50 = 21μM), PRMT6 (IC50 = 47μM) and PRMT5. It is a cell-permeable, selective co-activator related argin...
|
| T10968 |
DC0-NH2 |
The cytotoxicity of DC0-NH2 is 1000 times that of commonly used anti-cancer drugs (such as doxorubicin). It is the effect part of ADC. It is a simplified simula...
|
| T10969 |
DC1SMe |
DC1 is an ADC cytotoxin, similar to the small groove-binding DNA alkylating agent CC-1065. DC1 can be used to synthesize antibody-drug conjugates targeted to th...
|
| T10970 |
DC1 |
DC1 can be used to synthesize antibody-drug conjugates targeted to the treatment of cancer, is an ADC cytotoxin, similar to the small groove-binding DNA alkylat...
|
| T10971 |
DC10SMe |
DC10SMe is a DNA alkylating agent that can be used in the synthesis of antibody-drug conjugates (ADC). The IC50 of DC10SMe for Ramos, Namalwa and HL60 / s cance...
|
| T10972 |
DC4 |
DC4 can be used to synthesize antibody-drug conjugate (ADC), which is an ADC cytotoxin. DC4 can be used for targeted therapy of tumors. |
| T10973 |
DC41SMe |
DC41SMe is a DC1 derivative that is cytotoxic to Ramos, Namalwa and HL60 / s with IC50s ranging from 18-25 pM. DC1 is a simplified analogue of CC-1065, an antib...
|
| T10974 |
DC41 |
DC41 is a derivative of DC1. DC1 is a simplified analogue of CC-1065, an antibody conjugate of cytotoxic DNA alkylating agents, used for targeted treatment of c...
|
| T10975 |
DC44SMe |
The IC50 of DC44SMe for Ramos, Namalwa and HL60 / s cancer cells was 2.0 nM, 2.8 nM and 1.9 nM, respectively. DC44SMe can be used for targeted treatment of canc...
|
| T10976 |
DC4SMe |
The IC50s of DC4SMe on Ramos, Namalwa and HL60 / s cancer cells were 1.9 nM, 2.9 nM and 1.8 nM, respectively. DC4SMe can be used for targeted therapy of tumors....
|
| T10977 |
DCEBIO |
DCEBIO stimulates the secretion of Cl- through the activation of the hIK1 K + channel and the activation of the apical Cl- conductance. DCEBIO is a derivative o...
|
| T10978 |
DCG-IV |
DCG-IV is an effective agonist of class II mGluR. DCG-IV has anticonvulsant and neuroprotective effects. The EC50 of mGlu2R and mGlu3R are 0.35 and 0.09 μM, re...
|
| T10979 |
DCPIB |
DCPIB is a selective, reversible and effective volume-regulated anion channel (VRAC) inhibitor that voltage-dependently activates potassium channels TREK1 and T...
|
| T1098 |
Denatonium benzoate |
Denatonium, a quaternary ammonium cation, is a compound of a salt with an inert anion like saccharide or benzoate. Its structure is involved in the local anesth...
|
| T10982 |
ddATP |
ddATP is a dideoxynucleotide, used as a chain extension inhibitor for DNA polymerase, and used for DNA sequencing by the Sanger method. |
| T10983 |
DDP-38003 trihydrochloride |
DDP-38003 trihydrochloride is a novel, orally available histone lysine specific demethylase 1A (KDM1A / LSD1) inhibitor with IC50 of 84 nM. |
| T10983L |
DDP-38003 dihydrochloride |
DDP-38003 dihydrochloride is an orally available histone lysine-specific demethylase 1A (KDM1A/LSD1) inhibitor (IC50: 84 nM). |
| T10984 |
DDR-TRK-1 |
DDR-TRK-1 is a selective discoid domain receptor 1 (DDR1) inhibitor with IC50 value of 9.4 nM. DDR-TRK-1 also inhibits the TRK family. |
| T10985 |
DDR Inhibitor |
DDR inhibitor is a potent discidin domain receptor (DDR) inhibitor. The IC50 of DDR2 is 3.3 nM, and DDR1 has 53% inhibition at 1.5 nM. |
| T10986 |
DDX3-IN-1 |
DDX3-IN-1 is a DEAD-box polypeptide 3 (DDX3) inhibitor with CC50 of 50 and 36 μM for HIV and HCV, respectively. Antiviral activity. |
| T10987 |
Decarboxy Moxifloxacin |
Decarboxy Moxifloxacin is a decarboxylated compound of moxifloxacin. Moxifloxacin is an oral active 8-methoxyquinolone antibiotic used in acute bacterial sinusi...
|
| T10992 |
Delamanid D4 |
Delamanid D4 is deuterium-labeled Delamanid. Delamanid is a newer mycobacterial cell wall synthesis inhibitor that inhibits the synthesis of mucus acid. |
| T10993 |
δ-Amyrenone |
Delta-Amyrenone (Delta-Amyrone) has anti-inflammatory effects and is a pentacyclic triterpenoid compound of linear streptomyces. |
| T10997 |
Derazantinib Racemate |
Derazantinib Racemate is the racemate of Derazantinib; is a potent inhibitor of FGFR1-3. |
| T10998 |
Deriglidole |
Deriglidole is a peripheral adrenoceptor antagonist with high affinity for α2-adrenoceptor. |
| T10999 |
Desbutyl Lumefantrine |
Desbutyl Lumefantrine is a metabolite of lumefantrine with antimalarial activity. |
| T1100 |
Polymyxin B sulfate |
Polymyxin B sulphate is a mixture of polymyxins B1 and B2, obtained from Bacillus polymyxa strains. They are basic polypeptides of about eight amino acids and h...
|
| T11000 |
Descarbamoyl cefuroxime |
Descarbamoyl cefuroxime is also an intermediate in the synthesis of cephalosporin antibiotics. Decarbamyl cefuroxime is a degradation product of cefuroxime. |
| T11001 |
Desethyl chloroquine |
Desethyl chloroquine is the main deethyl metabolite of chloroquine. Chloroquine diphosphate is an inhibitor of autophagy and toll-like receptors (TLRs). Deethyl...
|
| T11001L |
Desethyl chloroquine diphosphate |
Desethyl chloroquine diphosphate is the main deethyl metabolite of chloroquine. Chloroquine diphosphate is an inhibitor of autophagy and toll-like receptors (TL...
|
| T11002 |
Desethylamiodarone hydrochloride |
Desethylamiodarone hydrochloride (N-desethylamiodarone hydrochloride) is formed by the CYP3A isozyme. Amiodarone is an antiarrhythmic drug that inhibits ATP-sen...
|
| T11003 |
Desfluoro-ezetimibe |
Desfluoro-ezetimibe is the defluorinated impurity of ezetimibe. Ezetimibe is an effective, metabolically stable cholesterol absorption inhibitor. Ezetimibe is a...
|
| T11006 |
Desmethyl ferroquine |
Desmethyl ferroquine is the active and major metabolite of Ferroquine.Desmethyl ferroquine shows significant activity against Chloroquine-susceptible and resist...
|
| T11007 |
Desmethyl Levofloxacin |
Desmethyl Levofloxacin is a metabolite of levofloxacin. Levofloxacin is a synthetic fluoroquinolone drug, an antibacterial agent that can inhibit the super-coil...
|
| T11008 |
Desmethylnortriptyline |
Desmethylnortriptyline is a metabolite of nortriptyline. Nortriptyline is a tricyclic antidepressant. It is the main active metabolite of amitriptyline and is u...
|
| T11009 |
Destruxin B |
Destruxin B is a cyclic peptide with insecticidal and anticancer activity isolated from the insect pathogenic fungus Metarhizium isopliae. Destruxin B induces a...
|
| T1101 |
Minocycline hydrochloride |
Minocycline is a tetracycline antibiotic with excellent absorption and tissue penetration that is used for several bacterial infections as well as treatment of ...
|
| T11011 |
Dexpramipexole dihydrochloride |
Dexpramipexole dihydrochloride ((R)-Pramipexole dihydrochloride) is a neuroprotective agent and is a weak non-ergoline dopamine agonist. |
| T11012 |
Dextran |
Dextran (Dextran 40) has an inhibitory effect on platelet aggregation and coagulation factors, and is used as an agent for increasing plasma volume. |
| T11013 |
Dextrorotation nimorazole phosphate ester |
Dextrorotation nimorazole phosphate ester is an anti-anaerobic and anti-parasitic agent. D-morpholine ornidazole organic phosphate is a newly developed, highly ...
|
| T11014 |
DFP00173 |
DFP00173 is a potent and selective aquaporin 3 (AQP3) inhibitor. DFP00173 inhibits mouse and human AQP3 with IC50 of ~0.1-0.4 μM. Compared with the homologous ...
|
| T11016 |
DGAT-1 inhibitor 2 |
DGAT-1 inhibitor 2 is an effective DGAT-1 inhibitor; anti-obesity drug. Objective: DGAT-1 acyl-CoA: diacylglycerol acyltransferase 1 (DGAT1) is one of two known...
|
| T11017 |
DGN462 |
DGN462 is an effective DNA alkylating agent with anti-tumor activity, as in acute myeloid leukemia (AML). DGN462 can be used as a cytotoxic component of antibod...
|
| T11018L |
(-)-DHMEQ |
(–)-DHMEQ is an effective inhibitor of NF-κB. |
| T11020 |
DHODH-IN-11 |
DHODH-IN-11 is a leflunomide derivative and weak dihydroorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.03. |
| T11021 |
DHODH-IN-12 |
DHODH-in -12 (Compound 12b) is a leflunomide derivative and a weak dihydrorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.07. |
| T11025 |
DHODH-IN-2 |
DHODH-IN-2 is an inhibitor of human dihydroorotate dehydrogenase (HsDHODH), which can inhibit measles virus replication, with a pMIC50 value of 8.6. |
| T11026 |
DHODH-IN-3 |
DHODH-IN-3 is an effective inhibitor of human dihydroorotate dehydrogenase (HsDHODH) with IC50 value of 261 nM. DHODH-IN-3 binds to the ubiquinone binding cavit...
|
| T11027 |
DHODH-IN-4 |
DHODH-IN-4 is a human and Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) inhibitor. The IC50 values of PfDHODH and HsDHODH are 4 μM and 0.18 μM, r...
|
| T11028 |
DHODH-IN-5 |
DHODH-in -5 is a potent inhibitor of human dihydrogen dehydrogenase (DHODH). For human recombinant DHODH, its pIC50 is 7.8. DHODH-IN-5 inhibits measles virus re...
|
| T11029 |
DHODH-IN-7 |
DHODH-IN-7 is a human dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of 0.91 μM. DHODH-IN-7 induces the differentiation of acute myeloid leukemia. |
| T11033 |
DI-591 |
DI-591 is an effective, high-affinity and cell-permeability inhibitor for DCN1-UBC12 interaction. DI-591 binds to DCN1 and DCN2 with Ki values of 12 and nM and ...
|
| T11035 |
diABZI STING agonist-1 (Tautomerism) |
diABZI STING agonist-1 Tautomerism is a selective stimulator of interferon gene (STING) receptor agonists, with EC50 of 130 and 186 nM for humans and mice, resp...
|
| T11037 |
Diacylglycerol acyltransferase inhibitor-1 |
Diacylglycerol acyltransferase inhibitor-1 is a diacylglycerol acyltransferase (DGAT1) inhibitor. |
| T11038 |
Dibutyryl-cGMP sodium |
Dibutyryl-cGMP sodium (Bt2cGMP sodium) is a cell-permeable cGMP analog. Dibutyryl-cGMP sodium preferentially activates cGMP-dependent protein kinase (PKG). Dibu...
|
| T11039 |
Didesethyl chloroquine |
Didesethyl chloroquine is an effective myocardial inhibitor. Diethylchloroquine (Bisdesethylchloroquine) is the main metabolite of the antimalarial drug chloroq...
|
| T11040 |
Dihydro Dutasteride |
Dihydro Dutasteride is a metabolite of Dutasteride. Dutasteride is an effective inhibitor of five α-reductase isozymes. |
| T11041 |
Dihydro-β-erythroidine hydrobromide |
Dihydro-β-erythroidine hydrobromide(DHβE) is a potent, oral active and competitive antagonist of neuronal nicotinic acetylcholine receptors (nAChRs). Dihydro-...
|
| T11042 |
Dihydrocytochalasin B |
Dihydrocytochalasin B (H2CB) is a cell division inhibitor that changes the morphology of cells, similar to cytochalasin B. Does not inhibit glucose transport. D...
|
| T11043 |
Dihydroergocristine mesylate |
Dihydroergocristine mesylate (DHEC mesylate) is an inhibitor of γ-secretase (GSI), which can reduce the production of Alzheimer's disease amyloid beta peptide,...
|
| T11045 |
Dimethyl fumarate D6 |
Dimethyl fumarate D6 is a deuterium labeled Dimethyl fumarate. can induces upregulation of antioxidant gene expression. |
| T11046 |
Dimethyl-SGD-1882 |
Dimethyl-SGD-1882 (Dimethyl-PBD dimer) is a highly efficient DNA alkylating agent used as antibody-drug conjugate (ADC) cytotoxin. PBD Dimer is a DNA alkylating...
|
| T11047 |
DiosMetin 7-O-β-D-Glucuronide |
DiosMetin 7-O-β-D-Glucuronide is an antioxidant constituent in the fruits of Luffa cylindrical[1]. |
| T11048 |
DIPQUO |
DIPQUO is an activator of bone marker alkaline phosphatase (ALP). DIPQUO promotes the differentiation of mouse and human osteoblasts by activating p38MAPK-β. T...
|
| T11049 |
Diprotin A TFA |
Diprotin A (TFA) is an inhibitor of dipeptidyl peptidase IV (DPP-IV). |
| T11050 |
Dipyrocetyl |
Dipyrocetyl is extracted from patent WO 2011132171 A1 and has anti-inflammatory and analgesic effects. |
| T11051 |
DIQ3 |
DIQ3 is non-toxic to normal human cell lines and is an effective anti-cancer agent. |
| T11052 |
Disitertide |
Disitertide (P144) is an inhibitor of TGF-β1. |
| T11053 |
DJ001 |
DJ001 is a highly specific, selective and non-competitive protein tyrosine phosphatase σ (PTPσ) inhibitor with IC50 of 1.43 μM. DJ001 promotes the regenerati...
|
| T11054 |
DL-Norvaline |
DL-Norvaline is a non-competitive inhibitor of arginase. Derivatives of L-norvaline. |
| T11057 |
DM3-SMe |
DM3-SMe is a maytansine derivative and tubulin inhibitor. It is a cytotoxic part of antibody-drug conjugates (ADCs) and can bind to antibodies via disulfide bon...
|
| T11058 |
DM3 |
DM3 (Maytansinoid DM3) is a maytansine mimic containing disulfide or thiol groups and a tubulin inhibitor. It is the cytotoxic part of antibody-drug conjugates ...
|
| T11059 |
DM4-SMe |
DM4-SMe is a cytotoxic part of antibody-drug conjugates (ADCs) and a metabolite of antibody-maytansin conjugates (AMCs) and tubulin inhibitors, which can also b...
|
| T11062 |
dmDNA31 |
dmDNA31 is a rifamycin antibiotic that can inhibit the DNA-dependent RNA polymerase of bacteria and has strong bactericidal activity against Staphylococcus aure...
|
| T11063 |
DMT1 blocker 1 |
DMT1 blocker 1 is a blocker of divalent metal transporter 1 (DMT1) with IC50 of 0.64 μM, which is expected to block the absorption of iron by intestinal cells ...
|
| T11064 |
DMT1 blocker 2 |
DMT1 blocker 2, compound 12f, is a direct inhibitor of divalent metal transporter 1 (DMT1) with an IC50 hydrogen peroxide value of 0.83, which is expected to bl...
|
| T11067 |
VX-984 |
VX-984 is a potent DNA-PK inhibitor. |
| T11068 |
DNA31 |
DNA31 is a potent RNA polymerase inhibitor. |
| T11069 |
DO-264 |
DO-264 is a selective active inhibitor containing a dehydrogenase domain of 12 (ABHD12) with IC50 of 11 nM. |
| T1107 |
Sarafloxacin hydrochloride |
Sarafloxacin hydrochloride, a quinolone antibiotic drug, is a hydrochloride salt form of sarafloxacin. |
| T11070 |
DO34 analog |
DO34 analog is a triazole DAGL(α) inhibitor extracted from patent WO2017096315 A1, compound 100. |
| T11070L |
DO34 |
DO34 is a highly potent and centrally active inhibitor of diacylglycerol lipase (IC50: 6 nM for DAGLα conversion of SAG to 2-AG). |
| T11071 |
Dofequidar fumarate |
Dofequidar fumarate(MS-209 fumarate), an orally active quinoline compound, has been reported to overcome MDR by inhibiting ABCB1/P-gp, ABCC1/MDR-associated prot...
|
| T11072 |
Dofetilide D4 |
Dofetilide D4 (UK 68789 D4) is a deuterium-labeled Dofetilide. Dofetilide is a class III antiarrhythmic drug. |
| T11073 |
Dofetilide N-oxide |
Dofetilide N-oxide (UK-116856) is a metabolite of dofetilide. Dofetilide can block potassium channels and is a tertiary antiarrhythmic drug. |
| T11074 |
Dolutegravir intermediate-1 |
Dolutegravir intermediate-1 is a new synthetic Dolutegravir intermediate extracted from patent WO 2016125192 A2. Dolutegravir is an integrase inhibitor develope...
|
| T11076 |
Dooku1 |
Dooku1 is an analog of Yoda1 and a selective antagonist of endogenous Piezo1 channels. Dooku1 inhibits Ca2+ entry induced by 2μMYoda1 with IC50 values of 1.3μ...
|
| T11077 |
Dopamine D2 receptor antagonist-1 |
Dopamine D2 receptor antagonist 1 is a negative allosteric modulator (NAM) of dopamine D2 receptor (D2R), with sub-mM affinity. |
| T11079 |
NMI 8739 |
NMI 8739 is a dopamine D2 autoreceptor agonist, which is an amine conjugate of the DHA carrier and the neurotransmitter dopamine. |
| T1108 |
Nithiamide |
Nithiamide is an orally available antiprotozoan agent used in the treatment of vaginal trichomoniasis. |
| T11085 |
Dot1L-IN-6 |
Dot1L-IN-6 is a potent disruptor of telomeric silencing 1-like protein (DOT1L) inhibitor with an IC50 SPA DOT1L of 0.19 nM. |
| T11086 |
DOTAP chloride |
DOTAP chloride is a useful and effective cationic lipid transfection DNA(plasmids, BacMIDs) and modified nucleic acids (antisense oligonucleotides) without the ...
|
| T11087 |
DOV-216,303 Free Base |
Dov-216,303 (free base) is an effective trihydroxytryptamine, norepinephrine and dopamine reuptake inhibitor with IC50 values of 14 nM, 20 nM and 78 nM for hSER...
|
| T11089 |
Doxercalciferol-D3 |
Doxercalciferol-d3 is the deuterated form of Doxercalciferol and ACTS as vitamin D receptor activator (VDRA), which is a vitamin D2 analogue. |
| T1109 |
Zucapsaicin |
Zucapsaicin is a medication used to treat osteoarthritis of the knee and Others neuropathic pain.Zucapsaicin is a synthetic cis isomer of natural capsaicin that...
|
| T11090 |
MC-DOXHZN |
Mc-doxhzn is a protein-binding prodrug of DOXUbicin (DNA topoisomerase II inhibitor) with acid sensitivity. |
| T11091 |
Doxylamine D5 succinate |
Doxylamine D5 succinate first generation antihistamine, deuterium-labeled Doxylamine, |
| T11093 |
DPPH |
The odd electrons of nitrogen atoms in DPPH are reduced by receiving a hydrogen atom from the antioxidant to the corresponding hydrazine.DPPH method can be used...
|
| T11094 |
DRAK2-IN-1 |
Drak2-in-1, a potent, selective and ATP-competitive DRAK2 inhibitor, has an IC50 and KIvalue of 3 nM and 0.26 nM, respectively.Drak2-in-1 also had an effect on ...
|
| T11095 |
DREADD agonist 21 dihydrochloride |
DREADD agonist 21 dihydrochloride is an effective human toadine acetylcholine M3 receptor (hM3Dq) agonist (EC50=1.7 nM). |
| T11095L |
DREADD agonist 21 |
In addition to being inactive at hM3, DREADD agonist 21, a potent full agonist of hM3Dq (EC50: 1.7 nM), is only 3.5-fold selective for hM3Dq over H1, 40-fold se...
|
| T11096 |
DRI-C21045 |
Dri-c21045 showed concentration-dependent inhibition of NF- B activation and all CD40L induced by B cell proliferation. IC50 was 17.1 M and 4.5 M, respectively....
|
| T11097 |
Drobuline hydrochloride |
Drobuline hydrochloride has the action of cardiac inhibitor, often used for anti-arrhythmia. |
| T11098 |
Droloxifene |
Droloxifene, a tamoxifen derivative, is an oral active and selective estrogen receptor modulator.Droloxifene induced p53 expression and apoptosis in McF-7 cells...
|
| T11099 |
Droxicainide |
Droxicainide is an antiarrhythmic agent. |
| T11100 |
DS-1040 Tosylate |
DS-1040 Tosylate is an oral active, selective thrombolytic inhibitor with IC50s of 5.92 nM and 8.01 nM for human and rat TAFIa, is an orally active, selective i...
|
| T11101 |
DS08210767 |
DS08210767 is a highly potent, orally bioavailable antagonist of PTHR1(IC50 : 90 nM). |
| T11103 |
DS18561882 |
DS18561882 also inhibited MTHFD1 (IC50=0.57).DS18561882 had good oral drug kinetics.DS18561882 is a potent isozyme-selective methylene tetrahydrofolate dehydrog...
|
| T11104 |
DS21360717 |
DS21360717 is an effective oral tyrosine kinase inhibitor with anticancer activity and IC50 of 0.49 nM. |
| T11105 |
DS88790512 |
DS88790512, IC50 at 11 nM, is an effective, selective, oral bioeffective TRPC6 inhibitor. |
| T11106 |
DSP-0565 |
DSP-0565 shows anti-convulsant activity in various models (scPTZ, MES, 6 Hz and amygdala kindling) with good safety margin. DSP-0565 (compound 17a) is a strong,...
|
| T11107 |
DSP-1053 |
Dsp-1053 is a powerful SERT (Ki=1.02 nM) inhibitor with partial 5-HT1A receptor (Ki=5.05 nM) agonizing activity. |
| T11108 |
DSR-6434 |
DSR-6434 has a strong antitumor effect. DSR-6434 is a potent and selective Toll-like receptor 7 (TLR7) agonist, with EC50s of 7.2 nM and 4.6 nM for human and mi...
|
| T11109 |
DU717 |
DU-717 is an antihypertensive agent. |
| T11113 |
Duloxetine D3 hydrochloride |
Duloxetine D3 hydrochloride is a serotonin-norepinephrine reuptake inhibitor (SNRI) with a Ki of 4.6 nM, used for treatment of major depressive disorder and gen...
|
| T11114 |
Duloxetine metabolite Para-Naphthol Duloxetine |
Para-Naphthol Duloxetine is a serotonin-norepinephrine reuptake inhibitor (SNRI)，is a metabolite of Duloxetine. |
| T11115 |
Duocarmycin GA |
Duocarmycin GA can be used against multi-drug resistant cell lines. Duocarmycin GA is an antibody drug conjugates (ADCs) toxin. Duocarmycin is a DNA alkylating ...
|
| T11116 |
Duocarmycin MA |
Duocarmycin MA can be used against multi-drug resistant cell lines.Duocarmycin MA is an antibody drug conjugates (ADCs) toxin. Duocarmycin is a DNA alkylating a...
|
| T11117 |
Duocarmycin MB |
Duocarmycin MB can be used against multi-drug resistant cell lines. Duocarmycin MB is an antibody drug conjugates (ADCs) toxin. Duocarmycin is a DNA alkylating...
|
| T11118 |
Duocarmycin SA |
Duocarmycin SA is an extremely potent cytotoxic agent capable of inducing a sequence-selective alkylation of duplex DNA.Duocarmycin SA is a potent antitumor ant...
|
| T11119 |
Duocarmycin |
Duocarmycin is a DNA minor groove binding alkylating agent and explored as drug–antibody conjugates (ADCs) . Duocarmycin is based on its characteristic curved...
|
| T11120 |
Duocarmycin TM |
Duocarmycin TM is a DNA alkylator. Duocarmycin TM is an exceptionally potent antitumor antibiotic. |
| T11121 |
Duoperone |
Duoperone is a neuroleptic agent and also a antiemetic agent in animal models. |
| T11122 |
DUPA(OtBu)-OH |
DUPA(OtBu)-OH is a DUPA precursor. DUPA is used as the targeting moiety to actively deliver Docetaxel (DTX) for treatment of Prostate-Specific Membrane Antigen ...
|
| T11123 |
DuP 105 |
DuP 105 is an orally active oxazolidinone, a new class of synthetic antimicrobial agent with activity against gram-positive bacteria. |
| T11124 |
Duramycin |
Duramycin is a cyclic peptide lantibiotic derived from Streptomyces cinnamoneuma. Duramycin interacts with phosphatidylethanolamine (PE) and has antibacteria...
|
| T11125 |
Durlobactam sodium salt |
For the treatment of drug-resistant Gram-negative bacteria including Acinetobacter baumannii. Durlobactam sodium salt is a broad-spectrum β-lactamase inhibitor...
|
| T11126 |
Durvalumab |
Durvalumab is an anti-PD-L1 monoclonal antibody, humanized.Durvalumab completely blocked the binding of PD-L1 to PD-1 and CD80, and the IC50s were 0.1 and 0.04 ...
|
| T11127 |
Dutogliptin tartrate |
Dutogliptin tartrate is an effective and selective oral dipeptide-peptide-4 (DPP4) inhibitor for the treatment of type 2 diabetes mellitus. |
| T11128 |
Dutogliptin |
Dutogliptin (PHX-1149 free base) is an oral, effective and selective dipeptide-peptide-4 (DPP4) inhibitor for the treatment of type 2 diabetes mellitus. |
| T1113 |
Imazalil |
Enilconazole is an Agricultural fungicide Enilconazole is a fungicide widely used in agriculture, particularly in the growing of citrus fruits. It is also calle...
|
| T11130 |
DVD-445 |
Dvd-445 has good anti-cancer effect.Dvd-445 is an effective peptide covalent thioredoxin reductase 1 (TrxR1) inhibitor with IC50 value of 0.60 mol/L M. |
| T11134 |
DZ2002 |
DZ2002 is a potent and reversible S-Adenosyl-L-homocysteine Hydrolase(SAHH; AdoHcy Hydrolase) inhibitor with Ki of 17.9 nM. IC50 value: 17.9 nM(Ki). |
| T11135 |
(E)-10-Hydroxy Nortriptyline maleate |
(E)-10-Hydroxy Nortriptyline maleate is a metabolite of Nortriptyline. Nortriptyline is a tricyclic antidepressant and the main active metabolite of Amitriptyli...
|
| T11138 |
(E)-LHF-535 |
(E)-LHF-535 is the E-isomer of LHF-535. LHF-535 is an antiviral , has EC50s of <1 μM, <1 μM, <1 μM, and 1-10 μM for Lassa, Machupo, Junin, and VSVg virus, ...
|
| T11138L |
LHF-535 |
LHF-535 is an antiviral compound. It has EC50s of <1 μM, <1 μM, <1 μM, and 1-10 μM for Lassa, Machupo, Junin, and VSVg virus, respectively. |
| T11139 |
(E/Z)-BCI |
(E/Z)-BCI attenuates LPS-induced inflammatory mediators and ROS production in macrophage cells via activating the Nrf2 signaling axis and inhibiting the NF-κB ...
|
| T1114 |
Ciclopirox ethanolamine |
Ciclopirox Olamine is a broad-spectrum antifungal agent with additional antibacterial and anti-inflammatory activities. |
| T11141 |
E64FC26 |
E64FC26 shows anti-myeloma activity.E64FC26 is a potent pan-inhibitor of the protein disulfide isomerase (PDI) family, with IC50s of 1.9, 20.9, 25.9, 16.3, and ...
|
| T11143 |
EB-47 |
EB-47 mimics the substrate NAD+ and extends from the nicotinamide to the adenosine subsite.EB-47, a potent and selective PARP-1/ARTD-1 inhibitor with an IC50 v...
|
| T11144 |
EC0488 |
EC0488 was used to synthesize EC0531, which has folic acid receptor specificity and anti-tumor activity. |
| T11145 |
EC1454 |
EC1454 is an anti-tumor compound. |
| T11146 |
EC359 |
EC359Kd, 10.2 nM, interacts directly with LIFR and effectively blocks LIF/LIFR interaction. It is a potent, selective, highly affinity, and oral active leukemia...
|
| T11147 |
EC5026 |
EC5026 has the potential to relieve pain by stabilizing natural analgesic and anti-inflammatory mediators. EC5026 (BPN-19186) is a first-in-class, potent and or...
|
| T11148 |
Ecastolol |
Ecastolol has anti-angina activity and is an adrenergic receptor antagonist. |
| T11150 |
Ecteinascidin 770 |
Ecteinascidin 770 (ET-770) inhibits U373MG cells and is a 1,2,3, 4-tetrahydroisoquinoline alkaloid with strong anticancer activity.IC50 is 4.83 nM. |
| T11151 |
Ecteinascidin-Analog-1 |
Ecteinascidins is a family of tetrahydroisoquinoline alkaloids with wide range of antitumor and antimicrobial activities. Ecteinascidin-Analog-1 is a useful int...
|
| T11152 |
Edaravone D5 |
Edaravone is a strong novel free radical scavenger, and inhibits MMP-9-related brain hemorrhage in rats treated with tissue plasminogen activator. Edaravone D5 ...
|
| T11153 |
EG00229 |
EG00229 selectively inhibits VEGF-A binding to NRP1 b1 domain with an IC50 of 3 μM, but has no effect on VEGFA binding to VEGFR-1 and VEGFR-2. EG00229 is a neu...
|
| T11154 |
EG01377 |
EG01377 has antiangiogenic, antimigratory, and antitumor effects.EG01377 is a neuropilin-1 (NRP1) antagonist, with a Kd of 1.32 μM for NRP1-b1, and IC50s of bo...
|
| T11156 |
Nazartinib S-enantiomer |
Nazartinib is an EGFR inhibitor. Nazartinib S-enantiomer is the less active S-enantiomer of Nazartinib. |
| T11156L |
Nazartinib mesylate |
Nazartinib mesylate is a novel, covalent mutant-selective inhibitor of EGFR (Ki and Kinact: 31 nM and 0.222/min on EGFR(L858R/790M) mutant). |
| T11165 |
EGLU |
EGLU interacts with (lS,3S)-ACPD-sensitive site with a Kd value of 66 μM. EGLU is an antidepressant agent.EGLU ((2S)-α-Ethylglutamic acid; (2S)-α-EGLU) is a...
|
| T11166 |
EHMT2-IN-1 |
EHMT2-IN-1 is a potent EHMT inhibitor, . Used in the research of blood disorder or cancer.with IC50s of all <100 nM for EHMT1 peptide, EHMT2 peptide and cellul...
|
| T11167 |
EHMT2-IN-2 |
EHMT2-IN-2 Used in the research of blood disease or cancer. EHMT2-IN-2 is a potent EHMT inhibitor, with IC50s of all <100 nM for EHMT1 peptide, EHMT2 peptide an...
|
| T11168 |
EHNA hydrochloride |
EHNA hydrochloride play roles in mediating diverse pharmacological responses, including antiviral, antitumour and antiarrhythmic effects. EHNA hydrochloride is...
|
| T11170 |
eIF4A3-IN-1 |
eIF4A3-IN-1 is a selective eukaryotic initiation factor 4A3 (eIF4A3) inhibitor (IC50=0.26 μM; Kd=0.043 μM), which binds to a non-ATP binding site of eIF4A3...
|
| T11171 |
eIF4A3-IN-2 |
eIF4A3-IN-2 is a highly selective and noncompetitive eukaryotic initiation factor 4A-3 inhibitor with an IC50 of 110 nM. |
| T11173 |
Elacestrant S enantiomer |
Elacestrant S enantiomer is a selective and orally available estrogen receptor (ERR) degrader with IC50 values of 48 and 870 nM for ERα and ERβ, respectively. |
| T11173L |
Elacestrant S enantiomer dihydrochloride |
Elacestrant (RAD1901) dihydrochloride is a selective and orally available estrogen receptor (ERR) degrader with IC50 values of 48 and 870 nM for ERα and ERβ...
|
| T11174 |
(R)-Elagolix |
Elagolix is a selective, highly potent, short-duration, orally-active, non-peptidethe gonadotropin-releasing hormone receptor (GnRHR) antagonist with KD of 54 p...
|
| T11175 |
Elenbecestat |
Elenbecestat is an effective oral bioutilization and CNS penetrating ACE-1 inhibitor for the treatment of Alzheimer's disease. |
| T11176 |
Eliglustat hemitartrate |
Eliglustat Hemitartrate, with an IC50 of 24 nM, is a specific, potent, oral active glucocerebral glycosidase inhibitor. |
| T11178 |
ELN 318463 |
ELN 318463 shows differential inhibition of presenilin (PS1)- and PS2-comprised γ-secretase with EC50s of 12 nM and 656 nM for PS1 and PS2, respectively. ELN ...
|
| T11178L |
ELN 318463 racemate |
ELN 318463 shows differential inhibition of presenilin (PS1)- and PS2-comprised γ-secretase with EC50s of 12nM and 656 nM for PS1and PS2, respectively. ELN3184...
|
| T11180 |
Embramine |
Embramine, used as an antihistamine and anticholinergic, is a monoethanolamine. |
| T11182 |
EMD638683 S-Form |
EMD638683 is a highly selective SGK1 inhibitor with IC50 of 3 μM. EMD638683 S-Form is the S-form of EMD638683. |
| T11184 |
EML4-ALK kinase inhibitor 1 |
EML4-ALK kinase inhibitor 1 is a potent oral active inhibitor of echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase (EML4-ALK), with an...
|
| T11187 |
EMT inhibitor-2 |
EMT inhibitor-2 inhibits CYP3A4 testosteron and CYP2C9 with IC50s of 49.72 and 5.54 μM, respectively. EMT inhibitor-2 inhibits epithelial-mesenchymal tran...
|
| T11188 |
Emixustat |
Emixustat, is an inhibitor of the visual cycle isomerase with an IC50 value of 4.4 nM in vitro. a novel visual cycle modulator. |
| T11188L |
Emixustat hydrochloride |
|
| T11191 |
EN6 |
EN6-mediated ATP6V1A modification decouples the v-ATPase from the Rags, leading to inhibition of mTORC1 signaling, increased lysosomal acidification and activat...
|
| T11192 |
Enalapril D5 maleate |
Enalapril D5 maleate is deuterium labeled Enalapril, which is an angiotensin converting enzyme (ACE) inhibitor. |
| T11193 |
Enalaprilat D5 Sodium Salt |
Enalaprilat D5 Sodium Salt is the deuterium labeled Enalaprilat, which is an angiotensin-converting enzyme (ACE) inhibitor. |
| T11194 |
Enalaprilat D5 |
Enalaprilat D5 is the deuterium labeled Enalaprilat, which is an angiotensin-converting enzyme (ACE) inhibitor. |
| T11195 |
Enantiomer of Sofosbuvir |
Enantiomer of Sofosbuvir is an enantiomer of Sofosbuvir, a prescription medicine for the treatment of patients with chronic hepatitis C. |
| T11197 |
Enclomiphene D4 hydrochloride |
Enclomiphene D4 hydrochloride ((E)-Clomiphene D4 hydrochloride; trans-Clomiphene D4 hydrochloride; Enclomifene D4 hydrochloride) is a potent and orally acti...
|
| T11200 |
Endoxifen E-isomer |
(Z)-Endoxifen is an active metabolite generated via actions of CYP3A4/5 and CYP2D6, is a more potent selective estrogen receptor modulator (SERM) than Tamoxifen...
|
| T11202 |
Enniatin complex |
Enniatin complex inhibits enzymes like acyl-CoA: cholesterol acyl transferase and induces apoptosis in several cancer lines . Enniatin complex is a mixture o...
|
| T11203 |
Enocyanin |
Enocyanin shows inhibitory effect on the leucine aminopeptidase, acid phosphatase, γ-glutamyl transpeptidase and esterase activity. Enocyanin is an anthocya...
|
| T11204 |
ENS-163 phosphate |
Ens-163 phosphate is a muscarinic M1 receptor agonist. It is selective. |
| T11205 |
ent-Ezetimibe |
Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator.ent-Ezetimibe (ent-SCH 58235) is the RRS-enantiomer of Ezetimibe. Ezetim...
|
| T11207 |
Entacapone sodium salt |
Entacapone sodium salt inhibits catechol-O-methyltransferase(COMT) with similar IC50 in different tissues including live, duodenum, kidney and lung, but entacap...
|
| T11208 |
Enzalutamide D3 |
Enzalutamide D3 is a deuterium labeled Enzalutamide . Enzalutamide is an androgen receptor (AR) antagonist with an IC50 of 36 nM in LNCaP prostate cells. |
| T11212 |
EPAC 5376753 |
EPAC 5376753 has an inhibitory effect on Epac1 in Swiss 3T3 cells with IC50 of 4.EPAC 5376753 is an allosteric inhibitor of EPAC, |
| T11214 |
EPI-589 |
EPI-589 has the potential for the treatment of amyotrophic lateral sclerosis (ALS). EPI-589, a quinone derivative, is a safe and well tolerated oxidoreductas...
|
| T11215 |
Episilvestrol |
Episilvestrol is a specific eIF4A-targeting translation inhibitor, with antitumor activity. Episilvestrol is a derivative of silvestrol, isolated from the fru...
|
| T11218 |
ε-Viniferin |
ε-Viniferin possesses potent antioxidant capacity. ε-Viniferin, the dimer of Resveratrol and isolated from Vitis vinifera, displays a potent inhibitory for...
|
| T11219 |
Equisetin |
Equisetin is a Quorum-sensing inhibitor (QSI) that attenuates QS-regulated virulence phenotypes in P. aeruginosa without affecting the growth of bacterias, serv...
|
| T11220 |
ER21355 |
ER21355 used for treatment of prostatic diseases. ER21355 is an inhibitor of phosphodiesterase 5 (PDE5). |
| T11221 |
ERAP1-IN-1 |
ERAP1-IN-1 competitively inhibits ERAP1 activity towards a nonamer peptide representative of physiological substrates.ERAP1-IN-1 is an endoplasmic reticulum a...
|
| T11223 |
Eriosematin |
Eriosematin has anti-proliferative and apoptosis-inducing properties and is a compound extracted from the root of Flemingia philippinensis in the Philippines. |
| T11227L |
Eravacycline dihydrochloride |
Eravacycline dihydrochloride is a potent and broad-spectrum antibacterial agent. |
| T11229 |
Erlotinib D6 |
|
| T11232 |
Erysotrine |
Erysotrine, shows antibacterial activities,isolated from seed pods of Erythrina latissima. |
| T11235 |
Estradiol 3-sulfamate |
.Estradiol 3-sulfamate inhibits estrone sulfatase with an IC50 of 251 nM and a Ki of 133 nM. Estradiol 3-sulfamate is a potent, long-acting, and orally activ...
|
| T11236 |
Estrogen receptor antagonist 1 |
Estrogen receptor antagonist 1 is a potent estrogen receptor (ER) antagonist. |
| T11237 |
Estrogen receptor antagonist 2 |
Estrogen receptor antagonist 2 is used for the study of breast cancer.Estrogen receptor antagonist 2 is a potent and orally active estrogen receptor (ER) antago...
|
| T11239 |
Ethacizine hydrochloride |
Ethacizine hydrochloride inhibits the depolarizing current responsible for the intraatrial and His-Purkinje-ventricular conduction. Ethacizine hydrochloride...
|
| T11240 |
Ethacrynic acid D5 |
Ethacrynic acid also inhibits L-type voltage-dependent and store-operated calcium channel, leading to relaxation of airway smooth muscle (ASM) cells. Ethacry...
|
| T11241 |
p38 MAPK-IN-2 |
p38 MAPK-IN-2 is an inhibitor of p38 kinase. |
| T11242 |
Ethyl glucuronide |
Ethyl glucuronide is an endogenous metabolite. |
| T11243 |
Ethyl tosylcarbamate |
Gliclazide is a whole-cell beta-cell ATP-sensitive potassium currents blocker with an IC50 of 184 nM. Ethyl tosylcarbamate is an intermediate in the synthesis ...
|
| T11244 |
Etimizol |
Etimizol was shown to relieve amnesia effectively in the origin of which there is the hypoxic component (hypobaric hypoxia, actinomycin D, mechanical injury of...
|
| T11245 |
Etiracetam |
Etiracetam is an acetylcholine agonist and a nootropic drug of the racetam family. Less active than its S-enantiomer Levetiracetam. |
| T11246 |
Etoricoxib D4 |
Etoricoxib D4 is a non steroidal anti-inflammatory agent, acting as a selective and orally active COX-2 inhibitor, with IC50s of 1.1 μM and 116 μM for COX-2 a...
|
| T11247 |
Etravirine D4 |
Etravirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used for the treatment of HIV. Etravirine D4 is the deuterium labeled Etravirine. |
| T11249 |
Exatecan |
Exatecan can be used in cancer research.Exatecan is a DNA topoisomerase I inhibitor, with an IC50 of 2.2 μM (0.975 μg/mL).. |
| T11250 |
Ezetimibe D4 |
Ezetimibe D4 is the deuterium labeled Ezetimibe. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator. |
| T11252 |
Ezetimibe phenoxy glucuronide-D4 |
Ezetimibe phenoxy glucuronide-D4 (Ezetimibe glucuronide-D4) is the deuterium labeled Ezetimibe phenoxy glucuronide. |
| T11253 |
Ezetimibe phenoxy glucuronide |
Ezetimibe phenoxy glucuronide (Ezetimibe glucuronide) is the active metabolite of Ezetimibe. Antihyperlipoproteinemic activity. |
| T11254 |
F-1 |
F-1 is IC50s of 2.1 nM, 2.3 nM, 1.3 nM and 3.9 nM for ALKWT, ROS1WT, ALKL1196M and ALKG1202R, respectively. F-1 is a potent ALK and ROS1 dual inhibitor, supp...
|
| T11256 |
FAAH inhibitor 1 |
FAAH inhibitor 1 is a potent fatty acid amide hydrolase (FAAH) inhibitor with an IC50 of 18±8 nM. |
| T11259 |
FadD32 Inhibitor-1 |
FadD32 inhibitor -1 has anti-tuberculosis activity and is an effective FadD32 inhibitor. |
| T1126 |
Penicillin V potassium salt |
Penicillin V potassium is a broad-spectrum penicillin antibiotic used orally in the treatment of mild to moderate infections by susceptible gram-positive organi...
|
| T11261 |
FAK inhibitor 5 |
FAK inhibitor 5 is a novel allosteric FAK inhibitor, with IC50 values in the low micromolar range. |
| T11262 |
Falintolol, (Z)- |
Falintolol, (Z)-, a new β-adrenergic antagonist, is characterized by the presence of an oxime function. |
| T11263 |
FAPI-2 |
Fapi-2 is a fibroblast activated protein (FAP) inhibitor used in cancer research. |
| T11264 |
FAPI-4 |
Api-4 is a fibroblast activated protein (FAP) inhibitor used in cancer research. |
| T11265 |
Faropenem daloxate |
Antibacterial Faropenem daloxate is useful for penem and antibiotics. Faropenem medoxomil has excellent in vitro activity against Streptococcus pneumoniae, Hae...
|
| T11266 |
FAS-IN-1 |
FAS-IN-1 is a potent inhibitor of Fatty acid synthase (FAS) wtih IC50 of 10 nM. |
| T11267 |
FASN-IN-1 |
FASN-IN-1 is a fatty acid synthase (FASN) inhibitor . |
| T11268 |
FD 12-9 |
FD 12-9, Anti-glioblastoma activity. is a flavonoid dimer, acts as a dual inhibitor of P-gp and BCRP, with EC50s of 285 nM and 0.9 nM, respectively. |
| T11269 |
FD-IN-1 |
FD-IN-1 is a factor D (FD) inhibitor with an IC50 of 12 nM.FD-IN-1 also inhibits factor XIa (FXIa) and Tryptase β2 with IC50s of 7.7 and 6.5µM, respective...
|
| T11270 |
Febuxostat D9 |
Febuxostat D9 is deuterium labeled Febuxostat, which is a selective xanthine oxidase inhibitor with Ki of 0.6 nM. |
| T11271 |
Fenclozine |
Fenclozine is a non-steroidal antiinflammatory drug. |
| T11272 |
Fenmetozole Tosylate |
Fenmetozole Tosylate , acts as an antidepressant drug. is an antagonist of the actions of ethanol, also antagonizes α2-adrenergic receptor, |
| T11273 |
Fenpiverinium D3 bromide |
Fenpiverinium bromide has anti-cholinergic and anti-spasmodic effects.Fenpiverinium D3 bromide is a deuterium labeled Fenpiverinium bromide. |
| T11274 |
Ferulenol |
Ferulenol shows good antimycobacterial activity and haemorrhagic action. Ferulenol, a sesquiterpene prenylated coumarin derivative, specifically inhibits suc...
|
| T11275 |
Fesoterodine L-mandelate |
Fesoterodine L-mandelate is a efficacious antimuscarinic agent for the overactive bladder (OAB). |
| T11276 |
Fexofenadine D6 |
Fexofenadine D6 is an antihistamine pharmaceutical drug.Fexofenadine D6 is deuterium labeled is Fexofenadine. |
| T11278 |
FG8119 |
FG8119 is a novel benzodiazepine agonist. |
| T11281 |
FGI-106 |
FGI-106 is active against Ebola, Rift Valley and Dengue Fever viruses with EC50s of 100 nM, 800 nM and 400-900 nM, respectively. FGI-106 also inhibits non-hemo...
|
| T11281L |
FGI-106 tetrahydrochloride |
FGI-106 tetrahydrochloride is active against Ebola, Rift Valley and Dengue Fever viruses with EC50s of 100 nM, 800 nM and 400-900 nM, respectively. FGI-106 t...
|
| T11282 |
FGTI-2734 |
FGTI-2734 can prevent membrane localization of KRAS, hence solving KRAS resistance problem and thwarting mutant KRAS patient-derived pancreatic tumors. FGTI-...
|
| T11282L |
FGTI-2734 mesylate |
FGTI-2734 mesylate can prevent membrane localization of KRAS, hence solving KRAS resistance problem and thwarting mutant KRAS patient-derived pancreatic tumor...
|
| T11283 |
Fibracillin |
Fibracillin is a penicillin antibiotic. |
| T11284 |
FIDAS-3 |
FIDAS-3 effectively competes against S-adenosylmethionine (SAM) for MAT2A binding. FIDAS-3 has anticancer activities. FIDAS-3 is a stilbene derivative and i...
|
| T11285 |
FIDAS-5 |
FIDAS-5 effectively competes against S-adenosylmethionine (SAM) for MAT2A binding. FIDAS-5 has anticancer activities. FIDAS-5 is a potent and orally active ...
|
| T11287 |
Filipin complex |
Filipin interacts with membrane sterols causing the alteration of membrane structure. Filipin III is the major component of Filipin. Filipin, produced as a mi...
|
| T11288 |
Filipin III |
Filipin interacts with membrane sterols causing the alteration of membrane structure. Filipin III is the major component of Filipin, a 28-membered ring penta...
|
| T11289 |
Finafloxacin |
Finafloxacin exhibits optimal efficacy in slightly acidic environments (pH 5.0-6.0), under which other fluoroquinolones lose activity. Finafloxacin is highly...
|
| T1129 |
Benfotiamine |
Benfotiamine is a synthetic S-acyl derivative of thiamine (vitamin B1)， used as an antioxidant dietary supplement. |
| T11290 |
FK-448 Free base |
FK-448 Free base is an effective and specific inhibitor of chymotrypsin, with an IC50 of 720 nM. |
| T11294 |
Flavanone hydrazone |
Flavanone hydrazine effectively inhibits lens protein-induced ocular inflammation.Flavanone hydrazine is a potent non-steroidal anti-inflammatory agent. |
| T11295 |
Flibanserin D4 |
Flibanserin is a full agonist of the serotonin 5-HT1A receptor (Ki=1 nM) and an antagonist of 5-HT2A (49 nM). Flibanserin D4 is a deuterium labeled Flibanserin...
|
| T11297 |
FF-10101 succinate |
FF-10101 succinate is a potent FLT3 inhibitor. |
| T11297L |
FF-10101 |
FF-10101 is a potent inhibitor of FLT3. |
| T11299 |
FLT3-IN-4 |
FLT3-IN-4 is a potent and orally effective Fms-like tyrosine receptor kinase 3 (FLT3; IC50=7 nM) inhibitor ,for treating acute myelogenous leukemia. |
| T11300 |
FLT3-IN-6 |
FLT3-IN-6 is a potent and selective inhibitor of FLT3-ITD (FLT3 mutation) with an IC50 of 1.336 nM. |
| T11301 |
Flomoxef |
Flomoxef is an antibiotic in oxacephem group and has excellent activity against various gram-positive bacteria. |
| T11301L |
Flomoxef sodium |
Flomoxef sodium is a oxacephem group antibiotic, with excellent activity against various Gram-positive bacteria. |
| T11303 |
Fluorobexarotene |
Fluorobexarotene possesses an apparent RXR binding affinity that is 75% greater than Bexarotene. Fluorobexarotene is a potent retinoid-X-receptor (RXR) agoni...
|
| T11304 |
Fluphenazine enanthate |
Fluphenazine enanthate is the first long-acting injectable (LAI) antipsychotic for the treatment of schizophrenia. |
| T11305 |
Flurofamide |
Flurofamide is an effective bacterial urease inhibitor and has potential in the treatment of infected urinary calculi. |
| T11306 |
Fluvastatin D6 sodium |
Fluvastatin sodium is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC50 of 8 nM.Fluvastatin D6 sodium is deuterium labeled Fluva...
|
| T11307 |
Fluxametamide |
Fluxametamide is an insecticide with wide spectrum, acts as an antagonist of GABA- and glutamate-gated chloride channels, with IC50 of 1.95 nM and 225 nM for M....
|
| T11310 |
FMK-MEA |
FMK-MEA is a potent and selective p90 Ribosomal S6 Kinase (RSK) inhibitor. |
| T11311 |
Foliglurax monohydrochloride |
Foliglurax monohydrochloride Antiparkinsonian effect. is a highly selective and potent, brain-penetrant metabotropic glutamate receptor 4 positive allosteri...
|
| T11312 |
Formycin A |
Formycin A shows antitumor and antiviral activities. Formycin A , a purine nucleoside antibiotic, is a potent human immunodeficiency virus type 1 (HIV-1) inh...
|
| T11313 |
Forodesine hydrochloride |
Forodesine hydrochloride is a potent human lymphocyte proliferation inhibitor. Forodesine hydrochloride could induce apoptosis in leukemic cells by increasing t...
|
| T11314 |
Fosmanogepix |
Fosmanogepix (APX001) is an N-phosphonooxymethyl prodrug which is rapidly and completely metabolized by systemic alkaline phosphatases to the active moiety, A...
|
| T11315 |
Fosmidomycin sodium salt |
Fosmidomycin sodium salt is active against both Gram-negative and Gram-positive bacteria. Fosmidomycin sodium salt is a phosphonic acid antibiotic and a antima...
|
| T11316 |
FOY 251 free base |
FOY 251 free base acts as a proteinase inhibitor. FOY 251 free base is an anti-proteolytic active metabolite camostate. |
| T11317 |
FPA-124 |
FPA-124 interacts with both the pleckstrin homology (PH) and the kinase domains of Akt. FPA-124 induces apoptosis. FPA-124, a cell-permeable copper complex, i...
|
| T11318 |
Dopexamine hydrochloride |
Dopexamine hydrochloride is a β2 adrenergic receptor agonist. |
| T11319 |
FR183998 free base |
FR183998 free base is a potent Na+/H+-exchange inhibitor, with IC50s of 0.3 nM, 3.1 nM and 6.5 nM by measurement of pHi change in rat lymphocytes, rat and human...
|
| T11322 |
Fradafiban |
Fradafiban binds to the human platelet GP IIb/IIIa complex with a Kd value of 148 nM. Fradafiban is a non-polypeptide platelet glycoprotein IIb/IIIa antagonist. |
| T11323 |
Frakefamide TFA |
Frakefamide is unable to penetrate the blood-brain-barrier and enter the central nervous system. Frakefamide TFA is a potent analgesic that acts as a periphe...
|
| T11323L |
Frakefamide |
Frakefamide is a potent analgesic. It acts as a peripheral active μ-selective receptor agonist. Frakefamide is unable to penetrate the blood-brain-barrier and ...
|
| T11325 |
Frondoside A |
possesses anticancer, anti-invasive, anti-metastasis, anti-angiogenic and pro-apoptosis properties with high safety.Frondoside A, a natural glycoside extracted ...
|
| T11327L |
FR 167653 free base |
FR 167653 free base is an orally active p38 MAPK inhibitor and is effective in treating inflammation, relieving trauma, and ischemia-reperfusion injury in vivo....
|
| T11330 |
FTI-2148 diTFA |
FTI-2148 diTFA is a RAS C-terminal mimetic dual farnesyl transferase (FT-1) and geranylgeranyl transferase-1 (GGT-1) inhibitor with IC50s of 1.4 nM and 1.7 μM,...
|
| T11330L |
FTI-2148 |
FTI-2148 is an inhibitor of RAS C-terminal mimetic dual farnesyl transferase (FT-1) and geranylgeranyl transferase-1 (GGT-1) (IC50s: 1.4 nM and 1.7 μM, re...
|
| T11331 |
FTI 276 TFA |
FTI 276 TFA is effective against plasmodium falciparum and humans.It is a protein-based nikyltransferase (PFT) inhibitor with an IC50s of 0.9 nM and 0.5 nM, res...
|
| T11331L |
FTI 276 |
FTI-276 is an inhibitor of protein farnesyltransferase (PFT) (IC50s: 0.9 and 0.5 nM for Plasmodium falciparum and human). |
| T11332 |
FUBP1–IN-1 |
FUBP1 - in-1, with an IC50 value of 11.0 M, is an effective FUSE binding protein 1 (FUBP1) inhibitor that can interfere with the binding of FUBP1 to its SINGLE-...
|
| T11333 |
Fulvene-5 |
Fulvene-5 has antitumor activity.Fulvene-5 is a potent NADPH oxidase 4 (NOX4) inhibitor with antioxidant properties. Fulvene-5 is a reactive oxygen species (R...
|
| T11334 |
Fulvestrant R enantiomer |
Fulvestrant R enantiomer is the less active R enantiomer of Fulvestrant. Fulvestrant is a potent estrogen receptor antagonist with an IC50 of 9.4 nM. |
| T11335 |
Fulvestrant S enantiomer |
Fulvestrant S enantiomer is the less active S enantiomer of Fulvestrant. Fulvestrant is a potent estrogen receptor antagonist with an IC50 of 9.4 nM. |
| T11336 |
Fumarate hydratase-IN-2 sodium salt |
Fumarate hydratase-IN-2 sodium salt is a cell-permeable and competitive fumarate hydratase inhibitor (Ki=4.5 μM) with nutrient-dependent cytotoxicity . |
| T11337 |
Fumarate hydratase-IN-1 |
Fumarate hydratase-IN-1 has antiproliferative activity against several cancer cell lines with a mean IC50 of 2.2 μM. Fumarate hydratase-IN-1 is a cell-permeab...
|
| T11338 |
Furamidine |
Furamidine is also a selective and cell-permeable protein arginine methyltransferase 1 (PRMT1) inhibitor with an IC50 of 9.4 μM. Furamidine is selective for P...
|
| T11339 |
Furegrelate sodium |
Furegrelate Sodium inhibits human platelet microsomal thromboxane A2 (TxA2) synthase with an IC50 of 15 nM. Furegrelate Sodium is being developed as an antiplat...
|
| T1134 |
Clofoctol |
Clofoctol is a bacteriostatic antibiotic with activity against Gram-positive bacteria，used in the treatment of upper and lower respiratory tract infections. |
| T11341 |
FXIa-IN-1 |
FXIa-IN-1 is a potent β-lactam covalent heparin-derived factor XIa (fXIa) inhibitor. |
| T11343 |
G0507 |
G0507 is a inhibitor of Escherichia coli growth and induces the extracytoplasmic σE stress response. G0507 acts as a chemical probe to dissect lipoprotein tra...
|
| T11344 |
G150 |
G150 inhibited interferon expression triggered by DSDNA with IC50 of 10.2 nM.G150 is an effective and highly selective inhibitor of human cyclic GMP-AMP synthas...
|
| T11346 |
G3-C12 |
G3-C12 shows anticancer activity. is a galectin-3 binding peptide, with Kd of 88 nM. |
| T11347 |
G6PD activator AG1 |
G6PD activator AG1 is a glucose-6-phosphate dehydrogenase (G6PD) activator with an EC50 of 3 µΜ. |
| T11348 |
G907 |
G907 traps MsbA in an inward-facing, lipopolysaccharide-bound conformation by wedging into an architecturally conserved transmembrane pocket. Bactericidal acti...
|
| T11349 |
GABAA receptor agent 1 |
GABAA receptor agent 1 has strong anticonvulsant activity and is a high affinity ligand of GABAA receptor. |
| T11351 |
Galanthamine N-Oxide |
Galanthamine N-Oxide inhibits electric eel acetylcholinesterase (AChE) with an EC50 of 26.2 μM. Galanthamine N-Oxide is a prominent inhibitor of substrate acc...
|
| T11352 |
Galidesivir triphosphate |
Galidesivir triphosphate is a substrate for viral RNA-dependent RNA polymerase (RDRP), resulting in termination of viral RNA replication and thus serves as an a...
|
| T11354 |
Gambogellic acid |
Gambogellic acid antitumor activity. is an xanthone isolated from the processed gamboge. |
| T11358 |
gamma-secretase modulator 1 |
γ-secretase inhibitior-1 is useful for Alzheimer's disease. γ-secretase inhibitior-1 is a gamma-secretase modulator. |
| T11358L |
gamma-secretase modulator 1 hydrochloride |
gamma-secretase inhibitior-1 is a gamma-secretase modulator, γ-secretase inhibitior-1 is useful for Alzheimer's disease. |
| T11359 |
gamma-secretase modulator 2 |
gamma-secretase modulator 2 is a potent and selective γ-secretase modulator for treatment of Alzheimer's disease .γ-secretase modulator is modulation of the a...
|
| T1136 |
Diastase |
Diastase is any one of a group of enzymes which catalyses the breakdown of starch into maltose. |
| T11360 |
gamma-secretase modulator 3 |
gamma-secretase modulator 3 is a gamma-secretase modulator. |
| T11361 |
γ-Secretase modulator 4 |
γ-Secretase modulator 4 is a potent γ-secretase modulator, reduces the Aβ42 level with IC50s of 0.017 μM and 0.014 μM in mouse and human, respectively. |
| T11362 |
gamma-Secretase Modulators |
gamma-Secretase Modulators is useful for Alzheimer's disease. IC50 value: Target: γ-secretase modulator.gamma-Secretase Modulators (Amyloid-β production inhib...
|
| T11363 |
Ganoderic acid F |
Ganoderic acid F exhibits antitumor and antimetastatic activities through inhibition of angiogenesis and alteration of proteins involving cell proliferation and...
|
| T11364 |
Ganoderic acid TR |
Ganoderic acid TR is a broad-spectrum inhibitor against influenza neuraminidases (NAs), particularly H1N1 and H5N1 neuraminidases. The IC50 values of 4.6 and 1...
|
| T11365 |
Ganodermanontriol |
Ganodermanontriol exhibits hepatoprotective activity. Ganodermanontriol, a sterol isolated from Ganoderma lucidum, induces anti-inflammatory activity in tert-b...
|
| T11367 |
Gastrofensin AN 5 free base |
Gastrofensin AN 5 free base, is an antiulcer agent. a 4-phenyl-tetrahydroisoquinoline derivative. |
| T11368 |
GATA4-NKX2-5-IN-1 |
GATA4-NKX2-5-IN-1 exhibits no activity on the protein kinases involved in the regulation of GATA4 phosphorylation, and it modulates the hypertrophic agonist-i...
|
| T11369 |
GB-110 |
GB-110 selectively induces PAR2-mediated intracellular Ca2+ release in HT29 cells with an EC50 of 0.28 μM. GB-110 is a potent, orally active, and nonpeptidic ...
|
| T11369L |
GB-110 hydrochloride |
GB-110 hydrochloride selectively induces PAR2-mediated intracellular Ca2+ release in HT29 cells with an EC50 of 0.28 μM. GB-110 hydrochloride is a potent, ora...
|
| T1137 |
Clorsulon |
Clorsulon is utilized for the treatment of Fasciola hepatica infections in calves and sheep. |
| T11370 |
GB-88 |
GB-88 is an selective , oral non-peptide antagonist of PAR2, inhibits PAR2 activated Ca2+ release with an IC50 of 2 µM. |
| T11371 |
GBR 12783 |
GBR 12783 can improve memory performance and increase hippocampal acetylcholine release in rats. GBR 12783 is a specific, potent and selective dopamine uptak...
|
| T11373 |
GCN2-IN-1 |
GCN2-IN-1 (A-92) is a potent general control nonderepressible 2 kinase (GCN2) inhibitor with an IC50 of 0.3-3 μM in the cell assay and an IC50 of <0.3 μM in t...
|
| T11374 |
GCN2-IN-6 |
GCN2-IN-6 is also a eIF2α kinase PERK inhibitor with an IC50 of 0.26 nM (in enzymatic assay) and 230 nM (in cells). GCN2-IN-6 is a potent, and orally availa...
|
| T11375 |
GCN2iB |
GCN2iB is an ATP-competitive inhibitor of a serine/threonine-protein kinase general control nonderepressible 2 (GCN2), with an IC50 of 2.4 nM. |
| T11376 |
GC 14 |
GC 14 is a selective thyroid hormone receptor antagonist, with IC50 values of 200 nM and 35 nM for hTRα and hTRβ, respectively. |
| T11377 |
GDC-0276 |
|
| T11378 |
GDC-0834 S-enantiomer |
GDC-0834 is a potent and selective BTK inhibitor.GDC-0834 (S-enantiomer) is the S-enantiomer of GDC-0834. |
| T11378L |
GDC-0834 Racemate |
GDC-0834 Racemate is the racemate form of GDC-0834, which is an effective and selective BTK inhibitor |
| T1138 |
Taurocholic acid sodium salt hydrate |
Taurocholic acid sodium salt hydrate is the product of conjugation of taurine with cholic acid. The sodium salt, the main ingredient of the bile of carnivorous ...
|
| T11380 |
GDC-0927 |
GDC-0927 is a novel,non-steroidal, potent, orally bioavailable, selective estrogen receptor antagonist. |
| T11382 |
GDP-α-D-mannose disodium |
|
| T11384 |
Gefitinib D8 |
Gefitinib is an EGFR tyrosine kinase inhibitor, with IC50 of 2-37 nM in NR6wtEGFR cells. Gefitinib D8 is a deuterium labeled Gefitinib. |
| T11385 |
Gefitinib N-oxide |
Gefitinib is an EGFR tyrosine kinase inhibitor, with IC50 of 2-37 nM in NR6wtEGFR cells. Gefitinib N-oxide is the N-oxide derivative of Gefitinib. |
| T11386 |
Gemcabene calcium |
Gemcabene calcium , a first-in-class lipid-lowering agent, lowers low-density lipoprotein cholesterol (LDL-C), decreases triglycerides, and raises high-density ...
|
| T11386L |
Gemcabene |
Gemcabene is a first-in-class lipid-lowering agent. It shows lowers low-density lipoprotein cholesterol (LDL-C) and decreases triglycerides. It also raises HDL-...
|
| T11387 |
Gemfibrozil 1-O-β-glucuronide |
Gemfibrozil 1-O-β-Glucuronide, a metabolite of Gemfibrozil , is a potent and competitive P450 (CYP) isoform CYP2C8 inhibitor with an IC50 of 4.07 μM. |
| T11388 |
Gemilukast |
Gemilukast is an orally active and potent dual cysteinyl leukotriene 1 and 2 receptors (CysLT1 and CysLT2) antagonist, with IC50s of 1.7, 25 nM for human CysLT1...
|
| T11389 |
Genz-123346 |
Genz-123346 blocks the conversion of ceramide to glucosylceramide (GL1) and inhibits GM1 with an IC50 value of 14 nM. Genz-123346 is a potent, orally availab...
|
| T11391 |
Gepotidacin S enantiomer |
Gepotidacin S enantiomer is an S enantionmer of gepotidacin. |
| T11391L |
Gepotidacin |
Gepotidacin is a novel triazaacenaphthylene inhibitor of bacterial type II topoisomerase. |
| T11393 |
GET73 |
GET73 significantly affects glutamate transmission in the hippocampus.GET73 is a γ-hydroxybutyric acid (GHB) analog, a naturally occurring neurotransmitter. ...
|
| T11394 |
GFB-8438 |
GFB-8438 shows excellent selectivity against TRPC6, other TRP family members, NaV 1.5, as well as limited activity against the hERG channel. GFB-8438 protects m...
|
| T11395 |
GF 15 |
GF 15 is a potent inhibitor of centrosomal clustering in tumor cells. |
| T11397 |
GGTI298 |
GGTI298 is a CAAZ peptidomimetic geranylgeranyltransferase I (GGTase I) inhibitor, strongly inhibiting the processing of geranylgeranylated Rap1A with little ef...
|
| T11398 |
Ginsenoside Ra3 |
Ginsenoside Ra3, isolated from Panax ginseng, possesses anti-cancer activity. |
| T11400 |
Gisadenafil besylate |
Gisadenafil besylate (UK 369003-26) is a specific, orally active phosphodiesterase 5 (PDE5) inhibitor ,prevents degradation of cyclic guanosine monophosphate (c...
|
| T11401 |
GKA50 |
GKA50 stimulates insulin release from mouse islets of Langerhans and MIN6 cells. GKA50 shows significant glucose lowering in high fat fed female rats. GKA50 ...
|
| T11402 |
GKI-1 |
GKI-1 robustly inhibits ROCK1 with an IC50 of 11 µM, but only weakly affected PKA. GKI-1 is a Greatwall (GWL) kinase inhibitor with IC50s of 4.9 and 2.5 µM a...
|
| T11403 |
Gln-AMS |
Gln-AMS is an aminoacyl-tRNA synthetases (AARS) inhibitor, which binds the A-domain within the NRPS enzymes. |
| T11403L |
Gln-AMS TFA |
Gln-AMS(TFA) inhibits glutaminyl-tRNA synthetase (GlnRS) with a Ki of 1.32 µM. Gln-AMS (TFA) is a type Ia aminoacyl-tRNA synthetase (AARS) inhibitor. |
| T11404 |
GLP-1 receptor agonist 3 |
GLP-1 receptor agonist 3 is a GLP-1 receptor agonist,Example 4A-1, has EC50s of 1.1 nM and 13 nM in Clone H6 and Clone C6 cell lines assay, respectively. |
| T11405 |
GLP-1 receptor agonist 4 |
GLP-1 receptor agonist 4 is a glucagon-like peptide-1 receptor (GLP-1R) agonist , has an EC50 of 64.5 nM. GLP-1 receptor agonist 4 can be used in the research ...
|
| T11406 |
TT-OAD2 free base |
TT-OAD2 free base has the potential for diabetes treatment. TT-OAD2 free base is a non-peptide glucagon-like peptide-1 (GLP-1) receptor agonist with an EC50 of...
|
| T11407 |
GLP-1 receptor agonist 2 |
GLP-1 receptor agonist 2 is a glucagon-like peptide-1 receptor (GLP-1R) agonist. |
| T11409 |
GLP-26 |
GLP-26 disrupts the encapsidation of pre-genomic RNA, causes nucleocapsid disassembly and reduces cccDNA pools. GLP-26 is a HBV capsid assembly modulators (C...
|
| T1141 |
Fenbendazole |
Fenbendazole is an antinematodal benzimidazole used in veterinary medicine. |
| T11410 |
GLPG0492 R enantiomer |
GLPG0492 R enantiomer is the R enantiomer of GLPG-0492, which is a novel selective androgen receptor modulator. |
| T11410L |
GLPG0492 |
GLPG0492 is a novel selective androgen receptor modulator. After oral dosing, it showed anabolic activity on muscle, strongly dissociated from the androgenic ac...
|
| T11411 |
GLPG1205 |
GLPG1205 is potent, selective and orally active GPR84 (a G-protein-coupled receptor) antagonist with a favorable PK/PD profile. GLPG1205 has anti-inflammatory ...
|
| T11412 |
GLS1-IN-1 |
GLS1-IN-1 is used in the research of GLS1 mediated diseases, such as cancer.GLS1-IN-1 is a GLS1 (the kidney –type glutaminase) inhibitor. |
| T11413 |
Glucagon receptor antagonists-1 |
Glucagon receptor antagonist -1 is a highly effective glucagon receptor antagonist. |
| T11414 |
Glucagon receptor antagonists-2 |
Glucagon receptor antagonist -2 is a highly effective glucagon receptor antagonist. |
| T11415 |
Glucagon receptor antagonists-3 |
Glucagon receptor antagonist -3 is a highly effective glucagon receptor antagonist. |
| T11416 |
Glucagon receptor antagonists-5 |
Glucagon receptor antagonists-5 has potential for the treatment of type 2 diabetes mellitus (T2DM).Glucagon receptor antagonists-5 is a potent and orally bioa...
|
| T11417 |
Glucocorticoid receptor agonist |
Glucocorticoid receptor agonist is an effective glucocorticoid receptor agonist. |
| T11418 |
Glucokise activator 1 |
Glucokinase activator 1 is a liver-directed glucokinase activator with an EC50 of 34 nM. |
| T11419 |
O6BTG-octylglucoside |
O6BTG-octylglucoside is a potent O6-methylguanine-DNAmethyl-transferase (MGMT) inhibitor, with IC50s of 10 nM in HeLa S3 cells and 32 nM in vitro (cell extract...
|
| T11420 |
GLUT4 activator 1 |
GLUT4 activator 1 is a potent glucose transporter type 4 (GLUT4) translocation activator with an EC50 of 0.14 μM. |
| T11421 |
Glutamise-IN-1 |
Glutaminase-IN-1 (CB839 derivative) shows improved cellular uptake and antitumor activity. Glutaminase-IN-1 , a CB839 derivative, is an allosteric inhibitor of...
|
| T11422 |
Glutaminyl Cyclase Inhibitor 3 |
Glutaminyl Cyclase Inhibitor 3 significantly reduced the brain concentrations of pyroform Aβ and total Aβ and restored cognitive functions.Glutaminyl Cyclase ...
|
| T11423 |
Glutaminyl Cyclase Inhibitor 4 |
Glutaminyl Cyclase Inhibitor 4 is a potent anti-Alzheimer’s agent. Glutaminyl Cyclase Inhibitor 4 is a potent, selective glutaminyl cyclase (QC) inhibitor ...
|
| T11424 |
Glutaminyl Cyclase Inhibitor 1 |
Glutaminyl Cyclase Inhibitor 1 is a glutaminyl cyclase inhibitor with an IC50 of 0.5 μM. |
| T11425 |
Glutaminyl Cyclase Inhibitor 2 |
Glutaminyl Cyclase Inhibitor 2 is a glutaminyl cyclase inhibitor with an IC50 of 1.23 μM. |
| T11428 |
Glyco-Obeticholic acid |
Glyco-obeticholic acid is an active metabolite of Obeticholic acid. Obeticholic acid is a farnesoid X receptor (FXR) agonist. |
| T11429 |
Glycolic acid oxidase inhibitor 1 |
Glycolic acid oxidase inhibitor 1 is a glycolate oxidase inhibitor. |
| T11430 |
Glycosidase-IN-1 |
Glycosidase-IN-1 be used to synthesize some immunosuppressive agents and β-glucosidase inhibitors. Glycosidase-IN-1 has hypoglycemic activity.Glycosidase-IN-1...
|
| T11431 |
Glycosidase-IN-2 |
Glycosidase-IN-2 has hypoglycemic activity. Glycosidase-IN-2 is an azasugar class of glycosidase inhibitor. |
| T11432 |
Glyoxalase I inhibitor free base |
Glyoxalase I inhibitor (free base) , candidate for anticancer agents. Glyoxalase I inhibitor (free base) is a potent Glyoxalase I (GLO1) inhibitor. |
| T11433 |
Glyoxalase I inhibitor |
Glyoxalase I inhibitor is , candidate for anticancer agents.Glyoxalase I inhibitor is a potent Glyoxalase I inhibitor. |
| T11434 |
GlyRS-IN-1 |
GlyRS-IN-1 can inhibit the growth of bacteria. is a glycyl-tRNA synthase (GlyRS) inhibitor . |
| T11435 |
GlyT1 Inhibitor 1 |
GlyT1 Inhibitor 1,Antipsychotic activity. is a potent and selective GlyT1 inhibitor with an IC50 of 38 nM for rGlyT1. |
| T11437 |
GNE-0439 |
GNE-0439 inhibits mutant N1742K channels (IC50=0.37 uM) in membrane potential assays. GNE-0439 possesses a carboxylic acid group, binds outside of the channe...
|
| T11438 |
GNE-1858 |
GNE-1858 is a potent and ATP-competitive hematopoietic progenitor kinase-1 (HPK1) inhibitor, with IC50s of 1.9 nM, 1.9 nM, and 4.5 nM for wild-type and the acti...
|
| T11439 |
GNE-616 |
GNE-616 shows >1000 nM Kd and >2500-fold selectivity over hNav1.1, hNav1.3, hNav1.4, and hNav1.5. Selectivity over hNav1.2 and hNav1.6 is more modest at 31- an...
|
| T11443 |
GNE 220 |
GNE-220 is a potent and selective inhibitor of MAP4K4 with an IC50 of 7 nM. |
| T11443L |
GNE 220 Hydrochloride |
GNE 220 is a potent and selective inhibitor of MAP4K4, with an IC50 of 7 nM. |
| T11444 |
GNF-6231 |
GNF-6231 shows IC50s of greater than 10 μM on all CYP isoforms tested . GNF-6231 have favorable potency and a PK profile across preclinical species upon oral ...
|
| T11445 |
GNF179 Metabolite |
GNF179 metabolite is the metabolite of GNF179, which is an optimized 8,8-dimethyl IP analog that exhibited the potency(4.8 nM against the multidrug resistant st...
|
| T11446 |
GNF362 |
GNF362 also inhibits Itpka and Itpkc with IC50 values of 20 nM and 19 nM, respectively. Inositol trisphosphate 3’ kinase B (Itpkb) is a Ca2+-dependent kinase...
|
| T11448 |
GOAT-IN-1 |
GOAT-IN-1 is an inhibitor of ghrelin O-acyltransferase (GOAT), which could be useful for the prophylaxis or treatment of obesity, diabetes, hyperlipidemia, meta...
|
| T1145 |
Diminazene Aceturate |
Diminazene is a trypanocidal agent. |
| T11450 |
Gosogliptin |
Gosogliptin is a potent and selective inhibitor of dipeptidyl peptidase-IV (DPP-IV). |
| T11451 |
GPI-1046 |
GPI-1046 is an analog of FK506, which is an immunophilin ligand that has been shown neuroprotective effects in neurodegenerative disease models. GPI-1046 readil...
|
| T11453 |
GPR120 modulator 1 |
GPR120 modulator 1 is useful for modulating G protein-coupled receptor 120 (GPR120). |
| T11454 |
GPR120 modulator 2 |
GPR120 modulator 2 regulates g-protein-coupled receptor 120 (GPR120). |
| T11455 |
GPR35 agonist 1 |
GPR35 agonist 1 showed good potency.It is a highly effective and specific G-protein-coupled receptor-35 (GPR35)/CXCR8 agonist with an EC50 of 5.8 nM. |
| T11456 |
GPR40 Activator 1 |
GPR40 Activator 1 is a potent GPR40 activator for treatment of type 2 diabetes. |
| T11457 |
GPR40 Activator 2 |
GPR40 Activator 2 is a potent GPR40 . |
| T11459 |
GPR40 agonist 1 |
GPR40 agonist 1 is an effective new GPR40 agonist with EC50 of 17 nM for rGPR40 and 2 nM for hGPR40. |
| T11461 |
NE 52-QQ57 |
NE 52-QQ57 has anti-inflammatory activity. NE 52-QQ57 is a selective, and orally available GPR4 antagonist with an IC50 of 70 nM. |
| T11464 |
GRL0617 |
GRL0617 is a selective and competitive SARS-CoVPLpro and deubiquitinase noncovalent inhibitor(IC50 : 0.6 μM, Ki : 0.49 μM). |
| T11465 |
GS-6207 |
GS-6207 displays a mean EC50 of 50 pM (20-160 pM) against 23 HIV-1 clinical isolates from different subtypes in peripheral blood mononuclear cells (PBMCs). GS-6...
|
| T11466 |
GSK-2793660 |
GSK-2793660 can be used for the reaearch of bronchiectasis. GSK-2793660 is an oral, irreversible inhibitor of Cathepsin C (CTSC). |
| T11472 |
GSK 525768A |
GSK 525768A has no activity towards BET. GSK 525768A is the inactive enantiomer of GSK525762A. |
| T11473 |
GSK-5498A |
GSK-5498A is a selective small molecule blocker of CARC (IC50, 1 μM); pro-inflammatory cytokine release from T-cells in a variety of species , and inhibits me...
|
| T11476 |
GSK-J2 |
GSK-J1 is a potent inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A. GSK-J2 is an isomer of GSK-J1 that does not have any specific activity. |
| T11477 |
GSK1059865 |
GSK1059865 is a potent orexin 1 receptor antagonist. |
| T1148 |
Menbutone |
Menbutone is a derivative of oxobutyric acid, and is a choleretic. Menbutone shows a rapid onset of action, reaching its maximum plasma level within 1 hour and ...
|
| T11480 |
GSK205 |
GSK205 is a potent, selective TRPV4 antagonist with an IC50 of 4.19 μM for inhibiting TRPV4-mediated Ca2+ influx. |
| T11481 |
GSK2239633A |
GSK2239633A inhibits the binding of [125I]-TARC to human CCR4 with a pIC50 of 7.96 ± 0.11. GSK2239633A is a CC-chemokine receptor 4 (CCR4) antagonist. |
| T11482 |
GSK2245035 |
GSK2245035 has pEC50s of 9.3 and 6.5 for IFNα and TFNα. GSK2245035 effectively suppresses allergen-induced Th2 cytokine production in human peripheral blood c...
|
| T11485 |
GSK2643943A |
GSK2643943A is a deubiquitylating enzyme (DUB) inhibitor, with an IC50 of 160 nM for USP20/Ub-Rho. |
| T11488 |
GSK2850163 |
GSK2850163 is a novel inhibitor of inositol-requiring enzyme-1 alpha (IRE1α) which can inhibit RNase activity and IRE1α kinase activity with IC50s of 200 an...
|
| T11488L |
GSK2850163 hydrochloride |
GSK2850163 hydrochloride can inhibit IRE1α kinase activity and RNase activity with IC50s of 20 and 200 nM, respectively. GSK2850163 hydrochloride is a novel i...
|
| T11489 |
GSK2850163 S entiomer |
GSK2850163 is an inositol-requiring enzyme-1 alpha (IRE1a) inhibitor. GSK2850163 S enantiomer is the inactive enantiomer of GSK2850163. |
| T11490 |
GSK2945 |
|
| T11490L |
GSK2945 hydrochloride |
GSK2945 hydrochloride enhances cholesterol 7α-hydroxylase (CYP7A1) level and cholesterol metabolism. GSK2945 hydrochloride is a class of tertiary amine, and i...
|
| T11492 |
GSK2983559 free acid |
GSK2983559 free acid has excellent activity in blocking many proinflammatory cytokine responses in vivo and in human inflammatory bowel disease explant samples....
|
| T11493 |
GSK3004774 |
GSK3004774 shows an EC50 of 50 nM for human CaSR. GSK3004774 is a potent, nonabsorbable agonist of CaSR, with an pEC50 of 7.3, 6.6 and 6.5 for human, mouse and ...
|
| T11494 |
GSK3532795 |
GSK3532795 is a potent, orally active, second-generation HIV-1 maturation inhibitor, with EC50s of 10.2, 1.9, 2.7 and 13 nM for HIV-1 WT(human serum), HIV-1 W...
|
| T11495 |
GSK4028 |
GSK4028 is the enantiomeric negative control of GSK4027, which is a PCAF/GCN5 bromodomain chemical probe,in a time-resolved fluorescence resonance energy transf...
|
| T11495L |
GSK 4027 |
GSK 4027 is a PCAF/GCN5 bromodomain chemical probe. In a time-resolved fluorescence resonance energy transfer (TR-FRET) assay, it has a pIC50 of 7.4±0.11 for P...
|
| T11496 |
GSK598809 |
GSK598809 is a selective and potent dopamine D3 Receptor (DRD3) antagonist, with a pKi of 8.9. |
| T11497 |
GSK656 |
GSK656 acting as an inhibitor of Mycobacterium tuberculosis (Mtb) leucyl-tRNA synthetase (LeuRS), is a potent antitubercular agent, with an IC50 of 0.2 μM. |
| T11498 |
GSK682753A |
GSK682753A is a selective and highly potent inverse agonist of the epstein-barr virus-induced receptor 2 (EBI2) with an IC50 of 53.6 nM. |
| T11499 |
GSK726701A |
GSK726701A is a new type of prostaglandin E2 receptor 4 (EP4) partial agonist with a pEC50 of 7.4. |
| T11502 |
Epelsiban |
Epelsiban is a selective, potent and orally bioavailable oxytocin receptor antagonist, with a pKi of 9.9 for human oxytocin receptor. |
| T11504 |
GSTO-IN-2 |
GSTO-IN-2 is a glutathione S-transferase inhibitor with IC50s of 1.4, 16.3, and 3.6 μM for GSTP1-1, GSTM1, and GSTA2. |
| T11505 |
GSTO1-IN-1 |
GSTO1-IN-1 is a potent glutathione S-transferase omega 1 (GSTO1) inhibitor with an IC50 of 31 nM. |
| T11506 |
Guaiapate |
Guaiapate is a cough suppressant. |
| T11507 |
Guancydine |
Guancydine is an antihypertensive agent. |
| T11508 |
Camicil |
Camicinal is a small molecule, selective motilin receptor agonist with pEC50 of 7.9. |
| T11508L |
Camicil hydrochloride |
Camicinal hydrochloride is a small molecule, selective motilin receptor agonist with pEC50 of 7.9. |
| T11509 |
Guanfu base H |
|
| T11510 |
Guanfu base I |
Guanfu base I has a potent anti-arrhythmic effect.Guanfu base I is an active metabolite of Guanfu base A, isolated from Aconitum coreanum. |
| T11511 |
Guanosine-5'-triphosphate disodium salt |
Guanosine-5'-triphosphate disodium salt is an activator of the signal transducing G proteins and also serves as an energy-rich precursor of mononucleotide uni...
|
| T11512 |
Guanoxabenz |
Guanoxabenz is an α2 adrenergic receptor agonist. |
| T11513 |
Gum arabic |
Gum Arabic is an anti-oxidant, and can protect against experimental hepatic-, renal- and cardiac toxicities. Gum Arabic also can be used in immunohistochemistr...
|
| T11514 |
Gusperimus trihydrochloride |
Gusperimus trihydrochloride is a derivative of the antitumor antibiotic spergualin with immunosuppressant activity. |
| T11515 |
Gut restricted-7 |
Gut restricted-7 decreases gut bacterial BSHs and decreases deconjugated bile acid levels in feces of mice. Gut restricted-7 (GR-7) is a potent, covalent and o...
|
| T11516 |
GV-196771A |
GV-196771A is an NMDA receptor antagonist. and is the sodium salt form of GV196771. |
| T11517 |
GV-58 |
GV-58 is a potent, selective N- and P/Q-type Ca2+ channels agonist with EC50 of 7.21/8.81 uM for N-type/P-Q-type Ca2+ channel; 20-fold less potent CDK inhibitor...
|
| T11519 |
GW768505A free base |
GW768505A free base has anti-angiogenic activity.GW768505A free base is a potent dual inhibitor of VEGFR2 (KDR) and Tie-2, with a pIC50 of 7.81 for VEGFR2. |
| T11520 |
GW806742X |
GW806742X has activity against VEGFR2. GW806742X is a Mixed Lineage Kinase Domain-Like protein (MLKL) inhibitor which binds the MLKL pseudokinase domain with a...
|
| T11522 |
GYKI 52466 dihydrochloride |
GYKI 52466 dihydrochloride is inactive against N-methyl-D-aspartate (NMDA) or γ-aminobutyric acid responses. GYKI 52466 dihydrochloride ia a muscle relaxant an...
|
| T11524 |
H-89 |
H-89 has weak inhibition on PKG, PKC, Casein Kinase, and others kinases. H-89 is a potent and selective inhibitor of cyclic AMP-dependent protein kinase (prot...
|
| T11525 |
GW311616 |
GW-311616 is a orally bioavailable,potent , long duration and selective human neutrophil elastase (HNE) inhibitor with IC50 value of 22 nM and Ki value of 0.31 ...
|
| T11525L |
GW311616 hydrochloride |
GW-311616 is a potent, long duration,orally bioavailable and selective human neutrophil elastase (HNE) inhibitor with IC50 value of 22 nM and Ki value of 0.31 n...
|
| T11526 |
DPP-IV-IN-2 |
DPP-IV-IN-2 is an inhibitor of both DP8/9 and dipeptidyl peptidase IV (DPIV) with IC50s of 0.1 and 0.95 μM, respectively. |
| T11527 |
H-Ser-His-OH |
H-Ser-His-OH, an endogenous metabolite,is a short peptide with hydrolysis cleavage activity. |
| T11528 |
H100 |
H100 is a Cl- transport inhibitor, no effect against KCl cotransporter, in human erythrocytes. with partial effects against both the NaK2Cl cotransporter a...
|
| T11529 |
H3B-120 |
H3B-120 has anti-cancer activity. H3B-120 is a highly selective, competitive and allosteric carbamoyl phosphate synthetase 1 (CPS1) inhibitor with an IC50 of 1...
|
| T11530 |
H3B-6545 Hydrochloride |
H3B-6545 Hydrochloride is an selective, oral estrogen receptor covalent antagonist (SERCA). |
| T11530L |
H3B-6545 |
H3B-6545 is an oral and selective antagonist of estrogen receptor covalent (SERCA). |
| T11533 |
HA155 |
HA-155 is a selective and potent autotaxin (ATX) inhibitor with an IC50 of 5.7 nM. |
| T11534 |
Haemanthamine |
Haemanthamine has pro-apoptotic, antioxidant, antiviral, antimalarial and anticonvulsant activities. Haemanthamine is a crinine-type alkaloid isolated from the...
|
| T11534L |
Haemanthamine hydrochloride |
Haemanthamine hydrochloride targets ribosomal that inhibits protein biosynthesis during the elongation stage of translation. Haemanthamine hydrochloride has pro...
|
| T11535 |
Haloperidol D4 |
Haloperidol D4 is deuterium labeled haloperidol. |
| T11536 |
Haloperidol D4' |
Haloperidol D4' is deuterium labeled haloperidol. |
| T11537 |
HAT-IN-1 |
HAT-IN-1 used in the research of cancer. is an inhibitor of HAT. |
| T11538 |
Hck-IN-1 |
Hck-IN-1 is a direct and wide HIV-1 Nef antagonists with an IC50 of 100-300 nM for wild-type HIV-1 replication. Hck-IN-1 binds pocket residue Asn126 and has ant...
|
| T11539 |
HCV-IN-29 |
HCV-IN-29 is a hepatitis C virus (HCV) inhibitor . |
| T11540 |
HCV-IN-3 |
HCV-IN-3 is a hepatitis C virus (HCV) NS3/4a protein inhibitor, with an IC50 of 20 μM, a Kd of 29 μM. |
| T11541 |
HCV-IN-30 |
HCV-IN-30 is a HCV NS5A replication complex inhibitor, with IC50s of 901 and 102 nM for genotypes 1a and 1b replicons, respectively. |
| T11545 |
hDDAH-1-IN-2 |
hDDAH-1-IN-2 reveals an excellent profile regarding cell toxicity/viability. hDDAH-1-IN-2 is a selective, orally active human dimethylarginine dimethylaminohyd...
|
| T11545L |
hDDAH-1-IN-2 sulfate |
hDDAH-1-IN-2 reveals an excellent profile regarding cell toxicity/viability. hDDAH-1-IN-2 is a selective, orally active human dimethylarginine dimethylaminohyd...
|
| T11546 |
hDHODH-IN-1 |
hDHODH-IN-1 has anti-inflammatory effect. hDHODH-IN-1 is a human dihydroorotate dehydrogenase (hDHODH) inhibitor. |
| T11547 |
hDHODH-IN-2 |
hDHODH-IN-1 has anti-inflammatory activity.hDHODH-IN-2 is an analogue of the active metabolite of Leflunomide. hDHODH-IN-2 is a human dihydroorotate dehydrogena...
|
| T11548 |
HCV-IN-7 |
HCV-IN-7 shows a superior pan-genotypic profile and a good pharmacokinetic profile coupled with a favorable liver uptake. HCV-IN-7 has anti-viral activity. HCV...
|
| T11548L |
HCV-IN-7 hydrochloride |
HCV-IN-7 hydrochloride shows a superior pan-genotypic profile and a good pharmacokinetic profile coupled with a favorable liver uptake. HCV-IN-7 hydrochloride h...
|
| T11549 |
Helioxanthin 8-1 |
Helioxanthin 8-1 is an analogue of helioxanthin, exhibites significant in vitro anti-HBV/HCV/HSV-1/HIV activity with EC50 of >5/10/1.4/15 uM. IC50 value: >5/10/...
|
| T11550 |
Helioxanthin derivative 5-4-2 |
Helioxanthin derivative 5-4-2 is an analogue of helioxanthin, exhibites significant in vitro anti-HBV activity with EC50 of 0.08 uM in HepG2.2.15 cells. Anti-H...
|
| T11551 |
Helvolic acid |
Helvolic acid is an antibiotic isolated from Xylaria sp, active against the Gram-positive bacteria. |
| T11552 |
hDDAH-1-IN-1 |
hDDAH-1-IN-1 TFA potently inhibits hDDAH-1 (Ki = 18 µM) without significantly affecting NOSs and arginase. |
| T11552L |
hDDAH-1-IN-1 TFA |
hDDAH-1-IN-1 TFA is a potent and selective non-amino acid catalytic site inhibitor of human dimethylarginine dimethylaminohydrolase-1 (hDDAH-1), with a Ki of ...
|
| T11553L |
Heptamidine |
Heptamidine is a useful tool for the investigation of Myotonic dystrophy (DM). Heptamidine is an effective Pentamidine-related inhibitor of the calcium-binding ...
|
| T11555 |
Heptasaccharide Glc4Xyl3 |
Heptasaccharide Glc4Xyl3, is used for the identification and analysis of diverse xyloglucan-active enzymes in nature. a covalent inhibitor of endo-xyloglucan...
|
| T11556 |
HET0016 |
HET0016 also is a selective CYP450 inhibitor, which has been shown to inhibit angiogenesis and tumor growth. HET0016 is a potent and selective 20-hydroxyeicosa...
|
| T11557 |
FASN-IN-3 |
FASN-IN-3 is a fatty acid synthase (FASN) inhibitor. |
| T11558 |
Hexyl gallate |
Hexylgallate , a alkyl ester derivative of gallic acid, exhibits potent antimalarial activity against Plasmodium falciparum, with IC50 of 0.11 mM. |
| T11559 |
HG-12-6 |
HG-12-6 can modulate IRAK4 activity in autoimmunity and inflammation. HG-12-6 is a type II inhibitor of IRAK4. HG-12-6 shows preferential binding to unphospho...
|
| T11564 |
HIV-1 inhibitor-3 |
HIV-1 inhibitor-3 is a HIV infection inhibitor. |
| T11565 |
HIV-1 integrase inhibitor 7 |
HIV-1 integrase inhibitor 7 is a potent HIV-1 integrase inhibitor, with an IC50 of 33.3 nM. |
| T11566 |
HIV-1 integrase inhibitor |
Hiv-1 integrase inhibitor is an effective anti-HIV drug. |
| T11567 |
HIV-1 integrase inhibitor 3 |
HIV-1 integrase inhibitor 3 is a HIV-1 integrase strand transfer (INST) inhibitor with an IC50 of 2.7 nM. |
| T11568 |
HIV-1 integrase inhibitor 4 |
HIV-1 integrase inhibitor 4 is a HIV-1 integrase strand transfer (INST) inhibitor with an IC50 of 3.7 nM. |
| T11573 |
HPN-01 |
HPN-01 displays greater 50-fold selectivity over a panel of more than 50 other kinases, including ALK5, CDK-2, EGFR, ErbB2, GSK3β, PLK1, Src, and VEGFR-2. HPN...
|
| T11574 |
HS79 |
HS-79 is able to inhibit the incorporation of tritiated acetate into lipids with an IC50 of 1.57 μM. HS-79 is an enantiomer of Fasnall, which is a selective f...
|
| T11575 |
HS80 |
HS-80 is able to inhibit the incorporation of tritiated acetate into lipids with an IC50 of 7.13 μM. HS-80 is an enantiomer of Fasnall, which is a selective f...
|
| T11576 |
HSL-IN-1 |
HSL-IN-1, a significantly reduced reactive metabolite liability. is a potent and orally active hormone sensitive lipase (HSL) inhibitor (IC50=2 nM). |
| T11577 |
HSL-IN-2 |
HSL-IN-2 is a selective and potent inhibitor of Hormone Sensitive Lipase (HSL), with an IC50 of 0.023 μM. |
| T11578L |
Encequidar mesylate |
Encequidar mesylate is a competitive and potent P-glycoprotein inhibitor. |
| T11579 |
HSL-IN-3 |
HSL-IN-3 , a boronic acid ester derivative, is an inhibitor of hormone-sensitive lipase (HSL). |
| T11580 |
HO-1-IN-1 |
HO-1-IN-1 is a heme oxygenase 1 (HO-1) inhibitor with an IC50 of 250 nM. |
| T11580L |
HO-1-IN-1 hydrochloride |
HO-1-IN-1 hydrochloride is a heme oxygenase 1 (HO-1) inhibitor with an IC50 of 250 nM. |
| T11581 |
HSR6071 |
HSR6071 is an antiallergic agent with potential for the treatment of asthma. |
| T11582 |
HSV-TK substrate |
HSV-TK substrate shows antitumor activity.HSV-TK substrate is a substrate for HSV-TK, and induces multi-log cytotoxicity in HSV-TK-expressing and bystander cell...
|
| T11583 |
HWL-088 |
HWL-088 significantly improves glucose tolerance in normal and diabetic models. HWL-088 is a highly potent free fatty acid receptor 1 (FFA1/GPR40) agonist be...
|
| T11584 |
Hydroxy desmethyl Bosentan |
Hydroxy desmethyl Bosentan (Ro 64-105) is a Bosentan metabolism produced by the cytochrome P450 enzymes CYP2C9 and CYP3A4 in the liver. |
| T11585 |
Hydroxy Itracozole D8 |
Hydroxy Itraconazole is an active metabolite of Itraconazole (ITZ), which is a triazole antifungal agent. Hydroxy Itraconazole D8 is the deuterium labeled Hydr...
|
| T11586 |
Hydroxy ziprasidone |
Hydroxy ziprasidone is an impurity of Ziprasidone. Ziprasidone, an antipsychotic agent, is a combined 5-HT (serotonin) and dopamine receptor antagonist. |
| T11587 |
Hydroxylammonium chloride |
Hydroxylammonium chloride is the hydrochloric acid salt of hydroxylamine, which is a biological intermediate in the anammox and in the nitrification. |
| T11588 |
Hydroxybupropion |
Hydroxybupropion inhibits norepinephrine uptake with an IC50 value of 1.7 μM. Hydroxybupropion is also a nACh receptor antagonis tis more potent than Bupropion...
|
| T1159 |
Leflunomide |
Leflunomide is an immunomodulatory agent used in the therapy of rheumatoid arthritis and psoriatic arthritis. |
| T11590 |
(-)-Hydroxycitric acid |
(-)-Hydroxycitric acid is a potent and competitive inhibitor of ATP citrate lyase. (-)-Hydroxycitric acid suppresses the fatty acid synthesis, lipogenesis, food...
|
| T11591 |
Hydroxyzine D4 |
Hydroxyzine D4 is deuterium labeled Hydroxyzine. Hydroxyzine has anticholinergic, anxiolytic and analgesic properties. Hydroxyzine is a heterocyclic histamine...
|
| T11592 |
Hydroxyzine D8 |
Hydroxyzine D8 is deuterium labeled Hydroxyzine. Hydroxyzine is a histamine H1-receptor antagonist. |
| T11593 |
I-OMe-Tyrphostin AG 538 |
I-OMe-Tyrphostin AG 538 inhibits IGF-1R-mediated signaling and is preferentially cytotoxic to nutrient-deprived PANC1 cells. I-OMe-Tyrphostin AG 538 is an ATP...
|
| T11594 |
I2906 |
I2906 showed antimycobacterial and cytotoxic activity against mycobacterium tuberculosis. IC50 Value: Target: Antibacterial Under in vitro conditions, I2906 sh...
|
| T11595 |
IACS-8779 |
IACS-8779 with robust systemic antitumor efficacy. is a highly potent stimulator of interferon genes (STING) agonist. |
| T11596 |
IACS-8803 |
IACS-8803 is a highly potent cyclic dinucleotide STING agonist with robust systemic antitumor efficacy. |
| T1160 |
Fusidine |
Fusidine is an antibiotic isolated from the fermentation broth of Fusidium coccineum. |
| T11601 |
Ibrutinib D5 |
Ibrutinib D5 is a deuterium labeled Ibrutinib. Ibrutinib is a selective, irreversible Btk inhibitor. |
| T11602 |
Ibrutinib dimer |
Ibrutinib dimer is an impurity of Ibrutinib. IIbrutinib dimer is a Dimer of Ibrutinib. brutinib is a selective, irreversible Btk inhibitor with an IC50 of 0.5 n...
|
| T11603 |
Ibrutinib-MPEA |
Ibrutinib-MPEA is ibrutinib derivative. Ibrutinib is a covalent and irreversible inhibitor of Bruton's tyrosine kinase (BTK) that has been used to treat haem...
|
| T11604 |
Ibuprofen D3 |
Ibuprofen D3 is a deuterium labeled Ibuprofen. Ibuprofen is a COX-1 and COX-2 inhibitor with IC50s of 13 μM and 370 μM. |
| T11606 |
ICA-105665 |
ICA-105665 inhibits liver mitochondrial function and bile salt export protein (BSEP) transport (IC50 of 311 μM). ICA-105665 can penetrate the blood-brain bar...
|
| T11608 |
Epanolol |
Epanolol is a potent β-adrenoceptor partial agonist with a greater affinity for β1- than β2-adrenoceptors. |
| T11609 |
ICI 153110 |
ICI 153110 is designed for the treatment of congestive cardiac failure. ICI 153110 is an orally active phosphodiesterase inhibitor with both vasodilating and i...
|
| T1161 |
Protionamide |
Protionamide is a thioamide derivative with antitubercular activity. |
| T11612 |
IDH1 Inhibitor 3 |
IDH1 Inhibitor 3 with an IC50 of 45 nM for IDH1R132H. is a mutant isocitric dehydrogenase 1 (IDH1) inhibitor. |
| T11613 |
IDH1 Inhibitor 1 |
IDH1 Inhibitor 1 Anticancer activity. is a potent, orally bioavailable, brain-penetrant and selective mutant IDH1 inhibitor with IC50s of 0.021 μM, 0.045 μ...
|
| T11616 |
IDO-IN-13 |
IDO-IN-13 is a potent indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor with an EC50 of 17 nM. |
| T11618 |
IDO-IN-4 |
IDO-IN-4 is an indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor. |
| T1162 |
Acipimox |
Acipimox is a niacin derivative and nicotinic acid analog with activity as a hypolipidemic agent. Acipimox has special application for the treatment of hyperlip...
|
| T11623 |
IDO/TDO-IN-1 |
IDO/TDO-IN-1 is a highly potent and orally active dual indoleamine-2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO) inhibitor with IC50s of 9.7 and ...
|
| T11625 |
IDO1 and HDAC1 Inhibitor |
IDO1 and HDAC1 Inhibitor is a dual IDO1 and HDAC1 inhibitor with IC50s of 69.0 nM and 66.5 nM, respectively. |
| T11629 |
Ifenprodil glucuronide |
Ifenprodil is a vasodilator and an inhibitor of platelet aggregation, and Ifenprodil glucuronide has no effect on platelet aggregation and arterial contraction....
|
| T11630 |
IFN alpha-IFR-IN-1 hydrochloride |
IFN alpha-IFNAR interaction inhibitor IFN alpha-IFNAR-IN-1 specifically inhibits MVA-induced IFN-α responses by BM-pDCs. IFN alpha-IFNAR-IN-1 inhibited the IFN...
|
| T11630L |
IFN alpha-IFR-IN-1 |
IFN alpha-IFNAR-IN-1 is a nonpeptidic, low-molecular-weight inhibitor of the interaction between IFN-α and IFNAR. It inhibit MVA-induced IFN-α responses by BM...
|
| T11637 |
Iloperidone metabolite Hydroxy Iloperidone |
Iloperidone metabolite Hydroxy Iloperidone is an atypical antipsychotic. Iloperidone metabolite Hydroxy Iloperidone is a metabolite of Iloperidone. |
| T11639 |
Imatinib D4 |
Imatinib D4 is a deuterium labeled Imatinib. Imatinib is an orally bioavailable tyrosine kinases inhibitor that selectively inhibits BCR/ABL, v-Abl, PDGFR and...
|
| T11640 |
Imatinib D8 |
Imatinib is an orally bioavailable tyrosine kinases inhibitor that selectively inhibits BCR/ABL, v-Abl, PDGFR and c-kit kinase activity. Imatinib D8 is a deu...
|
| T11641 |
N-Desmethyl imatinib |
N-Desmethyl imatinib is a metabolite of Imatinib, which is a multi-target inhibitor of v-Abl, c-Kit and PDGFR. |
| T11643 |
Impurity B of Calcitriol |
Impurity B of Calcitriol, Calcitriol is the hormonally active form of vitamin D, Calcitriol(1,25-Dihydroxyvitamin D3; Rocaltrol ) inhibits in vivo and in vitro ...
|
| T11644 |
Impurity C of Alfacalcidol |
Impurity of Alfacalcidol. Alfacalcidol (1-hydroxycholecalciferol; Alpha D3; 1.alpha.-Hydroxyvitamin D3) is a non-selective VDR activator medication. |
| T11645 |
Impurity C of Calcitriol |
Impurity C of Calcitriol, Calcitriol (1,25-Dihydroxyvitamin D3; Rocaltrol )exhibits antitumor activity; Calcitriol(1,25-Dihydroxyvitamin D3; Rocaltrol ) inhi...
|
| T11646 |
Impurity F of Calcipotriol |
Impurity F of Calcipotriol; Calcipotriol (MC 903; Calcipotriene) exhibits antiproliferative activity against human HL-60, HL60/MX2, MCF-7, T47D, SCC-25 and mous...
|
| T11647 |
INCB 3284 dimesylate |
INCB 3284 dimesylate can be used in the research of acute liver failure. INCB 3284 dimesylate is a potent, selective and orally bioavailable human CCR2 antag...
|
| T11648 |
INCB 3284 |
INCB 3284 can be used in the research of acute liver failure. INCB 3284 is a potent, selective and orally bioavailable human CCR2 antagonist, inhibiting monocyt...
|
| T11649 |
INCB054329 Racemate |
INCB054329 Racemate is an inhibitor of BET protein. |
| T11650 |
INCB3344 R-isomer |
INCB3344 is a potent CCR2 antagonist. INCB3344 R-isomer is the R-isomer of INCB3344. |
| T11652 |
Indirubin-3'-monoxime-5-sulphonic acid |
Indirubin-3'-monoxime-5-sulphonic acid is a potent and selective inhibitor of GSK-3β, CDK5, and CDK1 with IC50s of 80nM,5 nM, and 7 nM, respectively. |
| T11653 |
Indirubin-5-sulfonate |
Indirubin-5-sulfonate shows inhibitory activity against GSK-3β. Indirubin-5-sulfonate is a cyclin-dependent kinase (CDK) inhibitor, with IC50 values of 55 nM, ...
|
| T11654 |
Indirubin Derivative E804 |
Indirubin Derivative E804 is an effective inhibitor of IGF1R, which has an IC50 value of 0.65. |
| T11657 |
INH154 |
INH154 is a highly potent inhibitor for Nek2 and Hec1 binding (INH), with IC50s of 120 nM and 200 nM for INH in MB468 and Hela cells. |
| T11658 |
INO5042 |
INO5042 is an anti-inflammatory agent. |
| T11659 |
Inogatran |
Inogatran is a synthetic thrombin inhibitor, developed for the possible treatment and prophylaxis of venous and arterial thrombotic diseases. |
| T11661 |
INT-767 |
INT-767 is a dual farnesoid X receptor (FXR)/TGR5 agonist with mean EC50s of 30 and 630 nM, respectively. |
| T11662 |
INT-777 R-enantiomer |
INT-777 is the R-enantiomer of INT-777, less potent than INT-777,EC50 of 4.79 μM for TGR5. |
| T11663 |
Integrin-IN-2 |
Integrin-IN-2 is an orally bioavailable pan αv integrin inhibitor.Integrin-IN-2 can increases the αvβ6, αvβ3, αvβ5 and αvβ8 binding affinities with pIC...
|
| T11664 |
INY-03-041 |
INY-03-041 inhibits AKT1, AKT2 and AKT3 with IC50s of 2.0 nM, 6.8 nM and 3.5 nM, respectively. INY-03-041 is a potent, highly selective and PROTAC-based pan-AKT...
|
| T11665 |
Ionomycin calcium |
lonomycin calcium is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. also induces the activation of protein kinase...
|
| T11667 |
Ipragliflozin L-Proline |
Ipragliflozin is a highly potent and selective SGLT2 inhibitor with an IC50 of 2.8 nM; little and NO potency for SGLT1/3/4/5/6. |
| T11668 |
IQB-782 |
IQB-782 shows a potent mucolytic-expectorant activity. IQB-782 is a cysteine derivative. IQB-782 has inhibition for thrombin activatable fibrinolysis inhibitor ...
|
| T11669 |
IR415 |
IR415 selectively interacts with HBx (Kd=2 nM) and blocks HBV-mediated RNAi suppression, reverses the inhibitory effect of HBx protein on the activity of the di...
|
| T11670 |
IRAK inhibitor 3 |
IRAK inhibitor 3 is an interleukin-1 (IL-I) receptor-associated kinase (IRAK) kinase modulator. |
| T11672 |
IRAK inhibitor 4 |
IRAK inhibitor 4 is an interleukin-1 receptor associated kinase 4 inhibitor. |
| T11673 |
IRAK4-IN-4 |
IRAK4-IN-4 inhibits cyclic GMP-AMP synthase (cGAS) with an IC50 of 2.1 nM.IRAK4-IN-4 is an interleukin-1 receptor–associated kinase 4 (IRAK4) inhibitor, has a...
|
| T11674 |
IRAK4-IN-6 |
IRAK4-IN-6 ,targetes MyD88 L265P mutant diffuse large B cell lymphoma. is an orally efficacious and selective IRAK4 inhibitor with an IC50 of 4 nM. |
| T11675 |
Irbesartan D4 |
Irbesartan D4 is a highly potent and specific angiotensin II type 1 (AT1) receptor antagonist. is the deuterium labeled Irbesartan. |
| T11676 |
Iriflophenone 3-C-glucoside |
Iriflophenone 3-C-β-D-glucopyranoside,has antioxidant activity,isolated from Cyclopia genistoides. |
| T11677 |
Irindalone |
Irindalone is a novel serotonin 5-HT2 antagonist. |
| T11678 |
Iristectorin B |
Iristectorin B has anti-cancer activities in breast cancer.is an isoflavone from Iris tectorum. |
| T11679 |
Isavuconazole D4 |
Isavuconazole D4 is a deuterium labeled Isavuconazole. Isavuconazole is a triazole prodrug with antifungal activity against yeasts, molds, and dimorphic fungi. |
| T11680 |
Isoasatone A |
Isoasatone A is a natural product isolated from the plant Heterotropa takaoi M., with anti-insect activity. |
| T11681 |
Isochondrodendrine |
Isochondodendrine has strong antiplasmodial activity against Plasmodium falciparum. Isochondrodendrine is a class of bisbenzylisoquinoline alkaloid isolated fro...
|
| T11682 |
Isofistularin-3 |
Isofistularin-3, as a DNA demethylating agent, induces cell cycle arrest and sensitization to TRAIL in cancer cells. Isofistularin-3 can be used as an ADC cytot...
|
| T11683 |
Isoglycycoumarin |
Isoglycycoumarin is a highly selective probe for human cytochrome P450 2A6.Isoglycycoumarin is a flavonoid isolated from the roots of Glycyrrhiza uralensis. |
| T11684 |
Isoguvacine hydrochloride |
Isoguvacine hydrochloride is a GABA receptor agonist. |
| T11685 |
Isolongifolene |
Isolongifolene has antioxidant, anti-inflammatory, anticancer and neuroprotective properties. Isolongifolene is a tricyclic sesquiterpene isolated from Murraya ...
|
| T11688 |
ITI214 free base |
ITI-214 is a picomolar PDE1 inhibitor with excellent selectivity against other PDE family members and against a panel of enzymes, receptors, transporters, and i...
|
| T11689 |
ITI214 |
ITI-214 is a picomolar PDE1 inhibitor with excellent selectivity against other PDE family members and against a panel of enzymes, receptors, transporters, and i...
|
| T1169 |
Moguisteine |
Moguisteine is a new-type peripheral non-narcotic antitussive drug. |
| T11691 |
IV-23 |
IV-23 inhibits cell growths in vitro and in vivo, reduces colony formation, arrests cell cycle at M phase, and induces esophageal squamous cell carcinoma . IV-2...
|
| T11692 |
Ivabradine D3 Hydrochloride |
Ivabradine hydrochloride is a new If inhibitor with IC50 of 2.9 μM, and used as a pure heart rate lowering agent. Ivabradine D3 Hydrochloride is the deuterium ...
|
| T11693 |
IT1t |
IT1t inhibits CXCL12/CXCR4 interaction with an IC50 of 2.1 nM. is a potent CXCR4 antagonist. |
| T11693L |
IT1t dihydrochloride |
IT1t dihydrochloride inhibits CXCL12/CXCR4 interaction with an IC50 of 2.1 nM. is a potent CXCR4 antagonist. |
| T11694 |
Ivabradine D6 hydrochloride |
Ivabradine hydrochloride is a new If inhibitor with IC50 of 2.9 μM, and used as a pure heart rate lowering agent. Ivabradine D6 hydrochloride is the deuterium ...
|
| T11695 |
Ivabradine metabolite N-Demethyl Ivabradine hydrochloride |
N-Demethyl Ivabradine Hcl is a specific inhibitor of the funny channel.N-Demethyl Ivabradine Hcl is a metabolite of Ivabradine. |
| T11696 |
Ivachtin |
Ivachtin is a nonpeptide, noncompetitive and reversibl caspase-3 inhibitor with an IC50 of 23 nM. |
| T11697 |
IX 207-887 |
IX 207-887 inhibits the release of interleukin-1 (IL-1). IX 207-887 is a novel antiarthritic agent. |
| T11698 |
IZCZ-3 |
IZCZ-3,antitumor activity. is a potent c-MYC transcription inhibitor. |
| T11699 |
J-113863 |
J-113863 is also a potent antagonist of the human CCR3 (IC50 of 0.58 nM) , but a weak antagonist of the mouse CCR3 (IC50 of 460 nM). J-113863 is inactive agains...
|
| T11700 |
J-2156 |
The ED50 of J-2156 in rats for the relief of mechanical allodynia and mechanical hyperalgesia in the ipsilateral hindpaws was 3.7 and 8.0 mg/kg, respectively. J...
|
| T11702 |
J30-8 |
J30-8 exhibits neuroprotective activity in vitro and potential for the treatment of neurodegenerative diseases. J30-8 is a potent and isoform-selective inhibito...
|
| T11703 |
JAK-IN-1 |
JAK-IN-1 shows improved selectivity for JAK3 over JAK1. JAK-IN-1 is a JAK1/2/3 inhibitor with IC50s of 0.26, 0.8 and 3.2 nM, respectively. |
| T11705 |
JAK-IN-4 |
JAK-IN-4 is a prodrug of a JAK inhibitor, effective in murine collagen induced arthritis model. |
| T11715 |
JH-LPH-28 |
JH-LPH-28 displays outstanding antibiotic activity with a MIC value of 0.83 μg/mL. JH-LPH-28, a sulfonyl piperazine analog, is a potent UDP-2,3-diacylglucosami...
|
| T11716 |
JH-LPH-33 |
JH-LPH-33 displays outstanding antibiotic activity with a MIC value of 0.66 μg/mL. JH-LPH-33, a sulfonyl piperazine analog, is a potent UDP-2,3-diacylglucosami...
|
| T11718 |
JI051 |
JI051,Anti-cancer activity. is a stabilizer for the Hes1-PHB2 interaction, interacts with a cancer-associated protein chaperone prohibitin 2 (PHB2), induces ce...
|
| T11719 |
JMV 2959 hydrochloride |
JMV 2959 hydrochloride is a growth hormone secretagogue receptor type 1a (GHS-R1a) antagonist with an IC50 of 32±3 nM in LLC-PK1 cells. |
| T11719L |
JMV 2959 |
JMV 2959 is an antagonist of growth hormone secretagogue receptor type 1a (GHS-R1a) (IC50: 32 nM). |
| T1172 |
Diclazuril |
Diclazuril is a coccidiostat. |
| T11720 |
JNJ-18038683 |
JNJ-18038683 is a 5-Hydroxytryptamine Type 7 (5-HT7) receptor antagonist, with pKis of 8.19, 8.20 for rat and human 5-HT7 in HEK293 cells, respectively. |
| T11722 |
JNJ-37822681 dihydrochloride |
JNJ-37822681 has potential for the treatment of schizophrenia and bipolar disorder.JNJ-37822681 dihydrochloride is a potent, specific, centrally active, fast-di...
|
| T11724 |
JNJ-42226314 |
JNJ-42226314 demonstrates dose-dependent enhancement of the major endocannabinoid 2-arachidonoylglycerol (2-AG) as well as efficacy in models of neuropathic and...
|
| T11725 |
JNJ-47117096 hydrochloride |
JNJ-47117096 hydrochloride is potent and selective MELK inhibitor, with an IC50 of 23 nM, also effectively inhibits Flt3, with an IC50 of 18 nM. |
| T11726 |
JP1302 dihydrochloride |
JP1302 dihydrochloride is a selective, high affinity antagonist of the alpha2C-adrenoceptor (α2C-adrenoceptor), with a Kb value (antagonist activity) of 16 nM ...
|
| T11730 |
JTT 551 |
JTT 551 can be used in the research of type 2 diabetes mellitus. JTT 551 is selective a protein tyrosine phosphatase 1B (PTP1B) inhibitor, with Kis of 0.22 μM ...
|
| T11733 |
K-604 dihydrochloride |
K-604 dihydrochloride is a potent and selective acyl-CoA:cholesterol acyltransferase 1 inhibitor with an IC50 of 0.45±0.06 μM. |
| T11736 |
K-Ras G12C-IN-2 |
K-Ras G12C-IN-2 is a covalent kras g12c inhibitor. |
| T11737 |
K-Ras G12C-IN-3 |
K-ras G12C inhibitor For more information, please see the following patent. Heterocyclic compounds as covalent inhibitors of G12C mutant K-Ras protein useful fo...
|
| T11738 |
K-Ras G12C-IN-4 |
K-Ras G12C-IN-4, is a potent Covalent Inhibitor of KRASG12C.. |
| T11739 |
K145 |
K145 is inactive against SphK1 and other protein kinases. K145 induces cell apoptosis and has potently antitumor activity. K145 is a selective, substrate-compet...
|
| T11740 |
Delcasertib |
Delcasertib is a potent and selective δ-protein kinase C (δPKC) inhibitor. |
| T11741 |
KAN0438757 |
KAN0438757 is a selective and potent inhibitor of the metabolic kinase PFKFB3 with an IC50 of 0.19 μM. |
| T11745 |
KB SRC 4 |
KB SRC 4 has antitumor activity. KB SRC 4 is a potent, and highly selective c-Src inhibitor, with a Ki of 44 nM and a Kd of 86 nM, and shows no inhibition on c-...
|
| T11746 |
KCC2 blocker 1 |
KCC2 blocker 1 is a benzyl prolinate and has antiepileptic effect.KCC2 blocker 1 is an orally active and selective K+-Cl- cotransporter KCC2 blocker with an IC5...
|
| T11748 |
KDM2A/7A-IN-1 |
KDM2A/7A-IN-1 is a first-in-class, selective and cell-permeable inhibitor of histone lysine demethylases KDM2A/7A, with an IC50 of 0.16 μM for KDM2A. |
| T11750 |
KDOAM-25 citrate |
KDOAM-25 citrate increases global H3K4 methylation at transcriptional start sites and impairs proliferation in multiple myeloma MM1S cells. KDOAM-25 citrate is ...
|
| T11750L |
KDOAM-25 trihydrochloride |
KDOAM-25 trihydrochloride increases global H3K4 methylation at transcriptional start sites and impairs proliferation in multiple myeloma MM1S cells. KDOAM-25 tr...
|
| T11758L |
KI696 |
KI696 is an effective and selective inhibitor of KEAP1/NRF2 interaction. KI696 is a high-affinity probe that disrupts the Keap1/NRF2 interaction. |
| T11759 |
Kif15-IN-2 |
Kif15-IN-2 is used for the research of cellular proliferative diseases. Kif15-IN-2 is an inhibitor of the mitotic kinesin Kif15. |
| T11760 |
KIN101 |
KIN101, an isoflavone agonist of IRF-3 dependent signaling, induces IRF-3 nuclear translocation. KIN101 has broad-spectrum activity against RNA viruses. KIN101 ...
|
| T11762L |
Kira8 |
Kira8 is a mono-selective IRE1α inhibitor. That allosterically attenuates IRE1α RNase activity (IC50: 5.9 nM). |
| T11763 |
Ko-3290 |
Ko-3290 is an antagonist of β-adrenoceptor, with cardioselectivity and antilipolytic effects in animals. |
| T11764 |
KP496 |
KP496 is a selective, dual antagonist for Thromboxane A2 receptor and Leukotriene D4 receptor. |
| T11766 |
Eltanexor Z-isomer |
Eltanexor Z-isomer exhibits different inhibitory effects on Z138, MM15, 3T3 cell lines, with IC50s of 100 nM-50 μM, < 100 nM, > 30 μM, respectively.Eltanexor ...
|
| T11766L |
Eltanexor |
Eltanexor inhibits XPO1-dependent nuclear export (EC50=60.9 nM) by directly targeting XPO1. Eltanexor causes caspase-dependent apoptosis in a panel of leukemic ...
|
| T11772 |
KRAS inhibitor-4 |
KRAS inhibitor-4 developed as anticancer agents, is a potent KRAS inhibitor. |
| T11781 |
KRN2 |
KRN2 has potential to treat NFAT5-mediated Chronic Arthritis. KRN2 is a selective inhibitor of nuclear factor of activated T cells (NFAT5), with an IC50 of 100...
|
| T11782 |
KRN2 bromide |
KRN2 bromide is a selective inhibitor of nuclear factor of activated T cells , with an IC50 of 0.1 μM. |
| T11784 |
KT182 |
KT182 is a selective and potent inhibitor of α/β-hydrolase domain containing 6 (ABHD6), with an IC50 of 0.24 nM in Neuro2A cells. |
| T11785 |
KT203 |
KT203 is a potent and selective inhibitor of α/β-hydrolase domain containing 6 (ABHD6), with an IC50 of 0.31 nM in Neuro2A cells. |
| T11787 |
Kv3 modulator 1 |
Kv3 modulator 1 has the potential for inflammatory pain treatment. Kv3 modulator 1 is a Kv3 voltage-gated potassium channel modulator extracted from patent WO2...
|
| T11788 |
Kv3 modulator 2 |
Kv3 modulator 2 is a potent Kv3 channels modulator.has analgesic activity and is used in the prophylaxis or treatment of related disorders. |
| T11789 |
Kv3 modulator 3 |
Kv3 modulator 3 is a selective modulator of Kv3.1 and/or Kv3.2 and/or Kv3.3 channels .has analgesic activity for use in the prophylaxis o or treatment of pain...
|
| T11790 |
Kv3 modulator 4 |
Kv3 modulator 4 is a Kv3.1 (pEC50=5.45) and Kv3.2 modulator .Cyclobutyl structure. |
| T11791 |
KW-6055 |
KW-6055 has anti-amnesic activity, is a benzylpyridine derivative. |
| T11792 |
KW-8232 free base |
KW-8232 free base can reduces the biosynthesis of PGE2, is an anti-osteoporotic agent. |
| T11794 |
L-368,899 hydrochloride |
L-368,899 hydrochloride, used as a tocolytic agent, is a potent, selective, orally bioavailable, non-peptide oxytocin receptor antagonist, with IC50s of 8.9 nM ...
|
| T11795 |
L-4-Oxalysine hydrochloride |
L-4-Oxalysine hydrochloride has shown antitumor activities, is a natural product isolated from the culture media of Streptomyces roseovirdofuscus in China. |
| T11796 |
L-45 dihydrochloride |
L-45 dihydrochloride is the first selective, potent, and cell-active p300/CBP-associated factor (PCAF) bromodomain (Brd) inhibitor with a Kd of 126±15 nM. |
| T11796L |
L-45 |
L-45 is the first potent and cell-active bromodomain (Brd) inhibitor of p300/CBP-associated factor (PCAF) (Kd: 126±15 nM). |
| T11797 |
L-690488 |
L-690488 has more effective cell penetration than L-690330. L-690488 is a prodrug of L-690330 and is a selective inositol monophosphatase (IMPase) inhibitor. |
| T11798 |
L-692429 |
L-692429 binds to G protein-coupled receptor with a Ki of 63 nM. L-692429 is a benzolactam derivative and a nonpeptidyl growth hormone secretagogue (GHS) ago...
|
| T11800 |
L-803087 |
L-803087 facilitates AMPA-mediated hippocampal synaptic responses in vitro and increases kainate-induced seizures in mice.L-803087 is a potent and selective som...
|
| T11801 |
l-Atabrine dihydrochloride |
l-Atabrine dihydrochloride displays antiprion activity. l-Atabrine dihydrochloride is a less active enantiomer of quinacrine. |
| T11802 |
L-Canaline |
L-Canaline inhibits the growth of the malaria parasite Plasmodium falciparum with an IC50 of 297 nM. L-Canaline has anticancer and antiproliferative effects. L...
|
| T11803 |
L-Cysteinesulfinic acid |
L-Cysteinesulfinic acid is a potent agonist at several rat metabotropic glutamate receptors (mGluRs, pEC50s of 3.92±0.03, 4.6±0.2, 3.9±0.2, 2.7±0.2, 4.0±0....
|
| T11804 |
β3-AR agonist 2 |
β3-AR agonist 2 is a potent and selective agonist of β3-adrenergic receptor (β3-AR with an EC50 of 8 nM). |
| T11805 |
L-NIL |
L-NIL is a potent and selective inhibitor of inducible NO synthase with IC50s of 92 and 3.3 μM for rat brain constitutive NO synthase and mouse inducible NO sy...
|
| T11807 |
L002 |
L002 binds the acetyl-CoA pocket and competitively inhibits the FATp300 catalytic domain, blocks histone acetylation and p53 acetylation, and inhibits STAT3 act...
|
| T11810 |
L791943 |
L791943 is a selective, potent) inhibitor of Phosphodiesterase-4 (PDE4,IC50 of 4.2 nM). |
| T11811 |
Laetanine |
Laetanine, exhibits antiplasmodial activity, a noraporphine alkaloid from Litsea laeta. |
| T11812 |
L-Eflornithine |
L-Eflornithine is an irreversible ornithine decarboxylase (ODC) inhibitor with a KD of 1.3±0.3 µM, and a Kinact of 0.15±0.03 min-1. L-Eflornithine is an ena...
|
| T11812L |
L-Eflornithine monohydrochloride |
L-Eflornithine is an irreversible ornithine decarboxylase (ODC) inhibitor with a KD of 1.3±0.3 µM, and a Kinact of 0.15±0.03 min-1. L-Eflornithine monohydroc...
|
| T11813 |
Laflunimus |
Laflunimus suppresses immunoglobulin (Ig) secretion, with IC50 values of 2.5 and 2 µM for IgM and IgG, respectively. Laflunimus also is a prostaglandin endope...
|
| T11814 |
Lamivudine 13C,15N2 |
Lamivudine 13C,15N2 is a labelled impurity of Lamivudine (BCH-189). Lamivudine can inhibit HIV reverse transcriptase 1/2 and the reverse transcriptase of hepat...
|
| T11815 |
Lanopepden |
Lanopepden is a peptide deformylase inhibitor active against Staphylococcus aureus strains with MICs of 1 and 1 mg/L for ATCC 29213 and ATCC 25923 strain, respe...
|
| T11819 |
Lascufloxacin |
Lascufloxacin has the potential for various infectious diseases treatment, including lower respiratory tract infections.Lascufloxacin is a potent and orally a...
|
| T11820 |
LAT1-IN-1 |
LAT1-IN-1 (BCH) significantly inhibit cellular uptake of amino acids and mTOR phosphorylation, which induces the suppression of cancer growth and apoptosis. ...
|
| T11821 |
Latanoprost lactone diol |
Latanoprost lactone diol is an intermediate in the synthesis of Latanoprost. Latanoprost is a prostaglandin F2α analogue and an agonist for the FP prostanoid r...
|
| T11822 |
LAU159 |
LAU159 is a functionally selective positive α1β3 GABA(A) receptor modulator(EC50 : 2.2 μM). |
| T11825 |
LCB-2853 |
LCB-2853 with antiplatelet and antithrombotic activities, is an antagonist of thromboxane A2 (TXA2) receptor. |
| T11827 |
Pradigastat |
Pradigastat has anti-obesity and anti-diabetic effects. Pradigastat is a potent, selective and orally active diacylglycerol acyltransferase 1 (DGAT1) inhibitor...
|
| T11828 |
LDC7559 |
LDC7559 via blocking neutrophil extracellular trap (NET) in the late stages . Implement inhibition gasdermin D (GSDMD). |
| T11830 |
LDN-192960 hydrochloride |
LDN-192960 hydrochloride is an inhibitor of Dual-specificity Tyrosine-regulated Kinase 2 (DYRK2) and Haspin with IC50s of 48 nM and 10 nM, respectively. |
| T11831 |
LDN-27219 |
LDN-27219 is a potent hTGase inhibitor with IC50 of 0.6 uM. |
| T11832 |
Ledipasvir D-tartrate |
Ledipasvir D-tartrate with EC50 values of 34 pM against GT1a and 4 pM against GT1b replicon. is an inhibitor of the hepatitis C virus NS5A. |
| T11833 |
Ledipasvir (diacetone) |
Ledipasvir is an inhibitor of the hepatitis C virus NS5A, with EC50 values of 34 pM against GT1a and 4 pM against GT1b replicon.Ledipasvir diacetone (GS-5885 di...
|
| T11834 |
Leelamine hydrochloride |
Leelamine hydrochloride suppresses transcriptional activity of androgen receptor, which is known to regulate fatty acid synthesis[2,3].Leelamine hydrochloride i...
|
| T11835 |
LCL521 |
LCL521 also inhibits the lysosomal acid sphingomyelinase (ASMase). LCL521 is an acid ceramidase (ACDase) inhibitor. |
| T11835L |
LCL521 dihydrochloride |
LCL521 dihydrochloride is an acid ceramidase (ACDase) inhibitor. LCL521 also inhibits the lysosomal acid sphingomyelinase (ASMase). |
| T11836 |
Lefamulin acetate |
Lefamulin acetate (BC-3781 acetate) is the first semi-synthetic pleuromutilin for systemic treatment of bacterial infections in humans. Lefamulin acetate (BC-37...
|
| T11838 |
LEQ506 |
LEQ506 is a second-generation smoothened (Smo) inhibitor with IC50s of 4 and 2 nM in mouse and human, respectively. |
| T11840 |
Leu-AMS |
Leu-AMS shows cytotoxicity in cancer cells and normal cells, and inhibits the growth of bacteria.Leu-AMS , a leucine analogue, is a potent inhibitor of leucyl-t...
|
| T11841 |
Leu-AMS R enantiomer |
Leu-AMS R enantiomer is the R enatiomer of Leu-AMS. Leu-AMS is a potent inhibitor of leucyl-tRNA synthetase (LRS) and inhibits the growth of bacteria. |
| T11842 |
Levomecol |
Levomecol (Chloramphenicol)) stops bacterial growth by binding to the bacterial ribosome (blocking peptidyl transferase) and inhibiting protein synthesis. Levo...
|
| T11843 |
Levothyroxine acyl glucuronide |
Levothyroxine acyl glucuronide (Thyroxine Acyl-β-D-glucuronide), the acyl glucuronide formation of thyroxine (T4), an endogenous metabolite. |
| T11844 |
LG-100064 |
LG-100064 can be used in the research of cancer. LG-100064 is a retinoid-X-receptor (RXR) agonist, with EC50s of 330 nM, 200 nM, and 260 nM for RXRα, RXRβ an...
|
| T11845 |
LGD-6972 |
LGD-6972 is an antagonist of glucagon receptor. |
| T11847 |
Liarozole dihydrochloride |
Liarozole dihydrochloride is a cytochrome P450 (CYP450) dependent inhibitor, orally active, it also a potent inhibitor of estrogen (via inhibition of aromatase)...
|
| T11848 |
Licorice glycoside C2 |
Licorice glycoside C2 is a oleanane-type triterpene oligoglycoside isolated from Glycyrrhiza uralensis. |
| T11849 |
Lignin |
Lignin is the main component of plant cell walls and is a renewable aromatic polymer. Lignin has strongly antioxidant activity.Lignin (Lignine) is a natural com...
|
| T11851 |
Lin28-let-7a antagonist 1 |
Lin28-let-7a antagonist 1, with an IC50 of 4.03 μM for Lin28A-let-7a-1 interaction，and shows a clear antagonistic effect against the Lin28-let-7a interaction...
|
| T11852 |
Liclotide |
Linaclotide developed for the treatment of constipation-predominant irritable bowel syndrome (IBS-C) and chronic constipation, and is a potent and selective gu...
|
| T11853 |
Linezolid D3 |
Linezolid D3 is a deuterium labeled Linezolid. Linezolid is a synthetic antibiotic that acts by inhibiting the initiation of bacterial protein synthesis. |
| T11854 |
Lipofermata |
Lipofermata is a fatty acid transporter protein (FATP) inhibitor that prevents lipid transport to melanoma cells and reduces melanoma growth and invasion. |
| T11855 |
Lipopolysaccharides |
Lipopolysaccharide is a highly immunogenic antigen which can enhance immune responses.Lipopolysaccharides is an endotoxin derived from the outer leaflet of the ...
|
| T11856 |
LIT-001 free base |
LIT-001 free base improves social interaction in a mouse model of autism. LIT-001 free base is the first nonpeptide oxytocin receptor (OT-R) agonist (EC50=55 n...
|
| T11857 |
LIT-001 |
LIT-001 improves social interaction in a mouse model of autism.LIT-001 is the first nonpeptide oxytocin receptor (OT-R) agonist (EC50=55 nM; Ki=226 nM). |
| T11858 |
Lith-O-Asp |
Lith-O-Asp is a sialytransferase (ST) inhibitor,(IC50s：12-37 μM). |
| T11859 |
Litronesib Racemate |
Litronesib is a selective, allosteric inhibitor of kinesin Eg5.Litronesib (Racemate) is the racemate of litronesib. |
| T11860 |
LM-1484 |
LM-1484 displays a higher affinity for 3H-LTC4 sites and is an antagonist of CysLT1 receptor. |
| T11861 |
LM11A-31 dihydrochloride |
LM11A-31 dihydrochloride is a water-soluble, non-peptide with high blood-brain barrier permeability.LM11A-31 dihydrochloride, a p75NTR (neurotrophin receptor p7...
|
| T11862 |
LMD-009 |
LMD-009 mediates chemotaxis, inositol phosphate accumulation, and calcium release in high potencies with EC50s from 11 to 87 nM. LMD-009 is a selective CCR8 no...
|
| T11864 |
LNP023 |
LNP023 shows direct, reversible, and high-affinity binding to human FB (KD=7.9 nM).LNP023 is a highly potent factor B (FB) inhibitor with an IC50 value of 10 nM...
|
| T11865 |
Lodelaben |
Lodelaben is a human neutrophil elastase inhibitor with an IC50 and Ki of 0.5 and 1.5 μM, respectively. |
| T11866 |
LolCDE-IN-2 |
LolCDE-IN-2 inhibits E. coli MG1655 with a MIC of 2 μg/ml. Antibacterial activity. LolCDE-IN-2 is a potent Lol protein inhibitor. |
| T11867 |
Loperamide D6 hydrochloride |
Loperamide D6 hydrochloride is a deuterium labeled Loperamide hydrochloride. Loperamide hydrochloride is an opioid receptor agonist for the treatment of diarrh...
|
| T11869 |
Losartan (D4 Carboxylic Acid) |
Losartan D4 Carboxylic Acid is the deuterium labeled Losartan, which is an angiotensin II receptor antagonist. |
| T1187 |
Bifonazole |
Bifonazole acts to destabilize the fungal cytochrome p450 51 enzyme (also known as Lanosterol 14-alpha-demethylase). It works by inhibiting the production of a ...
|
| T11870 |
Losartan D4 |
Losartan D4 is the deuterium labeled Losartan. Losartan is an angiotensin II receptor antagonist, competing with the binding of angiotensin II to AT1 receptors...
|
| T11871 |
Loteprednol Etabote D5 |
Loteprednol Etabonate D5 is a deuterium labeled Loteprednol etabonate.Loteprednol etabonate (LE) exhibits anti-inflammatory activity and has been used in optome...
|
| T11872 |
LMP744 |
LMP744 is a DNA intercalator and Topoisomerase I (Top1) inhibitor with antitumor activity. |
| T11872L |
LMP744 hydrochloride |
LMP744 hydrochloride is a DNA intercalator and Topoisomerase I (Top1) inhibitor with antitumor activity. |
| T11874 |
Lp-PLA2-IN-3 |
Lp-PLA2-IN-3 is a potent and orally bioavailable lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor, with an IC50 of 14 nM for recombinant human Lp-PLA...
|
| T11876 |
LpxH-IN-AZ1 |
LpxH-IN-AZ1 is a potent inhibitor of Klebsiella pneumoniae LpxH with IC50 of 0.36 μM . LpxH-IN-AZ1, a sulfonyl piperazine compound, is a potent UDP-2,3-diacyl...
|
| T11877 |
LR-90 |
LR-90 is also used in the research of diabetic animal model.LR-90 is an advanced glycation end product (AGE) inhibitor, inhibits inflammatory responses in human...
|
| T11879 |
LS-102 |
LS-102 inhibits the autoubiquitination of synoviolin with an IC50 of 35 μM. LS-102 has the potential for rheumatoid arthritis treatment. LS-102 is a selective...
|
| T11882 |
LSD1-IN-7 benzenesulfote |
LSD1-IN-7 benzenesulfonate is a potent and orally active inhibitor of lysine specific demethylase-1 (LSD1) with anticancer activity. |
| T11883 |
LSD1-IN-7 Methylbenzenesulfote |
LSD1-IN-7 Methylbenzenesulfonate is a potent and orally active inhibitor of lysine specific demethylase-1 (LSD1) with anticancer activity. |
| T11884 |
LSN 3213128 |
LSN 3213128, anti-tumor activity. is a selective, nonclassical, orally bioavailable antifolate with potent and specific inhibitory activity for aminoimidazol...
|
| T11885 |
LSP-249 |
LSP-249 is a plasma kallikrein inhibitor under the study for angioedema, with an EC50 less than 100 nM in cell. |
| T11886 |
LTβR-IN-1 |
LTβR-IN-1 is potent in TWEAK-stimulated p52 translocation assays with an IC50 of 10 μM and did not alter TNF-α–induced p65 nuclear translocation. LTβR-IN...
|
| T11888 |
LtaS-IN-1 |
LtaS-IN-1 alone inhibits Enterococcus.spp 28 strains with varying MIC values ranging from 0.5 μg/mL to 64 μg/mL. LtaS-IN-1 combination with antibiotics aboli...
|
| T11889 |
LTV-1 |
LTV-1 has the potential for autoimmunity treatment. LTV-1 is a potent lymphoid tyrosine phosphatase (LYP) inhibitor in T cells with an IC50 of 508 nM. |
| T11890 |
Ludaconitine |
Ludaconitine, isolated from Aconitum spicatum (Bruhl) Stapf, exhibits antileishmanial activity with an IC50 of 36.10 μg/mL. |
| T11891 |
Lumefantrine D18 |
Lumefantrine D18 is an antimalarial drug, and is the deuterium labeled Lumefantrine. |
| T11892 |
Lurasidone D8 Hydrochloride |
Lurasidone D8 Hydrochloride is an inhibitor of Dopamine D2, 5-HT2A, 5-HT7, 5-HT1A and noradrenaline α2C, and is the deuterium labeled Lurasidone. |
| T11893 |
Lurasidone metabolite 14326 |
Lurasidone metabolite 14326 is an active metabolite of the atypical antipsychotic Lurasidone. |
| T11893L |
Lurasidone metabolite 14326 hydrochloride |
Lurasidone metabolite 14326 is an active metabolite of the atypical antipsychotic Lurasidone. |
| T11895 |
Luteolin-7-rutinoside |
Luteolin-7-rutinoside has both antifungal activities and anti-arthritic, can result in a combination therapy for the treatment of fungal arthritis due to C. al...
|
| T11897 |
Telotristat ethyl |
Telotristat ethyl (LX1606) is a orally-delivered, novel inhibitor of tryptophan hydroxylase that reduces serotonin production. |
| T11899 |
LXRβ agonist-2 |
LXRβ agonist-2 is a highly potent and β-selective liver X receptor (LXRβ) agonist with EC50 of 7 nM. |
| T11902 |
LY 344864 S-entiomer |
LY 344864 S-enantiomer is the S-enantiomer of LY344864. LY344864 is a 5-HT1F receptor agonist. |
| T11903 |
LY-411575 isomer 1 |
LY-411575 isomer 1 is a potent γ-secretase inhibitor. LY-411575 isomer 1 is an isomer of LY411575. |
| T11904 |
LY-411575 isomer 2 |
LY-411575 isomer 2 is a potent γ-secretase inhibitor. LY-411575 isomer 2 is an isomer of LY411575. |
| T11905 |
LY-411575 isomer 3 |
LY-411575 isomer 3 is a potent γ-secretase inhibitor. LY-411575 isomer 3 is an isomer of LY411575. |
| T11908 |
LY2365109 hydrochloride |
LY2365109 hydrochloride is a potent and selective GlyT1 inhibitor, with an IC50 of 15.8 nM for glycine uptake in cells over-expressing hGlyT1a. |
| T11909 |
LY2444296 |
LY2444296 exhibits anti-anxiety like effects. LY2444296 is an orally bioavailable, high-affinity and selective short-acting kappa opioid receptor (KOPR) antago...
|
| T11910 |
LY285434 |
LY285434 is a suitable angiotensin II receptor antagonist. |
| T11912 |
LY3154207 |
LY3154207 is a subtype selective, potent, and orally available human dopamine D1 receptor positive allosteric modulator (PAM) with minimal allosteric agonist ac...
|
| T11913 |
LY88074 Methyl ether |
LY88074 Methyl ether is useful for the inhibition of the various estrogen deficient conditions, which are associated with estrogendeprivation syndrome including...
|
| T11914 |
LY88074 Trimethyl ether |
LY88074 Trimethyl ether is useful for the inhibition of the various estrogen deficient conditions, which are associated with estrogen deprivation syndrome inclu...
|
| T11915 |
LY88074 |
Raloxifene is a selective estrogen receptor modulator, and reduces fracture risk at least in part by improving the mechanical properties of bone in a cell- and ...
|
| T11917 |
Lys-SMCC-DM1 |
DM1 is a tubulin inhibitor. Lys-SMCC-DM1 is the active metabolite of DM1. |
| T11918 |
Lysipressin |
Lysipressin, Induces contraction of the rabbit urinary bladder smooth muscle, activate adenylate-cyclase. Lysipressin is Antidiuretic hormone that have been f...
|
| T11919 |
LysRs-IN-1 |
LysRs-IN-1 is a Lysyl-tRNA synthetase (LysRs) inhibitor. |
| T1192 |
Protoporphyrin IX |
Protoporphyrin IX is a tetrapyrrole containing 4 methyl, 2 propionic and 2 vinyl side chains that is a metabolic precursor for hemes, cytochrome c, and chloroph...
|
| T11920 |
LysRs-IN-2 |
LysRs-IN-2 is a lysyl-tRNA synthetase (KRS) inhibitor with IC50s of 0.13 μM and 0.015 μM for Cryptosporidium parvum lysyl-tRNA synthetase (CpKRS) and Plasmod...
|
| T11922 |
LY 254155 |
LY 254155, an antifolate,binds to mFBP and inhibits hGARFT with Kis of 1.7±0.1 and 2.1±0.2 nM, respectively. |
| T11923 |
Methyl-3β-hydroxycholete |
Methyl-3β-hydroxycholenate is a ROR gamma modulator. |
| T11925 |
M‑89 |
M-89 inhibits the menin-mixed lineage leukemia (Menin-MLL) protein-protein interaction and has potential to treat MLL leukemia. M-89 is a highly potent and spe...
|
| T11926 |
m-Nifedipine |
m-Nifedipine is an impurity of Nifedipine. Nifedipine is a potent calcium channel blocker and drug of choice for cardiac insufficiencies. |
| T11927 |
M2 ion channel blocker |
M2 ion channel blocker ,Antiviral agent, is capable of inhibiting and blocking the activity of M2 ion channel. |
| T11929 |
M2N12 |
M2N12 also has promising activity against Cdc25A and Cdc25B with IC50 values of 0.53 μM and 1.39 μM. Anti-tumor activity. M2N12 is a potent and highly ...
|
| T11930 |
M8891 |
M8891 is an orally active, reversible and brain penetrant Methionine Aminopeptidase-2 (MetAP-2) inhibitor(IC50 :54nM;Ki:4.33 nM).M8891 inhibits growth of primar...
|
| T11933 |
MAC13772 |
MAC13772 is a novel antibacterial compound.MAC13772 is a potent inhibitor of the enzyme BioA (IC50=250 nM), the antepenultimate step in biotin biosynthesis. |
| T11934 |
Macitentan D4 |
Macitentan D4 (ACT-064992 D4) is a deuterium labeled Sulfamethoxazole. Macitentan has the potential for idiopathic pulmonary fibrosis (IPF) and pulmonary arteri...
|
| T11935 |
Macitentan (n-butyl alogue) |
Macitentan n-butyl analogue is a n-butyl analogue of Macitentan. Macitentan is an orally active, non-peptide dual antagonist of endothelin ETA and ETB receptor ...
|
| T11936 |
Macropa-NCS |
Macropa-NCS is conjugated to trastuzumab as well as to the prostate-specific membrane antigen-targeting compound RPS-070. |
| T11937 |
m-Tyramine |
m-Tyramine has effects on the adrenergic and dopaminergic receptor.m-Tyramine is an endogenous trace amine neuromodulator. |
| T11937L |
m-Tyramine hydrobromide |
m-Tyramine hydrobromide has effects on the adrenergic and dopaminergic receptor. m-Tyramine hydrobromide is an endogenous trace amine neuromodulator. |
| T11938 |
Macropa-NH2 hydrochloride |
Macropa-NCS is conjugated to Anti-Human HER2 as well as to the prostate-specific membrane antigen-targeting compound RPS-070 and is a promising therapeutic radi...
|
| T11940 |
Malic enzyme inhibitor ME1 |
Malic enzyme inhibitor ME1 is a potent inhibitor of Malic enzyme (ME1,IC50: 0.15μM). |
| T11941 |
Manitimus |
Manitimus is a potent immunosuppressive drug, and is an inhibitor of dehydroorotate dehydrogenase,. |
| T11942 |
MAP4K4-IN-3 |
MAP4K4 may be a viable target for antidiabetic agents, a serine/threonine protein kinase. |
| T11943 |
MAPK13-IN-1 |
MPAK13-IN-1 is a MAPK13 (p38δ) inhibitor(IC50: 620 nM). |
| T11945 |
MARK-IN-1 |
MARK-IN-1 is a potent microtubule affinity regulating kinase (MARK) inhibitor, (IC50<0.25 nM). |
| T11946 |
MARK-IN-2 |
MARK-IN-2 is a potent microtubule affinity regulating kinase (MARK) inhibitor,(IC50:5 nM). |
| T11947 |
MARK4 inhibitor 1 |
MARK4 inhibitor 1 inhibits cancer cell proliferation, metastasis and induces apoptosis. MARK4 inhibitor 1 is a potent microtubule affinity-regulating kinase 4 ...
|
| T11950 |
MAT2A inhibitor 2 |
MAT2A inhibitor 2 is a methionine adenosyltransferase 2A (MAT2A) inhibitor. |
| T11951 |
Mavoglurant racemate |
Mavoglurant is a novel, non-competitive mGlu5 receptor antagonist. Mavoglurant (racemate) is the racemate of mavoglurant. |
| T11951L |
Mavoglurant |
Mavoglurant is a structurally novel, non-competitive mGlu5 receptor antagonist. It has an IC50 of 30 nM in a functional assay with human mGluR5. |
| T11952 |
Maxacalcitol-D6 |
Maxacalcitol-D6 is a non-calcemic vitamin D3 analog and VDR ligand of VDR-like receptors.Maxacalcitol-D6 is the deuterated form of Maxacalcitol (22-Oxacalcitrio...
|
| T11954 |
MB-07344 |
MB-07344 has additive cholesterol lowering activity in combination with Atorvastatin in rabbits, dogs and monkeys. MB-07344 is a potent thyroid hormone recepto...
|
| T11954L |
MB-07344 sodium |
MB-07344 sodium has additive cholesterol lowering activity in combination with Atorvastatin in rabbits, dogs and monkeys. MB-07344 sodium is a potent thyroid h...
|
| T11955 |
MB-07729 |
MB-07729 is a potent fructose 1,6-bisphosphatase (FBPase) noncompetitive inhibitor with IC50 values of 189, 121, and 31 nM for rat, monkey and human, respective...
|
| T11956 |
MBC-11 triethylamine |
MBC-11 triethylamine has potential to treat tumor-induced bone disease (TIBD), is a first-in-class conjugate of the bone-targeting bisphosphonate etidronate cov...
|
| T11956L |
MBC-11 |
MBC-11 is a first-in-class conjugate of the bone-targeting bisphosphonate etidronate covalently linked to the antimetabolite cytarabine (araC). It also has the ...
|
| T11957 |
MBC-11 trisodium |
MBC-11 trisodium has potential to treat tumor-induced bone disease (TIBD).It is a first-in-class conjugate of the bone-targeting bisphosphonate HEDP covalently ...
|
| T11962 |
MC3482 |
MC3482 is a specific inhibitor of sirtuin5 (SIRT5). |
| T11963 |
MCB-3681 |
MCB-3681, active against gram-positive bacterium, is the antibacterial Oxaquin's active substance. |
| T11965 |
MCHR1 antagonist 3 |
MCHR1 antagonist 3 is used to regulate energy metabolism. MCHR1 antagonist 3 is a potent the melanin-concentrating hormone receptor-1 (MCHR1) antagonist. |
| T11966 |
MCHR1 antagonist 2 |
MCHR1 antagonist 2 also inhibits hERG, with an IC50 of 4.0 nM in IMR-32 cells. MCHR1 antagonist 2 is an antagonist of melanin concentrating hormone receptor 1,...
|
| T11967 |
Mcl-1 antagonist 1 |
Mcl-1 antagonist 1 is a Mcl-1 protein antagonist. |
| T11969 |
MCL-1/BCL-2-IN-2 |
MCL-1/BCL-2-IN-2 is a potent and selective Bcl-2 and Mcl-1 dual inhibitor. |
| T11970 |
MCL-1/BCL-2-IN-3 |
MCL-1/BCL-2-IN-3 is a selective and potent Mcl-1 and Bcl-2 dual inhibitor with IC50s of 5.95 and 4.78 μM, respectiely. |
| T11971 |
MCL-1/BCL-2-IN-4 |
MCL-1/BCL-2-IN-4 is a selective and potent Mcl-1 and Bcl-2 dual inhibitor. |
| T11976 |
Mcl1-IN-4 |
Mcl1-IN-4 is an inhibitor of Mcl1 ( IC50:0.2 μM). |
| T11978 |
McN3716 |
McN3716 is an inhibitor of carnitine palmitoyltransferase I (CPT-1). |
| T11980 |
MD-224 |
MD-224 is a highly potent and efficacious MDM2 degrader based on the proteolysistargeting chimera (PROTAC) concept，and as a new class of anticancer agent. |
| T11981 |
MDL 19301 |
MDL 19301 is a nonsteroidal, anti-inflammatory agent. |
| T11982 |
MDM2-IN-1 |
MDM2-IN-1 is a synthetic MDM2-p53 interaction (MDM2) inhibitor and contains the trans (D-)configuration. |
| T11983 |
MDRTB-IN-1 |
MDRTB-IN-1 (5aα) is an antibiotic which is against Mycobacterium tuberculosis H37Rv(MIC90 :10.5 μM). |
| T11984 |
Mebeverine acid D5 |
Mebeverine acid D5 is the deuterium labeled Mebeverine Acid. |
| T11985 |
Mebeverine D6 Hydrochloride |
Mebeverine D6 Hydrochloride is the deuterium labeled Mebeverine. |
| T11986 |
Mebeverine acid |
Mebeverine acid is a metabolite of Mebeverine. |
| T11987 |
Mebeverine alcohol |
Mebeverine alcohol is a metabolite of Mebeverine. |
| T11988 |
O-desmethyl Mebeverine acid |
O-desmethyl Mebeverine acid is a metabolite of Mebeverine. |
| T11989 |
Mebeverine metabolite O-desmethyl Mebeverine alcohol |
Mebeverine metabolite O-desmethyl Mebeverine alcohol is a potent α1 repector inhibitor, causing relaxation of the gastrointestinal tract. Mebeverine metabolit...
|
| T11990 |
Meclofenamic acid |
Meclofenamic acid is a non-selective gap-junction blocker and a highly selective inhibitor of fat mass and obesity-associated (FTO) enzyme inhibitor. Meclofena...
|
| T11991 |
Mefentrifluconazole |
Mefentrifluconazole is a potent, selective and orally active fungal CYP51 (Kd= 0.5 nM) inhibitor, but shows less inhibitory activity on human aromatase (IC50=0....
|
| T11995 |
Melatonin D5 |
Melatonin D5 is deuterium labeled Melatonin.Melatonin is a selective ATF-6 inhibitor and induces human hepatoma cell apoptosis through COX-2 downregulation. ...
|
| T11998 |
Meloxicam D4 |
Meloxicam D4 is deuterium labeled Meloxicam. Meloxicam is a non-steroidal antiinflammatory agent, inhibits COX activity,(Target:COX-1; IC50: 36.6 µM ;(Targe...
|
| T11999 |
Meluadrine tartrate |
Meluadrine tartrate is an endogenous metabolite. |
| T12000 |
MEN11467 |
MEN11467 is a orally- effective and selective peptidomimetic tachykinin NK1 receptor antagonist. |
| T12001 |
Menaquinone-7 |
Menaquinone-7 (Vitamin K2-7) is identified as the most bioactive cofactor for the carboxylation reaction of Gla-proteins. Supplementation with Menaquinone-7 (Vi...
|
| T12002 |
Menin-MLL inhibitor 4 |
Menin-MLL inhibitor 4 has antitumor activity.Menin-MLL inhibitor 4 is an inhibitor of Menin- MLL (mixed-lineage leukemia protein) interaction . |
| T12003 |
Mensacarcin |
Mensacarcin targets to mitochondria, affects energy metabolism in mitochondria, and activates caspase-dependent apoptotic pathways. Mensacarcin, an antibiotic, ...
|
| T12004 |
Meropenem trihydrate |
Meropenem trihydrate with broad-spectrum antibacterial activity,is a carbapenem antibiotic. |
| T12005 |
meta-Fexofenadine |
meta-Fexofenadine is an impurity of Fexofenadine. Fexofenadine, a H1R antagonist, is an anti-allergic agent used in seasonal allergic rhinitis and chronic idiop...
|
| T12006 |
Metarrestin |
Metarrestin is a first-in-class perinucleolar compartment inhibitor with a favorable PK profile, which effectively suppresses metastasis. Metarrestin disrupts ...
|
| T12007 |
MethADP sodium salt |
MethADP is a specific CD73 inhibitor. |
| T12008 |
MethADP |
MethADP is a specific inhibitor of CD73. |
| T12009 |
Telomerase-IN-1 |
Telomerase-IN-1 is a Telomerase inhibitor(IC50:0.19 μM). |
| T12011 |
Methimazole D3 |
Methimazole D3 is a deuterium labeled Methimazole. Methimazole is an antithyroid drug used for the treatment of the hyperthyroidism in humans and animals. |
| T12012 |
Methoxy-PEPy |
Methoxy-PEPy is a potent and highly selective mGlu5 receptor antagonist with IC50 of 1 nM. |
| T12013 |
Methyl 3-O-methylgallate |
Methyl 3-O-methylgallate (M3OMG) can protect neuronal cells from oxidative damage. Methyl 3-O-methylgallate (M3OMG) possesses antioxidant effect. |
| T12014 |
Methyl carnosate |
|
| T12015 |
Methyl homoveratrate |
Methyl homoveratrate, a metabolite of McN5691 in vivo, can be identified in plasma, urine and faecal extract. McN5691 (RWJ-26240) is a voltage-sensitive calcium...
|
| T12016 |
Methyl L-pyroglutamate |
Methyl L-pyroglutamate ((S)-Methyl 5-oxopyrrolidine-2-carboxylate;L-Pyroglutamic acid methyl ester) has anti-inflammatory activity, is isolated from P. oleracea...
|
| T12017 |
Methyllycaconitine citrate |
Methyllycaconitine citrate is a α7 neuronal nicotinic acetylcholine receptor (α7nAChR)antagonist. |
| T12018 |
Methylnaltrexone D3 Bromide |
Methylnaltrexone D3 Bromide is the deuterium labeled Methylnaltrexone Bromide. |
| T12019 |
Methylproamine |
Methylproamine is a DNA-binding radioprotector , acts by repair of transient radiation-induced oxidative species on DNA. |
| T12021 |
Metofenazate |
Metofenazate is an selective inhibitor of calmodulin . |
| T12023 |
Mexiletine D6 hydrochloride |
Mexiletine D6 hydrochloride is a non-selective voltage-gated sodium channel blocker,is a Class IB antianhythmic. |
| T12024 |
MF-094 |
MF-094 is a potent and selective inhibitor of USP30 (IC50 of 120 nM). |
| T12028 |
MGAT2-IN-1 |
MGAT2-IN-1 is an orally active monoacylglycerol acyltransferase (MGAT2)inhibitor (human and mouse MGAT2 with IC50 of 7.8 and 2.4 nM , respectively). |
| T12029 |
MGAT2-IN-2 |
MGAT2-IN-2 is a potent inhibitor of acyl CoA:monoacylglycerol acyltransferase 2 (MGAT2) (IC50 of 3.4 nM). |
| T12030 |
MG 1 |
MG 1 is an antagonist of α1 adrenergic receptor . |
| T12034 |
Microtubule inhibitor 1 |
Microtubule inhibitor 1 is an antitumor agent with microtubule polymerization inhibitory activity(IC50 = 9-16 nM, in cancer cells). |
| T12035 |
Midodrine D6 hydrochloride |
Midodrine D6 hydrochloride is a vasopressor/antihypotensive agent. |
| T12036 |
Midostaurin-D5 |
Midostaurin-D5 is a deuterium labeled Midostaurin. |
| T12037 |
Mifamurtide |
Mifamurtide is a drug against osteosarcoma, is an immunomodulator with antitumor effects. |
| T12038 |
Migalastat hydrochloride |
Migalastat hydrochloride is a potent and competitive α-galactosidase A (α-Gal A) inhibitor (human α-Gal A,IC50 of 0.04 μM ). |
| T12039 |
Miglustat |
Miglustat is an glucosylceramide synthase inhibitor, treatment Type I Gaucher disease (GD1). |
| T12042 |
Minnelide |
Minnelide is a prodrug of triptolide,and shows potent antitumor activity in a number of tumor types. |
| T12045 |
(-)-Hydroxycitric acid lactone |
(-)-Hydroxycitric acid lactone is an anti-obesity agent. |
| T12047 |
Misoprostol acid |
Misoprostol acid is an active metabolite of Misoprostol,can be used for non-steroidal anti-inflammatory drug-induced (NSAID) gastric ulcers. |
| T12048 |
Mito-apocynin (C2) |
Mito-apocynin (C2) is an orally active mitochondria-targeted triphenylphosphonium (TPP)-based compound, has antineuroinflammatory effects. |
| T12049 |
MitoTam bromide hydrobromide |
MitoTam bromide hydrobromide is an electron transport chain (ETC) inhibitor. |
| T12050 |
MitoTam iodide, hydriodide |
MitoTam iodide, hydriodide is an inhibitor of electron transport chain (ETC) |
| T12053 |
MJ33-OH lithium |
MJ33-OH lithium is a metabolite of MJ33. |
| T12055 |
MK 0893 |
MK 0893 is a potent, selective antagonist of glucagon receptor. |
| T12057 |
MK-0941 |
MK-0941 is an orally active and allosteric glucokinase activator, has potential in the treatment of type 2 diabetes. |
| T12059 |
Mitoquinone |
Mitoquinone is a TPP-based, mitochondrially targeted antioxidant . |
| T12059L |
Mitoquinone mesylate |
Mitoquinone mesylate is a TPP-based, mitochondrially targeted antioxidant . |
| T12060 |
MK-2894 sodium salt |
MK-2894 sodium salt is a highly potent and selective antagonist of second generation EP4. |
| T12061 |
MK-2894 |
MK-2894 is a highly potent and selective antagonist of second generation EP4 . |
| T12062 |
MK-4074 |
MK-4074 is a liver-specific acetyl-CoA carboxylase ACC1 and ACC2 inhibitor(IC50 of 3 nM). |
| T12063 |
MK-447 |
MK-447 is a nonsteroidal antiinflammatory agent. |
| T12064 |
Niraparib R-enantiomer |
Niraparib R-enantiomer is an inhibitor of PARP1(IC50 of 2.4 nM). |
| T12065 |
Grazoprevir sodium salt |
Grazoprevir sodium salt is a selective Hepatitis C virus NS3/4a protease inhibitor with broad activity across genotypes and resistant variants. |
| T12066 |
MK-7145 |
MK-7145 is an inhibitor of ROMK(IC50 of 0.045 μM). |
| T12067 |
MK-7246 S enantiomer |
MK-7246 S enantiomer is a potent and selective CRTH2 antagonist. |
| T12068 |
MK-8033 hydrochloride |
MK-8033 hydrochloride is a novel and specific dual ATP competitive inhibitor of c-Met/Ron (IC50:1 nM Wt c-Met) under investigation as a treatment for cancer. |
| T12070 |
MK-8719 |
MK-8719 is a highly potent and selective inhibitor of O-GlcNAcase (OGA) (hOGA, Ki=7.9 nM) . |
| T12071 |
MKC9989 |
MKC9989 is an inhibitor of Hydroxy aryl aldehydes (HAA). |
| T12072 |
ML-00253764 hydrochloride |
ML-00253764 hydrochloride is an antagonist of nonpeptidic melanocortin receptor 4 (MC4R) (Ki and IC50 of 0.16 µM and 0.103 µM, respectively). |
| T12073 |
ML-109 |
ML-109 is a potent agonist of thyroid stimulating hormone receptor (TSHR) (EC50 of 40 nM) |
| T12074 |
ML 145 |
ML 145 is a selective antagonist of GPR35/CXCR8 (IC50/EC50 of 20.1 nM) |
| T12075 |
ML-180 |
ML-180 is a potent orphan nuclear receptor liver receptor homolog 1 (LRH-1; NR5A2) inverse agonist (IC50 of 3.7 µM) . |
| T12076 |
ML218 hydrochloride |
ML218 hydrochloride is a selective and orally active T-type Ca2+ channels (Cav3.1, Cav3.2, Cav3.3) inhibitor (Cav3.2 and Cav3.3 with IC50s of 310 nM and 270 nM ...
|
| T12077 |
ML303 |
ML303 is an antagonist of pyrazolopyridine influenza virus nonstructural protein 1 (NS1) (IC90 : 155 nM). |
| T12078 |
ML334 |
ML334 is a potent, cell permeable NRF2 activator. |
| T12079 |
ML604440 |
ML604440 is a cell permeable proteasome β1i (LMP2) subunit inhibitor. |
| T1208 |
Citicoline sodium |
Citicoline is an endogenous intermediate in the synthesis of phosphatidylcholine. It also serves as a choline donor in the biosynthesis of the neurotransmitter ...
|
| T12080 |
MLS000544460 |
MLS000544460 is a highly selective and reversible Eya2 phosphatase inhibitor (Kd : 2.0 μM , IC50 : 4 μM). |
| T12081 |
MMAF-OMe |
MMAF-OMe is an antitubulin agent,and inhibits several tumor cell lines. |
| T12083 |
MMSET-IN-1 |
MMSET-IN-1 is an inhibitor of multiple myeloma SET domain (MMSET, aka NSD2/WHSC1) . |
| T12084 |
MMV008138 |
MMV008138 inhibits the growth of P. falciparum Dd2 strain (IC50 of 250 nM). |
| T12085 |
MN58b |
MN58b is a selective inhibitor of choline kinase α (CHKα). |
| T12086 |
Mocravimod hydrochloride |
Mocravimod hydrochloride is a potent and orally active sphingosine 1-phosphate receptor type 1(S1PR1) agonist. |
| T12087 |
Modecainide |
Modecainide is metabolite of Encainide, is an antiarrhythmic agent. |
| T12088 |
Mofegiline hydrochloride |
Mofegiline hydrochloride is a potent and selective enzyme-activated irreversible MAO-B inhibitor. |
| T12089 |
Mogroside I A1 |
Mogroside I A1 is a triterpenoid glycoside isolated from the extracts of Luo Han Guo, exhibiting antioxidant, antidiabetic and anticancer activities. |
| T12090 |
Mogroside I E1 |
Mogroside I E1 is a triterpenoid glycoside isolated from the extracts of Luo Han Guo, is a nonsugar sweetener. |
| T12093 |
Monascin |
Monascin is a kind of azaphilonoid pigments extracted from Monascus pilosus-fermented rice (red-mold rice),exhibits anti-tumor-initiating activity and anti-infl...
|
| T12094 |
Monobehenin |
Monobehenin has a strong inhibitory effect on the formation of bacterial biofilm. |
| T12095 |
Monomethyl fumarate |
Monomethyl fumarate is a potent agonist of GPR109A . |
| T12096 |
Morinidazole (R enantiomer) |
Morinidazole (R enantiomer) is the R-enantiomer of Morinidazole. |
| T12096L |
Morinidazole |
Morinidazole is a novel 5-nitroimidazole antimicrobial drug that undergoes extensive metabolism in humans via N+-glucuronidation and sulfation. Morinidazole als...
|
| T12098 |
MOZ-IN-2 |
MOZ-IN-2 is an protein MOZ inhibitor(IC50 of 125 μM). |
| T12099 |
MPDC |
MPDC is a competitive inhibitor of the Na+-dependent high-affinity glutamate transporter in forebrain synaptosomes. |
| T12101 |
MPP dihydrochloride |
MPP dihydrochloride is a highly selective antagonist of estrogen receptor alpha (ERα). |
| T12102 |
Mps1-IN-1 |
Mps1-IN-1 is a potent, selective and ATP-competitive inhibitor of Mps1 kinase (IC50 : 367 nM ) |
| T12104 |
MRGPRX1 agonist 1 |
MRGPRX1 agonist 1 is a highly potent MRGPRX1 (Mas-related G-protein-coupled receptor X1)agonist(EC50 of 50 nM). |
| T12105 |
MRK-016 |
MRK-016 is a selective, orally bioavailable inverse GABAA α5 receptor agonist. |
| T12106 |
MRL-494 |
MRL-494 is an antibacterial agent and is a small-molecule inhibitor of β-barrel assembly machine A (BamA) impervious to efflux and the outer membrane permeabil...
|
| T12109 |
MRT-83 |
MRT-83 is a potent Smo antagonist. |
| T12110 |
MRZ 2-514 |
MRZ 2-514 is a strychnine-insensitive modulatory site of the NMDA receptor (glycineB)antagonist(Ki of 33 μM). |
| T12111 |
MS31 |
MS31 is a potent and highly affinity inhibitor of spindlin 1 (SPIN1). |
| T12111L |
MS31 trihydrochloride |
MS31 trihydrochloride is a potent, highly affinity and selective fragment-like methyllysine reader protein spindlin 1 (SPIN1) inhibitor. |
| T12116 |
MSI-1436 |
MSI-1436 is a selective, non-competitive the enzyme protein-tyrosine phosphatase 1B (PTB1B)inhibitor(IC50 of appr 1 μM) |
| T12116L |
MSI-1701 |
MSI-1701 is an analogue of MSI-1436. |
| T12117 |
MSI-1436 lactate |
MSI-1436 lactate is a selective, non-competitive the enzyme protein-tyrosine phosphatase 1B (PTB1B)inhibitor(IC50 of appr 1 μM) |
| T12119 |
MT-3014 |
MT-3014 is a potent, highly selective and brain-penetrated inhibitor of phosphodiesterase 10A (PDE 10A)(human PDE 10A and bovine PDE 10A with IC50s of 0.062 nM...
|
| T12120 |
MT-7716 hydrochloride |
MT-7716 hydrochloride is a selective agonist of non-peptide nociceptin receptor (NOP) |
| T12120L |
MT-7716 free base |
MT-7716 free base is a selective non-peptide agonist of nociceptin receptor (NOP). It is used for promising potential treatment drugs for alcohol abuse and rela...
|
| T12121 |
MtbHU-IN-1 |
MtbHU-IN-1 is a Mycobacterium tuberculosis nucleoid-associated protein HU (MtbHU)inhibitor(binding to WT MtbHU with a Kd of 98 nM). |
| T12125 |
MuRF1-IN-1 |
MuRF1-IN-1 is an inhibitor of muscle ring finger 1. |
| T12126 |
MUT056399 |
MUT056399 is a highly potent inhibitor of the FabI enzyme of both S. aureus and E. coli (IC50s of 12 nM and 58 nM, respectively). |
| T12127 |
9-Propenyladenine |
9-Propenyladenine is a mutagenic impurity in tenofovir disoproxil fumarate. |
| T12128 |
Mutant IDH1-IN-2 |
Mutant IDH1-IN-2 is a mutant Isocitrate dehydrogenase (IDH) proteins inhibitor |
| T12129 |
Mutant IDH1-IN-4 |
Mutant IDH1-IN-4 is an mutant Isocitrate dehydrogenase 1 (IDH 1) inhibitor. |
| T12132 |
MYCi361 |
MYCi361 is an inhibitor of MYC (binding to MYC with Kd of 3.2 μM). |
| T12134 |
MYCMI-6 |
MYCMI-6 is a potent and selective inhibitor of endogenous MYC:MAX protein interactions. |
| T12135 |
Mycophenolic acid D3 |
Mycophenolic acid D3 is an immunosuppresant drug and has potent anti-proliferative activity. |
| T12137 |
N-(2-Hydroxypropyl)methacrylamide |
N-(2-Hydroxypropyl)methacrylamide is used to synthesize copolymers for the targeted delivery of antileishmanial agents in Visceral leishmaniasis (VL) . |
| T12138 |
N-(3-Hydroxytetradecanoyl)-DL-homoserine lactone |
N-(3-Hydroxytetradecanoyl)-DL-homoserine lactone has antibacterial activity. |
| T12139 |
N-(3-Methoxybenzyl)Palmitamide |
N-(3-Methoxybenzyl)Palmitamide is a promising FAAH inhibitor, treatment of pain, inflammation and CNS degenerative disorders. |
| T1214 |
Ribostamycin sulfate |
Ribostamycin, an aminoglycoside antibiotic, contains a neutral sugar moiety and is produced by Streptomyces ribosome. |
| T12140 |
N-Acetyl-Calicheamicin |
N-Acetyl-Calicheamicin is a derivative of Calicheamicin,and is a potent enediyne antitumor antibiotic |
| T12141 |
N-Boc-Val-Dil-Dap-Doe |
N-Boc-Val-Dil-Dap-Doe is used to synthesize Dolastatin 10 , which is a potent antimitotic peptide, inhibits tubulin polymerization. |
| T12143 |
N-deacetylated BMS-202 |
N-deacetylated BMS-202 is the deacetylated of BMS-202. |
| T12144 |
N-Desethyl Oxybutynin D5 hydrochloride |
N-Desethyl Oxybutynin D5 hydrochloride is the the active metabolite Oxybutynin, is deuterium labeled N-Desethyl Oxybutynin hydrochloride. |
| T12145 |
N-Desethyl Sunitinib |
N-Desethyl Sunitinib is a sunitinib metabolite. |
| T12147 |
N-Desmethyl Clomipramine hydrochloride |
N-Desmethyl Clomipramine hydrochloride is a primary plasma N-desmethyl Clomipramine metabolite . |
| T12148 |
N-Desmethyltamoxifen hydrochloride |
N-Desmethyltamoxifen hydrochloride is the major tamoxifen metabolite in humans. |
| T12148L |
N-Desmethyltamoxifen |
N-Desmethyltamoxifen is the major metabolite of tamoxifen in humans. N-Desmethyltamoxifen is also an effective regulator of ceramide metabolism in human AML cel...
|
| T12149 |
N-Me-L-Ala-maytansinol |
N-Me-L-Ala-maytansinol used for making antibody-drug conjugate (ADC),is a hydrophobic, cell permeable payload. |
| T12151 |
N-Methylmoranoline |
N-Methylmoranoline is an inhibitor of α-glucosidase. |
| T12154 |
N-Desethyl amodiaquine |
N-Desethyl amodiaquine dihydrochloride is an antiparasitic agent,is the major biologically active Amodiaquine metabolite . |
| T12154L |
N-Desethyl amodiaquine dihydrochloride |
N-Desethyl amodiaquine dihydrochloride is an antiparasitic agent,is the major biologically active Amodiaquine metabolite . |
| T12155 |
Y1 receptor antagonist 1 |
Y1 receptor antagonist 1 is an antagonist of neuropeptide Y1 receptor. |
| T12156 |
N-(2-Chloro-6-methylphenyl)-N'-4-pyridinylurea |
N-(2-Chloro-6-methylphenyl)-N'-4-pyridinylurea is an anticonvulsant agent, treatment of generalized tonic-clonic and partial seizures. |
| T12157 |
ETA antagonist 1 |
ETA antagonist 1 is an antagonist of ETA selective (IC50 of 0.08 μM). |
| T12158 |
N3PT |
N3PT is a potent and selective inhibitor of transketolase(TK) with IC50 of 22 nM for Apo-TK) |
| T12160 |
N6-Cyclohexyladenosine |
N6-Cyclohexyladenosine is a selective agonist of A1 receptor with EC50 of 8.2 nM). |
| T12161 |
N6-Ethyladenosine |
N6-Ethyladenosine is an adenosine derivative, acts as an agonist of Adenosine receptor(hA1AR and hA3AR with Kis of 4.9 and 4.7 nM , respectively). |
| T12162 |
N6-Methyladenosine 5'-monophosphate disodium salt |
N6-Methyladenosine 5'-monophosphate disodium salt is a glycogen phosphorylase b activator(Ka of 22 µM). |
| T12163 |
N6-(2-Phenylethyl)adenosine |
N6-(2-Phenylethyl)adenosine (N6-Phenethyladenosine) is a potent agonist of adenosine receptors (AR) (rat A1AR, human A1AR and hA3AR with Ki values of 11.8 nM, 3...
|
| T12164 |
N6-(4-Hydroxybenzyl)adenosine |
N6-(4-Hydroxybenzyl)adenosine is a platelet aggregation inhibitor. |
| T12165 |
nAChR agonist 1 |
nAChR agonist 1 is a brain-permeable and orally efficacious positive allosteric α7 nicotinic acetylcholine receptor (α7 nAChR)modulator. |
| T12166 |
Nacubactam |
Nacubactam is a potent inhibitor of non-β-lactam-β-lactamase with activity against class A and class C β-lactamases. |
| T12167 |
Nadolol D9 |
Nadolol D9 is the deuterium labeled Nadolol is a blocker of non-selective beta. |
| T12170 |
Naminterol |
Naminterol is a phenethanolamine derivative is an agonist of β2 adrenoceptor with bronchodilatory properties, and used for treatment of asthma. |
| T12172 |
NAN-190 hydrobromide |
NAN-190 hydrobromide is an antagonist of serotonin receptor 5-HT. |
| T12174 |
Naphthoquine phosphate |
Naphthoquine phosphate is antimalarial drug. |
| T12176 |
Naratriptan D3 Hydrochloride |
Naratriptan D3 Hydrochloride is the deuterium labeled Naratriptan, is a selective agonist of 5-HT1 receptor subtype. |
| T12177 |
Natalizumab |
Natalizumab used for the treatment of relapsing remitting multiple sclerosis and Crohn's disease. |
| T12178 |
Nateglinide D5 |
Nateglinide D5 is a deuterium labeled Nateglinide. |
| T12179 |
Nav1.1 activator 1 |
Nav1.1 activator 1 is a highly potent activator of Nav1.1 with BBB penetration. |
| T12180 |
Nav1.7-IN-6 |
Nav1.7-IN-6, a selective inhibitor of Nav1.7. |
| T12181 |
NaV1.7 inhibitor-1 |
NaV1.7 inhibitor-1, an efficacious inhibitor of voltage-gated sodium channel (NaV) 1.7 (IC50 of 0.6 nM for hNaV1.7). |
| T12182 |
Nav1.7-IN-2 |
Nav1.7-IN-2 is avoltage-gated sodium channels (Nav) inhibitor in particular Nav 1.7(IC50 of 80 nM). |
| T12183 |
Nav1.7-IN-3 |
Nav1.7-IN-3 is a selective and orally bioavailable inhibitor of voltage-gated sodium channel Nav1.7(IC50 of 8 nM). |
| T12184 |
Nav1.7 inhibitor |
Nav1.7 inhibitor is a potent inhibitor of Nav1.7. |
| T12185 |
Naveglitazar racemate |
Naveglitazar racemate is the racemate of Naveglitazar. |
| T12187 |
Naspm |
Naspm is a synthetic analogue of Joro spider toxin and is a antagonist iscalcium permeable AMPA (CP-AMPA) receptors. |
| T12187L |
Naspm trihydrochloride |
Naspm trihydrochloride is a synthetic analogue of Joro spider toxin and is an antagonist of calcium permeable AMPA (CP-AMPA) receptors. |
| T12189 |
NBDHEX |
NBDHEX is a potent inhibitor of glutathione S-transferase P1-1 (GSTP1-1) . |
| T1219 |
Sisomicin Sulfate |
Sisomicin Sulfate is the sulfate salt form of sisomicin, a broad-spectrum aminoglycoside antibiotic isolated from Micromonospora inyoensis. Sisomicin is structu...
|
| T12190 |
Trans (2,3)-Dihydrotetrabenazine |
Trans (2,3)-Dihydrotetrabenazine is a Tetrabenazine metabolite, shows inhibition activity on vesicular monoamine transporter (VMAT2). |
| T12192 |
NCGC00229600 |
NCGC00229600 is an allosteric inverse thyrotropin receptor (TSHR) agonist. |
| T12193 |
NCGC00247743 |
NCGC00247743 is an inhibitor of histone lysine demethylase KDM4. |
| T12194 |
NCGC00249987 |
NCGC00249987 is a highly selective and allosteric Tyr phosphatase activity of inhibitor of Eya2(Eya2 ED and MBP-Eya2 FL with IC50s of 3 μM and 6.9 μM ). |
| T12195 |
NCI172112 |
NCI172112 is is used to develop antitumor agents effective against CNS tumors. |
| T12197 |
NCT-506 |
NCT-506 is an orally bioavailable inhibitors of aldehyde dehydrogenase 1A1 (ALDH1A1) (IC50 of 7 nM). |
| T12198 |
NCX899 |
NCX899 shows inhibitory activity against angiotensin-converting enzyme (ACE) activity. |
| T12199 |
NB-598 Maleate |
NB-598 Maleate is a competitive squalene epoxidase (SE) inhibitor. |
| T1220 |
Ethidium bromide |
A trypanocidal agent and possible antiviral agent that is widely used in experimental cell biology and biochemistry. Ethidium has several experimentally useful ...
|
| T12200 |
Firsocostat S enantiomer |
Firsocostat S enantiomer is the less active S enantiomer of Firsocostat. |
| T12201 |
Nebracetam hydrochloride |
Nebracetam hydrochloride is an agonist nootropic M1-muscarinic. |
| T12203 |
Necrostatin 2 S enantiomer |
Necrostatin 2 S enantiomer is the S enantiomer of Necrostatin 2 |
| T12203L |
Necrostatin 2 |
Necrostatin 2 is an effective necroptosis inhibitor. Necrostatin 2 is also a RIPK1 inhibitor. EC50 for inhibition of necroptosis in FADD-deficient Jurkat T cell...
|
| T12206 |
NED-3238 |
NED-3238 is a highly potent inhibitor of arginase I and II (IC50 of 1.3 nM and 8.1 nM, respectively). |
| T12207 |
NEO 376 |
NEO 376 is a selective 5-HT1 receptor, GABA receptor and dopamine receptor modulator, showing anti-psychotic actively. |
| T12208 |
Nepafenac D5 |
Nepafenac D5 is the deuterium labeled Nepafenac, which is a selective inhibitor of COX-2 . |
| T12209 |
Netropsin dihydrochloride |
Netropsin dihydrochloride is a small-molecule MGB (minor-groove binder), inhibits the catalytic activity of isolated topoisomerase and interferes with the stabi...
|
| T12210 |
Netupitant D6 |
Netupitant D6 is the deuterium labeled Netupitant, which is a selective and orally active antagonist of neurokinin-1 receptor. |
| T12211 |
Netupitant metabolite Monohydroxy Netupitant |
Monohydroxy Netupitant is a highly selective antagonist of NK1 receptor, and is Netupitant metabolite. |
| T12212 |
Netupitant metabolite N-desmethyl Netupitant |
N-desmethyl Netupitant is a highly selective antagonist of NK1 receptor, and is Netupitant metabolite. |
| T12213 |
Netupitant metabolite Netupitant N-oxide |
Netupitant N-oxide is a highly selective antagonist of NK1 receptor, is Netupitant metabolite. |
| T12214 |
Neurotoxin Inhibitor |
Neurotoxin Inhibitor is an inhibitor of neurotoxin. |
| T12217 |
NF546 |
NF546 is a selective agonist of non-nucleotide P2Y11(pEC50 of 6.27). |
| T12219 |
NHE3-IN-1 |
NHE3-IN-1 is a inhibitor of sodium/proton exchanger type 3 (NHE-3). |
| T12220 |
NIC3 |
NIC3 is a selective nucleus accumbens-associated protein-1 (NAC1) inhibitor,with anti-cancer activity. |
| T12221 |
Nicardipine D3 hydrochloride |
Nicardipine D3 hydrochloride is the deuterium labeled Nicardipine hydrochloride. |
| T12222 |
Nifedipine D6 |
Nifedipine D6 is deuterium labeled nifedipine which is a potent blocker of calcium channel. |
| T12223 |
Nifursemizone |
Nifursemizone is an agent with antiprotozoal. |
| T12224 |
Nilotinib D6 |
Nilotinib D6 is a deuterium labeled Nilotinib which is an orally available inhibitor of Bcr-Abl tyrosine kinase ,and with antineoplastic activity. |
| T12225 |
Nevanimibe |
Nevanimibe is an orally active and selective inhibitor of acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1) (EC50 of 9 nM). |
| T12225L |
Nevanimibe hydrochloride |
Nevanimibe hydrochloride is an orally active and selective inhibitor of acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1) (EC50 of 9 nM). |
| T12226 |
NIM811 |
NIM811 is an orally bioavailable dual inhibitor of mitochondrial permeability transition and cyclophilin. |
| T12229 |
Niraparib metabolite M1 |
Niraparib metabolite M1 is niraparib metabolite, niraparib is a novel poly(ADP-Ribose) polymerase (PARP) inhibitor. |
| T1223 |
Ceftriaxone sodium |
Ceftriaxone sodium salt is a broad-spectrum cephalosporin antibiotic with a very long half-life and high penetrability to meninges, eyes and inner ears. |
| T12230 |
Nitazoxanide D4 |
Nitazoxanide D4 is the deuterium labeled Nitazoxanide. |
| T12231 |
NITD-349 |
NITD-349 is an inhibitor MmpL3, shows highly potent anti-mycobacterial activity. |
| T12232 |
Nitroxazepine |
Nitroxazepine is a serotonin-norepinephrine reuptake inhibitor, and treatment depression. |
| T12233 |
NK-1 Antagonist 1 |
NK-1 Antagonist 1 is a NK-1 receptor antagonist. |
| T12234 |
NMDA-IN-1 |
NMDA-IN-1 is a potent and NR2B-selective antagonist of NMDA(NMDA Ki of 0.85 nM; NR2B Ca2+ influx IC50 is 9.7 nM). |
| T12235 |
NMDI14 |
NMDI14 is an inhibitor of nonsense mediated RNA decay (NMD). |
| T12236 |
NMS-859 |
NMS-859 is a potent and covalent inhibitor of VCP (p97)(IC50s of 0.37 and 0.36 μM for wild-type VCP in the presence of 60 μM and 1 mM ATP in cells, respective...
|
| T12237 |
NMS-P715 |
NMS-P715 is a selective and ATP-competitive MPS1 inhibitor(IC50 of 182 nM). |
| T12238 |
NNC 55-0396 |
NNC 55-0396 is a highly selective blocker of T-type calcium channel(IC50 of 6.8 and > 100 μM for inhibition of Cav3.1 T-type channels and HVA currents respecti...
|
| T12239 |
NNC45-0781 |
NNC45-0781 is a tissue-selective partial-agonist of estrogen. |
| T1224 |
Cefuroxime sodium |
Cefuroxime Sodium is the sodium salt form of cefuroxime and a semi-synthetic, broad-spectrum, beta-lactamase resistant, second-generation cephalosporin antibiot...
|
| T12242 |
Norvancomycin hydrochloride |
Norvancomycin hydrochloride is used as treatment endocarditis, osteomyelitis, pneumonia, sepsis or soft tissue infections caused by Staphylococcus . |
| T12243 |
Norverapamil D7 |
Norverapamil D7 is a deuterium labeled Norverapamil . Norverapamil is a blocker of L-type calcium channel and an inhibitor of P-glycoprotein (P-gp) function . |
| T12246 |
CB-103 |
CB-103 is a orally active inhibitor of notch signaling pathway, with anti-tumor activity. |
| T12247 |
NOT Receptor Modulator 1 |
NOT Receptor Modulator 1 is a modulator of nuclear receptor NOT. |
| T12249 |
NPB |
NPB is a potent BAD phosphorylation inhibitor(at Ser99,IC50 of 0.41 μM.) |
| T12250 |
NPD-1335 |
NPD1335 is an inhibitor of Trypanosoma brucei phosphodiesterase B1. |
| T12251 |
NR1H4 activator 1 |
NR1H4 activator 1 is a potent and selective agonist of Famesoid X Receptor (FXR). |
| T12255 |
NS19504 |
NS19504 is a activator of Ca2+-activated K+ channel with EC50 of 11.0 µM. |
| T12256 |
NS8593 hydrochloride |
NS8593 hydrochloride is a potent and selective inhibitor of small conductance Ca2+-activated K+ channels (SK channels) . |
| T12257 |
NSC 146109 hydrochloride |
NSC 146109 hydrochloride is an activator of small-molecule p53 that target MDMX and could be of value in treating breast cancer. |
| T12258 |
NSC 601980 (analog) |
NSC 601980 analog is the analog of the NSC601980 which shows antitumor activity in the yeast screening experiment. |
| T12259 |
NSC 601980 |
NSC601980 shows antitumor activity in the yeast screening experiment, which can inhibit cell proliferation in the COLO 205 and HT29 (Log GI 50 of -6.6 and -6.9 ...
|
| T1226 |
Bacitracin |
Bacitracin, a mixture of related cyclic polypeptides, disrupts bacteria by interfering with cell wall and peptidoglycan synthesis. |
| T12260 |
NSC117079 |
NSC117079 is an inhibitor of PHLPP. |
| T12261 |
NSC232003 |
NSC232003 is a highly potent and cell-permeable inhibitor of UHRF1. |
| T12263 |
NSC305787 |
NSC305787 is an ezrin inhibitor(Kd of 5.85 μM), with antitumor activity. |
| T12263L |
NSC305787 hydrochloride |
NSC305787 hydrochloride is an inhibitor of ezrin (Kd: 5.85 μM). NSC305787 hydrochloride inhibits the phosphorylation of ezrin caused by PKCΙ (IC50: 8.3 μM). ...
|
| T12264 |
Fludazonium chloride |
Fludazonium chloride is an agent with anti-fungal. |
| T12265 |
NSC624206 |
NSC624206 is a ubiquitin E1 (UBA1) inhibitor(IC50 of ~9 μM). |
| T12266 |
Ilginatinib |
Ilginatinib is a highly active and orally bioavailable inhibitor of JAK2. |
| T12266L |
Ilginatinib maleate |
Ilginatinib maleate is a highly active and orally bioavailable inhibitor of JAK2. |
| T12266L2 |
Ilginatinib hydrochloride |
Ilginatinib hydrochloride is a highly active and orally bioavailable inhibitor of JAK2. |
| T12267 |
NSP-805 |
NSP-805 is a potent and selective guinea pig cardiac phosphodiesterase 3 (PDE3) inhibitor. |
| T12268 |
NTP42 |
NTP42 is an antagonist of thromboxane A2 (TXA2) receptor(IC50 of 3.278 nM) |
| T1227 |
Cepazine |
Cepazine is a second generation oral cephalosporin antibiotic. |
| T12271 |
NV03 |
NV03 is a potent and selective UHRF1 (Ubiquitin-like with PHD and RING finger domains 1)- H3K9me3 antagonist interaction by binding to UHRF1 tandem tudor domain...
|
| T12272 |
NVP-CGM097 stereoisomer |
NVP-CGM097 is a stereoisomer of NVP-CGM097, NVP-CGM097 is a potent and selective inhibitor of MDM2. |
| T12273 |
NVP-CGM097 sulfate |
NVP-CGM097 sulfate is a potent and selective inhibitor of MDM2 (hMDM2, IC50 of 1.7±0.1 nM). |
| T12274 |
Siremadlin R Enantiomer |
Siremadlin R Enantiomer is the R enantiomer of Siremadlin. Siremadlin is a potent and highly specific inhibitor of MDM-2/p53. |
| T12276 |
NVS-CRF38 |
NVS-CRF38 is an antagonist of corticotropin-releasing factor receptor 1 (CRF1). |
| T12277 |
NVS-ZP7-4 |
NVS-ZP7-4 is a inhibitor of Zinc transporter SLC39A7 (ZIP7). |
| T12279 |
O-Desmethyl apixaban |
O-Desmethyl apixaban is a metabolite of Apixaban that is a highly selective, reversible inhibitor of Factor Xa with Ki of 0.08 nM and 0.17 nM in human and rabbi...
|
| T12280 |
O-Desmethyl Midostaurin |
O-Desmethyl Midostaurin is the active Midostaurin metabolite via cytochrome P450 liver enzyme metabolism. |
| T12282 |
O-glycosylation-IN-1 |
O-glycosylation-IN-1 is a potent inhibitor of O-glycosylation and is used to reduce mucin on cell surfaces. |
| T12283 |
O-Methyl Atorvastatin hemicalcium |
O-Methyl Atorvastatin is an impurity of Atorvastatin that is an orally active inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, has the a...
|
| T12284 |
O-Propargyl-Puromycin |
O-Propargyl-Puromycin is a potent inhibitor of protein synthesis. |
| T12285 |
OBE022 |
OBE022 is an oral and selective antagonist of prostaglandin F2α (PGF2α) receptor(human and rat FP receptors with Kis of 1 nM, 26 nM , respectively). |
| T12286 |
Obtusifoliol |
Obtusifoliol is a specific inhibitor of CYP51(Trypanosoma brucei (TB) and human CYP51 with Kd values of 1.2 µM and 1.4 µM, respectively). |
| T12287 |
Octadecanedioic acid |
Octadecanedioic acid is a endogenous metabolite , is a long-chain dicarboxylic acid . |
| T12289 |
ODM-204 |
ODM-204 is novel nonsteroidal dual inhibitor of both androgen receptor and CYP17A1 enzyme(IC50s of 80 nM and 22 nM, respectively). |
| T12290 |
OICR-0547 |
OICR-0547 is a closely related derivative of OICR-9429. OICR-9429 is a novel small-molecule Wdr5-MLL interaction antagonist. |
| T12291 |
Olanzapine D3 |
Olanzapine D3 is the deuterium labeled Olanzapine. |
| T12292 |
Olaparib D5 |
Olaparib D5 is a deuterium labeled Olaparib. Olaparib is a potent and oral inhibitor of PARP. |
| T12293 |
Olcegepant hydrochloride |
Olcegepant hydrochloride is a potent and selective non-peptidethe calcitonin gene-related peptide 1 (CGRP1) receptor antagonist (with IC50 of 0.03 nM for human ...
|
| T12293L |
Olcegepant |
Olcegepant is an effective and selective non-peptide calcitonin gene-related peptide 1 (CGRP1) receptor antagonist (IC50 of 0.03 nM and Ki of 14.4 pM for human ...
|
| T12294 |
Oleanolic acid hemiphthalate disodium salt |
Oleanolic acid hemiphthalate disodium salt is an agent with anti-inflammatory. |
| T12295 |
Oleoylcarnitine |
Oleoylcarnitine is a endogenous metabolite. |
| T12296 |
Oleoylethanolamide |
Oleoylethanolamide is a high affinity endogenous agonist of PPAR-α. |
| T12297 |
Oleuropeinic acid |
oleuropeinic acid is present initially in olive tissues or formed by the thermal treatment, is an antioxidant-soluble fiber. |
| T12298 |
Oligomycin B |
Oligomycin B is an antibiotic isolated from marine Streptomyces, is an eukaryotic ATP synthase inhibitor, induces apoptosis. |
| T12299 |
Oligomycin C |
Oligomycin C is an antifungal agent isolated from Streptomyces strain. |
| T1230 |
Pamabrom |
Pamabrom is a diuretic, used for the relief of temporary water weight gain, bloating, swelling and full feeling associated with the premenstrual and menstrual p...
|
| T12300 |
Olmesartan D4 |
Olmesartan D4 is the deuterium labeled Olmesartan. Olmesartan is an antagonist of angiotensin II receptor (AT1R) used to treat high blood pressure. |
| T12302 |
OMDM-1 |
OMDM-1 is a selective and metabolically stable anandamide cellular uptake (ACU)inhibitor(Ki of 2.4 μM). |
| T12303 |
OMDM-2 |
OMDM-2 is a selective and metabolically stable anandamide cellular uptake (ACU)inhibitor(Ki of 3.0 μM). |
| T12304 |
OMDM-3 |
OMDM-3 is a selective and metabolically stable anandamide cellular uptake (ACU)inhibitor(Ki of 16.6 μM). |
| T12305 |
OMDM-4 |
OMDM-4 is a selective and metabolically stable anandamide cellular uptake (ACU)inhibitor(Ki of 17.7 μM). |
| T12306 |
OMDM-5 |
OMDM-5 is a selective anandamide cellular uptake (ACU)inhibitor(Ki of 4.8 μM). |
| T12307 |
OMDM-6 |
OMDM-6 is a hybrid vanilloid receptor type 1 (VR1, TRPV1) agonist with EC50 of 75 nM and cannabinoid receptor type 1 (CB1) (Ki=3.2 μM). |
| T12308 |
Omeprazole D3 |
Omeprazole D3 is deuterium labeled Omeprazole. Omeprazole is a proton pump inhibitor (PPI) |
| T12309 |
Omeprazole metabolite Omeprazole sulfone |
Omeprazole sulfone is a Omeprazole metabolite, is a proton pump inhibitor. |
| T12313 |
Ophiobolin B |
Ophiobolin B is a sesterterpene Helminthosporium oryzae metabolite, inhibits proton extrusion from maize coleoptiles. |
| T12316 |
Oral antiplatelet agent 1 |
Oral antiplatelet agent 1 is a potent antiplatelet agent with an IC50 of 2.94 μM in vitro. |
| T12317 |
Orelabrutinib |
Orelabrutinib is an orally active and irreversible inhibitor of Bruton's tyrosine kinase (BTK). |
| T12318 |
Org-10490 |
Org-10490 is an dopamine D1 receptor and dopamine D2 receptor antagonist, and treatment for psychiatric disease. |
| T12320 |
ORL1 antagonist 1 |
ORL1 antagonist 1 is an o antagonist of pioid receptor-like 1 (ORL1) (IC50 of 61 nM). |
| T12321 |
ORM-10103 |
ORM-10103 is a specific the Na+/Ca2+ exchanger (NCX) inhibitor. |
| T12323 |
ORM-15341 |
ORM-15341 is a potent and full antagonist for human AR (hAR)( with IC50 values of 38 nM as shown by transactivation assays in AR-HEK293 cells) |
| T12324 |
Ornidazole (Levo-) |
Ornidazole Levo- is the levo-isomer of Ornidazole. |
| T12325 |
Orotic acid-6-C14 |
Orotic acid-6-C14 is an endogenous metabolite. |
| T12326 |
OSMI-2 |
OSMI-2 is a cell-permeable inhibitor of O-linked N-acetylglucosamine transferase (OGT). |
| T12327 |
