Popular Searches
Diphenyleneiodonium chlorideEpacadostatGilteritinibDinaciclibRo-3306
TargetMol | Star Product
Wikimole
TargetMol | New Product
New Product
TargetMol | Compound Library
Compound Library
Contact Us
Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty
TOPBioactivityChemical infoStorage&SolubilityCalculator

Nav1.7-IN-8

😃Good
Catalog No. T38911Cas No. 1432913-44-4
Alias Nav1.7-IN-8

Nav1.7-IN-8 is a highly potent and selective inhibitor of NaV1.7, exhibiting greater selectivity for inhibiting NaV1.7 compared to the subtypes hNaV1.1 and hNaV1.5. Additionally, Nav1.7-IN-8 has inhibitory effects on CYP2C9 and CYP3A4, with IC50 values of 0.17 μM and 0.077 μM, respectively. Notably, Nav1.7-IN-8 demonstrates significant analgesic properties in rodent models of both acute and inflammatory pain.

Nav1.7-IN-8

Nav1.7-IN-8

😃Good
Catalog No. T38911Alias Nav1.7-IN-8Cas No. 1432913-44-4
Nav1.7-IN-8 is a highly potent and selective inhibitor of NaV1.7, exhibiting greater selectivity for inhibiting NaV1.7 compared to the subtypes hNaV1.1 and hNaV1.5. Additionally, Nav1.7-IN-8 has inhibitory effects on CYP2C9 and CYP3A4, with IC50 values of 0.17 μM and 0.077 μM, respectively. Notably, Nav1.7-IN-8 demonstrates significant analgesic properties in rodent models of both acute and inflammatory pain.
Pack SizePriceAvailabilityQuantity
25 mg$2,428 Backorder
Bulk & Custom
Add to Cart
Questions
View More
Contact us for more batch information
Resource Download
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity
Description
Nav1.7-IN-8 is a highly potent and selective inhibitor of NaV1.7, exhibiting greater selectivity for inhibiting NaV1.7 compared to the subtypes hNaV1.1 and hNaV1.5. Additionally, Nav1.7-IN-8 has inhibitory effects on CYP2C9 and CYP3A4, with IC50 values of 0.17 μM and 0.077 μM, respectively. Notably, Nav1.7-IN-8 demonstrates significant analgesic properties in rodent models of both acute and inflammatory pain.
Targets&IC50
CYP2C9:0.17 μM (IC50), CYP3A4:0.077 μM (IC50)
In vitro
The plasma protein binding of Nav1.7-IN-8 in rats is extremely high, with a free fraction of approximately 1.1% [1].
In vivo
Nav1.7-IN-8, administered intraperitoneally (i.p.) at doses ranging from 0 to 100 mpk for one hour, significantly reduces the pain response during phase 2a of the formalin assay in both rats and mice in a dose-dependent manner. Furthermore, when administered at 10 to 100 mpk over two days, it demonstrates a consistent dose-dependent decrease in pain response across these animal models, indicating its potential as an effective analgesic[1].
AliasNav1.7-IN-8
Chemical Properties
Molecular Weight535.93
FormulaC21H12ClF2N5O4S2
Cas No.1432913-44-4
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Sci Citations

Calculator

  • Molarity Calculator
  • Dilution Calculator
  • Reconstitution Calculator
  • Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
%Tween 80
%ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Nav-1.7-IN-8Nav1.7 IN 8Nav1.7IN8
Related Tags: buy Nav1.7-IN-8 | purchase Nav1.7-IN-8 | Nav1.7-IN-8 cost | order Nav1.7-IN-8 | Nav1.7-IN-8 chemical structure | Nav1.7-IN-8 in vivo | Nav1.7-IN-8 in vitro | Nav1.7-IN-8 formula | Nav1.7-IN-8 molecular weight
TargetMol | Logo

Copyright © 2015-2025 TargetMol Chemicals Inc. All Rights Reserved.