Shopping Cart

Your shopping cart is currently empty

Nicotinic acid hydrazide

Name: Nicotinic acid hydrazide
Brand: TargetMol
SKU: T0664
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

😃Good

Catalog No. T0664Cas No. 553-53-7

Nicotinic acid hydrazide (NAH) is a hydrazide derivative of nicotinic acid, a heterocyclic organic compound. It is a peroxidase inhibitor and can form solid metal complexes with strong biological activity.

Nicotinic acid hydrazide

Copy Product Info

😃Good

Purity: 97.79%

Catalog No. T0664Cas No. 553-53-7

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 g	$29	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:97.79%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Nicotinic acid hydrazide AI Summary

Nicotinic acid hydrazide exhibits diverse bioactivity across various pathogens. It has been tested for its antitubercular properties, showing a minimum inhibitory concentration (MIC) of 2.0 µg/mL against Mycobacterium tuberculosis BCG and a pMIC value of 2.7 against Mycobacterium tuberculosis var. bovis strain at 310K. Additionally, it demonstrates lower antitubercular activity against isoniazid-resistant Mycobacterium tuberculosis CN-40 with an MIC greater than 20.0 µg/mL. The compound shows broad-spectrum antimicrobial activity, with MIC values for various microorganisms including Candida albicans, Escherichia coli, Staphylococcus aureus, and Bacillus subtilis, recording -logMIC values ranging from 0.74 to 1.04. It has notable antimicrobial activities against multiple bacterial strains such as Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa. Nicotinic acid hydrazide also exhibits trypanosomicidal activity, with IC50 values greater than 150,000 nM against the axenic epimastigote stage of Trypanosoma cruzi Tulahuen 2 and greater than 73,000 nM against the amastigote stage of Trypanosoma cruzi Tulahuen C4. Moreover, it demonstrates cytotoxicity against human HeLa cells and shows antimalarial activity against CQ-sensitive Plasmodium falciparum 3D7, with an IC50 greater than 50.0 µg/mL. Nicotinic acid hydrazide also possesses notable lipophilicity with a log P value of -2.322, which may influence its bioactivity profile and pharmacokinetic properties..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Chemical Properties

Molecular Weight	137.14
Formula	C₆H₇N₃O
Cas No.	553-53-7
Smiles	NNC(=O)C1=CN=CC=C1
Relative Density.	1.2620 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (364.59 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	7.2918 mL	36.4591 mL	72.9182 mL	364.5909 mL
5 mM	1.4584 mL	7.2918 mL	14.5836 mL	72.9182 mL
10 mM	0.7292 mL	3.6459 mL	7.2918 mL	36.4591 mL
20 mM	0.3646 mL	1.8230 mL	3.6459 mL	18.2295 mL
50 mM	0.1458 mL	0.7292 mL	1.4584 mL	7.2918 mL
100 mM	0.0729 mL	0.3646 mL	0.7292 mL	3.6459 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc