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Zastaprazan

Name: Zastaprazan
Brand: TargetMol
SKU: T39583
Rating: 4.5 (1 reviews)

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Catalog No. T39583Cas No. 2133852-18-1

Alias Polysialic acid sodium salt

Zastaprazan (JP-1366, compound 6) is a potassium-competitive acid blocker and proton pump inhibitor that suppresses gastric acid secretion, indicated for gastro-oesophageal reflux disease (GERD).

Zastaprazan

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Purity: 99.97%

Catalog No. T39583Alias Polysialic acid sodium saltCas No. 2133852-18-1

Zastaprazan (JP-1366, compound 6) is a potassium-competitive acid blocker and proton pump inhibitor that suppresses gastric acid secretion, indicated for gastro-oesophageal reflux disease (GERD).

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Purity:99.97%

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Product Introduction

Bioactivity

Description	Zastaprazan (JP-1366, compound 6) is a potassium-competitive acid blocker and proton pump inhibitor that suppresses gastric acid secretion, indicated for gastro-oesophageal reflux disease (GERD).
Synonyms	Polysialic acid sodium salt

Chemical Properties

Molecular Weight	362.48
Formula	C₂₂H₂₆N₄O
Cas No.	2133852-18-1
Smiles	Cc1nc2c(NCc3c(C)cccc3C)cc(cn2c1C)C(=O)N1CCC1
Relative Density.	1.21 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 25.00 mg/mL (68.97 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.52 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7588 mL	13.7939 mL	27.5877 mL	137.9386 mL
5 mM	0.5518 mL	2.7588 mL	5.5175 mL	27.5877 mL
10 mM	0.2759 mL	1.3794 mL	2.7588 mL	13.7939 mL
20 mM	0.1379 mL	0.6897 mL	1.3794 mL	6.8969 mL
50 mM	0.0552 mL	0.2759 mL	0.5518 mL	2.7588 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc