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Zastaprazan

Name: Zastaprazan
Brand: TargetMol
SKU: T39583
Rating: 4.5 (1 reviews)

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Catalog No. T39583Cas No. 2133852-18-1

Alias Polysialic acid sodium salt

Zastaprazan (JP-1366, compound 6) is a potassium-competitive acid blocker and proton pump inhibitor that suppresses gastric acid secretion, indicated for gastro-oesophageal reflux disease (GERD).

Zastaprazan

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Purity: 99.97%

Catalog No. T39583Alias Polysialic acid sodium saltCas No. 2133852-18-1

Zastaprazan (JP-1366, compound 6) is a potassium-competitive acid blocker and proton pump inhibitor that suppresses gastric acid secretion, indicated for gastro-oesophageal reflux disease (GERD).

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Batch Information

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Purity:99.97%

Appearance:Solid

Color:White

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Product Introduction

Bioactivity

Description	Zastaprazan (JP-1366, compound 6) is a potassium-competitive acid blocker and proton pump inhibitor that suppresses gastric acid secretion, indicated for gastro-oesophageal reflux disease (GERD).
Synonyms	Polysialic acid sodium salt

Chemical Properties

Molecular Weight	362.48
Formula	C₂₂H₂₆N₄O
Cas No.	2133852-18-1
Smiles	Cc1nc2c(NCc3c(C)cccc3C)cc(cn2c1C)C(=O)N1CCC1
Relative Density.	1.21 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 25 mg/mL (68.97 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.52 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7588 mL	13.7939 mL	27.5877 mL	137.9386 mL
5 mM	0.5518 mL	2.7588 mL	5.5175 mL	27.5877 mL
10 mM	0.2759 mL	1.3794 mL	2.7588 mL	13.7939 mL
20 mM	0.1379 mL	0.6897 mL	1.3794 mL	6.8969 mL
50 mM	0.0552 mL	0.2759 mL	0.5518 mL	2.7588 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc