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CPDS

Name: CPDS
Brand: TargetMol
SKU: T9807
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9807Cas No. 15658-35-2

CPDS is a non permeant thiol agent which affects several mitochondrial functions. In rat liver mitochondria, CPDS inhibits only the Pi/OH- carrier; both CPDS and n-butylmalonate are necessary to inhibit completely Pi entry.

CPDS

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Purity: 99.93%

Catalog No. T9807Cas No. 15658-35-2

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$37	In Stock	In Stock
25 mg	$58	In Stock	In Stock
50 mg	$89	In Stock	In Stock
100 mg	$125	In Stock	In Stock
500 mg	$316	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$31	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.93%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

CPDS AI Summary

CPDS exhibits a diverse range of bioactivities. It acts as a potent inhibitor of enzymes such as AHAS in Arabidopsis thaliana (Ki value of 15200.0 nM), HSD17B4 (potency of 1584.9 nM), Cytochrome P450 2C19 (2511.9 nM), ALDH1A1 (4466.8 nM), Anthrax Lethal Toxin Internalization (5011.9 nM), HPGD (3981.1 nM), and HADH2 (50.1 nM). Additionally, it shows activity in Cytochrome panel assays (AC50 values below 10 uM) and inhibits human HDAC6 activity against both commercial and custom peptide substrates (20.65% and 8.66% inhibition, respectively). In herbicidal activity assays, CPDS demonstrates inhibition of Brassica campestris L root growth by 12.1% at 100 ug/ml concentration and 6.0% at 10 ug/ml concentration. In antiviral studies, CPDS shows inhibition of SARS-CoV-2 induced cytotoxicity in Caco-2 cells with a high percentage inhibition of 100.52% at 20 µM for SARS-CoV-2 3CL-Pro protease (IC50: 240.0 nM), although it shows less activity against MERS_3CL Pro protease (IC50 > 10,000.0 nM and 8.0% inhibition at 10 µM), and had minimal effect on SARS-CoV-2 in VERO-6 cells (-0.06% inhibition at 10 uM). Moreover, this compound demonstrates growth inhibition in various human tumor cell lines with a GI50 of 100,000.0 nM for most cell lines and 72,276.98 nM for the NCI-H226 Non-Small Cell Lung cell line..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Chemical Properties

Molecular Weight	308.33
Formula	C₁₂H₈N₂O₄S₂
Cas No.	15658-35-2
Smiles	OC(=O)c1ccc(SSc2ccc(cn2)C(O)=O)nc1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (178.38 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 2.5 mg/mL (8.11 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2433 mL	16.2164 mL	32.4328 mL	162.1639 mL
5 mM	0.6487 mL	3.2433 mL	6.4866 mL	32.4328 mL
10 mM	0.3243 mL	1.6216 mL	3.2433 mL	16.2164 mL
20 mM	0.1622 mL	0.8108 mL	1.6216 mL	8.1082 mL
50 mM	0.0649 mL	0.3243 mL	0.6487 mL	3.2433 mL
100 mM	0.0324 mL	0.1622 mL	0.3243 mL	1.6216 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc