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SU 4313

Name: SU 4313
Brand: TargetMol
SKU: T3568
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3568Cas No. 186611-55-2

SU 4313 is a bioactive chemical.

SU 4313

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Purity: 99.89%

Catalog No. T3568Cas No. 186611-55-2

SU 4313 is a bioactive chemical.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$30	In Stock	In Stock
5 mg	$64	In Stock	In Stock
10 mg	$98	In Stock	In Stock
25 mg	$179	In Stock	In Stock
50 mg	$263	In Stock	In Stock
100 mg	$392	In Stock	In Stock
200 mg	$575	-	In Stock
1 mL x 10 mM (in DMSO)	$71	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.89%

Appearance:Solid

Color:White to Yellow

Resource Download

COA HNMR HPLC

Product Introduction

SU 4313 AI Summary

SU 4313 exhibits inhibitory activity against multiple receptors and enzymes. It inhibits vascular endothelial growth factor receptor 2 (VEGFR2 or FLK1) with an IC50 value of 5248.07 nM. Additionally, it inhibits tyrosine phosphorylation on several receptors, including human Platelet-derived growth factor receptor beta (IC50 = 24200.0 nM), murine VEGF receptor (IC50 = 5200.0 nM), human Epidermal growth factor receptor (IC50 = 18500.0 nM), human Her-2 receptor tyrosine kinase (IC50 = 16900.0 nM), and human Insulin-like growth factor I receptor (IC50 = 10000.0 nM). SU 4313 also shows significant inhibitory activity against AmpC beta-Lactamase with an IC50 of 6000.0 nM, and against beta-Lactamase, displaying 95.0% inhibition at 20 uM in the absence of detergent Triton X-100, which drops to 27.0% in the presence of 0.01% Triton X-100. It further inhibits chymotrypsinogen, cloned Dihydrofolate reductase (cDHFR), and Beta-galactosidase, with IC50 values of 30000.0 nM, 30000.0 nM, and 55000.0 nM respectively. Notably, the compound forms aggregates as observed by dynamic light scattering at a concentration of 10.0 uM, and its inhibitory activity is influenced by varying potassium phosphate buffer concentrations, with IC50 values ranging from 3000.0 nM to 7000.0 nM. SU 4313 also shows improved inhibitory activity against beta-lactamase when preincubated, leading to a fold decrease in IC50..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	SU 4313 is a bioactive chemical.
Targets&IC50	PDGFR:14.5 μM, IGF-1R:8.0 μM, FLK1:18.8 μM, EGFR:11 μM, HER2:16.9 μM

Chemical Properties

Molecular Weight	263.33
Formula	C₁₈H₁₇NO
Cas No.	186611-55-2
Smiles	C(=C1C=2C(NC1=O)=CC=CC2)C3=CC=C(C(C)C)C=C3
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 65 mg/mL (246.84 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 5 mg/mL (18.99 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7975 mL	18.9876 mL	37.9752 mL	189.8758 mL
5 mM	0.7595 mL	3.7975 mL	7.5950 mL	37.9752 mL
10 mM	0.3798 mL	1.8988 mL	3.7975 mL	18.9876 mL
20 mM	0.1899 mL	0.9494 mL	1.8988 mL	9.4938 mL
50 mM	0.0760 mL	0.3798 mL	0.7595 mL	3.7975 mL
100 mM	0.0380 mL	0.1899 mL	0.3798 mL	1.8988 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc