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CGP 25454A
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Catalog No. T10779Cas No. 104391-26-6
CGP 25454A is a novel and selective antagonist of the presynaptic dopamine autoreceptor (CGP 25454A).
CGP 25454A
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Catalog No. T10779Cas No. 104391-26-6
CGP 25454A is a novel and selective antagonist of the presynaptic dopamine autoreceptor (CGP 25454A).
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 2 mg | $134 | 5 days | 5 days | |
| 5 mg | $228 | 5 days | 5 days | |
| 25 mg | $613 | 6-8 weeks | 6-8 weeks | |
| 50 mg | $797 | 6-8 weeks | 6-8 weeks | |
| 100 mg | $1,360 | 6-8 weeks | 6-8 weeks |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | CGP 25454A is a novel and selective antagonist of the presynaptic dopamine autoreceptor (CGP 25454A). |
| In vitro | CGP 25454A increases the field-stimulated [3H]- and [14C]-overflow from rat striatal slices preloaded with [3H]dopamine and [14C]choline, indicating that CGP 25454A is able to enhance the release of both dopamine (DA) and acetylcholine (ACh). However, CGP 25454A is 12.9 times more potent in increasing, by 1/6 of the apparent maximal increase, the release of [3H]DA than that of [14C]ACh. |
| In vivo | CGP 25454A increase [3H]spiperone binding to receptors of the D2 family in rat striatum by 90-110% (ED50: 13 mg/kg i.p.). At 30-100 mg/kg, CGP 25454A inhibits [3H]spiperone binding in the pituitary of the same animals as a result of a blockade of postsynaptic DA receptors. |
| Molecular Weight | 346.25 |
| Formula | C15H21Cl2N3O2 |
| Cas No. | 104391-26-6 |
| Smiles | Cl.CCN(CC)CCNC(=O)c1cc(C#N)c(Cl)cc1OC |
| Relative Density. | no data available |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 3.5 mg/mL (10.11 mM), Sonication is recommended. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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