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Cadralazine (Synonyms: ISF-2469, ISF2469, ISF 2469)

Name: Cadralazine
Brand: TargetMol
SKU: T26939
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T26939 Copy Product Info

Purity: 99.65%

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Cadralazine (ISF 2469) is a peripheral arteriolar vasodilator and can be used in studies about acting as an antihypertensive drug.

Cadralazine

Copy Product Info

🥰Excellent

Catalog No. T26939

Synonyms ISF-2469, ISF2469, ISF 2469

Cadralazine (ISF 2469) is a peripheral arteriolar vasodilator and can be used in studies about acting as an antihypertensive drug.

Cas No. 64241-34-5

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Pack Size	Price	USA Stock	Global Stock
5 mg	$39	-	In Stock
10 mg	$64	-	In Stock
25 mg	$133	-	In Stock
50 mg	$215	-	In Stock
100 mg	$305	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.65%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Cadralazine AI Summary

Cadralazine demonstrates bioactivity in blocking the entry of the Ebola virus, with an AC50 ranging from 2.818 µM to 3162.3 nM, indicating potential inhibitory effects on the virus's entry process. Additionally, the compound exhibits antiviral activity by inhibiting SARS-CoV-2-induced cytotoxicity in both Caco-2 and Vero-6 cells. Specifically, in Caco-2 cells, Cadralazine shows a 2.11% inhibition rate at a concentration of 10 µM after 48 hours. In Vero-6 cells, the compound exhibits a 0.05% inhibition rate under similar conditions. Further, Cadralazine inhibits the SARS-CoV-2 3CL-Pro protease at a concentration of 20 µM, although it shows an inhibition percentage of -6.669%. Additionally, the compound inhibits human HDAC6 enzyme activity, showing a decrease of 12.37% in a commercial peptide substrate assay and an increase of 2.11% in a custom peptide substrate assay. Beyond these activities, Cadralazine has demonstrated a wide range of binding affinities for various receptors and enzymes, such as human ADRB2, human OPRK1, human HTR2C, and more, with AC50 values typically exceeding 30000.0 nM. It has been evaluated for inhibition of enzymes like human PTGS2 (AC50 of 2500.0 nM) and human PDE4D (AC50 greater than 30000.0 nM). The compound also shows agonist and antagonist activities for receptors including human HRH2, human ADRA2A, human HTR1A, and human DRD1, with AC50 values generally greater than 30000.0 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Cadralazine (ISF 2469) is a peripheral arteriolar vasodilator and can be used in studies about acting as an antihypertensive drug.
Synonyms	ISF-2469, ISF2469, ISF 2469

Chemical Properties

Molecular Weight	283.33
Formula	C₁₂H₂₁N₅O₃
Cas No.	64241-34-5
Smiles	N(CC(C)O)(CC)C1=CC=C(NNC(OCC)=O)N=N1
Relative Density.	1.1585 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 200 mg/mL (705.89 mM), Sonication and heating to 60℃ are recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (17.65 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5295 mL	17.6473 mL	35.2945 mL	176.4727 mL
5 mM	0.7059 mL	3.5295 mL	7.0589 mL	35.2945 mL
10 mM	0.3529 mL	1.7647 mL	3.5295 mL	17.6473 mL
20 mM	0.1765 mL	0.8824 mL	1.7647 mL	8.8236 mL
50 mM	0.0706 mL	0.3529 mL	0.7059 mL	3.5295 mL
100 mM	0.0353 mL	0.1765 mL	0.3529 mL	1.7647 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc