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PLX7683
(Synonyms: PLX-7683) Copy Product Info
🥰Excellent
Synonyms: PLX-7683
Catalog No. T70308 Copy Product Info
Purity: 97.60%
🥰Excellent
PLX7683 is a paradox breaker. PLX7683 overcomes several known mechanisms of resistance to first-generation RAF inhibitors by dissociating MAPK pathway inhibition from paradoxical activation. PLX7683 is used in kinase signaling research systems to investigate RAF pathway regulation, resistance mutation mechanisms, and MAPK cascade modulation in cancer cell models.
Cas No. 1652573-86-8
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 25 mg | $1,520 | - | In Stock | |
| 50 mg | $1,980 | - | In Stock | |
| 100 mg | $2,500 | 1-2 weeks | 1-2 weeks |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:97.60%
Appearance:Solid
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | PLX7683 is a paradox breaker. PLX7683 overcomes several known mechanisms of resistance to first-generation RAF inhibitors by dissociating MAPK pathway inhibition from paradoxical activation. PLX7683 is used in kinase signaling research systems to investigate RAF pathway regulation, resistance mutation mechanisms, and MAPK cascade modulation in cancer cell models. |
| Synonyms | PLX-7683 |
| Molecular Weight | 504.94 |
| Formula | C23H19ClF2N4O3S |
| Cas No. | 1652573-86-8 |
| Smiles | O=C(C1=CNC2=NC=C(C=C21)C=3C=CC(Cl)=CC3)C=4C(F)=CC=C(NS(=O)(=O)N(C)CC)C4F |
| Storage | Keep away from direct sunlight,Keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: PLX7683 chemical structure | PLX7683 formula | PLX7683 molecular weight
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