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TAMRA-PEG4-tetrazine

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Catalog No. T18749

TAMRA-PEG4-tetrazine is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

TAMRA-PEG4-tetrazine

TAMRA-PEG4-tetrazine

😃Good
Catalog No. T18749
TAMRA-PEG4-tetrazine is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
TAMRA-PEG4-tetrazine is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
In vitro
PROTACs consist of two distinct ligands linked together: one ligand targets an E3 ubiquitin ligase and the other binds to the target protein. Utilizing the intracellular ubiquitin-proteasome system, PROTACs facilitate the selective degradation of specific proteins [1].
Chemical Properties
Molecular Weight846.94
FormulaC45H50N8O9
Smiles[O-]C(C(C=C(C(NCCOCCOCCOCCOCCC(NCC1=CC=C(C2=NN=CN=N2)C=C1)=O)=O)C=C3)=C3C4=C(C=CC(N(C)C)=C5)C5=[O+]C6=C4C=CC(N(C)C)=C6)=O.[O-]C(C7=C(C8=C9C=CC(N(C)C)=CC9=[O+]C%10=C8C=CC(N(C)C)=C%10)C=C(C(NCCOCCOCCOCCOCCC(NCC%11=CC=C(C=C%11)C%12=NN=CN=N%12)=O)=O)C=C7)=O
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Stock solution preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
The above example illustrates how to use "In Vivo Formulation Calculator" and does not represent a recommended formulation for any specific compound. Please select an appropriate dissolution method based on your experimental animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

TAMRA-PEG4-tetrazineTAMRA-PEG-4-tetrazineTAMRAPEG4tetrazineTAMRA PEG4 tetrazinePEGs
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