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Sardomozide (Synonyms: SAM-486A, CGP 48664)

Name: Sardomozide
Brand: TargetMol
SKU: T12833
Rating: 4.5 (1 reviews)

Catalog No. T12833 Copy Product Info

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Sardomozide is an inhibitor of S-adenosylmethionine decarboxylase (SAMDC)(IC50 of 5 nM).

Sardomozide

Copy Product Info

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Catalog No. T12833

Synonyms SAM-486A, CGP 48664

Sardomozide is an inhibitor of S-adenosylmethionine decarboxylase (SAMDC)(IC50 of 5 nM).

Cas No. 149400-88-4

Pack Size	Price	USA Stock	Global Stock
25 mg	$1,520	1-2 weeks	1-2 weeks
50 mg	$1,980	1-2 weeks	1-2 weeks
100 mg	$2,500	1-2 weeks	1-2 weeks

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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Custom-made molecule. TargetMol’s expert synthesis team delivers cost-effective solutions. Contact us for inquiries. Committed to serving you.However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

Bioactivity

Description	Sardomozide is an inhibitor of S-adenosylmethionine decarboxylase (SAMDC)(IC50 of 5 nM).
Targets&IC50	SAMDC:5 nM
In vitro	Sardomozide acts as an inhibitor of S-adenosylmethionine decarboxylase (SAMDC), showing potency with an IC50 value of 5 nM in cell assays. With a 48-hour exposure to 3 μM of Sardomozide, the activity of intracellular SAMDC is diminished to 10% compared to the control[1]. Additionally, in cells grown in the presence of Sardomozide, specifically CHO/664 cells treated with DENSPM, there is an absence of vacuole formation. These cells also exhibit inhibited growth and maintain DENSPM levels comparable to those in parental CHO cells[2].
Synonyms	SAM-486A, CGP 48664

Chemical Properties

Molecular Weight	230.27
Formula	C₁₁H₁₄N₆
Cas No.	149400-88-4
Smiles	C(=N)(N)C1=C2C(C(=NNC(=N)N)CC2)=CC=C1
Relative Density.	1.54 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

SardomozideSAMDCCGP-48664CGP48664