Shopping Cart

Remove All

Your shopping cart is currently empty

Proceed to checkout Continue shopping

Conantokin-R

Name: Conantokin-R
Brand: TargetMol
SKU: T38388
Rating: 4.5 (1 reviews)

😃Good

Catalog No. T38388Cas No. 202925-60-8

Conantokin-R is an NMDA receptor peptide antagonist (IC50=93 nM); Conantokin-R exhibits anticonvulsant activity; Conantokin-R binds Zn2+ and Mg2+ (Kds 0.15 μM and 6.5 μM, respectively).

Conantokin-R

😃Good

Catalog No. T38388Cas No. 202925-60-8

Conantokin-R is an NMDA receptor peptide antagonist (IC50=93 nM); Conantokin-R exhibits anticonvulsant activity; Conantokin-R binds Zn2+ and Mg2+ (Kds 0.15 μM and 6.5 μM, respectively).

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
2 mg	$1,250	Inquiry	Inquiry

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Resource Download

Product Introduction

Bioactivity

Description

Conantokin-R is an NMDA receptor peptide antagonist (IC50=93 nM); Conantokin-R exhibits anticonvulsant activity; Conantokin-R binds Zn2+ and Mg2+ (Kds 0.15 μM and 6.5 μM, respectively).

Chemical Properties

Molecular Weight	3098.38
Formula	C₁₂₇H₂₀₁N₃₅O₄₉S₃
Cas No.	202925-60-8
Smiles	CC[C@H](C)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C(O)=O)C(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C(O)=O)C(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C(O)=O)C(O)=O)NC(=O)[C@H](CC(C(O)=O)C(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)CN)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC1=O)C(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(O)=O \|@@:135\|
Sequence	Gly-Glu-{Gla}-{Gla}-Val-Ala-Lys-Met-Ala-Ala-{Gla}-Leu-Ala-Arg-{Gla}-Asn-Ile-Ala-Lys-Gly-Cys-Lys-Val-Asn-Cys-Tyr-Pro (Disulfide bridge:Cys21-Cys25)
Sequence Short	GE-{Gla}-{Gla}-VAKMAA-{Gla}-LAR-{Gla}-NIAKGCKVNCYP (Disulfide bridge:Cys21-Cys25)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mM, Sonication is recommended.

Ethanol: 40 mM, Sonication is recommended.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	0.3227 mL	1.6137 mL	3.2275 mL	16.1375 mL
5 mM	0.0645 mL	0.3227 mL	0.6455 mL	3.2275 mL
10 mM	0.0323 mL	0.1614 mL	0.3227 mL	1.6137 mL
20 mM	0.0161 mL	0.0807 mL	0.1614 mL	0.8069 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0065 mL	0.0323 mL	0.0645 mL	0.3227 mL
100 mM	0.0032 mL	0.0161 mL	0.0323 mL	0.1614 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc