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Bucetin

Name: Bucetin
Brand: TargetMol
SKU: T0442
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0442Cas No. 1083-57-4

Alias 3-Hydroxy-p-butyrophenetidide

Bucetin (3-Hydroxy-p-butyrophenetidide) is a pharmaceutical drug that functions as an analgesic and antipyretic. It was withdrawn from use in 1986 due to renal toxicity.

Bucetin

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Purity: 99.60%

Catalog No. T0442Alias 3-Hydroxy-p-butyrophenetidideCas No. 1083-57-4

Bucetin (3-Hydroxy-p-butyrophenetidide) is a pharmaceutical drug that functions as an analgesic and antipyretic. It was withdrawn from use in 1986 due to renal toxicity.

Pack Size	Price	USA Warehouse	Global Warehouse
100 mg	$30	In Stock	In Stock
500 mg	$67	In Stock	In Stock
1 g	$98	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$30	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.60%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bucetin AI Summary

Bucetin demonstrates various antiviral activities. In studies involving Ebola virus, it blocks viral entry with an AC50 value of 44.67 µM and 44668.4 nM in specific screenings. For SARS-CoV-2, compound 1078605 shows limited effectiveness; it exhibits an inhibition index of 0.7181 in Vero E6 cell viability assays and a negative inhibition percentage of -1.39% and -0.08% in cytotoxicity assays using Caco-2 and Vero-6 cells, respectively. Additionally, it inhibits the SARS-CoV-2 3CL-Pro protease by 12.55% at 20 µM and has an IC50 value greater than 19952.62 nM in Vero-6 cell assays, indicating moderate to weak antiviral activity under tested conditions. Furthermore, compound 1078605 inhibits the human HDAC6 enzyme with varying inhibition rates of -26.19% and -8.25%, depending on the peptide substrate used in the enzymatic assays..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Bucetin (3-Hydroxy-p-butyrophenetidide) is a pharmaceutical drug that functions as an analgesic and antipyretic. It was withdrawn from use in 1986 due to renal toxicity.
Synonyms	3-Hydroxy-p-butyrophenetidide

Chemical Properties

Molecular Weight	223.27
Formula	C₁₂H₁₇NO₃
Cas No.	1083-57-4
Smiles	CCOc1ccc(NC(=O)CC(C)O)cc1
Relative Density.	1.1223 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 6 mg/mL (26.87 mM), Sonication is recommended.

DMSO: 50 mg/mL (223.94 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	4.4789 mL	22.3944 mL	44.7888 mL	223.9441 mL
5 mM	0.8958 mL	4.4789 mL	8.9578 mL	44.7888 mL
10 mM	0.4479 mL	2.2394 mL	4.4789 mL	22.3944 mL
20 mM	0.2239 mL	1.1197 mL	2.2394 mL	11.1972 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0896 mL	0.4479 mL	0.8958 mL	4.4789 mL
100 mM	0.0448 mL	0.2239 mL	0.4479 mL	2.2394 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc