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tCFA15

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Catalog No. T13917Cas No. 220757-88-0

tCFA15, a trimethyl cyclohexenonic long-chain fatty alcohol with a 15-carbon atom side chain, may regulate Notch signaling and promote neuronal differentiation.

tCFA15

tCFA15

😃Good
Catalog No. T13917Cas No. 220757-88-0
tCFA15, a trimethyl cyclohexenonic long-chain fatty alcohol with a 15-carbon atom side chain, may regulate Notch signaling and promote neuronal differentiation.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
5 mg$3156-8 weeks6-8 weeks
25 mg$9876-8 weeks6-8 weeks
50 mg$1,3606-8 weeks6-8 weeks
100 mg$1,9906-8 weeks6-8 weeks
1 mL x 10 mM (in DMSO)$3186-8 weeks6-8 weeks
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
tCFA15, a trimethyl cyclohexenonic long-chain fatty alcohol with a 15-carbon atom side chain, may regulate Notch signaling and promote neuronal differentiation.
In vitro
tCFA15 (10 nM-1μM) dose-dependently promotes the differentiation of neural stem cell-derived neurospheres by promoting neurons at the expense of astrocytes, and this effect is through Notch1. tCFA15 (1 μM) specifically decreases the level of Notch1 mRNA in spheres, and such an effect is also observed in decreases Notch1 expression in neuronal and glial cell cultures[1]. tCFA15 stimulates arginine vasopressin secretion in nerve terminals of the neurohypophysis[2].
Chemical Properties
Molecular Weight364.61
FormulaC24H44O2
Cas No.220757-88-0
Relative Density.0.910 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 130 mg/mL (356.55 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (9.05 mM), Sonication is recommeded.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.7427 mL13.7133 mL27.4266 mL137.1328 mL
5 mM0.5485 mL2.7427 mL5.4853 mL27.4266 mL
10 mM0.2743 mL1.3713 mL2.7427 mL13.7133 mL
20 mM0.1371 mL0.6857 mL1.3713 mL6.8566 mL
50 mM0.0549 mL0.2743 mL0.5485 mL2.7427 mL
100 mM0.0274 mL0.1371 mL0.2743 mL1.3713 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

tCFA-15tCFA15Notch1
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