D,L-erythro-PDMP, an erythro isomer of PDMP, exhibits growth inhibition on cultured rabbit skin fibroblasts. Additionally, this compound serves as an effective inhibitor of UDP-glucose: ceramide glucosyltransferase.

D,L-erythro-PDMP at concentrations of 0, 12, 25, 50 μM over periods of 0, 4, 7, and 10 days demonstrates a dose-dependent inhibition of rabbit skin fibroblast proliferation, as evidenced by reduced cell growth[1]. A concentration of 50 μM of D,L-erythro-PDMP, when applied for 3 days, results in cytotoxic effects, altering the cell morphology of rabbit skin fibroblasts[1]. Furthermore, treatment with D,L-erythro-PDMP at a concentration of 40 μM for 24 hours in MDCK cells leads to a significant increase in glucosyltransferase activity, quantified at 14.6 nmol/h per mg of protein[2]. Additionally, a 40 μM concentration of D,L-erythro-PDMP administered for 6 hours offers protective effects against synthase loss in cells challenged with cycloheximide[2]. These findings are supported by cell proliferation and cytotoxicity assays on rabbit skin fibroblast cell lines, illustrating D,L-erythro-PDMP's capacity to modulate cell growth and viability in a concentration and time-dependent manner[1].