Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PKSI-527 is an inhibitor of plasma kallikrein (Ki = 0.81 μM). It is selective for plasma kallikrein over glandular kallikrein, plasmin, thrombin, urokinase, and Factor Xa (Kis = <500, 390, <500, 200, and <500 μM, respectively). PKSI-527 reduces bradykinin generation induced by kaolin and λ-carrageenan ex vivo in human plasma. It also prolongs partial thromboplastin and euglobulin clot lysis times.
Pack Size | Availability | Price/USD | Quantity |
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2 mg | 5 days | $ 78.00 |
Description | PKSI-527 is an inhibitor of plasma kallikrein (Ki = 0.81 μM). It is selective for plasma kallikrein over glandular kallikrein, plasmin, thrombin, urokinase, and Factor Xa (Kis = >500, 390, >500, 200, and >500 μM, respectively). PKSI-527 reduces bradykinin generation induced by kaolin and λ-carrageenan ex vivo in human plasma. It also prolongs partial thromboplastin and euglobulin clot lysis times. |
In vivo | In vivo, PKSI-527 (300 mg/kg per day) reduces hyperplasia, pannus formation, and infiltration of inflammatory cells in the tarsal joint of mice with collagen-induced arthritis. |
Molecular Weight | 473.99 |
Formula | C25H32ClN3O4 |
CAS No. | 128837-71-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 10 mM
You can also refer to dose conversion for different animals. More
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PKSI-527 128837-71-8 PKSI 527 PKSI527 inhibitor inhibit