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SR 1555 (hydrochloride) (1386439-51-5 free base)
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Catalog No. T23387
Alias SR 1555 (hydrochloride)
SR 1555 is a novel RORγ-specific synthetic ligand.
SR 1555 (hydrochloride) (1386439-51-5 free base)
😃Good
Catalog No. T23387Alias SR 1555 (hydrochloride)
SR 1555 is a novel RORγ-specific synthetic ligand.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $148 | 4-6 weeks | |
| 10 mg | $263 | 4-6 weeks | |
| 25 mg | $576 | 4-6 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | SR 1555 is a novel RORγ-specific synthetic ligand. |
| In vitro | In vitro: In a GAL4-NR chimeric co-transfection assay, SR1555 was devoid of LXR, FXR, and RORα activity, but it dose-dependently repressed the activity at RORγ (IC50: ≈ 1.5 μM). In competitive radioligand binding assays, SR1555 bound to RORγ (IC50: 1 μM). SR1555 specifically targeted RORγ and inhibited its transcriptional activity leading to suppression of IL-17 gene expression. EL4 cells treated SR1555 (10 μM) for 24 h inhibited Il17a gene expression by greater than 70%, demonstrating that SR1555 could inhibit the expression of this TH17 mediated cytokine. SR1555 not only inhibited TH17 cell development and function but also increased the frequency of T regulatory cells [1]. |
| Synonyms | SR 1555 (hydrochloride) |
| Molecular Weight | 496.9 |
| Formula | C22H22F6N2O2·HCl |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||
| Solubility Information | Ethanol: ≤1.6 mg/mL, Sonication is recommended. DMSO: 3 mg/mL (6.04 mM), Sonication is recommended. | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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