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SR 1555 (hydrochloride) (1386439-51-5 free base)
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Catalog No. T23387
Alias SR 1555 (hydrochloride)
SR 1555 is a novel RORγ-specific synthetic ligand.
SR 1555 (hydrochloride) (1386439-51-5 free base)
Copy Product Info😃Good
Catalog No. T23387Alias SR 1555 (hydrochloride)
SR 1555 is a novel RORγ-specific synthetic ligand.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 mg | $148 | 4-6 weeks | 4-6 weeks | |
| 10 mg | $263 | 4-6 weeks | 4-6 weeks | |
| 25 mg | $576 | 4-6 weeks | 4-6 weeks |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | SR 1555 is a novel RORγ-specific synthetic ligand. |
| In vitro | In vitro: In a GAL4-NR chimeric co-transfection assay, SR1555 was devoid of LXR, FXR, and RORα activity, but it dose-dependently repressed the activity at RORγ (IC50: ≈ 1.5 μM). In competitive radioligand binding assays, SR1555 bound to RORγ (IC50: 1 μM). SR1555 specifically targeted RORγ and inhibited its transcriptional activity leading to suppression of IL-17 gene expression. EL4 cells treated SR1555 (10 μM) for 24 h inhibited Il17a gene expression by greater than 70%, demonstrating that SR1555 could inhibit the expression of this TH17 mediated cytokine. SR1555 not only inhibited TH17 cell development and function but also increased the frequency of T regulatory cells [1]. |
| Synonyms | SR 1555 (hydrochloride) |
| Molecular Weight | 496.9 |
| Formula | C22H22F6N2O2·HCl |
| Smiles | O=C(C)N(CC1)CCN1CC2=CC=C(C3=CC=C(C(O)(C(F)(F)F)C(F)(F)F)C=C3)C=C2.Cl |
| Relative Density. | no data available |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||
| Solubility Information | Ethanol: ≤1.6 mg/mL, Sonication is recommended. DMSO: 3 mg/mL (6.04 mM), Sonication is recommended. | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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