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UCB-J

Catalog No. T39069 CAS 1604786-87-9

UCB-J is a radioligand for the synaptic vesicle protein 2A (SV2A), utilized in positron emission tomography (PET)[4].

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UCB-J, CAS 1604786-87-9

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

UCB-J is a radioligand for the synaptic vesicle protein 2A (SV2A), utilized in positron emission tomography (PET)[4].

In vivo

UCB-J demonstrates a significant unbound fraction (0.46 ± 0.02) and undergoes moderate metabolic rates in plasma, with 39% ± 5% and 24% ± 3% of the parent compound remaining after 30 and 90 minutes, respectively[3]. This compound also exhibits substantial uptake and rapid kinetics within the monkey brain[3]. Notably, pretreatment of an animal with UCB-J (150 μg/kg, iv) results in a reduction of the whole brain Standard Uptake Value (SUV) to levels comparable to those of the centrum semiovale, thereby highlighting [18F]7's in vivo binding specificity towards SV2A[4].

Molecular Weight	320.315
Formula	C17H15F3N2O
CAS No.	1604786-87-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Joël Mercier, et al. Discovery of heterocyclic nonacetamide synaptic vesicle protein 2A (SV2A) ligands with single-digit nanomolar potency: opening avenues towards the first SV2A positron emission tomography (PET) ligands. ChemMedChem. 2014 Apr;9(4):693-8. 2. Aline Delva, et al. Loss of Presynaptic Terminal Integrity in the Substantia Nigra in Early Parkinson's Disease. Mov Disord. 2020 Aug 7. 3. Nabeel B Nabulsi, et al. Synthesis and Preclinical Evaluation of 11C-UCB-J as a PET Tracer for Imaging the Synaptic Vesicle Glycoprotein 2A in the Brain. J Nucl Med. 2016 May;57(5):777-84. 4. Zhengxin Cai, et al. Synthesis and Preclinical Evaluation of an 18 F-Labeled Synaptic Vesicle Glycoprotein 2A PET Imaging Probe: [ 18 F]SynVesT-2. ACS Chem Neurosci. 2020 Feb 19;11(4):592-603.

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Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

UCB-J 1604786-87-9 UCB J UCBJ inhibitor inhibit

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