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midesteine

Name: midesteine
Brand: TargetMol
SKU: T68099
Price: 46 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T68099Cas No. 94149-41-4

Alias MR-889

Midesteine (MR-889) is a small molecule neutrophil elastase inhibitor used in the treatment of bronchitis, asthma and chronic lung disease.

midesteine

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Purity: 99.98%

Catalog No. T68099Alias MR-889Cas No. 94149-41-4

Midesteine (MR-889) is a small molecule neutrophil elastase inhibitor used in the treatment of bronchitis, asthma and chronic lung disease.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$46	In Stock	In Stock
5 mg	$113	In Stock	In Stock
10 mg	$168	In Stock	In Stock
25 mg	$281	In Stock	In Stock
50 mg	$398	In Stock	In Stock
100 mg	$569	In Stock	In Stock
200 mg	$796	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.98%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

midesteine AI Summary

midesteine inhibits human neutrophil elastase with an IC50 value of 1000.0 nM. The inhibition was measured using N-methylsuccinyl-Ala-Ala-Pro-Val-7-amino-4-methyl-coumarin as the substrate, monitored every 30 seconds for 10 minutes by a fluorescence microplate reader. Additionally, midesteine demonstrates activity in inhibiting neutrophil elastase in human whole blood, with a Ki value of 1400.0 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Midesteine (MR-889) is a small molecule neutrophil elastase inhibitor used in the treatment of bronchitis, asthma and chronic lung disease.
Synonyms	MR-889

Chemical Properties

Molecular Weight	315.43
Formula	C₁₂H₁₃NO₃S₃
Cas No.	94149-41-4
Smiles	N(C(C(SC(=O)C1=CC=CS1)C)=O)C2C(=O)SCC2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (158.51 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1703 mL	15.8514 mL	31.7028 mL	158.5138 mL
5 mM	0.6341 mL	3.1703 mL	6.3406 mL	31.7028 mL
10 mM	0.3170 mL	1.5851 mL	3.1703 mL	15.8514 mL
20 mM	0.1585 mL	0.7926 mL	1.5851 mL	7.9257 mL
50 mM	0.0634 mL	0.3170 mL	0.6341 mL	3.1703 mL
100 mM	0.0317 mL	0.1585 mL	0.3170 mL	1.5851 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc