5-cis Carbaprostacyclin

Name: 5-cis Carbaprostacyclin
Brand: TargetMol
SKU: T36236
Rating: 4.5 (1 reviews)

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Catalog No. T36236Cas No. 69609-77-4

5-cis Carbaprostacyclin, a stable analog of PGI2 and an isomer of carbaprostacyclin, is a weak inhibitor of human platelet aggregation with an IC50 of 2.8 μM compared to 0.3 μM for carbaprostacyclin. It is a much weaker effector of rabbit mesenteric artery relaxation with an EC50 of 104 μM compared to 5.9 μM for carbaprostacyclin and even antagonizes the adenylate cyclase activation induced by carbaprostacyclin.

5-cis Carbaprostacyclin

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Catalog No. T36236Cas No. 69609-77-4

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
500 μg	$398	35 days	35 days
1 mg	$753	35 days	35 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Product Introduction

Bioactivity

Description

Chemical Properties

Molecular Weight	350.49
Formula	C₂₁H₃₄O₄
Cas No.	69609-77-4
Smiles	C(=C/[C@H](CCCCC)O)\[C@@H]1[C@@]2([C@@](C\C(=C\CCCC(O)=O)\C2)(C[C@H]1O)[H])[H]

Storage & Solubility Information

Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Solubility Information	Ethanol: >20 mg/mL (from 6B-PGI2), Sonication is recommended. DMF: >10 mg/mL (from 6B-PGI2), Sonication is recommended. DMSO: >5 mg/mL (from 6B-PGI2), Sonication is recommended. PBS (pH 7.2): >80 μg/mL (from 6B-PGI2), Sonication is recommended.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc