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Norflurazon

Name: Norflurazon
Brand: TargetMol
SKU: T8176
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T8176Cas No. 27314-13-2

Norflurazon is an excellent weed controlling agent being practiced in the agricultural lands.

Norflurazon

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Purity: 99.69%

Catalog No. T8176Cas No. 27314-13-2

Norflurazon is an excellent weed controlling agent being practiced in the agricultural lands.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$35	-	In Stock
5 mg	$56	In Stock	In Stock
10 mg	$98	-	In Stock
25 mg	$162	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.69%

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Norflurazon AI Summary

Norflurazon exhibits diverse bioactivities, functioning as both an agonist and antagonist in various receptor pathways and showcasing significant herbicidal and phytotoxic properties. It acts as an agonist for retinoid X receptor alpha, androgen receptor, Aryl hydrocarbon Receptor (AhR), rat pregnane X receptor (rPXR), human pregnane X receptor (PXR), and the antioxidant response element (ARE) signaling pathways, with potencies ranging from 10,870.7 nM to 50,118.7 nM. Additionally, it demonstrates antagonistic activity towards androgen receptor signaling with a potency of 39,810.7 nM. In terms of herbicidal activity, Norflurazon effectively inhibits the growth of Poa annua (99.0% at 32 ppm) and Arabidopsis thaliana (99.0% at 10 ppm). It also provides 100% residual control of glyphosate-resistant Conyza canadensis (horseweed) at 1680 g a.i./ha when applied in autumn and spring, 4 to 8 weeks post-treatment. The compound is also active against Glycine max (soybean) under various soil conditions, inducing chlorophyll bleaching in shoots with IC50 values between 0.08 mg kg-1 and 1.98 mg kg-1 depending on soil type and pH. Phytotoxic effects of Norflurazon are observed in Scenedesmus acutus, showing IC50 values of 208.93 nM for growth inhibition, 186.21 nM for reduced chlorophyll levels, and 208.93 nM for inhibition of carotenoid biosynthesis. Furthermore, Norflurazon inhibits phytoene desaturase enzymes from Capsicum annuum (pepper) and Synechococcus PCC 7942 with IC50 values of 29.0 nM and 31.62 nM, respectively, within 8 hours as determined using Dixon plot analysis. This inhibition impacts colored carotenoid formation in both cell-free and cellular assays, demonstrating its broad-spectrum herbicidal efficacy..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Norflurazon is an excellent weed controlling agent being practiced in the agricultural lands.

Chemical Properties

Molecular Weight	303.67
Formula	C₁₂H₉ClF₃N₃O
Cas No.	27314-13-2
Smiles	CNC1=C(Cl)C(=O)N(N=C1)C1=CC(=CC=C1)C(F)(F)F
Relative Density.	1.4395 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 25 mg/mL (82.33 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2930 mL	16.4652 mL	32.9305 mL	164.6524 mL
5 mM	0.6586 mL	3.2930 mL	6.5861 mL	32.9305 mL
10 mM	0.3293 mL	1.6465 mL	3.2930 mL	16.4652 mL
20 mM	0.1647 mL	0.8233 mL	1.6465 mL	8.2326 mL
50 mM	0.0659 mL	0.3293 mL	0.6586 mL	3.2930 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc