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Conophylline
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Catalog No. T13624Cas No. 142741-24-0
Conophylline is a natural alkaloid extracted from a tropical plant Ervatamia microphylla. Conophylline is a differentiation inducer of for pancreatic cells and suppresses HSC and induces apoptosis.
Conophylline
😃Good
Catalog No. T13624Cas No. 142741-24-0
Conophylline is a natural alkaloid extracted from a tropical plant Ervatamia microphylla. Conophylline is a differentiation inducer of for pancreatic cells and suppresses HSC and induces apoptosis.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 mg | $1,690 | Inquiry | Inquiry |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Conophylline is a natural alkaloid extracted from a tropical plant Ervatamia microphylla. Conophylline is a differentiation inducer of for pancreatic cells and suppresses HSC and induces apoptosis. |
| In vitro | Conophylline (100 ng/ml; 48 hours) reproduces differentiation-inducing activity but not the apoptosis-inducing activity of activin. Conophylline (100 ng/ml; 72 hours) exhibits the differentiation-inducing activity in AR42J cells and converts these cells to endocrine cells. Conophylline increases the expression of neurogenin-3 by activating p38 mitogen-activated protein kinase to induce differentiation of AR42J cells [1]. Conophylline inhibits DNA synthesis induced by serum. Conophylline reduces the expression of α-SMA and collagen-1 in rat HSC and Lx-2 cells. Conophylline also promotes activation of caspase-3 and induces apoptosis in Lx-2 Cells [2]. |
| In vivo | Conophylline (0.9 mg/kg; p.o.; daily; for 12 weeks) attenuates the formation of the liver fibrosis induced by TAA in vivo [2]. |
| Molecular Weight | 794.89 |
| Formula | C44H50N4O10 |
| Cas No. | 142741-24-0 |
| Smiles | CCC12CC(C(=O)OC)=C3Nc4cc5OC6C(N7CCC89C7C(CC)(CC(C(=O)OC)=C8Nc7c9cc(O)c(OC)c7OC)C6O)c5cc4C33CCN(CC4OC14)C23 |
| Relative Density. | 1.53 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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