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Orotirelin

Name: Orotirelin
Brand: TargetMol
SKU: T33824
Price: 258 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T33824Cas No. 62305-86-6

Alias Orotireline, CG 3509

Orotirelin(CG 3509), a thyrotropin-releasing hormone analog, reversed pentobarbital-induced sleep time.Orotirelin may be beneficial in animals with focal cerebral ischemia.

Orotirelin

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Purity: 98.92%

Catalog No. T33824Alias Orotireline, CG 3509Cas No. 62305-86-6

Orotirelin(CG 3509), a thyrotropin-releasing hormone analog, reversed pentobarbital-induced sleep time.Orotirelin may be beneficial in animals with focal cerebral ischemia.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$258	In Stock	In Stock
5 mg	$642	In Stock	In Stock
10 mg	$913	In Stock	In Stock
25 mg	$1,370	In Stock	In Stock
50 mg	$1,850	In Stock	In Stock
100 mg	$2,500	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.92%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Orotirelin(CG 3509), a thyrotropin-releasing hormone analog, reversed pentobarbital-induced sleep time.Orotirelin may be beneficial in animals with focal cerebral ischemia.
In vivo	CG 3509 (2 μg; intrathecal administration; twice daily for 5 days; adult rats) on wet-dog shake (WDS) and forepaw-licking (FPL) behaviours and spinal cord TRH and indoleamine levels and choline acetyltransferase (ChAT) activity was examined. A rapid behavioural tolerance developed to repeated intrathecal injections of CG 3509; WDS and FPL behaviours were reduced by 57% and 34%, respectively, following the fifth injection and remained reduced at the ninth injection. Repeated CG 3509 administration selectively elevated ChAT activity and the level of 5-hydroxytryptamine (5-HT) in the ventral but not in the dorsal horn of the spinal cord, while 5-hydroxy indole acetic acid and TRH levels were unaltered in either region.[2]
Synonyms	Orotireline, CG 3509

Chemical Properties

Molecular Weight	389.37
Formula	C₁₆H₁₉N₇O₅
Cas No.	62305-86-6
Smiles	C([C@H](CC1=CN=CN1)NC(=O)C2=CC(=O)NC(=O)N2)(=O)N3[C@H](C(N)=O)CCC3
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (128.41 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5683 mL	12.8413 mL	25.6825 mL	128.4126 mL
5 mM	0.5137 mL	2.5683 mL	5.1365 mL	25.6825 mL
10 mM	0.2568 mL	1.2841 mL	2.5683 mL	12.8413 mL
20 mM	0.1284 mL	0.6421 mL	1.2841 mL	6.4206 mL
50 mM	0.0514 mL	0.2568 mL	0.5137 mL	2.5683 mL
100 mM	0.0257 mL	0.1284 mL	0.2568 mL	1.2841 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc