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Orotirelin

🥰Excellent
Catalog No. T33824Cas No. 62305-86-6
Alias Orotireline, CG 3509

Orotirelin(CG 3509), a thyrotropin-releasing hormone analog, reversed pentobarbital-induced sleep time.Orotirelin may be beneficial in animals with focal cerebral ischemia.

Orotirelin

Orotirelin

🥰Excellent
Purity: 99.08%
Catalog No. T33824Alias Orotireline, CG 3509Cas No. 62305-86-6
Orotirelin(CG 3509), a thyrotropin-releasing hormone analog, reversed pentobarbital-induced sleep time.Orotirelin may be beneficial in animals with focal cerebral ischemia.
Pack SizePriceAvailabilityQuantity
1 mg$258In Stock
5 mg$642In Stock
10 mg$913In Stock
25 mg$1,370In Stock
50 mg$1,850In Stock
100 mg$2,500In Stock
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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Purity:99.08%
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Product Introduction

Bioactivity
Description
Orotirelin(CG 3509), a thyrotropin-releasing hormone analog, reversed pentobarbital-induced sleep time.Orotirelin may be beneficial in animals with focal cerebral ischemia.
In vivo
CG 3509 (2 μg; intrathecal administration; twice daily for 5 days; adult rats) on wet-dog shake (WDS) and forepaw-licking (FPL) behaviours and spinal cord TRH and indoleamine levels and choline acetyltransferase (ChAT) activity was examined. A rapid behavioural tolerance developed to repeated intrathecal injections of CG 3509; WDS and FPL behaviours were reduced by 57% and 34%, respectively, following the fifth injection and remained reduced at the ninth injection. Repeated CG 3509 administration selectively elevated ChAT activity and the level of 5-hydroxytryptamine (5-HT) in the ventral but not in the dorsal horn of the spinal cord, while 5-hydroxy indole acetic acid and TRH levels were unaltered in either region.[2]
AliasOrotireline, CG 3509
Chemical Properties
Molecular Weight389.37
FormulaC16H19N7O5
Cas No.62305-86-6
SmilesC([C@H](CC1=CN=CN1)NC(=O)C2=CC(=O)NC(=O)N2)(=O)N3[C@H](C(N)=O)CCC3
Relative Density.1.31g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 50 mg/mL (128.41 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.5683 mL12.8413 mL25.6825 mL128.4126 mL
5 mM0.5137 mL2.5683 mL5.1365 mL25.6825 mL
10 mM0.2568 mL1.2841 mL2.5683 mL12.8413 mL
20 mM0.1284 mL0.6421 mL1.2841 mL6.4206 mL
50 mM0.0514 mL0.2568 mL0.5137 mL2.5683 mL
100 mM0.0257 mL0.1284 mL0.2568 mL1.2841 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
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