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Antisauvagine-30 TFA (220673-95-0 free base)
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Catalog No. T10338
Alias aSvg-30 TFA, Antisauvagine-30 TFA
Antisauvagine-30 TFA (aSvg-30 TFA) is a highly selective and competitive antagonist of CRF2 receptor peptidic. It shows a Kd of 1.4 nM and 150 nM for mCRFR2β and CRFR1, respectively.
Antisauvagine-30 TFA (220673-95-0 free base)
😃Good
Catalog No. T10338Alias aSvg-30 TFA, Antisauvagine-30 TFA
Antisauvagine-30 TFA (aSvg-30 TFA) is a highly selective and competitive antagonist of CRF2 receptor peptidic. It shows a Kd of 1.4 nM and 150 nM for mCRFR2β and CRFR1, respectively.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $531 | Backorder | |
| 5 mg | $1,586 | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Antisauvagine-30 TFA (aSvg-30 TFA) is a highly selective and competitive antagonist of CRF2 receptor peptidic. It shows a Kd of 1.4 nM and 150 nM for mCRFR2β and CRFR1, respectively. |
| Targets&IC50 | CRFR2β (mouse):(kd)1.4 nM , CRFR1:150 nM (kd) |
| In vitro | Antisauvagine-30 prevents stress-enhanced fear conditioning and Mek-1/2-dependent activation of Erk-1/2 and p90Rsk-1. It did not affect the phosphorylation of the PKA regulatory subunit II of stressed mice [1][2]. |
| In vivo | Antisauvagine-30 (i.h. 400 ng/0.5 μl per mouse) selectively prevents the stress-induced enhancement of fear conditioning without affecting the fear conditioning of nonstressed mice[2]. Antisauvagine-30 injected i.c.v. elicits a significant anxiogenic effect [3]. |
| Synonyms | aSvg-30 TFA, Antisauvagine-30 TFA |
| Molecular Weight | 3764.28 |
| Formula | C163H275N48F3O49S |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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