Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Glucagon receptor antagonist I is a competitive antagonist of the glucagon receptor (GCGR; IC50 = 181 nM). It blocks glucagon-induced glycogenolysis in primary human hepatocytes and isolated liver. Glucagon receptor antagonist I, at 50 mg/kg, reduces the increase in glucose levels observed after intraperitoneal administration of glucagon in humanized mice. Glucagon receptor antagonist inactive control does not prevent glucagon-mediated actions.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | 35 days | $ 330.00 | |
5 mg | 35 days | $ 1,190.00 |
Description | Glucagon receptor antagonist I is a competitive antagonist of the glucagon receptor (GCGR; IC50 = 181 nM). It blocks glucagon-induced glycogenolysis in primary human hepatocytes and isolated liver. Glucagon receptor antagonist I, at 50 mg/kg, reduces the increase in glucose levels observed after intraperitoneal administration of glucagon in humanized mice. Glucagon receptor antagonist inactive control does not prevent glucagon-mediated actions. |
Molecular Weight | 346.53 |
Formula | C20H30N2OS |
CAS No. | 438618-32-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: Soluble
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Glucagon Receptor Antagonist I 438618-32-7 inhibitor inhibit