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Emixustat

Name: Emixustat
Brand: TargetMol
SKU: T11188
Rating: 4.5 (1 reviews)

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Catalog No. T11188Cas No. 1141777-14-1

Alias ACU-4429

Emixustat, is an inhibitor of the visual cycle isomerase with an IC50 value of 4.4 nM in vitro. a novel visual cycle modulator.

Emixustat

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Catalog No. T11188Alias ACU-4429Cas No. 1141777-14-1

Emixustat, is an inhibitor of the visual cycle isomerase with an IC50 value of 4.4 nM in vitro. a novel visual cycle modulator.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$98	5 days	5 days
5 mg	$226	5 days	5 days
25 mg	$766	1-2 weeks	1-2 weeks
50 mg	$996	1-2 weeks	1-2 weeks
100 mg	$1,740	1-2 weeks	1-2 weeks
1 mL x 10 mM (in DMSO)	$189	5 days	5 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	Emixustat, is an inhibitor of the visual cycle isomerase with an IC50 value of 4.4 nM in vitro. a novel visual cycle modulator.
Targets&IC50	Visual cycle isomerase:4.4 nM
In vitro	Emixustat strongly inhibits 11-cis-retinol production with an IC50 value of 232±3 nM.Emixustat potently inhibits isomerase activity in vitro (IC50=4.4 nM). Treatment of emixustat shows a concentration dependent reduction of 11-cis-ROL production .
In vivo	Pre-treatment with a single dose of emixustat (0.3 mg/kg) provides a 50% protective effect against light-induced photoreceptor cell loss, while higher doses (1-3 mg/kg) are nearly 100% effective. In Abca4-/- mice, chronic (3-month) emixustat treatment markedly reduces lipofuscin autofluorescence and lowers A2E levels by 60% (ED50=0.47 mg/kg). In the retinopathy of prematurity rodent model, emixustat administered during ischemia and reperfusion injury results in a 30% reduction in retinal neovascularization (ED50=0.46 mg/kg). Emixustat reduces the production of visual chromophore (11-cis retinal) in wild-type mice after a single oral dose (ED50=0.18 mg/kg). In albino mice, emixustat effectively prevents photoreceptor cell death caused by intense light exposure.
Synonyms	ACU-4429

Chemical Properties

Molecular Weight	263.38
Formula	C₁₆H₂₅NO₂
Cas No.	1141777-14-1
Smiles	NCC[C@@H](O)c1cccc(OCC2CCCCC2)c1
Relative Density.	1.065 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 43 mg/mL (163.26 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7968 mL	18.9840 mL	37.9680 mL	189.8398 mL
5 mM	0.7594 mL	3.7968 mL	7.5936 mL	37.9680 mL
10 mM	0.3797 mL	1.8984 mL	3.7968 mL	18.9840 mL
20 mM	0.1898 mL	0.9492 mL	1.8984 mL	9.4920 mL
50 mM	0.0759 mL	0.3797 mL	0.7594 mL	3.7968 mL
100 mM	0.0380 mL	0.1898 mL	0.3797 mL	1.8984 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

visual cycle isomeraseEmixustatACU4429ACU 4429