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Coproporphyrin III

Name: Coproporphyrin III
Brand: TargetMol
SKU: T19247
Rating: 4.5 (1 reviews)

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Catalog No. T19247Cas No. 14643-66-4

Alias Zincphyrin

Coproporphyrin III is a derivative of porphyrin.

Coproporphyrin III

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Catalog No. T19247Alias ZincphyrinCas No. 14643-66-4

Coproporphyrin III is a derivative of porphyrin.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
50 mg	Inquiry	Inquiry	Inquiry

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	Coproporphyrin III is a derivative of porphyrin.
In vitro	Coproporphyrin III methyl ester is repeatedly isolated in a considerable amount from both feces and urine. A great increase of coproporphyrin III excretion is unaccompanied by symptoms or signs of porphyria, metal, or chemical poisoning or liver disease [1]. In the presence of the porphyrin precursor, 5-aminolevulinate (ALA), the addition of insulin causes a striking increase in the accumulation of uroporphyrin I and coproporphyrin III. Antioxidants abolish the uroporphyrin I accumulation and increases coproporphyrin III [2].
In vivo	Urinary porphyrin and DMA profile can be used as an early warning biomarker for chronic MMA exposure before the onset of cancer. After 4 weeks the level of coproporphyrin III concentration significantly increases in all the treatment groups compared to the control [3].
Synonyms	Zincphyrin

Chemical Properties

Molecular Weight	654.72
Formula	C₃₆H₃₈N₄O₈
Cas No.	14643-66-4
Smiles	Cc1c(CCC(O)=O)c2cc3[nH]c(cc4nc(cc5[nH]c(cc1n2)c(C)c5CCC(O)=O)c(C)c4CCC(O)=O)c(C)c3CCC(O)=O
Relative Density.	1.366 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 83.3 mg/mL (127.23 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (5.04 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5274 mL	7.6369 mL	15.2737 mL	76.3685 mL
5 mM	0.3055 mL	1.5274 mL	3.0547 mL	15.2737 mL
10 mM	0.1527 mL	0.7637 mL	1.5274 mL	7.6369 mL
20 mM	0.0764 mL	0.3818 mL	0.7637 mL	3.8184 mL
50 mM	0.0305 mL	0.1527 mL	0.3055 mL	1.5274 mL
100 mM	0.0153 mL	0.0764 mL	0.1527 mL	0.7637 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc