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CDK ligand for PROTAC hydrochloride

Name: CDK ligand for PROTAC hydrochloride
Brand: TargetMol
SKU: T10734L
Rating: 4.5 (1 reviews)

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Catalog No. T10734L

CDK ligand for PROTAC hydrochloride is a CDK inhibitor with antitumor activity. It has been used to design PROTAC CDK4/6 degraders.

CDK ligand for PROTAC hydrochloride

😃Good

Catalog No. T10734L

CDK ligand for PROTAC hydrochloride is a CDK inhibitor with antitumor activity. It has been used to design PROTAC CDK4/6 degraders.

Pack Size	Price	Availability
5 mg	$311	Backorder
10 mg	$486	Backorder
25 mg	$873	Backorder
50 mg	$1,454	Backorder
100 mg	$1,981	Backorder
200 mg	Inquiry	Backorder
500 mg	Inquiry	Backorder
1 mL x 10 mM (in DMSO)	$362	Backorder

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Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Product Introduction

Bioactivity

Description

CDK ligand for PROTAC hydrochloride is a CDK inhibitor with antitumor activity. It has been used to design PROTAC CDK4/6 degraders.

Chemical Properties

Molecular Weight	531
Formula	C₂₅H₂₉ClF₂N₈O
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 125 mg/mL (235.40 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8832 mL	9.4162 mL	18.8324 mL	94.1620 mL
5 mM	0.3766 mL	1.8832 mL	3.7665 mL	18.8324 mL
10 mM	0.1883 mL	0.9416 mL	1.8832 mL	9.4162 mL
20 mM	0.0942 mL	0.4708 mL	0.9416 mL	4.7081 mL
50 mM	0.0377 mL	0.1883 mL	0.3766 mL	1.8832 mL
100 mM	0.0188 mL	0.0942 mL	0.1883 mL	0.9416 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

CDK ligand for PROTAC hydrochlorideCDK ligand for PROTAC Hydrochloride

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