WAY-100135 dihydrochloride

Name: WAY-100135 dihydrochloride
Brand: TargetMol
SKU: T38975
Rating: 4.5 (1 reviews)

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Catalog No. T38975Cas No. 149055-79-8

WAY-100135 dihydrochloride is a potent and selective antagonist of both presynaptic and postsynaptic 5-HT 1A receptors, exhibiting an IC 50 value of 34 nM specifically at the rat hippocampal 5-HT 1A receptor. This compound displays promising antipsychotic effects.

WAY-100135 dihydrochloride

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Catalog No. T38975Cas No. 149055-79-8

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Product Introduction

Bioactivity

Description	WAY-100135 dihydrochloride is a potent and selective antagonist of both presynaptic and postsynaptic 5-HT 1A receptors, exhibiting an IC 50 value of 34 nM specifically at the rat hippocampal 5-HT 1A receptor. This compound displays promising antipsychotic effects.
Targets&IC50	5-HT1A receptor:34 nM (IC50)
In vitro	WAY100135, at concentrations ranging from 0.1 to 1 µM, counteracts the contractions induced by 5-carboxamidoiodotryptamine following electrical stimulation in the guinea-pig ileum, exhibiting a pA2 value of 7.2[1]. Furthermore, at a dose of 10 µM, WAY-100135 dihydrochloride inhibits the dampening effect of 8-OH-DPAT on both excitatory and inhibitory postsynaptic currents in MVM neurons[2].
In vivo	WAY100135, administered at a dose of 2.5 mg/kg, results in a peak inhibitory effect of 30% on the firing activity of raphe neurons, while a 0.5 mg/kg intravenous (i.v.) dose counters the firing inhibition caused by 8-OH-DPAT in anesthetized rats. Additionally, WAY-100135 dihydrochloride at a concentration of 10 mM in a 1 μL volume for microinjection completely mitigates all behavioral deficits in rats induced by 5-HT.

Chemical Properties

Molecular Weight	468.46
Formula	C₂₄H₃₅Cl₂N₃O₂
Cas No.	149055-79-8
Smiles	Cl.Cl.COc1ccccc1N1CCN(CC(C(=O)NC(C)(C)C)c2ccccc2)CC1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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