Powder: -20°C for 3 years | In solvent: -80°C for 1 year
WAY-100135 dihydrochloride is a potent and selective antagonist of both presynaptic and postsynaptic 5-HT 1A receptors, exhibiting an IC 50 value of 34 nM specifically at the rat hippocampal 5-HT 1A receptor. This compound displays promising antipsychotic effects.
Description | WAY-100135 dihydrochloride is a potent and selective antagonist of both presynaptic and postsynaptic 5-HT 1A receptors, exhibiting an IC 50 value of 34 nM specifically at the rat hippocampal 5-HT 1A receptor. This compound displays promising antipsychotic effects. |
Targets&IC50 | 5-HT1A receptor:34 nM (IC50) |
In vitro | WAY100135, at concentrations ranging from 0.1 to 1 µM, counteracts the contractions induced by 5-carboxamidoiodotryptamine following electrical stimulation in the guinea-pig ileum, exhibiting a pA2 value of 7.2[1]. Furthermore, at a dose of 10 µM, WAY-100135 dihydrochloride inhibits the dampening effect of 8-OH-DPAT on both excitatory and inhibitory postsynaptic currents in MVM neurons[2]. |
In vivo | WAY100135, administered at a dose of 2.5 mg/kg, results in a peak inhibitory effect of 30% on the firing activity of raphe neurons, while a 0.5 mg/kg intravenous (i.v.) dose counters the firing inhibition caused by 8-OH-DPAT in anesthetized rats. Additionally, WAY-100135 dihydrochloride at a concentration of 10 mM in a 1 μL volume for microinjection completely mitigates all behavioral deficits in rats induced by 5-HT. |
Molecular Weight | 468.46 |
Formula | C24H35Cl2N3O2 |
CAS No. | 149055-79-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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WAY-100135 dihydrochloride 149055-79-8 WAY100135 WAY100135 Dihydrochloride WAY 100135 WAY 100135 dihydrochloride WAY-100135 Dihydrochloride WAY-100135 WAY100135 dihydrochloride WAY 100135 Dihydrochloride inhibitor inhibit