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TM608
🥰Excellent
Catalog No. T34892Cas No. 1956343-52-4
Alias TM-608, TM 608
TM608 is a potent selective c-Met inhibitor that targets mitochondria and kills erlotinib-resistant lung cancer cells, rapidly accumulates in mitochondria, and inhibits MET activation in high MET expression, erlotinib-resistant HCC827B cells (total cell lysates and mitochondrial portions).
TM608
🥰Excellent
Catalog No. T34892Alias TM-608, TM 608Cas No. 1956343-52-4
TM608 is a potent selective c-Met inhibitor that targets mitochondria and kills erlotinib-resistant lung cancer cells, rapidly accumulates in mitochondria, and inhibits MET activation in high MET expression, erlotinib-resistant HCC827B cells (total cell lysates and mitochondrial portions).
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Product Introduction
Bioactivity
Chemical Properties
| Description | TM608 is a potent selective c-Met inhibitor that targets mitochondria and kills erlotinib-resistant lung cancer cells, rapidly accumulates in mitochondria, and inhibits MET activation in high MET expression, erlotinib-resistant HCC827B cells (total cell lysates and mitochondrial portions). |
| Synonyms | TM-608, TM 608 |
| Molecular Weight | 873.62 |
| Formula | C43H37BrCl2N3O4PS |
| Cas No. | 1956343-52-4 |
| Smiles | [P+](CCNC(=O)C=1C(C)=C(/C=C\2/C=3C(NC2=O)=CC=C(S(CC4=C(Cl)C=CC=C4Cl)(=O)=O)C3)NC1C)(C5=CC=CC=C5)(C6=CC=CC=C6)C7=CC=CC=C7.[Br-] |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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