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Rapacuronium bromide

Name: Rapacuronium bromide
Brand: TargetMol
SKU: T12690
Rating: 4.5 (1 reviews)

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Catalog No. T12690Cas No. 156137-99-4

Alias Org 9487

Rapacuronium bromide is an allosteric muscarinic acetylcholine receptor (mAChR) modulator.

Rapacuronium bromide

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Catalog No. T12690Alias Org 9487Cas No. 156137-99-4

Rapacuronium bromide is an allosteric muscarinic acetylcholine receptor (mAChR) modulator.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$347	6-8 weeks	6-8 weeks
25 mg	$987	6-8 weeks	6-8 weeks
50 mg	$1,320	6-8 weeks	6-8 weeks
100 mg	$2,150	6-8 weeks	6-8 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	Rapacuronium bromide is an allosteric muscarinic acetylcholine receptor (mAChR) modulator.
In vitro	Rapacuronium accelerates the rate of ACh binding but decreases its affinity under equilibrium conditions.?This results in potentiation of receptor activation at low concentrations of rapacuronium (1 microM) but not at high concentrations (10 microM).?These observations highlight the relevance and necessity of performing physiological tests under non-equilibrium conditions in evaluating the functional effects of allosteric modulators at muscarinic receptors.
In vivo	The neuromuscular effects of Rapacuronium were assessed over time following the administration of twice the ED90 doses in rats (ED90: 5953±199 μg/kg) and guinea pigs (ED90: 187±16 μg/kg) [2].
Synonyms	Org 9487

Chemical Properties

Molecular Weight	677.8
Formula	C₃₇H₆₁BrN₂O₄
Cas No.	156137-99-4
Smiles	[Br-].[H][C@@]12C[C@@H]([C@H](OC(=O)CC)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC[C@@]2([H])C[C@H](OC(C)=O)[C@H](C[C@]12C)N1CCCCC1)[N+]1(CC=C)CCCCC1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 125 mg/mL (184.42 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (4.87 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.4754 mL	7.3768 mL	14.7536 mL	73.7681 mL
5 mM	0.2951 mL	1.4754 mL	2.9507 mL	14.7536 mL
10 mM	0.1475 mL	0.7377 mL	1.4754 mL	7.3768 mL
20 mM	0.0738 mL	0.3688 mL	0.7377 mL	3.6884 mL
50 mM	0.0295 mL	0.1475 mL	0.2951 mL	1.4754 mL
100 mM	0.0148 mL	0.0738 mL	0.1475 mL	0.7377 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc