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Caprolactam

Name: Caprolactam
Brand: TargetMol
SKU: T20386
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T20386Cas No. 105-60-2

Caprolactam is a natural product used in the manufacture of synthetic fibers of the polyamide type.

Caprolactam

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Purity: 99.93%

Catalog No. T20386Cas No. 105-60-2

Caprolactam is a natural product used in the manufacture of synthetic fibers of the polyamide type.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
25 g	$29	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.93%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Caprolactam AI Summary

Caprolactam exhibits notable bioactivities and physicochemical properties. It causes a significant percentage of benzidine-positive cells after 6 days of exposure in murine leukemia cells at a concentration of 20.0 mM, with cell growth decreasing to 81.0% on day 6 compared to 95.0% on day 3 at 1*10^5 cells/mL. Furthermore, it results in 82.0% benzidine-positive murine erythroleukemia cells on day 6. In addition to its effect on cells, Caprolactam demonstrates anticonvulsant properties, providing protection from clonic seizures induced by pentylenetetrazole and tonic hindlimb seizures induced by maximal electroshock at an effective dose greater than 300.0 mg/kg. However, it also exhibits neurotoxicity in a rotarod test with a toxic dose below 300.0 mg/kg. The compound has a moderate IC50 value of 17400.0 nM for displacing radioligand [35S]TBPS from the Gamma-aminobutyric acid A receptor binding site and a low Protective Index (PI) of less than 1.0. Additionally, Caprolactam has been characterized with a second order hydrolysis rate constant k2 of 3.21 M^-1 s^-1 and exhibits a LogD7.4 value of -0.08, indicating its distribution characteristics in a specific pH environment..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Caprolactam is a natural product used in the manufacture of synthetic fibers of the polyamide type.

Chemical Properties

Molecular Weight	113.16
Formula	C₆H₁₁NO
Cas No.	105-60-2
Smiles	O=C1CCCCCN1
Relative Density.	1.105. Temperature:20 °C.

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (441.85 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	8.8370 mL	44.1852 mL	88.3704 mL	441.8522 mL
5 mM	1.7674 mL	8.8370 mL	17.6741 mL	88.3704 mL
10 mM	0.8837 mL	4.4185 mL	8.8370 mL	44.1852 mL
20 mM	0.4419 mL	2.2093 mL	4.4185 mL	22.0926 mL
50 mM	0.1767 mL	0.8837 mL	1.7674 mL	8.8370 mL
100 mM	0.0884 mL	0.4419 mL	0.8837 mL	4.4185 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc