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AC260584

Name: AC260584
Brand: TargetMol
SKU: T14092
Rating: 4.5 (1 reviews)

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Catalog No. T14092Cas No. 560083-42-3

AC260584 is an allosteric agonist of the M1 muscarinic receptor with a pEC50 of 7.6.

AC260584

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Catalog No. T14092Cas No. 560083-42-3

AC260584 is an allosteric agonist of the M1 muscarinic receptor with a pEC50 of 7.6.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$327	6-8 weeks	6-8 weeks
25 mg	$1,140	6-8 weeks	6-8 weeks
50 mg	$1,490	6-8 weeks	6-8 weeks
100 mg	$1,990	6-8 weeks	6-8 weeks
1 mL x 10 mM (in DMSO)	$270	6-8 weeks	6-8 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	AC260584 is an allosteric agonist of the M1 muscarinic receptor with a pEC50 of 7.6.
Targets&IC50	M1:（pEC50）7.6
In vitro	AC260584 is identified as a potent (pEC50=7.6-7.7) and efficacious (90-98% of carbachol) agonist for the muscarinic M1 receptor, exhibiting significant functional selectivity over the M2, M3, M4, and M5 subtypes of muscarinic receptors. This selectivity profile of AC260584 is consistent across native tissues expressing mAChRs and recombinant systems.
In vivo	In rodent studies, AC260584 has been shown to activate the phosphorylation of extracellular signal-regulated kinase 1 and 2 (ERK1/2) in the hippocampus, prefrontal cortex, and perirhinal cortex. This activation is contingent upon the activation of muscarinic M1 receptors, as evidenced by its absence in M1 receptor knockout mice. Furthermore, AC260584 enhances cognitive performance in mice, as demonstrated in the novel object recognition test, with this effect being inhibited by the muscarinic receptor antagonist pirenzepine. Additionally, AC260584 has been noted for its oral bioavailability in rodents. At doses of 3 and 10 mg/kg, AC260584 significantly boosts dopamine release in the medial prefrontal cortex and hippocampus, while only the 10 mg/kg dose notably increases acetylcholine release in these areas.

Chemical Properties

Molecular Weight	348.45
Formula	C₂₀H₂₉FN₂O₂
Cas No.	560083-42-3
Smiles	CCCCC1CCN(CCCN2C(=O)COc3cc(F)ccc23)CC1
Relative Density.	1.098 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (143.49 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2.5 mg/mL (7.17 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8699 mL	14.3493 mL	28.6985 mL	143.4926 mL
5 mM	0.5740 mL	2.8699 mL	5.7397 mL	28.6985 mL
10 mM	0.2870 mL	1.4349 mL	2.8699 mL	14.3493 mL
20 mM	0.1435 mL	0.7175 mL	1.4349 mL	7.1746 mL
50 mM	0.0574 mL	0.2870 mL	0.5740 mL	2.8699 mL
100 mM	0.0287 mL	0.1435 mL	0.2870 mL	1.4349 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc