SSR411298

Name: SSR411298
Brand: TargetMol
SKU: T40775
Rating: 4.5 (1 reviews)

Copy Product Info

🥰Excellent

Catalog No. T40775Cas No. 666860-59-9

Alias SSR411298

SSR411298 is a reversible, orally active compound that selectively inhibits fatty acid amide hydrolase (FAAH). Its potential lies in the field of post-traumatic stress disorder (PTSD) research.

SSR411298

Copy Product Info

🥰Excellent

Catalog No. T40775Alias SSR411298Cas No. 666860-59-9

SSR411298 is a reversible, orally active compound that selectively inhibits fatty acid amide hydrolase (FAAH). Its potential lies in the field of post-traumatic stress disorder (PTSD) research.

Product information is being updated, if you want to purchase, please click the bulk custom button.

Add to Quotation

Questions

Resource Download

Product Introduction

Bioactivity

Description	SSR411298 is a reversible, orally active compound that selectively inhibits fatty acid amide hydrolase (FAAH). Its potential lies in the field of post-traumatic stress disorder (PTSD) research.
In vitro	SSR411298, at concentrations ranging from 0.1 to 10,000 nM, exhibits a concentration-dependent inhibition of mouse brain fatty acid amide hydrolase (FAAH)[1]. In ex-vivo experiments, the compound achieves maximal FAAH inhibition at doses between 0.3 and 30 mg/kg[1].
In vivo	SSR411298 administered orally at doses of 0.3, 1, and 3 mg/kg twice daily for two days—60 minutes before a pretest, immediately afterward, and 60 minutes before a second testing session—demonstrates significant antidepressant-like effects in both the rat forced-swimming test and the mouse chronic mild stress model. This compound notably reverses the development of inadequate coping responses to chronic stress in male Wistar rats weighing 235-290 g[1]. Additionally, a single dose of SSR411298 (0.3, 1, 3, 10 mg/kg; orally; two hours before euthanasia) significantly increases the levels of tissue AEA, PEA, and OEA in the hippocampus, without affecting 2-AG levels[1].
Synonyms	SSR411298

Chemical Properties

Molecular Weight	402.447
Formula	C₂₁H₂₆N₂O₆
Cas No.	666860-59-9
Smiles	COc1ccc2c(cccc2c1)[C@H]1CO[C@H](CCCNC(=O)OCC(N)=O)OC1 \|wU:15.17,wD:12.13,(-17.34,8.47,;-17.34,6.93,;-16,6.16,;-14.67,6.93,;-13.34,6.16,;-13.34,4.62,;-12,3.85,;-12,2.31,;-13.34,1.54,;-14.67,2.31,;-14.67,3.85,;-16,4.62,;-10.67,4.62,;-9.34,3.85,;-8,4.62,;-8,6.16,;-6.67,6.93,;-5.33,6.16,;-4,6.93,;-2.67,6.16,;-1.33,6.93,;-1.33,8.47,;,6.16,;1.33,6.93,;2.67,6.16,;4,6.93,;2.67,4.62,;-9.34,6.93,;-10.67,6.16,)\|

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc