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4-Oxoisotretinoin

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Catalog No. T3559Cas No. 71748-58-8
Alias Ro 22-6595, Oxoretinoic acid, 4-Oxoisotretinoin

4-Oxoisotretinoin (Ro 22-6595) is the major blood metabolite.

4-Oxoisotretinoin

4-Oxoisotretinoin

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Purity: 99.69%
Catalog No. T3559Alias Ro 22-6595, Oxoretinoic acid, 4-OxoisotretinoinCas No. 71748-58-8
4-Oxoisotretinoin (Ro 22-6595) is the major blood metabolite.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$30In StockIn Stock
5 mg$64In StockIn Stock
10 mg$98In StockIn Stock
25 mg$198In StockIn Stock
50 mg$328In StockIn Stock
100 mg$492In StockIn Stock
1 mL x 10 mM (in DMSO)$73In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Batch Information

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Purity:99.69%
Appearance:Solid
Color:Yellow
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Product Introduction

Bioactivity
Description
4-Oxoisotretinoin (Ro 22-6595) is the major blood metabolite.
SynonymsRo 22-6595, Oxoretinoic acid, 4-Oxoisotretinoin
Chemical Properties
Molecular Weight314.42
FormulaC20H26O3
Cas No.71748-58-8
SmilesC(=C/C(=C/C=C/C(=C\C(O)=O)/C)/C)\C=1C(C)(C)CCC(=O)C1C
Relative Density.1.07g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 55 mg/mL (174.93 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.1805 mL15.9023 mL31.8046 mL159.0230 mL
5 mM0.6361 mL3.1805 mL6.3609 mL31.8046 mL
10 mM0.3180 mL1.5902 mL3.1805 mL15.9023 mL
20 mM0.1590 mL0.7951 mL1.5902 mL7.9511 mL
50 mM0.0636 mL0.3180 mL0.6361 mL3.1805 mL
100 mM0.0318 mL0.1590 mL0.3180 mL1.5902 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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