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NAV26
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Catalog No. T24520Cas No. 1198160-14-3
Alias NAV-26, NAV 26
NAV26 (compound 26) is a selective voltage-gated sodium channel Nav1.7 blocker with an IC50 of 0.37 μM, and is extensively used in pain research to investigate Nav1.7-mediated nociceptive signaling, validate analgesic targets. NAV26 (compound 26) support the development of novel pain therapeutics with improved specificity and reduced central nervous system side effects.
NAV26
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Purity: 99.93%
Catalog No. T24520Alias NAV-26, NAV 26Cas No. 1198160-14-3
NAV26 (compound 26) is a selective voltage-gated sodium channel Nav1.7 blocker with an IC50 of 0.37 μM, and is extensively used in pain research to investigate Nav1.7-mediated nociceptive signaling, validate analgesic targets. NAV26 (compound 26) support the development of novel pain therapeutics with improved specificity and reduced central nervous system side effects.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $78 | - | In Stock | |
| 5 mg | $189 | - | In Stock | |
| 10 mg | $278 | - | In Stock | |
| 25 mg | $493 | - | In Stock | |
| 50 mg | $693 | - | In Stock | |
| 100 mg | $979 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.93%
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Product Introduction
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Chemical Properties
Storage & Solubility Information
| Description | NAV26 (compound 26) is a selective voltage-gated sodium channel Nav1.7 blocker with an IC50 of 0.37 μM, and is extensively used in pain research to investigate Nav1.7-mediated nociceptive signaling, validate analgesic targets. NAV26 (compound 26) support the development of novel pain therapeutics with improved specificity and reduced central nervous system side effects. |
| Targets&IC50 | Nav1.7:0.37 μM |
| In vitro | NAV26 functions as a state-dependent blocker of NaV1.7, a channel subtype validated for pain modulation. In electrophysiological assays, it exhibits an IC₅₀ of 0.37 μM for NaV1.7 [2]. |
| Synonyms | NAV-26, NAV 26 |
| Molecular Weight | 434.41 |
| Formula | C22H21F3N2O4 |
| Cas No. | 1198160-14-3 |
| Smiles | O=C1C=2C=CC=CC2C(C(=O)NCC3=CC=C(OC(F)(F)F)C=C3)N1C4CCOCC4 |
| Relative Density. | no data available |
| Color | White |
| Appearance | Solid |
| Storage | store at low temperature | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 100 mg/mL (230.2 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Stock solution preparation method: 2 mg of drug dissolved in 50 μL DMSO (stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyThe above example illustrates how to use "In Vivo Formulation Calculator" and does not represent a recommended formulation for any specific compound. Please select an appropriate dissolution method based on your experimental animals and route of administration.
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