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NAV26
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Catalog No. T24520Cas No. 1198160-14-3
Alias NAV-26, NAV 26
NAV26 (compound 26) is a selective voltage-gated sodium channel Nav1.7 blocker with an IC50 of 0.37 μM, and is extensively used in pain research to investigate Nav1.7-mediated nociceptive signaling, validate analgesic targets. NAV26 (compound 26) support the development of novel pain therapeutics with improved specificity and reduced central nervous system side effects.
NAV26
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Purity: 99.93%
Catalog No. T24520Alias NAV-26, NAV 26Cas No. 1198160-14-3
NAV26 (compound 26) is a selective voltage-gated sodium channel Nav1.7 blocker with an IC50 of 0.37 μM, and is extensively used in pain research to investigate Nav1.7-mediated nociceptive signaling, validate analgesic targets. NAV26 (compound 26) support the development of novel pain therapeutics with improved specificity and reduced central nervous system side effects.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $78 | - | In Stock | |
| 5 mg | $189 | - | In Stock | |
| 10 mg | $278 | - | In Stock | |
| 25 mg | $493 | - | In Stock | |
| 50 mg | $693 | - | In Stock | |
| 100 mg | $979 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.93%
Appearance:Solid
Color:White
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Product Introduction
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Chemical Properties
Storage & Solubility Information
| Description | NAV26 (compound 26) is a selective voltage-gated sodium channel Nav1.7 blocker with an IC50 of 0.37 μM, and is extensively used in pain research to investigate Nav1.7-mediated nociceptive signaling, validate analgesic targets. NAV26 (compound 26) support the development of novel pain therapeutics with improved specificity and reduced central nervous system side effects. |
| Targets&IC50 | Nav1.7:0.37 μM |
| In vitro | NAV26 functions as a state-dependent blocker of NaV1.7, a channel subtype validated for pain modulation. In electrophysiological assays, it exhibits an IC₅₀ of 0.37 μM for NaV1.7 [2]. |
| Synonyms | NAV-26, NAV 26 |
| Molecular Weight | 434.41 |
| Formula | C22H21F3N2O4 |
| Cas No. | 1198160-14-3 |
| Smiles | O=C1C=2C=CC=CC2C(C(=O)NCC3=CC=C(OC(F)(F)F)C=C3)N1C4CCOCC4 |
| Relative Density. | no data available |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 100 mg/mL (230.2 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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