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6-Methoxyflavone

Name: 6-Methoxyflavone
Brand: TargetMol
SKU: TN3175
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TN3175Cas No. 26964-24-9

6-Methoxyflavone is one of the methoxyflavone isolated form Pimelea decora. Synthesis of 6-methoxyflavone from p-dihydroxybenzene has been reported.

6-Methoxyflavone

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Purity: 99.94%

Catalog No. TN3175Cas No. 26964-24-9

6-Methoxyflavone is one of the methoxyflavone isolated form Pimelea decora. Synthesis of 6-methoxyflavone from p-dihydroxybenzene has been reported.

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$31	In Stock	In Stock
100 mg	$52	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$39	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.94%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

6-Methoxyflavone AI Summary

6-Methoxyflavone exhibits a comprehensive profile of biological activities across several systems. It shows affinity for the Benzodiazepine receptor in rat cortical membranes with a Ki value of 570.0 nM and interacts with the GABA system with a GABA ratio of 1.51. It also binds to the GABAA receptor with a logKi value of -0.066. Intraperitoneal administration of 20 mg/kg in rats provides 29.0% protection against gastric damage. 6-Methoxyflavone acts as an agonist at the glucocorticoid and androgen receptors in human MDA-kb2 cells, with EC150 values of 0.7 µM and a selectivity ratio to DHT and Dex EC150 of 1400.0 and 3.6, respectively. The compound inhibits efflux pumps like BCRP, P-gp, and MDR1 with moderate to high potency. Furthermore, 6-Methoxyflavone shows antifeedant activity against Spodoptera litura F., with an ED50 of 0.15 µmol/cm². It inhibits EWS/Fli transcriptional activity (AbsAC35 of 8.22 µM) and demonstrates cytotoxicity in TC71 cells (Max_Activity of 0.9 µM) and in A549 and HepG2 cells (AC50 > 52000.0 nM). It inhibits Bursicon-induced LGR2-mediated cAMP production (AC50 of 5460.0 nM) and does not significantly inhibit human TNKS1 (IC50 > 10000.0 nM). The compound also exhibits cytotoxicity against LPS-stimulated RAW264.7 cells, showing 115.93% cell viability at 20 µM and inhibiting nitric oxide production by 22.17%. Additionally, it inhibits CYP450 enzymes in human liver microsomes, affecting the formation of 20-HETE and EpETrE at 10 µM with inhibition percentages of <15.0% and 16.0%, respectively. This multifaceted activity profile highlights the potential therapeutic applications of 6-Methoxyflavone across various biological pathways..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

6-Methoxyflavone is one of the methoxyflavone isolated form Pimelea decora. Synthesis of 6-methoxyflavone from p-dihydroxybenzene has been reported.

Chemical Properties

Molecular Weight	252.26
Formula	C₁₆H₁₂O₃
Cas No.	26964-24-9
Smiles	COc1ccc2oc(cc(=O)c2c1)-c1ccccc1
Relative Density.	1.24 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 11 mg/mL (43.61 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.9642 mL	19.8208 mL	39.6416 mL	198.2082 mL
5 mM	0.7928 mL	3.9642 mL	7.9283 mL	39.6416 mL
10 mM	0.3964 mL	1.9821 mL	3.9642 mL	19.8208 mL
20 mM	0.1982 mL	0.9910 mL	1.9821 mL	9.9104 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc