Powder: -20°C for 3 years | In solvent: -80°C for 2 years
MLS-0437605 is a potent and selective inhibitor of dual-specificity phosphatase 3 (DUSP3), with an IC50 of 3.7 μM. It exhibits higher selectivity towards DUSP3 in comparison to DUSP22 and other protein tyrosine phosphatases (PTPs).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | 5 days | $ 49.00 |
Description | MLS-0437605 is a potent and selective inhibitor of dual-specificity phosphatase 3 (DUSP3), with an IC50 of 3.7 μM. It exhibits higher selectivity towards DUSP3 in comparison to DUSP22 and other protein tyrosine phosphatases (PTPs). |
In vitro | MLS-0437605 efficiently inhibits platelet aggregation in response to collagen related peptide (CRP) and rhodocytin, but not after stimulation with thromboxane. MLS-0437605 causes a decrease in pY of a ~70-kDa band after stimulation with CRP or rhodocytin. Tyrosine phosphorylation of immunoprecipitated Syk and PLCγ2 is also reduced by MLS-0437605[1]. |
Molecular Weight | 342.35 |
Formula | C16H11FN4O2S |
CAS No. | 862975-18-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
( < 1 mg/ml refers to the product slightly soluble or insoluble )
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MLS-0437605 862975-18-6 MLS 0437605 MLS0437605 inhibitor inhibit