Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MLS-0437605 is a potent and selective inhibitor of dual-specificity phosphatase 3 (DUSP3), with an IC50 of 3.7 μM. It exhibits higher selectivity towards DUSP3 in comparison to DUSP22 and other protein tyrosine phosphatases (PTPs).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | 5 days | $ 595.00 | |
5 mg | 5 days | $ 970.00 |
Description | MLS-0437605 is a potent and selective inhibitor of dual-specificity phosphatase 3 (DUSP3), with an IC50 of 3.7 μM. It exhibits higher selectivity towards DUSP3 in comparison to DUSP22 and other protein tyrosine phosphatases (PTPs). |
In vitro | MLS-0437605 effectively suppresses platelet aggregation induced by collagen-related peptide (CRP) and rhodocytin, without affecting the response to thromboxane. It also reduces the phosphorylation of tyrosine (pY) in approximately a 70-kDa protein following stimulation with CRP or rhodocytin. Additionally, MLS-0437605 diminishes the tyrosine phosphorylation of Syk and PLCγ2 proteins that have been immunoprecipitated[1]. |
Molecular Weight | 342.35 |
Formula | C16H11FN4O2S |
CAS No. | 862975-18-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
MLS-0437605 862975-18-6 MLS 0437605 MLS0437605 inhibitor inhibit