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MLS-0437605

Catalog No. T40968 CAS 862975-18-6

MLS-0437605 is a potent and selective inhibitor of dual-specificity phosphatase 3 (DUSP3), with an IC50 of 3.7 μM. It exhibits higher selectivity towards DUSP3 in comparison to DUSP22 and other protein tyrosine phosphatases (PTPs).

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MLS-0437605, CAS 862975-18-6

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1 mg	5 days	$ 49.00

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	MLS-0437605 is a potent and selective inhibitor of dual-specificity phosphatase 3 (DUSP3), with an IC50 of 3.7 μM. It exhibits higher selectivity towards DUSP3 in comparison to DUSP22 and other protein tyrosine phosphatases (PTPs).
In vitro	MLS-0437605 efficiently inhibits platelet aggregation in response to collagen related peptide (CRP) and rhodocytin, but not after stimulation with thromboxane. MLS-0437605 causes a decrease in pY of a ~70-kDa band after stimulation with CRP or rhodocytin. Tyrosine phosphorylation of immunoprecipitated Syk and PLCγ2 is also reduced by MLS-0437605[1].

Molecular Weight	342.35
Formula	C16H11FN4O2S
CAS No.	862975-18-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Lucia Musumeci, et al. Dual-specificity phosphatase 3 deficiency or inhibition limits platelet activation and arterial thrombosis. Circulation. 2015 Feb 17;131(7):656-68.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

MLS-0437605 862975-18-6 MLS 0437605 MLS0437605 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.