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Norswertianolin
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Catalog No. T40629Cas No. 54954-12-0
Norswertianolin, a compound isolated from G. acuta, is a small molecule activator of CSE, which enhances the H-generation 2S activity of CSE and can be used in the study of cardiovascular diseases.
Norswertianolin
🥰Excellent
Purity: 98.06%
Catalog No. T40629Cas No. 54954-12-0
Norswertianolin, a compound isolated from G. acuta, is a small molecule activator of CSE, which enhances the H-generation 2S activity of CSE and can be used in the study of cardiovascular diseases.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $147 | In Stock | |
| 5 mg | $378 | In Stock | |
| 10 mg | $612 | In Stock | |
| 25 mg | $953 | In Stock | |
| 50 mg | $1,280 | In Stock |
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Purity:98.06%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Norswertianolin, a compound isolated from G. acuta, is a small molecule activator of CSE, which enhances the H-generation 2S activity of CSE and can be used in the study of cardiovascular diseases. |
| In vitro | Norswertianolin (3.125-50 μM) was able to protect against H2O2-induced damage in H9c2 cells. In addition, Norswertianolin significantly increased the transcript levels of HO-1 and GCLC in H9c2 cells. [1] In HepG2 cells, high concentrations of Norswertianolin (0~150 μM) were able to increase the expression level of CSE protein. [2] |
| In vivo | Animal experiments showed that Norswertianolin (4.4 mg/kg/day, subcutaneous injection for one week) improved CSE/H₂S production and attenuated renal tubular injury induced by acute ischemia/reperfusion, and exerted antioxidant effects by decreasing ROS levels. In addition, it has antihypertensive, inhibits vascular remodeling and reduces inflammation. [2] |
| Molecular Weight | 422.34 |
| Formula | C19H18O11 |
| Cas No. | 54954-12-0 |
| Smiles | O(C1=C2C(OC=3C(C2=O)=C(O)C=C(O)C3)=C(O)C=C1)[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O |
| Color | Yellow |
| Appearance | Solid |
Storage & Solubility Information
| Storage | keep away from direct sunlight,keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 20 mg/mL (47.36 mM), Sonication is recommended. | |||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.74 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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