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Norswertianolin

Catalog No. T40629 CAS 54954-12-0

Norswertianolin, a compound isolated from G. acuta, functions as a CSE activator and shows promise as a potential cardiovascular therapeutic.

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Norswertianolin, CAS 54954-12-0

Pack Size	Availability	Price/USD	Quantity
5 mg	Inquiry	$ 698.00
10 mg	Inquiry	$ 1,120.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	Norswertianolin, a compound isolated from G. acuta, functions as a CSE activator and shows promise as a potential cardiovascular therapeutic.
In vitro	Norswertianolin, at concentrations ranging from 3.125 to 50 μM in H9c2 cells, exhibits protective effects against damage induced by H2O2. It notably enhances the transcription levels of HO-1 and GCLC in these cells. Additionally, when used in higher concentrations up to 150 μM in HepG2 cells, Norswertianolin significantly elevates the CSE protein level.
In vivo	Norswertianolin, administered subcutaneously at a dosage of 4.4 mg/kg/day for one week, enhances CSE/H2S production and mitigates renal tubular injury in acute ischemia/reperfusion (I/R). Additionally, it lowers I/R-induced reactive oxygen species, as evidenced by decreased DHE fluorescence intensity. This compound also exhibits anti-hypertensive properties, prevents vascular remodeling, and diminishes inflammatory responses. These effects were observed in an animal model using male Sprague Dawley rats aged 10 to 12 weeks.

Molecular Weight	422.34
Formula	C19H18O11
CAS No.	54954-12-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Ren K, et al. Effects of Four Compounds from Gentianella acuta (Michx.) Hulten on Hydrogen Peroxide-Induced Injury in H9c2 Cells. Biomed Res Int. 2019;2019:2692970. Published 2019 Jan 20. 2. Niu Y, et al. Norswertianolin Promotes Cystathionine γ-Lyase Activity and Attenuates Renal Ischemia/Reperfusion Injury and Hypertension. Front Pharmacol. 2021;12:677212. Published 2021 Jul 14. doi:10.3389/fphar.2021.677212

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Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Norswertianolin 54954-12-0 inhibitor inhibit

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