Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Tiludronate (Tiludronic Acid) disodium hemihydrate is an orally active bisphosphonate compound that functions as an osteoregulator. It is primarily utilized in metabolic bone disorder research. This compound acts as a potent inhibitor of the osteoclast vacuolar H+ -ATPase and possesses antiresorptive and anti-inflammatory properties[4].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | Inquiry | $ 1,520.00 |
Description | Tiludronate (Tiludronic Acid) disodium hemihydrate is an orally active bisphosphonate compound that functions as an osteoregulator. It is primarily utilized in metabolic bone disorder research. This compound acts as a potent inhibitor of the osteoclast vacuolar H+ -ATPase and possesses antiresorptive and anti-inflammatory properties[4]. |
In vitro | Tiludronate exhibits significantly enhanced potency in inhibiting proton transport, with a five-fold greater efficacy in kidney-derived vesicles (IC 50 =1.1 mM) and an even more pronounced, ten-thousand-fold increase in vesicles sourced from osteoclasts (IC 50 =466 nM). Additionally, it effectively inhibits proton transport in yeast microsomal preparations (IC 50 =3.5 microM) and disrupts the function of purified yeast V-ATPase. Notably, Tiludronate's inhibition of proton transport mediated by osteoclast V-ATPase is characterized by its rapid onset, pH-dependence, and reversibility[3]. |
In vivo | Tiludronate exhibits a dose-dependent inhibitory effect on bone resorption, primarily by diminishing the mature osteoclasts' ability to secrete protons into the resorption space and promoting their detachment from the bone matrix. Furthermore, Tiludronate has been evaluated in various osteoporosis models, notably preventing the reduction in skeletal mass in the castrated male rat model (doses ranging from 5-200 mg/kg; orally). This prevention was confirmed through physical assessments of bone weight and density, as well as chemical analyses of calcium and phosphate content[3]. |
Synonyms | Tiludronic acid disodium hemihydrate |
Molecular Weight | 747.18 |
Formula | C14H20Cl2Na4O13P4S2 |
CAS No. | 155453-10-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Tiludronate disodium hemihydrate 155453-10-4 Tiludronic acid disodium hemihydrate Tiludronic acid Tiludronate Tiludronic acid disodium Hemihydrate Tiludronate disodium Hemihydrate inhibitor inhibit