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Relutrigine

Name: Relutrigine
Brand: TargetMol
SKU: T69652
Price: 289 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T69652Cas No. 2392951-29-8

Alias PRAX-562, PRAX562, PRAX 562

Relutrigine (PRAX-562) is an orally active, long-acting sodium current inhibitor that preferentially suppresses sustained INa induced by TX-II or SCN8A N1768D mutations (IC50=141/75 nM). It reduces neuronal intrinsic excitability and may be used for anticonvulsant therapy.

Relutrigine

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Purity: 99.68%

Catalog No. T69652Alias PRAX-562, PRAX562, PRAX 562Cas No. 2392951-29-8

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$289	-	In Stock
5 mg	$723	-	In Stock
10 mg	$1,120	-	In Stock
25 mg	$1,670	-	In Stock
50 mg	$2,180	-	In Stock
100 mg	$2,800	-	In Stock
1 mL x 10 mM (in DMSO)	$648	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.68%

Appearance:Solid

Color:Orange

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Relutrigine (PRAX-562) is an orally active, long-acting sodium current inhibitor that preferentially suppresses sustained INa induced by TX-II or SCN8A N1768D mutations (IC50=141/75 nM). It reduces neuronal intrinsic excitability and may be used for anticonvulsant therapy.
In vitro	Relutrigine (0.001–10,000 µM) inhibits the hNaV1.6 sustained sodium channel with a persistent INa preference. Relutrigine (0.3 µM) significantly reduces intrinsic excitability in wild-type CA1 pyramidal neurons [1].
In vivo	Relutrigine (0.3–40 mg/kg; oral; single dose) dose-dependently protected against maximal electroconvulsive seizure (MES)-induced tonic hindlimb seizures in male CD-1 mice [1].
Synonyms	PRAX-562, PRAX562, PRAX 562

Chemical Properties

Molecular Weight	407.27
Formula	C₁₅H₁₁F₆N₅O₂
Cas No.	2392951-29-8
Smiles	C(OCC)(F)(F)C=1N2C(=NN1)C=NC(=C2)C=3C=C(F)C(OCC(F)(F)F)=NC3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (196.43 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4554 mL	12.2769 mL	24.5537 mL	122.7687 mL
5 mM	0.4911 mL	2.4554 mL	4.9107 mL	24.5537 mL
10 mM	0.2455 mL	1.2277 mL	2.4554 mL	12.2769 mL
20 mM	0.1228 mL	0.6138 mL	1.2277 mL	6.1384 mL
50 mM	0.0491 mL	0.2455 mL	0.4911 mL	2.4554 mL
100 mM	0.0246 mL	0.1228 mL	0.2455 mL	1.2277 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc