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ACT-451840
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Catalog No. T203012Cas No. 1984890-99-4
Alias ACT451840
ACT-451840 is capable of eliminating both sensitive and resistant strains of Plasmodium falciparum and has the advantages of oral activity, potency, low toxicity, rapid onset of action in all asexual blood stages of Plasmodium, and a mechanism of action similar to that of artemisinin derivatives. In in vivo experiments, ACT-451840 showed excellent antimalarial effects at a dose of 30 mg/kg, with a parasite reduction rate of 99.80%.
ACT-451840
😃Good
Purity: 96.07%
Catalog No. T203012Alias ACT451840Cas No. 1984890-99-4
ACT-451840 is capable of eliminating both sensitive and resistant strains of Plasmodium falciparum and has the advantages of oral activity, potency, low toxicity, rapid onset of action in all asexual blood stages of Plasmodium, and a mechanism of action similar to that of artemisinin derivatives. In in vivo experiments, ACT-451840 showed excellent antimalarial effects at a dose of 30 mg/kg, with a parasite reduction rate of 99.80%.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $107 | - | In Stock | |
| 5 mg | $235 | - | In Stock | |
| 10 mg | $375 | - | In Stock | |
| 25 mg | $730 | - | In Stock | |
| 50 mg | $1,170 | - | In Stock | |
| 100 mg | $1,830 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $245 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:96.07%
Appearance:Solid
Color:Yellow
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | ACT-451840 is capable of eliminating both sensitive and resistant strains of Plasmodium falciparum and has the advantages of oral activity, potency, low toxicity, rapid onset of action in all asexual blood stages of Plasmodium, and a mechanism of action similar to that of artemisinin derivatives. In in vivo experiments, ACT-451840 showed excellent antimalarial effects at a dose of 30 mg/kg, with a parasite reduction rate of 99.80%. |
| In vitro | ACT-451840 has a 50% inhibitory concentration of 0.4 nM against the drug-susceptible P. falciparum NF54 strain; ACT-451840 effectively blocks male gamete formation from the gametocyte stage at a 50% inhibitory concentration of 5.89 nM, and blocks mosquito oocyst development in a dose-dependent manner at a 50% inhibitory concentration of 30 nM. [2] |
| In vivo | In the in vivo efficacy model, the 90% effective dose against P. falciparum of ACT-451840 was 3.7 mg/kg and the 90% effective dose against P. berghei was 13 mg/kg. |
| Synonyms | ACT451840 |
| Molecular Weight | 750.97 |
| Formula | C47H54N6O3 |
| Cas No. | 1984890-99-4 |
| Smiles | CC(=O)N1CCN(CC1)c1ccc(CN([C@@H](Cc2ccccc2)C(=O)N2CCN(Cc3ccc(cc3)C#N)CC2)C(=O)\C=C\c2ccc(cc2)C(C)(C)C)cc1 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 30 mg/mL (39.95 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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