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ACT-451840

🥰Excellent
Catalog No. T203012Cas No. 1984890-99-4
Alias ACT451840

ACT-451840 is capable of eliminating both sensitive and resistant strains of Plasmodium falciparum and has the advantages of oral activity, potency, low toxicity, rapid onset of action in all asexual blood stages of Plasmodium, and a mechanism of action similar to that of artemisinin derivatives. In in vivo experiments, ACT-451840 showed excellent antimalarial effects at a dose of 30 mg/kg, with a parasite reduction rate of 99.80%.

ACT-451840

ACT-451840

🥰Excellent
Purity: 96.07%
Catalog No. T203012Alias ACT451840Cas No. 1984890-99-4
ACT-451840 is capable of eliminating both sensitive and resistant strains of Plasmodium falciparum and has the advantages of oral activity, potency, low toxicity, rapid onset of action in all asexual blood stages of Plasmodium, and a mechanism of action similar to that of artemisinin derivatives. In in vivo experiments, ACT-451840 showed excellent antimalarial effects at a dose of 30 mg/kg, with a parasite reduction rate of 99.80%.
Pack SizePriceAvailabilityQuantity
1 mg$107In Stock
5 mg$235In Stock
10 mg$375In Stock
25 mg$730In Stock
50 mg$1,170In Stock
100 mg$1,830In Stock
1 mL x 10 mM (in DMSO)$245In Stock
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Purity:96.07%
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Product Introduction

Bioactivity
Description
ACT-451840 is capable of eliminating both sensitive and resistant strains of Plasmodium falciparum and has the advantages of oral activity, potency, low toxicity, rapid onset of action in all asexual blood stages of Plasmodium, and a mechanism of action similar to that of artemisinin derivatives. In in vivo experiments, ACT-451840 showed excellent antimalarial effects at a dose of 30 mg/kg, with a parasite reduction rate of 99.80%.
In vitro
ACT-451840 has a 50% inhibitory concentration of 0.4 nM against the drug-susceptible P. falciparum NF54 strain; ACT-451840 effectively blocks male gamete formation from the gametocyte stage at a 50% inhibitory concentration of 5.89 nM, and blocks mosquito oocyst development in a dose-dependent manner at a 50% inhibitory concentration of 30 nM. [2]
In vivo
In the in vivo efficacy model, the 90% effective dose against P. falciparum of ACT-451840 was 3.7 mg/kg and the 90% effective dose against P. berghei was 13 mg/kg.
AliasACT451840
Chemical Properties
Molecular Weight750.97
FormulaC47H54N6O3
Cas No.1984890-99-4
SmilesCC(=O)N1CCN(CC1)c1ccc(CN([C@@H](Cc2ccccc2)C(=O)N2CCN(Cc3ccc(cc3)C#N)CC2)C(=O)\C=C\c2ccc(cc2)C(C)(C)C)cc1
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 30.00 mg/mL (39.95 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.3316 mL6.6581 mL13.3161 mL66.5806 mL
5 mM0.2663 mL1.3316 mL2.6632 mL13.3161 mL
10 mM0.1332 mL0.6658 mL1.3316 mL6.6581 mL
20 mM0.0666 mL0.3329 mL0.6658 mL3.3290 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
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2 Enter the in vivo formulation:
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