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Corrector C4

Name: Corrector C4
Brand: TargetMol
SKU: T31014
Price: 195 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T31014Cas No. 421580-53-2

Alias Corrector C-4, Corrector C 4, Corr-4a, Corr4a, Corr 4a

Corrector C4, a corrector commonly used to study cystic fibrosis mutants, works by alleviating the interaction between CFTR transmembrane domain mutants and protein homeostasis.

Corrector C4

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Purity: 99.98%

Catalog No. T31014Alias Corrector C-4, Corrector C 4, Corr-4a, Corr4a, Corr 4aCas No. 421580-53-2

Corrector C4, a corrector commonly used to study cystic fibrosis mutants, works by alleviating the interaction between CFTR transmembrane domain mutants and protein homeostasis.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$195	In Stock	In Stock
5 mg	$483	In Stock	In Stock
10 mg	$692	In Stock	In Stock
25 mg	$1,080	In Stock	In Stock
50 mg	$1,490	In Stock	In Stock
100 mg	$1,970	In Stock	In Stock
500 mg	$3,930	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.98%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Corrector C4 AI Summary

Corrector C4 exhibits corrector activity on the human CFTR deltaF508 mutant expressed in FRT cells, evidenced by increases in iodide influx and YFP-based fluorescence analysis, with an EC50 value ranging from 1096.48 nM to 2300.0 nM. The compound shows a Vmax value of 122.0 microM/s and a Kd value of 900.0 nM, along with an IC50 value of 6000.0 nM for iodide influx assessed by fluorescence assay. Beyond its role as a CFTR corrector, Corrector C4 demonstrates a broad spectrum of bioactivities including modulation of Lamin A splicing, SMN2 splice variant expression, and inhibition of tau fibril formation, AMP beta-lactamase, ALDH1A1, Jumonji Domain Containing 2E, Cruzain, Menin-MLL interaction, HPGD, Eya2, Histone Lysine Methyltransferase G9a, BAZ2B, and TCP-1 ring complex. It exhibits anti-tumor efficacy in certain human colon tumor cells and shows potential against malarial parasite plastids with potencies ranging from 707.9 nM to 199526.2 nM across different assays. Its physicochemical properties include a Log P value of 5.96, a solubility of 20.0 nM, an apparent permeability of 8.1 x 10^-6 cm/s, and membrane retention of 37.9%. The compound maintains metabolic stability, with approximately 55% remaining after 1-hour incubation with CYP3A4 and a human plasma half-life of 86.6 hours. Additionally, it has a binding affinity to human serum albumin with a dissociation constant of 11680.0 nM and a Bmax of 88.82%. Corrector C4 is soluble in 50 mM ammonium acetate buffer at 250 μM and demonstrates efficacy in correcting defective trafficking of the CFTR protein with demonstrated activities in various cell lines upon pre-incubation and forskolin/genistein stimulation..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Corrector C4, a corrector commonly used to study cystic fibrosis mutants, works by alleviating the interaction between CFTR transmembrane domain mutants and protein homeostasis.
Synonyms	Corrector C-4, Corrector C 4, Corr-4a, Corr4a, Corr 4a

Chemical Properties

Molecular Weight	456.97
Formula	C₂₁H₁₇ClN₄O₂S₂
Cas No.	421580-53-2
Smiles	CC1=C(C=2N=C(NC3=C(OC)C=CC(Cl)=C3)SC2)SC(NC(=O)C4=CC=CC=C4)=N1
Relative Density.	1.440 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (131.3 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1883 mL	10.9416 mL	21.8833 mL	109.4164 mL
5 mM	0.4377 mL	2.1883 mL	4.3767 mL	21.8833 mL
10 mM	0.2188 mL	1.0942 mL	2.1883 mL	10.9416 mL
20 mM	0.1094 mL	0.5471 mL	1.0942 mL	5.4708 mL
50 mM	0.0438 mL	0.2188 mL	0.4377 mL	2.1883 mL
100 mM	0.0219 mL	0.1094 mL	0.2188 mL	1.0942 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc