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YKL-5-124 TFA (1957203-01-8 free base) (Synonyms: YKL-5-124 TFA)

Name: YKL-5-124 TFA (1957203-01-8 free base)
Brand: TargetMol
SKU: T13367
Rating: 4.5 (1 reviews)

Catalog No. T13367 Copy Product Info

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YKL-5-124 TFA is a potent, selective, irreversible and covalent inhibitor of CDK7 (IC50s of 53.5 nM and 9.7 nM for CDK7 and CDK7/Mat1/CycH, respectively).

YKL-5-124 TFA (1957203-01-8 free base)

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Catalog No. T13367

Synonyms YKL-5-124 TFA

YKL-5-124 TFA is a potent, selective, irreversible and covalent inhibitor of CDK7 (IC50s of 53.5 nM and 9.7 nM for CDK7 and CDK7/Mat1/CycH, respectively).

Pack Size	Price	USA Stock	Global Stock
25 mg	$1,670	8-10 weeks	8-10 weeks
50 mg	$2,180	8-10 weeks	8-10 weeks
100 mg	$2,800	8-10 weeks	8-10 weeks

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

Bioactivity

Description	YKL-5-124 TFA is a potent, selective, irreversible and covalent inhibitor of CDK7 (IC50s of 53.5 nM and 9.7 nM for CDK7 and CDK7/Mat1/CycH, respectively).
Targets&IC50	CDK9:3020 nM, CDK2:1300 nM, CDK7:53.5 nM, CDK7-CyclinH-MAT1:9.7 nM
In vitro	In G1- and G2/M-phase cells and a corresponding loss of S-phase cells, YKL-5-124 (0-2000 nM; 72 hours; HAP1 cells) treatment causes a dose-dependent increase . YKL-5-124 (0-2000 nM; 24 hours; HAP1 WT cells) treatment inhibits CDK1 T-loop phosphorylation, and to a lesser extent CDK2 T-loop phosphorylation in a concentration-dependent fashion.
Synonyms	YKL-5-124 TFA

Chemical Properties

Molecular Weight	629.63
Formula	C₃₀H₃₄F₃N₇O₅
Smiles	CC1(C)N(C(N[C@@H](C2=CC=CC=C2)CN(C)C)=O)CC3=C1NN=C3NC(C4=CC=C(NC(C=C)=O)C=C4)=O.FC(F)(C(O)=O)F
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (158.82 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5882 mL	7.9412 mL	15.8823 mL	79.4117 mL
5 mM	0.3176 mL	1.5882 mL	3.1765 mL	15.8823 mL
10 mM	0.1588 mL	0.7941 mL	1.5882 mL	7.9412 mL
20 mM	0.0794 mL	0.3971 mL	0.7941 mL	3.9706 mL
50 mM	0.0318 mL	0.1588 mL	0.3176 mL	1.5882 mL
100 mM	0.0159 mL	0.0794 mL	0.1588 mL	0.7941 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

YKL5124 TFA (1957203018 free base)YKL 5 124 TFA (1957203 01 8 free base)CDK9CDK7/Mat1/CycHCDK7CDK21957203-01-8 free base1957203-01-8

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